Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?

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Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?

REVIEW | Updated：2023-02-28

- Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?
- Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?
- 解放军医学杂志（英文版） 2022年9卷第5期页码：592-602
- Affiliations：
  
  1.Sir William Dunn School of Pathology, University of Oxford, Oxford OX1 3RE, UK
  2.Department of Laboratory Medicine, Ren Ji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200127, China
- Author bio：
  
  * hzlgy496@hotmail.com
- Funds：
  
  the Wellcome Trust, BBSRC, and the National Natural Science Foundation of China(81802065;102908/Z/13/Z)
- DOI：10.1186/s40779-021-00362-z
  中图分类号：
- 纸质出版：2022-10
- Accepted：
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Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?[J]. 解放军医学杂志（英文版）, 2022,9(5):592-602.

Shen Z, Tang CM, Liu GY. Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?. Mil Med Res. 2022;9(1):3.
Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?[J]. 解放军医学杂志（英文版）, 2022,9(5):592-602. DOI： 10.1186/s40779-021-00362-z.

Shen Z, Tang CM, Liu GY. Towards a better understanding of antimicrobial resistance dissemination: what can be learnt from studying model conjugative plasmids?. Mil Med Res. 2022;9(1):3. DOI： 10.1186/s40779-021-00362-z.

摘要

Abstract

Bacteria can evolve rapidly by acquiring new traits such as virulence

metabolic properties

and most importantly

antimicrobial resistance

through horizontal gene transfer (HGT). Multidrug resistance in bacteria

especially in Gram-negative organisms

has become a global public health threat often through the spread of mobile genetic elements. Conjugation represents a major form of HGT and involves the transfer of DNA from a donor bacterium to a recipient by direct contact. Conjugative plasmids

a major vehicle for the dissemination of antimicrobial resistance

are selfish elements capable of mediating their own transmission through conjugation. To spread to and survive in a new bacterial host

conjugative plasmids have evolved mechanisms to circumvent both host defense systems and compete with co-resident plasmids. Such mechanisms have mostly been studied in model plasmids such as the F plasmid

rather than in conjugative plasmids that confer antimicrobial resistance (AMR) in important human pathogens. A better understanding of these mechanisms is crucial for predicting the flow of antimicrobial resistance-conferring conjugative plasmids among bacterial populations and guiding the rational design of strategies to halt the spread of antimicrobial resistance. Here

we review mechanisms employed by conjugative plasmids that promote their transmission and establishment in Gram-negative bacteria

by following the life cycle of conjugative plasmids.

关键词

Keywords

references

Thomas CM , Nielsen KM . Mechanisms of, and barriers to, horizontal gene transfer between bacteria . Nat Rev Microbiol . 2005 ; 3 ( 9 ): 711 - 21 .

Norman A , Hansen LH , Sørensen SJ . Conjugative plasmids: vessels of the communal gene pool . Philos Trans R Soc Lond B Biol Sci . 2009 ; 364 ( 1527 ): 2275 - 89 .

Partridge SR , Kwong SM , Firth N , Jensen SO . Mobile genetic elements associated with antimicrobial resistance . Clin Microbiol Rev . 2018 ; 31 ( 4 ): e00088 - e117 .

Von Wintersdorff CJ , Penders J , Van Niekerk JM , Mills ND , Majumder S , Van Alphen LB , et al . Dissemination of antimicrobial resistance in microbial ecosystems through horizontal gene transfer . Front Microbiol . 2016 ; 7 : 173 .

Soucy SM , Huang J , Gogarten JP . Horizontal gene transfer: building the web of life . Nat Rev Genet . 2015 ; 16 ( 8 ): 472 - 82 .

World Health Organization . The evolving threat of antimicrobial resistance: options for action . World Health Organization , Geneva ; 2012 . http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.646.1286&rep=rep1&type=pdf http://citeseerx.ist.psu.edu/viewdoc/download?doi=10.1.1.646.1286&rep=rep1&type=pdf .

