The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

De-Chao Feng; Wei-Zhen Zhu; Jie Wang; Deng-Xiong Li; Xu Shi; Qiao Xiong; Jia You; Ping Han; Shi Qiu; Qiang Wei; Lu Yang

doi:10.1186/s40779-024-00526-7

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The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

REVIEW | Updated：2025-12-13

- The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy
- The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy
- “单细胞和空间转录组学的进步使人们能够对细胞命运的复杂调控进行详细的分子理解，为个性化医疗的发展做出了重大贡献。这篇综述概述了单细胞RNA测序（scRNA-seq）在前列腺癌症研究中的意义，强调了诊断、治疗和耐药性特征的关键分子靶点。这些研究有望为去势耐受性前列腺癌症的免疫疗法和其他创新治疗策略的发展提供新的见解。”
- MMR 2025年12卷第2期页码：220-241
- Affiliations：
  
  1.Department of Urology, Institute of Urology, West China Hospital, Sichuan University, Chengdu 610041, China
  2.Division of Surgery & Interventional Science, University College London, London WC1E 6BT, UK
- Author bio：
  
  *fdcfenix@stu.scu.edu.cn; dechao.feng@ucl.ac.uk;
  weiqiang@scu.edu.cn;
  wyclefue@scu.edu.cn
- Funds：
  
  This program was supported by the Chinese Scholarship Council(202206240086);the National Natural Science Foundation of China(81974099;82170785;81974098;82170784);the National Key Research and Development Program of China(2021YFC2009303);the Program from Science and Technology Department of Sichuan Province(2021YFH0172);the Young Investigator Award of Sichuan University 2017(2017SCU04A17);the Technology Innovation Research and Development Project of Chengdu Science and Technology Bureau(2019-YF05-00296-SN);the Sichuan University–Panzhihua Science and Technology Cooperation Special Fund(2020CDPZH-4)
- DOI：10.1186/s40779-024-00526-7
  中图分类号：
- 纸质出版：2025-02
- Accepted：
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The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy[J]. MMR, 2025,12(2):220-241.

Cite this article as: Feng DC, Zhu WZ, Wang J, Li DX, Shi X, Xiong Q, et al. The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy. Mil Med Res. 2024;11(1):21.
The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy[J]. MMR, 2025,12(2):220-241. DOI： 10.1186/s40779-024-00526-7.

Cite this article as: Feng DC, Zhu WZ, Wang J, Li DX, Shi X, Xiong Q, et al. The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy. Mil Med Res. 2024;11(1):21. DOI： 10.1186/s40779-024-00526-7.

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The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

The implications of single-cell RNA-seq analysis in prostate cancer: unraveling tumor heterogeneity, therapeutic implications and pathways towards personalized therapy

DOI：10.1186/s40779-024-00526-7