Military traumatic brain injury: a challenge straddling neurology and psychiatry
Military traumatic brain injury: a challenge straddling neurology and psychiatry
- 解放军医学杂志（英文版） 2022年9卷第6期 页码：686-704
- Affiliations：
1.Department of Psychiatry, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
2.the Key Laboratory of Mental Disorder’s Management in Zhejiang Province, Hangzhou 310003, China
3.Brain Research Institute of Zhejiang University, Hangzhou 310003, China
4.Zhejiang Engineering Center for Mathematical Mental Health, Hangzhou 310003, China
5.MOE Frontier Science Center for Brain Science and Brain-Machine Integration, Zhejiang University, Hangzhou 310003, China
- Author bio：
* dorhushaohua@zju.edu.cn;
laijianbo@zju.edu.cn
- Funds：the Zhejiang Provincial Key Research and Development Program(2021C03107)
DOI：10.1186/s40779-021-00363-y
中图分类号：-
纸质出版：2022-12
- Accepted：
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Military traumatic brain injury: a challenge straddling neurology and psychiatry[J]. 解放军医学杂志（英文版）, 2022,9(6):686-704.
Kong LZ, Zhang RL, Hu SH, Lai JB. Military traumatic brain injury: a challenge straddling neurology and psychiatry. Mil Med Res. 2022;9(1):2.
Military traumatic brain injury: a challenge straddling neurology and psychiatry[J]. 解放军医学杂志（英文版）, 2022,9(6):686-704. DOI： 10.1186/s40779-021-00363-y.
Kong LZ, Zhang RL, Hu SH, Lai JB. Military traumatic brain injury: a challenge straddling neurology and psychiatry. Mil Med Res. 2022;9(1):2. DOI： 10.1186/s40779-021-00363-y.
摘要
Abstract
Military psychiatry
a new subcategory of psychiatry
has become an invaluable
intangible effect of the war. In this review
we begin by examining related military research
summarizing the related epidemiological data
neuropathology
and the research achievements of diagnosis and treatment technology
and discussing its comorbidity and sequelae. To date
advances in neuroimaging and molecular biology have greatly boosted the studies on military traumatic brain injury (TBI). In particular
in terms of pathophysiological mechanisms
several preclinical studies have identified abnormal protein accumulation
blood–brain barrier damage
and brain metabolism abnormalities involved in the development of TBI. As an important concept in the field of psychiatry
TBI is based on organic injury
which is largely different from many other mental disorders. Therefore
military TBI is both neuropathic and psychopathic
and is an emerging challenge at the intersection of neurology and psychiatry.
关键词
Keywords
references
Myers CS . A contribution to the study of shell shock . Lancet . 1915 ; 185 ( 4772 ): 316 - 20 .
Mott FW . The effects of high explosives upon the central nervous system . Lancet . 1916 ; 187 ( 4824 ): 331 - 8 .
Battle casualties: incidence, mortality, and logistic considerations . JAMA . 1952 ; 150 ( 13 ): 1357 .
Hs M . Punch drunk . JAMA . 1928 ; 91 : 1103 - 7 .
Johnson J . Organic psychosyndromes due to boxing . Br J Psychiatry . 1969 ; 115 ( 518 ): 45 - 53 .
Omalu BI , DeKosky ST , Minster RL , Kamboh MI , Hamilton RL , Wecht CH . Chronic traumatic encephalopathy in a National Football League player . Neurosurgery . 2005 ; 57 ( 1 ): 128–34 (discussion-34) .
Vaishnavi S , Rao V , Fann JR . Neuropsychiatric problems after traumatic brain injury: unraveling the silent epidemic . Psychosomatics . 2009 ; 50 ( 3 ): 198 - 205 .
Kotapka MJ , Graham DI , Adams JH , Gennarelli TA . Hippocampal pathology in fatal non-missile human head injury . Acta Neuropathol . 1992 ; 83 ( 5 ): 530 - 4 .
Wojcik BE , Stein CR , Bagg K , Humphrey RJ , Orosco J . Traumatic brain injury hospitalizations of U.S. army soldiers deployed to Afghanistan and Iraq . Am J Prev Med . 2010 ; 38 ( 1 Suppl ): S108 - 16 .
Boyle E , Cancelliere C , Hartvigsen J , Carroll LJ , Holm LW , Cassidy JD . Systematic review of prognosis after mild traumatic brain injury in the military: results of the International Collaboration on Mild Traumatic Brain Injury Prognosis . Arch Phys Med Rehabil . 2014 ; 95 ( 3 Suppl ): S230 - 7 .
Terrio H , Brenner LA , Ivins BJ , Cho JM , Helmick K , Schwab K , et al . Traumatic brain injury screening: preliminary findings in a US Army Brigade Combat Team . J Head Trauma Rehabil . 2009 ; 24 ( 1 ): 14 - 23 .
Betz J , Zhuo J , Roy A , Shanmuganathan K , Gullapalli RP . Prognostic value of diffusion tensor imaging parameters in severe traumatic brain injury . J Neurotrauma . 2012 ; 29 ( 7 ): 1292 - 305 .
Rona RJ , Jones M , Fear NT , Hull L , Murphy D , Machell L , et al . Mild traumatic brain injury in UK military personnel returning from Afghanistan and Iraq: cohort and cross-sectional analyses . J Head Trauma Rehabil . 2012 ; 27 ( 1 ): 33 - 44 .
Garber BG , Rusu C , Zamorski MA . Deployment-related mild traumatic brain injury, mental health problems, and post-concussive symptoms in Canadian Armed Forces personnel . BMC Psychiatry . 2014 ; 14 : 325 .
Bhattrai A , Irimia A , van Horn JD . Neuroimaging of traumatic brain injury in military personnel: an overview . J Clin Neurosci . 2019 ; 70 : 1 - 10 .