O’Neill J . Tackling drug-resistant infections globally: final report and recommendations . United Kingdom : Review on Antimicrobial Resistance . 2016 .

Rice LB . Federal funding for the study of antimicrobial resistance in nosocomial pathogens: no ESKAPE . J Infect Dis . 2008 ; 197 ( 8 ): 1079 - 81 .

De Oliveira DMP , Forde BM , Kidd TJ , Harris PNA , Schembri MA , Beatson SA , et al . Antimicrobial resistance in ESKAPE pathogens . Clin Microbiol Rev . 2020 ; 33 ( 3 ): e00181 - 219 .

Smillie C , Garcillán-Barcia MP , Francia MV , Rocha EPC , De La Cruz F . Mobility of plasmids . Microbiol Mol Biol Rev . 2010 ; 74 ( 3 ): 434 - 52 .

Schröder G , Lanka E . The mating pair formation system of conjugative plasmids-A versatile secretion machinery for transfer of proteins and DNA . Plasmid . 2005 ; 54 ( 1 ): 1 - 25 .

Botelho J , Schulenburg H . The role of integrative and conjugative elements in antibiotic resistance evolution . Trends Microbiol . 2021 ; 29 ( 1 ): 8 - 18 .

Wang R , Van Dorp L , Shaw LP , Bradley P , Wang Q , Wang X , et al . The global distribution and spread of the mobilized colistin resistance gene mcr-1 . Nat Commun . 2018 ; 9 ( 1 ): 1179 .

Wu W , Feng Y , Tang G , Qiao F , Mcnally A , Zong Z . NDM metallo-β-lactamases and their bacterial producers in health care settings . Clin Microbiol Rev . 2019 ; 32 ( 2 ): e00115 - 118 .

Yang X , Dong N , Chan EW , Zhang R , Chen S . Carbapenem resistance encoding and virulence-encoding conjugative plasmids in Klebsiella pneumoniae . Trends Microbiol . 2021 ; 29 ( 1 ): 65 - 83 .

Liu YY , Wang Y , Walsh TR , Yi LX , Zhang R , Spencer J , et al . Emergence of plasmid-mediated colistin resistance mechanism MCR-1 in animals and human beings in China: a microbiological and molecular biological study . Lancet Infect Dis . 2016 ; 16 ( 2 ): 161 - 8 .

Quan J , Li X , Chen Y , Jiang Y , Zhou Z , Zhang H , et al . Prevalence of mcr-1 in Escherichia coli and Klebsiella pneumoniae recovered from bloodstream infections in China: a multicentre longitudinal study . Lancet Infect Dis . 2017 ; 17 ( 4 ): 400 - 10 .

Cox KEL , Schildbach JF . Sequence of the R1 plasmid and comparison to F and R100 . Plasmid . 2017 ; 91 : 53 - 60 .

Guglielmini J , Néron B , Abby SS , Garcillán-Barcia MP , De La Cruz F , Rocha EP . Key components of the eight classes of type IV secretion systems involved in bacterial conjugation or protein secretion . Nucleic Acids Res . 2014 ; 42 ( 9 ): 5715 - 27 .

Garcillán-Barcia MP , Francia MV , De La Cruz F . The diversity of conjugative relaxases and its application in plasmid classification . FEMS Microbiol Rev . 2009 ; 33 ( 3 ): 657 - 87 .

Cabezón E , Ripoll-Rozada J , Peña A , De La Cruz F , Arechaga I . Towards an integrated model of bacterial conjugation . FEMS Microbiol Rev . 2015 ; 39 ( 1 ): 81 - 95 .

Virolle C , Goldlust K , Djermoun S , Bigot S , Lesterlin C . Plasmid transfer by conjugation in gram-negative bacteria: from the cellular to the community level . Genes (Basel) . 2020 ; 11 ( 11 ): 1239 .

