Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity
Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity
- MMR 2023年10卷第4期 页码：499-528
- Affiliations：
1.Department of Orthopedics, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, China
2.Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration, Wuhan 430022, China
3.Department of Chemical and Biomolecular Engineering, Ohio University, Athens, OH 45701, USA
4.Key Laboratory of Biorheological Science and Technology, Ministry of Education College of Bioengineering, Chongqing University, Chongqing 400044, China
5.Department of Plastic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02152, USA
6.Department of Orthopaedics, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China
7.Department of Physics, Center for Hybrid Nanostructure (CHyN), University of Hamburg, Hamburg 22761, Germany
8.Joint Laboratory of Optofluidic Technology and System, National Center for International Research on Green Optoelectronics, South China Academy of Advanced Optoelectronics, South China Normal University, Guangzhou 510006, China
9.Skeletal Biology Laboratory, Department of Orthopedic Surgery, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02120, USA
10.Harvard Stem Cell Institute, Harvard University, Cambridge, MA 02138, USA
- Author bio：
* qianfeng@cqu.edu.cn;
szhou@bwh.harvard.edu;
liuguohui@hust.edu.cn
- Funds：the National Natural Science Foundation of China(82002313;82072444;31900963);the Hubei Province Key Laboratory of Oral and Maxillofacial Development and Regeneration(2020kqhm008;2021kqhm002);the Health Commission of Hubei Province(WJ2019Z009);the Wuhan Union Hospital "Pharmaceutical Technology Nursing" special fund(2019xhyn021);the China Postdoctoral Science Foundation(2021TQ0118);the Gillian Reny Stepping Strong Center for Trauma Innovation Research Scholars Fund(110768)
DOI：10.1186/s40779-022-00426-8
中图分类号：-
纸质出版：2023-08
- Accepted：
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Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity[J]. MMR, 2023,10(4):499-528.
Xiong Y, Mi BB, Lin Z, Hu YQ, Yu L, Zha KK, et al. Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity. Mil Med Res. 2022;9(1):65.
Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity[J]. MMR, 2023,10(4):499-528. DOI： 10.1186/s40779-022-00426-8.
Xiong Y, Mi BB, Lin Z, Hu YQ, Yu L, Zha KK, et al. Role of the immune microenvironment in bone, cartilage, and soft tissue regeneration: from mechanism to therapeutic opportunity. Mil Med Res. 2022;9(1):65. DOI： 10.1186/s40779-022-00426-8.
摘要
Abstract
Bone
cartilage
and soft tissue regeneration is a complex spatiotemporal process recruiting a variety of cell types
whose activity and interplay must be precisely mediated for effective healing post-injury. Although extensive strides have been made in the understanding of the immune microenvironment processes governing bone
cartilage
and soft tissue regeneration
effective clinical translation of these mechanisms remains a challenge. Regulation of the immune microenvironment is increasingly becoming a favorable target for bone
cartilage
and soft tissue regeneration; therefore
an in-depth understanding of the communication between immune cells and functional tissue cells would be valuable. Herein
we review the regulatory role of the immune microenvironment in the promotion and maintenance of stem cell states in the context of bone
cartilage
and soft tissue repair and regeneration. We discuss the roles of various immune cell subsets in bone
cartilage
and soft tissue repair and regeneration processes and introduce novel strategies
for example
biomaterial-targeting of immune cell activity
aimed at regulating healing. Understanding the mechanisms of the crosstalk between the immune microenvironment and regeneration pathways may shed light on new therapeutic opportunities for enhancing bone
cartilage
and soft tissue regeneration through regulation of the immune microenvironment.
关键词
Keywords
references
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