Kim LH , Quon JL , Sun FW , Wortman KM , Adamson MM , Harris OA . Traumatic brain injury among female veterans: a review of sex differences in military neurosurgery . Neurosurg Focus . 2018 ; 45 ( 6 ): E16 .
Moss WC , King MJ , Blackman EG . Skull flexure from blast waves: a mechanism for brain injury with implications for helmet design . Phys Rev Lett . 2009 ; 103 ( 10 ): 108702 .
Cernak I , Noble-Haeusslein LJ . Traumatic brain injury: an overview of pathobiology with emphasis on military populations . J Cereb Blood Flow Metab . 2010 ; 30 ( 2 ): 255 - 66 .
Critchley M . Medical aspects of boxing, particularly from a neurological standpoint . Br Med J . 1957 ; 1 ( 5015 ): 357 - 62 .
Jones C , Harasym J , Miguel-Cruz A , Chisholm S , Smith-Macdonald L , Bremault-Phillips S . Neurocognitive assessment tools for military personnel with mild traumatic brain injury: scoping literature review . JMIR Ment Health . 2021 ; 8 ( 2 ): e26360 .
Mccrory P , Meeuwisse W , Johnston K , Dvorak J , Aubry M , Molloy M , et al . Consensus statement on concussion in sport—the 3rd international conference on concussion in sport held in Zurich, November 2008 . J Sci Med Sport . 2009 ; 12 ( 3 ): 340 - 51 .
Reith FC , van den Brande R , Synnot A , Gruen R , Maas AI . The reliability of the Glasgow Coma Scale: a systematic review . Intensive Care Med . 2016 ; 42 ( 1 ): 3 - 15 .
Tschiffely AE , Haque A , Haran FJ , Cunningham CA , Mehalick ML , May T , et al . Recovery from mild traumatic brain injury following uncomplicated mounted and dismounted blast: a natural history approach . Mil Med . 2018 ; 183 ( 3–4 ): e140 - 7 .
Korn A , Golan H , Melamed I , Pascual-Marqui R , Friedman A . Focal cortical dysfunction and blood–brain barrier disruption in patients with Postconcussion syndrome . J Clin Neurophysiol . 2005 ; 22 ( 1 ): 1 - 9 .
Iwata A , Stys PK , Wolf JA , Chen XH , Taylor AG , Meaney DF , et al . Traumatic axonal injury induces proteolytic cleavage of the voltage-gated sodium channels modulated by tetrodotoxin and protease inhibitors . J Neurosci . 2004 ; 24 ( 19 ): 4605 - 13 .
Giza CC , Hovda DA . The neurometabolic cascade of concussion . J Athl Train . 2001 ; 36 ( 3 ): 228 - 35 .
Wu Y , Wu H , Guo X , Pluimer B , Zhao Z . Blood-brain barrier dysfunction in mild traumatic brain injury: evidence from preclinical murine models . Front Physiol . 2020 ; 11 : 1030 .
Povlishock JT . Pathobiology of traumatically induced axonal injury in animals and man . Ann Emerg Med . 1993 ; 22 ( 6 ): 980 - 6 .
Povlishock JT , Marmarou A , Mcintosh T , Trojanowski JQ , Moroi J . Impact acceleration injury in the rat: evidence for focal axolemmal change and related neurofilament sidearm alteration . J Neuropathol Exp Neurol . 1997 ; 56 ( 4 ): 347 - 59 .
Maxwell WL , Povlishock JT , Graham DL . A mechanistic analysis of nondisruptive axonal injury: a review . J Neurotrauma . 1997 ; 14 ( 7 ): 419 - 40 .
Bell RS , Vo AH , Neal CJ , Tigno J , Roberts R , Mossop C , et al . Military traumatic brain and spinal column injury: a 5-year study of the impact blast and other military grade weaponry on the central nervous system . J Trauma . 2009 ; 66 ( 4 Suppl ): S104 - 11 .
Goldstein LE , Fisher AM , Tagge CA , Zhang XL , Velisek L , Sullivan JA , et al . Chronic traumatic encephalopathy in blast-exposed military veterans and a blast neurotrauma mouse model . Sci Transl Med . 2012 ; 4 ( 134 ): 134ra60 .
Bauman RA , Ling G , Tong L , Januszkiewicz A , Agoston D , Delanerolle N , et al . An introductory characterization of a combat-casualty-care relevant swine model of closed head injury resulting from exposure to explosive blast . J Neurotrauma . 2009 ; 26 ( 6 ): 841 - 60 .
Hussain SF , Raza Z , Cash ATG , Zampieri T , Mazzoli RA , Kardon RH , et al . Traumatic brain injury and sight loss in military and veteran populations—a review . Mil Med Res . 2021 ; 8 ( 1 ): 42 .
Lu J , Ng KC , Ling G , Wu J , Poon DJ , Kan EM , et al . Effect of blast exposure on the brain structure and cognition in Macaca fascicularis . J Neurotrauma . 2012 ; 29 ( 7 ): 1434 - 54 .
Peskind ER , Petrie EC , Cross DJ , Pagulayan K , Mccraw K , Hoff D , et al . Cerebrocerebellar hypometabolism associated with repetitive blast exposure mild traumatic brain injury in 12 Iraq war Veterans with persistent post-concussive symptoms . Neuroimage . 2011 ; 54 ( Suppl 1 ): S76 - 82 .
Petrie EC , Cross DJ , Yarnykh VL , Richards T , Martin NM , Pagulayan K , et al . Neuroimaging, behavioral, and psychological sequelae of repetitive combined blast/impact mild traumatic brain injury in Iraq and Afghanistan war veterans . J Neurotrauma . 2014 ; 31 ( 5 ): 425 - 36 .
McKee AC , Robinson ME . Military-related traumatic brain injury and neurodegeneration . Alzheimers Dement . 2014 ; 10 ( 3 Suppl ): S242 - 53 .
