Acellular scaffold-based approach for <italic style="font-style: italic">in situ</italic> genetic engineering of host T-cells in solid tumor immunotherapy

Hiren Y. Dandia; Mamatha M. Pillai; Deepak Sharma; Meghna Suvarna; Neha Dalal; Ayush Madhok; Arvind Ingle; Shubhada V. Chiplunkar; Sanjeev Galande; Prakriti Tayalia

doi:10.1186/s40779-023-00503-6

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Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy

RESEARCH | Updated：2025-02-24

- Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy
- Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy
- “靶向T细胞治疗在治疗血液系统恶性肿瘤方面取得了重大进展，但在实体瘤方面面临挑战。专家们开发了一种基于聚乙二醇的3D支架系统，该系统提供了一种创新的原位定位方法，用于编程T细胞以靶向实体瘤，为T细胞的体外操作提供了一个可行的替代方案。”
- MMR 2025年12卷第1期页码：16-35
- Affiliations：
  
  1.Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
  2.Radiation Biology and Health Sciences Division, Bhabha Atomic Research Centre, Mumbai 400085, India
  3.Centre of Excellence in Epigenetics, Department of Biology, Indian Institute of Science Education and Research, Pune 411008, India
  4.Advanced Centre for Treatment, Research and Education in Cancer (ACTREC), Tata Memorial Centre, Kharghar, Mumbai 410210, India
- Author bio：
  
  *prakriti@iitb.ac.in
- Funds：
  
  We would like to thank all the funding agencies that have made this work possible: Department of Biotechnology (DBT, Govt of India)(BT/PR31315/MED/32/667/2019);DBT along with Wadhwani Research Center for Bioengineering, IIT Bombay(BT/INF/22/SP23026/2017);Department of Biotechnology (DBT, Govt of India)(BT/INF/22/SP17358/2016)
- DOI：10.1186/s40779-023-00503-6
  中图分类号：
- 纸质出版：2025-01
- Accepted：
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Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy[J]. MMR, 2025,12(1):16-35.

Cite this article as: Dandia HY, Pillai MM, Sharma D, Suvarna M, Dalal N, Madhok A, et al. Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy. Mil Med Res. 2024;11(1):3.
Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy[J]. MMR, 2025,12(1):16-35. DOI： 10.1186/s40779-023-00503-6.

Cite this article as: Dandia HY, Pillai MM, Sharma D, Suvarna M, Dalal N, Madhok A, et al. Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy. Mil Med Res. 2024;11(1):3. DOI： 10.1186/s40779-023-00503-6.

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Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy

Acellular scaffold-based approach for in situ genetic engineering of host T-cells in solid tumor immunotherapy

DOI：10.1186/s40779-023-00503-6