Single-cell transcriptome profiling of sepsis identifies <italic style="font-style: italic">HLA-DR<sup>low</sup></italic><italic style="font-style: italic">S100A<sup>high</sup></italic> monocytes with immunosuppressive function

Ren-Qi Yao; Peng-Yue Zhao; Zhi-Xuan Li; Yu-Yang Liu; Li-Yu Zheng; Yu Duan; Lu Wang; Rong-Li Yang; Hong-Jun Kang; Ji-Wei Hao; Jing-Yan Li; Ning Dong; Yao Wu; Xiao-Hui Du; Feng Zhu; Chao Ren; Guo-Sheng Wu; Zhao-Fan Xia; Yong-Ming Yao

doi:10.1186/s40779-023-00462-y

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Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function

RESEARCH | Updated：2024-01-23

- Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function
- Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function
- MMR 2023年10卷第6期页码：778-797
- Affiliations：
  
  1.Translational Medicine Research Center, Medical Innovation Research Division and the Fourth Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  2.Department of Burn Surgery, the First Affiliated Hospital of Naval Medical University, Shanghai 200433, China
  3.Research Unit of Key Techniques for Treatment of Burns and Combined Burns and Trauma Injury, Chinese Academy of Medical Sciences, Beijing 100730, China
  4.Department of General Surgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  5.Department of Neurosurgery, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  6.Department of Critical Care Medicine, the First Medical Center of Chinese PLA General Hospital, Beijing 100853, China
  7.Intensive Care Unit, Dalian Municipal Central Hospital Affiliated Dalian University of Technology, Dalian 116033, Liaoning, China
  8.Department of Emergency, the Second Hospital of Hebei Medical University, Shijiazhuang 050000, China
  9.Department of Pulmonary and Critical Care Medicine, Beijing Chaoyang Hospital, Capital Medical University, Beijing 100020, China
- Author bio：
  
  *: drwuguosheng@sina.cn;
  xiazhaofan_smmu@163.com;
  c_ff@sina.com
- Funds：
  
  the Key Project of National Natural Science Foundation of China(82130062;82241062;81930057);National Key Research and Development Program of China(2022YFA1104604);the Key Project of Military Medical Innovation Program of Chinese PLA(18CXZ026;BLJ18J006);the CAMS Innovation Fund for Medical Sciences(2019-I2M-5-076)
- DOI：10.1186/s40779-023-00462-y
  中图分类号：
- 纸质出版：2023-12
- Accepted：
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Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function[J]. MMR, 2023,10(6):778-797.

Cite this article as: Yao RQ, Zhao PY, Li ZX, Liu YY, Zheng LY, Duan Y, et al. Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function. Mil Med Res. 2023;10(1):27.
Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function[J]. MMR, 2023,10(6):778-797. DOI： 10.1186/s40779-023-00462-y.

Cite this article as: Yao RQ, Zhao PY, Li ZX, Liu YY, Zheng LY, Duan Y, et al. Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function. Mil Med Res. 2023;10(1):27. DOI： 10.1186/s40779-023-00462-y.

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Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function

Single-cell transcriptome profiling of sepsis identifies HLA-DRlowS100Ahigh monocytes with immunosuppressive function

DOI：10.1186/s40779-023-00462-y

Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function

Single-cell transcriptome profiling of sepsis identifies HLA-DR^lowS100A^high monocytes with immunosuppressive function