Omalu B , Hammers JL , Bailes J , Hamilton RL , Kamboh MI , Webster G , et al . Chronic traumatic encephalopathy in an Iraqi war veteran with posttraumatic stress disorder who committed suicide . Neurosurg Focus . 2011 ; 31 ( 5 ): E3 .
Logsdon AF , Meabon JS , Cline MM , Bullock KM , Raskind MA , Peskind ER , et al . Blast exposure elicits blood–brain barrier disruption and repair mediated by tight junction integrity and nitric oxide dependent processes . Sci Rep . 2018 ; 8 ( 1 ): 11344 .
Bashir A , Abebe ZA , Mcinnes KA , Button EB , Tatarnikov I , Cheng WH , et al . Increased severity of the CHIMERA model induces acute vascular injury, sub-acute deficits in memory recall, and chronic white matter gliosis . Exp Neurol . 2020 ; 324 : 113116 .
Tagge CA , Fisher AM , Minaeva OV , Gaudreau-Balderrama A , Moncaster JA , Zhang XL , et al . Concussion, microvascular injury, and early tauopathy in young athletes after impact head injury and an impact concussion mouse model . Brain . 2018 ; 141 ( 2 ): 422 - 58 .
Li S , Li H , He XF , Li G , Zhang Q , Liang FY , et al . Transgenic overexpression of slit2 enhances disruption of blood–brain barrier and increases cell death after traumatic brain injury in mice . Neurosci Lett . 2016 ; 631 : 85 - 90 .
Bordone MP , Salman MM , Titus HE , Amini E , Andersen JV , Chakraborti B , et al . The energetic brain—a review from students to students . J Neurochem . 2019 ; 151 ( 2 ): 139 - 65 .
Dienel GA . Fueling and imaging brain activation . ASN Neuro . 2012 ; 4 ( 5 ): AN20120021 .
Ebert D , Haller RG , Walton ME . Energy contribution of octanoate to intact rat brain metabolism measured by 13C nuclear magnetic resonance spectroscopy . J Neurosci . 2003 ; 23 ( 13 ): 5928 - 35 .
Glenn TC , Kelly DF , Boscardin WJ , Mcarthur DL , Vespa P , Oertel M , et al . Energy dysfunction as a predictor of outcome after moderate or severe head injury: indices of oxygen, glucose, and lactate metabolism . J Cereb Blood Flow Metab . 2003 ; 23 ( 10 ): 1239 - 50 .
Xing G , Ren M , Watson WD , O’neill JT , Verma A . Traumatic brain injury-induced expression and phosphorylation of pyruvate dehydrogenase: a mechanism of dysregulated glucose metabolism . Neurosci Lett . 2009 ; 454 ( 1 ): 38 - 42 .
Simard JM , Kent TA , Chen M , Tarasov KV , Gerzanich V . Brain oedema in focal ischaemia: molecular pathophysiology and theoretical implications . Lancet Neurol . 2007 ; 6 ( 3 ): 258 - 68 .
Kempski O . Cerebral edema . Semin Nephrol . 2001 ; 21 ( 3 ): 303 - 7 .
Young W , Rappaport ZH , Chalif DJ , Flamm ES . Regional brain sodium, potassium, and water changes in the rat middle cerebral artery occlusion model of ischemia . Stroke . 1987 ; 18 ( 4 ): 751 - 9 .
Hacke W , Kaste M , Fieschi C , Von Kummer R , Davalos A , Meier D , et al . Randomised double-blind placebo-controlled trial of thrombolytic therapy with intravenous alteplase in acute ischaemic stroke (ECASS II). Second European-Australasian Acute Stroke Study Investigators . Lancet . 1998 ; 352 ( 9136 ): 1245 - 51 .
Oklinski MK , Lim JS , Choi HJ , Oklinska P , Skowronski MT , Kwon TH . Immunolocalization of water channel proteins AQP1 and AQP4 in rat spinal cord . J Histochem Cytochem . 2014 ; 62 ( 8 ): 598 - 611 .
Kitchen P , Salman MM , Halsey AM , Clarke-Bland C , Macdonald JA , Ishida H , et al . Targeting aquaporin-4 subcellular localization to treat central nervous system edema . Cell . 2020 ; 181 ( 4 ): 784 - 99 .
Sylvain NJ , Salman MM , Pushie MJ , Hou H , Meher V , Herlo R , et al . The effects of trifluoperazine on brain edema, aquaporin-4 expression and metabolic markers during the acute phase of stroke using photothrombotic mouse model . Biochim Biophys Acta Biomembr . 2021 ; 1863 ( 5 ): 183573 .
Cash A , Theus MH . Mechanisms of blood–brain barrier dysfunction in traumatic brain injury . Int J Mol Sci . 2020 ; 21 ( 9 ): 3344 .
Corrigan F , Mander KA , Leonard AV , Vink R . Neurogenic inflammation after traumatic brain injury and its potentiation of classical inflammation . J Neuroinflamm . 2016 ; 13 ( 1 ): 264 .
Guilfoyle MR , Carpenter KL , Helmy A , Pickard JD , Menon DK , Hutchinson PJ . Matrix metalloproteinase expression in contusional traumatic brain injury: a paired microdialysis study . J Neurotrauma . 2015 ; 32 ( 20 ): 1553 - 9 .
Ralay Ranaivo H , Hodge JN , Choi N , Wainwright MS . Albumin induces upregulation of matrix metalloproteinase-9 in astrocytes via MAPK and reactive oxygen species-dependent pathways . J Neuroinflamm . 2012 ; 9 : 68 .
Rodrigues SF , Granger DN . Blood cells and endothelial barrier function . Tissue Barriers . 2015 ; 3 ( 1–2 ): e978720 .
Abdul-Muneer PM , Chandra N , Haorah J . Interactions of oxidative stress and neurovascular inflammation in the pathogenesis of traumatic brain injury . Mol Neurobiol . 2015 ; 51 ( 3 ): 966 - 79 .