Christie PJ . The mosaic type IV secretion systems . EcoSal Plus . 2016 ; 7 ( 1 ): 10 .

Grohmann E , Christie PJ , Waksman G , Backert S . Type IV secretion in Gram-negative and Gram-positive bacteria . Mol Microbiol . 2018 ; 107 ( 4 ): 455 - 71 .

Baltrus DA . Exploring the costs of horizontal gene transfer . Trends Ecol Evol . 2013 ; 28 ( 8 ): 489 - 95 .

Koraimann G , Wagner MA . Social behavior and decision making in bacterial conjugation . Front Cell Infect Microbiol . 2014 ; 4 : 54 .

Lu J , Peng Y , Wan S , Frost LS , Raivio T , Glover JNM . Cooperative function of TraJ and ArcA in regulating the F plasmid tra operon . J Bacteriol . 2019 ; 201 ( 1 ): e00448 - 518 .

Rodriguez-Maillard JM , Arutyunov D , Frost LS . The F plasmid transfer activator TraJ is a dimeric helix-turn-helix DNA-binding protein . FEMS Microbiol Lett . 2010 ; 310 ( 2 ): 112 - 9 .

Mark Glover JN , Chaulk SG , Edwards RA , Arthur D , Lu J , Frost LS . The FinO family of bacterial RNA chaperones . Plasmid . 2015 ; 78 : 79 - 87 .

Frost L , Lee S , Yanchar N , Paranchych W . finP and fisO mutations in FinP anti-sense RNA suggest a model for FinOP action in the repression of bacterial conjugation by the Flac plasmid JCFL0 . Mol Gen Genet . 1989 ; 218 ( 1 ): 152 - 60 .

Koraimann G , Teferle K , Markolin G , Woger W , Högenauer G . The FinOP repressor system of plasmid R1 analysis of the antisense RNA control of traJ expression and conjugative DNA transfer . Mol Microbiol . 1996 ; 21 ( 4 ): 811 - 21 .

van Biesen T , Frost LS . The FinO protein of IncF plasmids binds FinP antisense RNA and its target, traJ mRNA, and promotes duplex formation . Mol Microbiol . 1994 ; 14 ( 3 ): 427 - 36 .

Arthur DC , Edwards RA , Tsutakawa S , Tainer JA , Frost LS , Glover JN . Mapping interactions between the RNA chaperone FinO and its RNA targets . Nucleic Acids Res . 2011 ; 39 ( 10 ): 4450 - 63 .

Zahrl D , Wagner M , Bischof K , Koraimann G . Expression and assembly of a functional type IV secretion system elicit extracytoplasmic and cytoplasmic stress responses in Escherichia coli . J Bacteriol . 2006 ; 188 ( 18 ): 6611 - 21 .

Bidlack JE , Silverman PM . An active type IV secretion system encoded by the F plasmid sensitizes Escherichia coli to bile salts . J Bacteriol . 2004 ; 186 ( 16 ): 5202 - 9 .

Grace ED , Gopalkrishnan S , Girard ME , Blankschien MD , Ross W , Gourse RL , et al . Activation of the σE-dependent stress pathway by conjugative TraR may anticipate conjugational stress . J Bacteriol . 2015 ; 197 ( 5 ): 924 - 31 .

Bates S , Roscoe RA , Althorpe NJ , Brammar WJ , Wilkins BM . Expression of leading region genes on IncI1 plasmid ColIb-P9: genetic evidence for single-stranded DNA transcription . Microbiology (Reading) . 1999 ; 145 ( Pt 10 ): 2655 - 62 .

Manwaring NP , Skurray RA , Firth N . Nucleotide sequence of the F plasmid leading region . Plasmid . 1999 ; 41 ( 3 ): 219 - 25 .

