Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury

Yan Wang; Hong-Qian Lv; Xuan Chao; Wen-Xin Xu; Yun Liu; Gui-Xia Ling; Peng Zhang

doi:10.1186/s40779-022-00376-1

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Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury

REVIEW | Updated：2023-02-28

- Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury
- Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury
- 解放军医学杂志（英文版） 2022年9卷第5期页码：603-617
- Affiliations：
  
  1.Shenyang Pharmaceutical University, 103 Wenhua Road, Shenyang 110016, China
  2.Center for Nanotechnology in Drug Delivery, Eshelman School of Pharmacy, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA
- Author bio：
  
  * pharlab@163.com;
  zhangpenglab@163.com
- Funds：
- DOI：10.1186/s40779-022-00376-1
  中图分类号：
- 纸质出版：2022-10
- Accepted：
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Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury[J]. 解放军医学杂志（英文版）, 2022,9(5):603-617.

Wang Y, Lv HQ, Chao X, Xu WX, Liu Y, Ling GX, et al. Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury. Mil Med Res. 2022;9(1):16.
Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury[J]. 解放军医学杂志（英文版）, 2022,9(5):603-617. DOI： 10.1186/s40779-022-00376-1.

Wang Y, Lv HQ, Chao X, Xu WX, Liu Y, Ling GX, et al. Multimodal therapy strategies based on hydrogels for the repair of spinal cord injury. Mil Med Res. 2022;9(1):16. DOI： 10.1186/s40779-022-00376-1.

摘要

Abstract

Spinal cord injury (SCI) is a serious traumatic disease of the central nervous system

which can give rise to the loss of motor and sensory function. Due to its complex pathological mechanism

the treatment of this disease still faces a huge challenge. Hydrogels with good biocompatibility and biodegradability can well imitate the extracellular matrix in the microenvironment of spinal cord. Hydrogels have been regarded as promising SCI repair material in recent years and continuous studies have confirmed that hydrogel-based therapy can effectively eliminate inflammation and promote spinal cord repair and regeneration to improve SCI. In this review

hydrogel-based multimodal therapeutic strategies to repair SCI are provided

and a combination of hydrogel scaffolds and other therapeutic modalities are discussed

with particular emphasis on the repair mechanism of SCI.

关键词

Keywords

references

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