Pun PB , Lu J , Moochhala S . Involvement of ROS in BBB dysfunction . Free Radic Res . 2009 ; 43 ( 4 ): 348 - 64 .
van Landeghem FK , Weiss T , Oehmichen M , Von Deimling A . Decreased expression of glutamate transporters in astrocytes after human traumatic brain injury . J Neurotrauma . 2006 ; 23 ( 10 ): 1518 - 28 .
Jiang X , Andjelkovic AV , Zhu L , Yang T , Bennett MVL , Chen J , et al . Blood–brain barrier dysfunction and recovery after ischemic stroke . Prog Neurobiol . 2018 ; 163–164 : 144 - 71 .
Simon DW , McGeachy MJ , Bayir H , Clark RS , Loane DJ , Kochanek PM . The far-reaching scope of neuroinflammation after traumatic brain injury . Nat Rev Neurol . 2017 ; 13 ( 3 ): 171 - 91 .
Morganti-Kossmann MC , Rancan M , Otto VI , Stahel PF , Kossmann T . Role of cerebral inflammation after traumatic brain injury: a revisited concept . Shock . 2001 ; 16 ( 3 ): 165 - 77 .
Morganti-Kossmann MC , Rancan M , Stahel PF , Kossmann T . Inflammatory response in acute traumatic brain injury: a double-edged sword . Curr Opin Crit Care . 2002 ; 8 ( 2 ): 101 - 5 .
Colton CA . Heterogeneity of microglial activation in the innate immune response in the brain . J Neuroimmune Pharmacol . 2009 ; 4 ( 4 ): 399 - 418 .
Shaklai S , Peretz R , Spasser R , Simantov M , Groswasser Z . Long-term functional outcome after moderate-to-severe paediatric traumatic brain injury . Brain Inj . 2014 ; 28 ( 7 ): 915 - 21 .
Thau-Zuchman O , Shohami E , Alexandrovich AG , Leker RR . Combination of vascular endothelial and fibroblast growth factor 2 for induction of neurogenesis and angiogenesis after traumatic brain injury . J Mol Neurosci . 2012 ; 47 ( 1 ): 166 - 72 .
Chiu CC , Liao YE , Yang LY , Wang JY , Tweedie D , Karnati HK , et al . Neuroinflammation in animal models of traumatic brain injury . J Neurosci Methods . 2016 ; 272 : 38 - 49 .
Deselms H , Maggio N , Rubovitch V , Chapman J , Schreiber S , Tweedie D , et al . Novel pharmaceutical treatments for minimal traumatic brain injury and evaluation of animal models and methodologies supporting their development . J Neurosci Methods . 2016 ; 272 : 69 - 76 .
Washington PM , Villapol S , Burns MP . Polypathology and dementia after brain trauma: Does brain injury trigger distinct neurodegenerative diseases, or should they be classified together as traumatic encephalopathy? Exp Neurol . 2016 ; 275 ( Pt 3 ): 381 - 8 .
McKee AC , Daneshvar DH , Alvarez VE , Stein TD . The neuropathology of sport . Acta Neuropathol . 2014 ; 127 ( 1 ): 29 - 51 .
Wang JZ , Xia YY , Grundke-Iqbal I , Iqbal K . Abnormal hyperphosphorylation of tau: sites, regulation, and molecular mechanism of neurofibrillary degeneration . J Alzheimers Dis . 2013 ; 33 ( Suppl 1 ): S123 - 39 .
Montejo de Garcini E , Serrano L , Avila J . Self assembly of microtubule associated protein tau into filaments resembling those found in Alzheimer disease . Biochem Biophys Res Commun . 1986 ; 141 ( 2 ): 790 - 6 .
Clarimon J , Molina-Porcel L , Gomez-Isla T , Blesa R , Guardia-Laguarta C , Gonzalez-Neira A , et al . Early-onset familial lewy body dementia with extensive tauopathy: a clinical, genetic, and neuropathological study . J Neuropathol Exp Neurol . 2009 ; 68 ( 1 ): 73 - 82 .
Wszolek ZK , Tsuboi Y , Ghetti B , Pickering-Brown S , Baba Y , Cheshire WP . Frontotemporal dementia and Parkinsonism linked to chromosome 17 (FTDP-17) . Orphanet J Rare Dis . 2006 ; 1 : 30 .
Perez M , Valpuesta JM , De Garcini EM , Quintana C , Arrasate M , Lopez Carrascosa JL , et al . Ferritin is associated with the aberrant tau filaments present in progressive supranuclear palsy . Am J Pathol . 1998 ; 152 ( 6 ): 1531 - 9 .
Hardy J , Selkoe DJ . The amyloid hypothesis of Alzheimer’s disease: progress and problems on the road to therapeutics . Science . 2002 ; 297 ( 5580 ): 353 - 6 .
Polymeropoulos MH , Lavedan C , Leroy E , Ide SE , Dehejia A , Dutra A , et al . Mutation in the α-synuclein gene identified in families with Parkinson’s disease . Science . 1997 ; 276 ( 5321 ): 2045 - 7 .
Neumann M , Sampathu DM , Kwong LK , Truax AC , Micsenyi MC , Chou TT , et al . Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis . Science . 2006 ; 314 ( 5796 ): 130 - 3 .
Ikonomovic MD , Uryu K , Abrahamson EE , Ciallella JR , Trojanowski JQ , Lee VM , et al . Alzheimer’s pathology in human temporal cortex surgically excised after severe brain injury . Exp Neurol . 2004 ; 190 ( 1 ): 192 - 203 .
Johnson VE , Stewart W , Smith DH . Widespread τ and amyloid-β pathology many years after a single traumatic brain injury in humans . Brain Pathol . 2012 ; 22 ( 2 ): 142 - 9 .