Jones AL , Barth PT , Wilkins BM . Zygotic induction of plasmid ssb and psiB genes following conjugative transfer of Incl1 plasmid Collb-P9 . Mol Microbiol . 1992 ; 6 ( 5 ): 605 - 13 .

Masai H , Arai K . Frpo: a novel single-stranded DNA promoter for transcription and for primer RNA synthesis of DNA replication . Cell . 1997 ; 89 ( 6 ): 897 - 907 .

Althorpe NJ , Chilley PM , Thomas AT , Brammar WJ , Wilkins BM . Transient transcriptional activation of the IncI1 plasmid anti-restriction gene (ardA) and SOS inhibition gene (psiB) early in conjugating recipient bacteria . Mol Microbiol . 1999 ; 31 ( 1 ): 133 - 42 .

Raghunathan S , Kozlov AG , Lohman TM , Waksman G . Structure of the DNA binding domain of E. coli SSB bound to ssDNA . Nat Struct Biol . 2000 ; 7 ( 8 ): 648 - 52 .

Savvides SN , Raghunathan S , Fütterer K , Kozlov AG , Lohman TM , Waksman G . The C-terminal domain of full-length E. coli SSB is disordered even when bound to DNA . Protein Sci . 2004 ; 13 ( 7 ): 1942 - 7 .

Shamoo Y , Friedman AM , Parsons MR , Konigsberg WH , Steitz TA . Crystal structure of a replication fork single-stranded DNA binding protein (T4 gp32) complexed to DNA . Nature . 1995 ; 376 ( 6538 ): 362 - 6 .

Bianco PR . The tale of SSB . Prog Biophys Mol Biol . 2017 ; 127 : 111 - 8 .

Zhou R , Kozlov AG , Roy R , Zhang J , Korolev S , Lohman TM , et al . SSB functions as a sliding platform that migrates on DNA via reptation . Cell . 2011 ; 146 ( 2 ): 222 - 32 .

Harami GM , Kovacs ZJ , Pancsa R , Palinkas J , Barath V , Tarnok K , et al . Phase separation by ssDNA binding protein controlled via proteinprotein and protein-DNA interactions . Proc Natl Acad Sci U S A . 2020 ; 117 ( 42 ): 26206 - 17 .

Costes A , Lecointe F , Mcgovern S , Quevillon-Cheruel S , Polard P . The C-terminal domain of the bacterial SSB protein acts as a DNA maintenance hub at active chromosome replication forks . PLoS Genet . 2010 ; 6 ( 12 ): e1001238 .

Marceau AH , Bahng S , Massoni SC , George NP , Sandler SJ , Marians KJ , et al . Structure of the SSB-DNA polymerase III interface and its role in DNA replication . EMBO J . 2011 ; 30 ( 20 ): 4236 - 47 .

Roy R , Kozlov AG , Lohman TM , Ha T . SSB protein diffusion on single-stranded DNA stimulates RecA filament formation . Nature . 2009 ; 461 ( 7267 ): 1092 - 7 .

Shinn MK , Kozlov AG , Lohman TM . Allosteric effects of SSB C-terminal tail on assembly of E. coli RecOR proteins . Nucleic Acids Res . 2021 ; 49 ( 4 ): 1987 - 2004 .

Nolivos S , Cayron J , Dedieu A , Page A , Delolme F , Lesterlin C . Role of AcrAB-TolC multidrug efflux pump in drug-resistance acquisition by plasmid transfer . Science . 2019 ; 364 ( 6442 ): 778 - 82 .

Roy D , Huguet KT , Grenier F , Burrus V . IncC conjugative plasmids and SXT/R391 elements repair double-strand breaks caused by CRISPR-Cas during conjugation . Nucleic Acids Res . 2020 ; 48 ( 16 ): 8815 - 27 .

Baharoglu Z , Bikard D , Mazel D . Conjugative DNA transfer induces the bacterial SOS response and promotes antibiotic resistance development through integron activation . PLoS Genet . 2010 ; 6 ( 10 ): e1001165 .

