Bioengineered skin organoids: from development to applications

Zi-Xuan Hong; Shun-Tian Zhu; Hao Li; Jing-Zhi Luo; Yu Yang; Yang An; Xi Wang; Kai Wang

doi:10.1186/s40779-023-00475-7

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Bioengineered skin organoids: from development to applications

REVIEW | Updated：2025-12-13

- Bioengineered skin organoids: from development to applications
- Bioengineered skin organoids: from development to applications
- MMR 2024年11卷第3期页码：449-466
- Affiliations：
  
  1.Department of Physiology and Pathophysiology, School of Basic Medical Sciences, State Key Laboratory of Vascular Homeostasis and Remodeling, Peking University, Beijing 100191, China
  2.Department of Hepatopancreatobiliary Surgery, the Third Affiliated Hospital of Soochow University, Changzhou 213000, Jiangsu, China
  3.Department of Plastic Surgery, Peking University Third Hospital, Beijing 100191, China
  4.Clinical Stem Cell Research Center, Peking University Third Hospital, Beijing 100191, China
  5.State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, Beijing 100037, China
  6.Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Capital Medical University, Beijing 100050, China
- Author bio：
  
  *anyangdoctor@163.com;
  Wangxi-nicky@pku.edu.cn;
  kai.wang88@pku.edu.cn
- Funds：
  
  the National Key Research and Development Program of China(2022YFA1104800);the Beijing Nova Program(20220484100);the National Natural Science Foundation of China(81873939);the Open Research Fund of State Key Laboratory of Cardiovascular Disease, Fuwai Hospital(2022KF-04);the Clinical Medicine Plus X-Young Scholars Project, Peking University(PKU2022LCXQ003);the Emerging Engineering Interdisciplinary-Young Scholars Project, Peking University;the Fundamental Research Funds for the Central Universities(PKU2023XGK011);the Open Research Fund of State Key Laboratory of Digital Medical Engineering, Southeast University(2023K-01);the Open Research Fund of Beijing Key Laboratory of Metabolic Disorder Related Cardiovascular Disease, Beijing, China(DXWL2023-01);the Science and Technology Bureau Foundation Application Project of Changzhou(CJ20220118)
- DOI：10.1186/s40779-023-00475-7
  中图分类号：
- 纸质出版：2024-06
- Accepted：
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Bioengineered skin organoids: from development to applications[J]. MMR, 2024,11(3):449-466.

Cite this article as: Hong ZX, Zhu ST, Li H, Luo JZ, Yang Y, An Y, et al. Bioengineered skin organoids: from development to applications. Mil Med Res. 2023;10(1):40.
Bioengineered skin organoids: from development to applications[J]. MMR, 2024,11(3):449-466. DOI： 10.1186/s40779-023-00475-7.

Cite this article as: Hong ZX, Zhu ST, Li H, Luo JZ, Yang Y, An Y, et al. Bioengineered skin organoids: from development to applications. Mil Med Res. 2023;10(1):40. DOI： 10.1186/s40779-023-00475-7.

摘要

Abstract

Signifcant advancements have been made in recent years in the development of highly sophisticated skin organoids. Serving as three-dimensional (3D) models that mimic human skin

these organoids have evolved into complex structures and are increasingly recognized as efective alternatives to traditional culture models and human skin due to their ability to overcome the limitations of two-dimensional (2D) systems and ethical concerns. The inherent plasticity of skin organoids allows for their construction into physiological and pathological models

enabling the study of skin development and dynamic changes. This review provides an overview of the pivotal work in the progression from 3D layered epidermis to cyst-like skin organoids with appendages. Furthermore

it highlights the latest advancements in organoid construction facilitated by state-of-the-art engineering techniques

such as 3D printing and microfuidic devices. The review also summarizes and discusses the diverse applications of skin organoids in developmental biology

disease modelling

regenerative medicine

and personalized medicine

while considering their prospects and limitations.

关键词

Keywords

references

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