Johnson VE , Stewart W , Graham DI , Stewart JE , Praestgaard AH , Smith DH . A neprilysin polymorphism and amyloid-beta plaques after traumatic brain injury . J Neurotrauma . 2009 ; 26 ( 8 ): 1197 - 202 .
Deane R , Sagare A , Hamm K , Parisi M , Lane S , Finn MB , et al . apoE isoform-specific disruption of amyloid beta peptide clearance from mouse brain . J Clin Investig . 2008 ; 118 ( 12 ): 4002 - 13 .
Younkin SG . The role of A beta 42 in Alzheimer’s disease . J Physiol Paris . 1998 ; 92 ( 3–4 ): 289 - 92 .
Salman MM , Kitchen P , Halsey A , Wang MX , Tornroth-Horsefield S , Conner AC , et al . Emerging roles for dynamic aquaporin-4 subcellular relocalization in CNS water homeostasis . Brain . 2021 . https://doi.org/10.1093/brain/awab311 https://doi.org/10.1093/brain/awab311 .
Salman MM , Kitchen P , Iliff JJ , Bill RM . Aquaporin 4 and glymphatic flow have central roles in brain fluid homeostasis . Nat Rev Neurosci . 2021 ; 22 ( 10 ): 650 - 1 .
Ringstad G , Vatnehol SAS , Eide PK . Glymphatic MRI in idiopathic normal pressure hydrocephalus . Brain . 2017 ; 140 ( 10 ): 2691 - 705 .
Iliff JJ , Lee H , Yu M , Feng T , Logan J , Nedergaard M , et al . Brain-wide pathway for waste clearance captured by contrast-enhanced MRI . J Clin Investig . 2013 ; 123 ( 3 ): 1299 - 309 .
Iliff JJ , Wang M , Liao Y , Plogg BA , Peng W , Gundersen GA , et al . A paravascular pathway facilitates CSF flow through the brain parenchyma and the clearance of interstitial solutes, including amyloid beta . Sci Transl Med . 2012 ; 4 ( 147 ): 147ra11 .
Xu Z , Xiao N , Chen Y , Huang H , Marshall C , Gao J , et al . Deletion of aquaporin-4 in APP/PS1 mice exacerbates brain Abeta accumulation and memory deficits . Mol Neurodegener . 2015 ; 10 : 58 .
Mestre H , Hablitz LM , Xavier AL , Feng W , Zou W , Pu T , et al . Aquaporin-4-dependent glymphatic solute transport in the rodent brain . Elife . 2018 ; 7 : e40070 .
Swanson TM , Isaacson BM , Cyborski CM , French LM , Tsao JW , Pasquina PF . Traumatic brain injury incidence, clinical overview, and policies in the US military health system since 2000 . Public Health Rep . 2017 ; 132 ( 2 ): 251 - 9 .
Yuh EL , Cooper SR , Ferguson AR , Manley GT . Quantitative CT improves outcome prediction in acute traumatic brain injury . J Neurotrauma . 2012 ; 29 ( 5 ): 735 - 46 .
Lopez-Larson M , King JB , Mcglade E , Bueler E , Stoeckel A , Epstein DJ , et al . Enlarged thalamic volumes and increased fractional anisotropy in the thalamic radiations in veterans with suicide behaviors . Front Psychiatry . 2013 ; 4 : 83 .
Haacke Em RW , Wu B , Kou Z . The presence of venous damage and microbleeds in traumatic brain injury and the potential future role of angiographic and perfusion magnetic resonance imaging . In: Kreipke CW , Rafols JA , editors. Cerebral blood flow, metabolism, and head trauma . New York : Springer ; 2013 . p. 75 – 94 .
Nathan DE , Bellgowan JF , French LM , Wolf J , Oakes TR , Mielke J , et al . Assessing the impact of post-traumatic stress symptoms on the resting-state default mode network in a military chronic mild traumatic brain injury sample . Brain Connect . 2017 ; 7 ( 4 ): 236 - 49 .
Zhou Y , Milham MP , Lui YW , Miles L , Reaume J , Sodickson DK , et al . Default-mode network disruption in mild traumatic brain injury . Radiology . 2012 ; 265 ( 3 ): 882 - 92 .
Witt ST , Lovejoy DW , Pearlson GD , Stevens MC . Decreased prefrontal cortex activity in mild traumatic brain injury during performance of an auditory oddball task . Brain Imaging Behav . 2010 ; 4 ( 3–4 ): 232 - 47 .
Strigo IA , Spadoni AD , Lohr J , Simmons AN . Too hard to control: compromised pain anticipation and modulation in mild traumatic brain injury . Transl Psychiatry . 2014 ; 4 : e340 .
Taber KH , Hurley RA , Haswell CC , Rowland JA , Hurt SD , Lamar CD , et al . White matter compromise in veterans exposed to primary blast forces . J Head Trauma Rehabil . 2015 ; 30 ( 1 ): E15 - 25 .
Lipton ML , Gulko E , Zimmerman ME , Friedman BW , Kim M , Gellella E , et al . Diffusion-tensor imaging implicates prefrontal axonal injury in executive function impairment following very mild traumatic brain injury . Radiology . 2009 ; 252 ( 3 ): 816 - 24 .
Doshi H , Wiseman N , Liu J , Wang W , Welch RD , O’neil BJ , et al . Cerebral hemodynamic changes of mild traumatic brain injury at the acute stage . PLoS One . 2015 ; 10 ( 2 ): e0118061 .
Gasparovic C , Yeo R , Mannell M , Ling J , Elgie R , Phillips J , et al . Neurometabolite concentrations in gray and white matter in mild traumatic brain injury: an 1H-magnetic resonance spectroscopy study . J Neurotrauma . 2009 ; 26 ( 10 ): 1635 - 43 .
