Endophilin A2 controls touch and mechanical allodynia <italic style="font-style: italic">via</italic> kinesin-mediated Piezo2 trafficking

Man-Xiu Xie; Ren-Chun Lai; Yi-Bin Xiao; Xi Zhang; Xian-Ying Cao; Xiao-Yu Tian; An-Nan Chen; Zi-Yi Chen; Yan Cao; Xiao Li; Xiao-Long Zhang

doi:10.1186/s40779-024-00520-z

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Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

RESEARCH | Updated：2025-12-13

- Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
- Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking
- “在机械疼痛研究领域，KIF5B/EndoA2/Petrio2复合物对于Piezo2的传输以及维持触觉和机械超敏信号的传递至关重要。Expert EndoA2通过驱动蛋白介导的感觉神经元中的Piezo2运输来调节触觉和机械性异常性疼痛，这为治疗机械性疼痛提供了一个潜在的新靶点。”
- MMR 2025年12卷第2期页码：157-183
- Affiliations：
  
  1.Department of Anesthesiology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Guangzhou 510060, China
  2.Medical Research Institute, Guangdong Provincial People’s Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou 510080, China
  3.Pain Research Center and Department of Physiology, Zhongshan School of Medicine of Sun Yat-sen University, Guangzhou 510080, China
  4.Engineering Technology Research Center for Elderly Health Management in Hainan Province, Haikou 571137, China
  5.College of Food Science and Technology, Hainan University, Haikou 570228, China
- Author bio：
  
  *zhangxiaolong@gdph.org.cn
- Funds：
  
  the National Natural Science Foundation of China(82271241;82001172;81801112);the Guangdong Basic and Applied Basic Research Foundation(2022A1515012389;2022A1515012543);the Young Talent Support Project of Guangzhou Association for Science and Technology(QT20220101169);the Excellent Young Talents Project of Guangdong Provincial People’s Hospital, Guangdong Academy of Medical Sciences(KY012021188);the Science and Technology Projects in Guangzhou(202201010792)
- DOI：10.1186/s40779-024-00520-z
  中图分类号：
- 纸质出版：2025-02
- Accepted：
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Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking[J]. MMR, 2025,12(2):157-183.

Cite this article as: Xie MX, Lai RC, Xiao YB, Zhang X, Cao XY, Tian XY, et al. Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking. Mil Med Res. 2024;11(1):17.
Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking[J]. MMR, 2025,12(2):157-183. DOI： 10.1186/s40779-024-00520-z.

Cite this article as: Xie MX, Lai RC, Xiao YB, Zhang X, Cao XY, Tian XY, et al. Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking. Mil Med Res. 2024;11(1):17. DOI： 10.1186/s40779-024-00520-z.

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Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

Endophilin A2 controls touch and mechanical allodynia via kinesin-mediated Piezo2 trafficking

DOI：10.1186/s40779-024-00520-z