<italic style="font-style: italic">P. gingivalis</italic> in oral-prostate axis exacerbates benign prostatic hyperplasia <italic style="font-style: italic">via</italic> IL-6/IL-6R pathway

Shuang-Ying Wang; Yi Cai; Xiao Hu; Fei Li; Xin-Hang Qian; Ling-Yun Xia; Bo Gao; Lan Wu; Wen-Zhong Xie; Jia-Min Gu; Tong Deng; Cong Zhu; Hai-Chang Jia; Wan-Qi Peng; Jiao Huang; Cheng Fang; Xian-Tao Zeng

doi:10.1186/s40779-024-00533-8

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P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

RESEARCH | Updated：2025-12-13

- P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
- P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway
- “在良性前列腺增生（BPH）领域，一项由专家领导的研究探讨了牙龈卟啉单胞菌（P.gingivalis）在BPH发展中的作用和机制。研究发现，牙龈卟啉单胞菌感染可促进BPH，这可能通过炎症和Akt信号通路影响BPH的进展。”
- MMR 2025年12卷第4期页码：469-487
- Affiliations：
  
  1.Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  2.Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  3.Department of Urology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China
  4.Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China
  5.Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China
  6.Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  7.Henan Provincial Engineering Research Center for Microecological Regulatory of Oral Environment and Oral Implantology, Kaifeng University Health Science Center, Kaifeng 475000, Henan, China
  8.School of Stomatology, Jinan University, Guangzhou 510632, China
- Author bio：
  
  *huangjiao1019@163.com;
  vitsippa@whu.edu.cn;
  zengxiantao1128@163.com
- Funds：
  
  the National Natural Science Foundation of China(82200862;82370778);the Hubei Provincial Natural Science Foundation(2022CFB681;2023AFA061;2019CFB760);the Hubei Province Health and Family Planning Scientific Research Project(WJ2023M058;WJ2019H035);the Key Scientific Research Project of Education Department of Henan Province(22A320038);the Fundamental Research Funds for the Central Universities(2042023kf1019;2042023kf0051;2042022kf0072);the Zhongnan Hospital of Wuhan University, Science Technology and Innovation Seed Fund(CXPY2022074);the Young Top-notch Talent Cultivation Program of Hubei Province
- DOI：10.1186/s40779-024-00533-8
  中图分类号：
- 纸质出版：2025-04
- Accepted：
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P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway[J]. MMR, 2025,12(4):469-487.

Cite this article as: Wang SY, Cai Y, Hu X, Li F, Qian XH, Xia LY, et al. P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway. Mil Med Res. 2024;11(1):30.
P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway[J]. MMR, 2025,12(4):469-487. DOI： 10.1186/s40779-024-00533-8.

Cite this article as: Wang SY, Cai Y, Hu X, Li F, Qian XH, Xia LY, et al. P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway. Mil Med Res. 2024;11(1):30. DOI： 10.1186/s40779-024-00533-8.

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P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

P. gingivalis in oral-prostate axis exacerbates benign prostatic hyperplasia via IL-6/IL-6R pathway

DOI：10.1186/s40779-024-00533-8