Hetherington HP , Hamid H , Kulas J , Ling G , Bandak F , De Lanerolle NC , et al . MRSI of the medial temporal lobe at 7 T in explosive blast mild traumatic brain injury . Magn Reson Med . 2014 ; 71 ( 4 ): 1358 - 67 .
Green SM . Cheerio, laddie! bidding farewell to the Glasgow Coma Scale . Ann Emerg Med . 2011 ; 58 ( 5 ): 427 - 30 .
Management of Concussion/mTBI Working Group . VA/DoD clinical practice guideline for management of concussion/mild traumatic brain injury . Washington : US Department of Veterans Affairs, US Department of Defense ; 2016 .
Shenton ME , Hamoda HM , Schneiderman JS , Bouix S , Pasternak O , Rathi Y , et al . A review of magnetic resonance imaging and diffusion tensor imaging findings in mild traumatic brain injury . Brain Imaging Behav . 2012 ; 6 ( 2 ): 137 - 92 .
Palacios EM , Sala-Llonch R , Junque C , Fernandez-Espejo D , Roig T , Tormos JM , et al . Long-term declarative memory deficits in diffuse TBI: correlations with cortical thickness, white matter integrity and hippocampal volume . Cortex . 2013 ; 49 ( 3 ): 646 - 57 .
Liu MC , Akinyi L , Scharf D , Mo J , Larner SF , Muller U , et al . Ubiquitin C-terminal hydrolase-L1 as a biomarker for ischemic and traumatic brain injury in rats . Eur J Neurosci . 2010 ; 31 ( 4 ): 722 - 32 .
Bohmer AE , Oses JP , Schmidt AP , Peron CS , Krebs CL , Oppitz PP , et al . Neuron-specific enolase, S100B, and glial fibrillary acidic protein levels as outcome predictors in patients with severe traumatic brain injury . Neurosurgery . 2011 ; 68 ( 6 ): 1624–30 (discussion 30–1) .
Vos PE , Jacobs B , Andriessen TM , Lamers KJ , Borm GF , Beems T , et al . GFAP and S100B are biomarkers of traumatic brain injury: an observational cohort study . Neurology . 2010 ; 75 ( 20 ): 1786 - 93 .
Schulte S , Podlog LW , Hamson-Utley JJ , Strathmann FG , Struder HK . A systematic review of the biomarker S100B: implications for sport-related concussion management . J Athl Train . 2014 ; 49 ( 6 ): 830 - 50 .
Thelin EP , Frostell A , Mulder J , Mitsios N , Damberg P , Aski SN , et al . Lesion size is exacerbated in hypoxic rats whereas hypoxia-inducible factor-1 alpha and vascular endothelial growth factor increase in injured normoxic rats: a prospective cohort study of secondary hypoxia in focal traumatic brain injury . Front Neurol . 2016 ; 7 : 23 .
Pike BR , Flint J , Dutta S , Johnson E , Wang KK , Hayes RL . Accumulation of non-erythroid alpha II-spectrin and calpain-cleaved alpha II-spectrin breakdown products in cerebrospinal fluid after traumatic brain injury in rats . J Neurochem . 2001 ; 78 ( 6 ): 1297 - 306 .
Martinez-Morillo E , Childs C , Garcia BP , Alvarez Menendez FV , Romaschin AD , Cervellin G , et al . Neurofilament medium polypeptide (NFM) protein concentration is increased in CSF and serum samples from patients with brain injury . Clin Chem Lab Med . 2015 ; 53 ( 10 ): 1575 - 84 .
Ringger NC , O’steen BE , Brabham JG , Silver X , Pineda J , Wang KK , et al . A novel marker for traumatic brain injury: CSF alphaII-spectrin breakdown product levels . J Neurotrauma . 2004 ; 21 ( 10 ): 1443 - 56 .
Smith DH , Chen XH , Nonaka M , Trojanowski JQ , Lee VM , Saatman KE , et al . Accumulation of amyloid beta and tau and the formation of neurofilament inclusions following diffuse brain injury in the pig . J Neuropathol Exp Neurol . 1999 ; 58 ( 9 ): 982 - 92 .
Dambinova SA , Khounteev GA , Izykenova GA , Zavolokov IG , Ilyukhina AY , Skoromets AA . Blood test detecting autoantibodies to N-methyld-aspartate neuroreceptors for evaluation of patients with transient ischemic attack and stroke . Clin Chem . 2003 ; 49 ( 10 ): 1752 - 62 .
Papa L , Robicsek SA , Brophy GM , Wang KKW , Hannay HJ , Heaton S , et al . Temporal profile of microtubule-associated protein 2: a novel indicator of diffuse brain injury severity and early mortality after brain trauma . J Neurotrauma . 2018 ; 35 ( 1 ): 32 - 40 .
Korley FK , Diaz-Arrastia R , Wu AH , Yue JK , Manley GT , Sair HI , et al . Circulating brain-derived neurotrophic factor has diagnostic and prognostic value in traumatic brain injury . J Neurotrauma . 2016 ; 33 ( 2 ): 215 - 25 .
Yang J , Korley FK , Dai M , Everett AD . Serum neurogranin measurement as a biomarker of acute traumatic brain injury . Clin Biochem . 2015 ; 48 ( 13–14 ): 843 - 8 .
Redell JB , Moore AN , Ward NH 3rd , Hergenroeder GW , Dash PK . Human traumatic brain injury alters plasma microRNA levels . J Neurotrauma . 2010 ; 27 ( 12 ): 2147 - 56 .
Rodrigues Filho EM , Simon D , Ikuta N , Klovan C , Dannebrock FA , Oliveira De Oliveira C , et al . Elevated cell-free plasma DNA level as an independent predictor of mortality in patients with severe traumatic brain injury . J Neurotrauma . 2014 ; 31 ( 19 ): 1639 - 46 .
