Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

Ying Chen; Xing Wang; Sheng Tao; Qi Wang; Pan-Qin Ma; Zi-Biao Li; Yun-Long Wu; Da-Wei Li

doi:10.1186/s40779-023-00473-9

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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties

REVIEW | Updated：2025-12-13

- Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties
- Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties
- MMR 2024年11卷第4期页码：543-566
- Affiliations：
  
  1.Fujian Provincial Key Laboratory of Innovative Drug Target Research and State Key Laboratory of Cellular Stress Biology, School of Pharmaceutical Sciences, Xiamen University, Xiamen 361102, Fujian, China
  2.Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100090, China
  3.University of Chinese Academy of Sciences, Beijing 100049, China
  4.Senior Department of Orthopedics, the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100091, China
  5.Institute of Materials Research and Engineering, A*STAR (Agency for Science, Technology and Research), Singapore 138634, Singapore
- Author bio：
  
  Ying Chen, Xing Wang and Sheng Tao contributed equally to this work
  *lizb@imre.a-star.edu.sg;
  wuyl@xmu.edu.cn;
  ldw309@126.com
- Funds：
  
  the National Key Research and Development Program of China(2020YFA0908100);the National Natural Science Foundation of China(81972081;81971724;81773661;51973226;82173750);the Youth Innovation Promotion Association CAS(2019031);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2020R01018;2021B42001;2022C02037);the A*STAR Research Grant for Support of This Project
- DOI：10.1186/s40779-023-00473-9
  中图分类号：
- 纸质出版：2024-08
- Accepted：
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Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties[J]. MMR, 2024,11(4):543-566.

Cite this article as: Chen Y, Wang X, Tao S, Wang Q, Ma PQ, Li ZB, et al. Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties. Mil Med Res. 2023;10(1):37.
Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties[J]. MMR, 2024,11(4):543-566. DOI： 10.1186/s40779-023-00473-9.

Cite this article as: Chen Y, Wang X, Tao S, Wang Q, Ma PQ, Li ZB, et al. Research advances in smart responsive-hydrogel dressings with potential clinical diabetic wound healing properties. Mil Med Res. 2023;10(1):37. DOI： 10.1186/s40779-023-00473-9.

摘要

Abstract

The treatment of chronic and non-healing wounds in diabetic patients remains a major medical problem. Recent reports have shown that hydrogel wound dressings might be an effective strategy for treating diabetic wounds due to their excellent hydrophilicity

good drug-loading ability and sustained drug release properties. As a typical example

hyaluronic acid dressing (Healoderm) has been demonstrated in clinical trials to improve wound-healing efficiency and healing rates for diabetic foot ulcers. However

the drug release and degradation behavior of clinically-used hydrogel wound dressings cannot be adjusted according to the wound microenvironment. Due to the intricacy of diabetic wounds

antibiotics and other medications are frequently combined with hydrogel dressings in clinical practice

although these medications are easily hindered by the hostile environment. In this case

scientists have created responsive-hydrogel dressings based on the microenvironment features of diabetic wounds (such as high glucose and low pH) or combined with external stimuli (such as light or magnetic field) to achieve controllable drug release

gel degradation

and microenvironment improvements in order to overcome these clinical issues. These responsive-hydrogel dressings are anticipated to play a significant role in diabetic therapeutic wound dressings. Here

we review recent advances on responsive-hydrogel dressings towards diabetic wound healing

with focus on hydrogel structure design

the principle of responsiveness

and the behavior of degradation. Last but not least

the advantages and limitations of these responsive-hydrogels in clinical applications will also be discussed. We hope that this review will contribute to furthering progress on hydrogels as an improved dressing for diabetic wound healing and practical clinical application.

关键词

Keywords

references

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