Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3

Qin Zhang; Fang-Xing Yu; Yang-Lin Wu; Cheng-Yuan Yang; Nai-Cheng Liu; Xu Zhu; Pi-Ming Zhao; Zhong-Ya Wang; Jun Lin

doi:10.1186/s40779-022-00393-0

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Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3

LETTER TO THE EDITOR | Updated：2023-07-21

- Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3
- Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3
- MMR 2023年10卷第3期页码：418-420
- Affiliations：
  
  1.Department of Orthopaedics, Suzhou Dushu Lake Hospital, Dushu Lake Hospital Affiliated to Soochow University, Medical Center of Soochow University, Suzhou 215001, Jiangsu, China
  2.Department of Orthopaedics, the First Affiliated Hospital of Soochow University, Soochow University, Suzhou 215006, Jiangsu, China
  3.Department of Gene Therapy, CureGenetics Co., Ltd., Suzhou 215021, Jiangsu, China
- Author bio：
  
  * linjun@suda.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(81871789;82172387);the Natural Science Foundation of Jiangsu Province(BK20180052);the Gusu Health Talents Program(GSWS2020023)
- DOI：10.1186/s40779-022-00393-0
  中图分类号：
- 纸质出版：2023-06
- Accepted：
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Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3[J]. MMR, 2023,10(3):418-420.

Cite this article as: Zhang Q, Yu FX, Wu YL, Yang CY, Liu NC, Zhu X, et al. Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3. Mil Med Res. 2022;9(1):34.
Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3[J]. MMR, 2023,10(3):418-420. DOI： 10.1186/s40779-022-00393-0.

Cite this article as: Zhang Q, Yu FX, Wu YL, Yang CY, Liu NC, Zhu X, et al. Novel gene therapy for rheumatoid arthritis with single local injection: adeno-associated virus-mediated delivery of A20/TNFAIP3. Mil Med Res. 2022;9(1):34. DOI： 10.1186/s40779-022-00393-0.

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Vande Walle L , van Opdenbosch N , Jacques P , Fossoul A , Verheugen E , Vogel P , et al . Negative regulation of the NLRP3 inflammasome by A20 protects against arthritis . Nature . 2014 ; 512 ( 7512 ): 69 - 73 .

Matmati M , Jacques P , Maelfait J , Verheugen E , Kool M , Sze M , et al . A20 (TNFAIP3) deficiency in myeloid cells triggers erosive polyarthritis resembling rheumatoid arthritis . Nat Genet . 2011 ; 43 ( 9 ): 908 - 12 .

Polykratis A , Martens A , Eren RO , Shirasaki Y , Yamagishi M , Yamaguchi Y , et al . A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain . Nat Cell Biol . 2019 ; 21 ( 6 ): 731 - 42 .

Duong BH , Onizawa M , Oses-Prieto JA , Advincula R , Burlingame A , Malynn BA , et al . A20 restricts ubiquitination of pro-interleukin-1β protein complexes and suppresses NLRP3 inflammasome activity . Immunity . 2015 ; 42 ( 1 ): 55 - 67 .

Kang WS , Kwon JS , Kim HB , Jeong HY , Kang HJ , Jeong MH , et al . A macrophage-specific synthetic promoter for therapeutic application of adiponectin . Gene Ther . 2014 ; 21 ( 4 ): 353 - 62 .

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