Moyron RB , Gonda A , Selleck MJ , Luo-Owen X , Catalano RD , O’callahan T , et al . Differential protein expression in exosomal samples taken from trauma patients . Proteom Clin Appl . 2017 . https://doi.org/10.1002/prca.201700061 https://doi.org/10.1002/prca.201700061 .
Oh EJ , Kim YM , Jegal DW , Kahng J , Park YJ , Han K . Diagnostic value of Elecsys S100 as a marker of acute brain injury in the emergency department . J Clin Lab Anal . 2007 ; 21 ( 6 ): 387 - 92 .
Berger RP , Adelson PD , Pierce MC , Dulani T , Cassidy LD , Kochanek PM . Serum neuron-specific enolase, S100B, and myelin basic protein concentrations after inflicted and noninflicted traumatic brain injury in children . J Neurosurg . 2005 ; 103 ( 1 Suppl ): 61 - 8 .
Morries LD , Cassano P , Henderson TA . Treatments for traumatic brain injury with emphasis on transcranial near-infrared laser phototherapy . Neuropsychiatr Dis Treat . 2015 ; 11 : 2159 - 75 .
Neurobehavioral Guidelines Working G , Warden DL , Gordon B , Mcallister TW , Silver JM , Barth JT , et al . Guidelines for the pharmacologic treatment of neurobehavioral sequelae of traumatic brain injury . J Neurotrauma . 2006 ; 23 ( 10 ): 1468 - 501 .
Prins ML , Matsumoto JH . The collective therapeutic potential of cerebral ketone metabolism in traumatic brain injury . J Lipid Res . 2014 ; 55 ( 12 ): 2450 - 7 .
Diamond BJ , Shiflett SC , Feiwel N , Matheis RJ , Noskin O , Richards JA , et al . Ginkgo biloba extract: mechanisms and clinical indications . Arch Phys Med Rehabil . 2000 ; 81 ( 5 ): 668 - 78 .
Başkaya MK , Doğan A , Rao AM , Dempsey RJ . Neuroprotective effects of citicoline on brain edema and blood–brain barrier breakdown after traumatic brain injury . J Neurosurg . 2000 ; 92 ( 3 ): 448 - 52 .
Hakkarainen H , Hakamies L . Piracetam in the treatment of post-concussional syndrome. A double-blind study . Eur Neurol . 1978 ; 17 ( 1 ): 50 - 5 .
Hasadsri L , Wang BH , Lee JV , Erdman JW , Llano DA , Barbey AK , et al . Omega-3 fatty acids as a putative treatment for traumatic brain injury . J Neurotrauma . 2013 ; 30 ( 11 ): 897 - 906 .
Cifu DX , Cohen SI , Lew HL , Jaffee M , Sigford B . The history and evolution of traumatic brain injury rehabilitation in military service members and veterans . Am J Phys Med Rehabil . 2010 ; 89 ( 8 ): 688 - 94 .
Schwab KA , Warden D , Lux WE , Shupenko LA , Zitnay G . Defense and veterans brain injury center: peacetime and wartime missions . J Rehabil Res Dev . 2007 ; 44 ( 7 ): xiii - xxi .
Baig MR , Beck RD , Wilson JL , Lemmer JA , Meraj A , Meyer EC , et al . Quetiapine augmentation of prolonged exposure therapy in veterans with PTSD and a history of mild traumatic brain injury: design and methodology of a pilot study . Mil Med Res . 2020 ; 7 ( 1 ): 46 .
Liu M , Wang AJ , Chen Y , Zhao G , Jiang Z , Wang X , et al . Efficacy and safety of erythropoietin for traumatic brain injury . BMC Neurol . 2020 ; 20 ( 1 ): 399 .
Lyons MWH , Blackshaw WJ . Does magnesium sulfate have a role in the management of severe traumatic brain injury in civilian and military populations? A systematic review and meta-analysis . J R Army Med Corps . 2018 ; 164 ( 6 ): 442 - 9 .
Kondo A , Shahpasand K , Mannix R , Qiu J , Moncaster J , Chen CH , et al . Antibody against early driver of neurodegeneration cis P-tau blocks brain injury and tauopathy . Nature . 2015 ; 523 ( 7561 ): 431 - 6 .
Chung H , Dai T , Sharma SK , Huang YY , Carroll JD , Hamblin MR . The nuts and bolts of low-level laser (light) therapy . Ann Biomed Eng . 2012 ; 40 ( 2 ): 516 - 33 .
Yang Z , Wu Y , Zhang H , Jin P , Wang W , Hou J , et al . Low-level laser irradiation alters cardiac cytokine expression following acute myocardial infarction: a potential mechanism for laser therapy . Photomed Laser Surg . 2011 ; 29 ( 6 ): 391 - 8 .
Harch PG , Andrews SR , Fogarty EF , Amen D , Pezzullo JC , Lucarini J , et al . A phase I study of low-pressure hyperbaric oxygen therapy for blast-induced post-concussion syndrome and post-traumatic stress disorder . J Neurotrauma . 2012 ; 29 ( 1 ): 168 - 85 .
Harch PG , Andrews SR , Rowe CJ , Lischka JR , Townsend MH , Yu Q , et al . Hyperbaric oxygen therapy for mild traumatic brain injury persistent postconcussion syndrome: a randomized controlled trial . Med Gas Res . 2020 ; 10 ( 1 ): 8 - 20 .
Cicerone KD , Dahlberg C , Kalmar K , Langenbahn DM , Malec JF , Bergquist TF , et al . Evidence-based cognitive rehabilitation: recommendations for clinical practice . Arch Phys Med Rehabil . 2000 ; 81 ( 12 ): 1596 - 615 .
Nagappan PG , Chen H , Wang DY . Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury . Mil Med Res . 2020 ; 7 ( 1 ): 30 .
