Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

Kai-Wei Jia; Ren-Qi Yao; Yi-Wen Fan; Ding-Ji Zhang; Ye Zhou; Min-Jun Wang; Li-Yuan Zhang; Yue Dong; Zhi-Xuan Li; Su-Yuan Wang; Mu Wang; Yun-Hui Li; Lu-Xin Zhang; Ting Lei; Liang-Chen Gui; Shan Lu; Ying-Yun Yang; Si-Xian Wang; Yi-Zhi Yu; Yong-Ming Yao; Jin Hou

doi:10.1186/s40779-024-00524-9

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Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

RESEARCH | Updated：2025-12-13

- Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
- Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis
- “在肝脏缺血/再灌注损伤领域，本研究介绍了其研究进展。xx专家验证了干扰素-α刺激DHX58促进m6A修饰的Gpx4 mRNA翻译的猜想，这为预防肝脏I/R损伤期间的肝铁下垂提供了解决方案。”
- MMR 2025年12卷第2期页码：184-203
- Affiliations：
  
  1.National Key Laboratory of Medical Immunology & Institute of Immunology, Naval Medical University, Shanghai 200433, China
  2.Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  3.Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of the Chinese PLA General Hospital, Beijing 100853, China
  4.Center for Immunotherapy, Chinese Academy of Medical Sciences, Beijing 100005, China
- Author bio：
  
  *c_ff@sina.com;
  houjin@immunol.org
- Funds：
  
  the National Key Research and Development Program of China(2023YFC2505900);the National Natural Science Foundation of China(92269204;82171755;92369106;82171749;82171811;82073184);the Military Outstanding Youth Program(2020QN06119;01-SWKJYCJJ07;23SWAQ53);the Program of Leading Talents in Shanghai, and Shanghai Shuguang Program(20SG39)
- DOI：10.1186/s40779-024-00524-9
  中图分类号：
- 纸质出版：2025-02
- Accepted：
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Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis[J]. MMR, 2025,12(2):184-203.

Cite this article as: Jia KW, Yao RQ, Fan YW, Zhang DJ, Zhou Y, Wang MJ, et al. Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis. Mil Med Res. 2024;11(1):22.
Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis[J]. MMR, 2025,12(2):184-203. DOI： 10.1186/s40779-024-00524-9.

Cite this article as: Jia KW, Yao RQ, Fan YW, Zhang DJ, Zhou Y, Wang MJ, et al. Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis. Mil Med Res. 2024;11(1):22. DOI： 10.1186/s40779-024-00524-9.

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Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

Interferon-α stimulates DExH-box helicase 58 to prevent hepatocyte ferroptosis

DOI：10.1186/s40779-024-00524-9