Vanderploeg RD , Schwab K , Walker WC , Fraser JA , Sigford BJ , Date ES , et al . Rehabilitation of traumatic brain injury in active duty military personnel and veterans: defense and veterans brain injury center randomized controlled trial of two rehabilitation approaches . Arch Phys Med Rehabil . 2008 ; 89 ( 12 ): 2227 - 38 .
Lew HL , Poole JH , Vanderploeg RD , Goodrich GL , Dekelboum S , Guillory SB , et al . Program development and defining characteristics of returning military in a VA Polytrauma Network Site . J Rehabil Res Dev . 2007 ; 44 ( 7 ): 1027 - 34 .
Cicerone KD , Kalmar K . Persistent postconcussion syndrome: the structure of subjective complaints after mild traumatic brain injury . J Head Trauma Rehabil . 1995 ; 10 ( 3 ): 1 - 17 .
Wagner AK , Zitelli KT . A Rehabilomics focused perspective on molecular mechanisms underlying neurological injury, complications, and recovery after severe TBI . Pathophysiology . 2013 ; 20 ( 1 ): 39 - 48 .
Gavett BE , Stern RA , McKee AC . Chronic traumatic encephalopathy: a potential late effect of sport-related concussive and subconcussive head trauma . Clin Sports Med . 2011 ; 30 ( 1 ): 179 - 88 .
Kennedy JE , Lu LH , Reid MW , Leal FO , Cooper DB . Correlates of depression in U.S. military service members with a history of mild traumatic brain injury . Mil Med . 2019 ; 184 ( Suppl 1 ): 148 - 54 .
van Praag DLG , Cnossen MC , Polinder S , Wilson L , Maas AIR . Post-traumatic stress disorder after civilian traumatic brain injury: a systematic review and meta-analysis of prevalence rates . J Neurotrauma . 2019 ; 36 ( 23 ): 3220 - 32 .
Hoge CW , Mcgurk D , Thomas JL , Cox AL , Engel CC , Castro CA . Mild traumatic brain injury in U.S. Soldiers returning from Iraq . N Engl J Med . 2008 ; 358 ( 5 ): 453 - 63 .
Raza Z , Hussain SF , Ftouni S , Spitz G , Caplin N , Foster RG , et al . Dementia in military and veteran populations: a review of risk factors-traumatic brain injury, post-traumatic stress disorder, deployment, and sleep . Mil Med Res . 2021 ; 8 ( 1 ): 55 .
Vincent AS , Roebuck-Spencer TM , Cernich A . Cognitive changes and dementia risk after traumatic brain injury: implications for aging military personnel . Alzheimers Dement . 2014 ; 10 ( 3 Suppl ): S174 - 87 .
Mohamed AZ , Cumming P , Götz J , Nasrallah F , Department of Defense Alzheimer’s Disease Neuroimaging I . Tauopathy in veterans with longterm posttraumatic stress disorder and traumatic brain injury . Eur J Nucl Med Mol Imaging . 2019 ; 46 ( 5 ): 1139 - 51 .
Barnes DE , Kaup A , Kirby KA , Byers AL , Diaz-Arrastia R , Yaffe K . Traumatic brain injury and risk of dementia in older veterans . Neurology . 2014 ; 83 ( 4 ): 312 - 9 .
Plassman BL , Havlik RJ , Steffens DC , Helms MJ , Newman TN , Drosdick D , et al . Documented head injury in early adulthood and risk of Alzheimer’s disease and other dementias . Neurology . 2000 ; 55 ( 8 ): 1158 - 66 .
Bjork JM , Grant SJ . Does traumatic brain injury increase risk for substance abuse? J Neurotrauma . 2009 ; 26 ( 7 ): 1077 - 82 .
Chen YH , Chiu WT , Chu SF , Lin HC . Increased risk of schizophrenia following traumatic brain injury: a 5-year follow-up study in Taiwan . Psychol Med . 2011 ; 41 ( 6 ): 1271 - 7 .
Jones E , Wessely S . Battle for the mind: World War 1 and the birth of military psychiatry . Lancet . 2014 ; 384 ( 9955 ): 1708 - 14 .
Zafonte RD . Update on biotechnology for TBI rehabilitation: a look at the future . J Head Trauma Rehabil . 2006 ; 21 ( 5 ): 403 - 7 .
Aldewachi H , Al-Zidan RN , Conner MT , Salman MM . High-throughput screening platforms in the discovery of novel drugs for neurodegenerative diseases . Bioengineering (Basel) . 2021 ; 8 ( 2 ): 30 .
Salman MM , Al-Obaidi Z , Kitchen P , Loreto A , Bill RM , Wade-Martins R . Advances in applying computer-aided drug design for neurodegenerative diseases . Int J Mol Sci . 2021 ; 22 ( 9 ): 4688 .
Wevers NR , Kasi DG , Gray T , Wilschut KJ , Smith B , Van Vught R , et al . A perfused human blood–brain barrier on-a-chip for high-throughput assessment of barrier function and antibody transport . Fluids Barriers CNS . 2018 ; 15 ( 1 ): 23 .
Salman MM , Marsh G , Kusters I , Delince M , Di Caprio G , Upadhyayula S , et al . Design and validation of a human brain endothelial microvesselon-a-chip open microfluidic model enabling advanced optical imaging . Front Bioeng Biotechnol . 2020 ; 8 : 573775 .
Wang SN , Wang Z , Xu TY , Cheng MH , Li WL , Miao CY . Cerebral organoids repair ischemic stroke brain injury . Transl Stroke Res . 2020 ; 11 ( 5 ): 983 - 1000 .
Chae S , Sun Y , Choi YJ , Ha DH , Jeon IH , Cho DW . 3D cell-printing of tendon-bone interface using tissue-derived extracellular matrix bioinks for chronic rotator cuff repair . Biofabrication . 2020 . https://doi.org/10.1088/1758-5090/abd159 https://doi.org/10.1088/1758-5090/abd159 .
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