Maslowska KH , Makiela-Dzbenska K , Fijalkowska IJ . The SOS system: a complex and tightly regulated response to DNA damage . Environ Mol Mutagen . 2019 ; 60 ( 4 ): 368 - 84 .

Michel B . After 30 years of study, the bacterial SOS response still surprises us . PLoS Biol . 2005 ; 3 ( 7 ): e255 .

Baharoglu Z , Mazel D . SOS, the formidable strategy of bacteria against aggressions . FEMS Microbiol Rev . 2014 ; 38 ( 6 ): 1126 - 45 .

Murata M , Nakamura K , Kosaka T , Ota N , Osawa A , Muro R , et al . Cell Lysis Directed by SulA in Response to DNA Damage in Escherichia coli . Int J Mol Sci . 2021 ; 22 ( 9 ).

Petrova V , Satyshur KA , George NP , Mccaslin D , Cox MM , Keck JL . X-ray crystal structure of the bacterial conjugation factor PsiB, a negative regulator of RecA . J Biol Chem . 2010 ; 285 ( 40 ): 30615 - 21 .

Bagdasarian M , Bailone A , Angulo JF , Scholz P , Bagdasarian M , Devoret R . PsiB, and anti-SOS protein, is transiently expressed by the F sex factor during its transmission to an Escherichia coli K-12 recipient . Mol Microbiol . 1992 ; 6 ( 7 ): 885 - 93 .

Al Mamun AAM , Kishida K , Christie PJ . Protein transfer through an F plasmid-encoded type IV secretion system suppresses the matinginduced SOS response . mBio . 2021 ; 12 ( 4 ): e01629 - 21 .

Petrova V , Chitteni-Pattu S , Drees JC , Inman RB , Cox MM . An SOS inhibitor that binds to free RecA protein: the PsiB protein . Mol Cell . 2009 ; 36 ( 1 ): 121 - 30 .

Loenen WA , Dryden DT , Raleigh EA , Wilson GG . Type I restriction enzymes and their relatives . Nucleic Acids Res . 2014 ; 42 ( 1 ): 20 - 44 .

Loenen WA , Dryden DT , Raleigh EA , Wilson GG , Murray NE . Highlights of the DNA cutters: a short history of the restriction enzymes . Nucleic Acids Res . 2014 ; 42 ( 1 ): 3 - 19 .

Rao DN , Dryden DT , Bheemanaik S . Type III restriction-modification enzymes: a historical perspective . Nucleic Acids Res . 2014 ; 42 ( 1 ): 45 - 55 .

Tock MR , Dryden DT . The biology of restriction and anti-restriction . Curr Opin Microbiol . 2005 ; 8 ( 4 ): 466 - 72 .

Wilkins BM . Plasmid promiscuity: meeting the challenge of DNA immigration control . Environ Microbiol . 2002 ; 4 ( 9 ): 495 - 500 .

Delver EP , Kotova VU , Zavilgelsky GB , Belogurov AA . Nucleotide sequence of the gene (ard) encoding the antirestriction protein of plasmid ColIb-P9 . J Bacteriol . 1991 ; 173 ( 18 ): 5887 - 92 .

Nekrasov SV , Agafonova OV , Belogurova NG , Delver EP , Belogurov AA . Plasmid-encoded antirestriction protein ArdA can discriminate between type I methyltransferase and complete restriction-modification system . J Mol Biol . 2007 ; 365 ( 2 ): 284 - 97 .

Mcmahon SA , Roberts GA , Johnson KA , Cooper LP , Liu H , White JH , et al . Extensive DNA mimicry by the ArdA anti-restriction protein and its role in the spread of antibiotic resistance . Nucleic Acids Res . 2009 ; 37 ( 15 ): 4887 - 97 .

Gao Y , Cao D , Zhu J , Feng H , Luo X , Liu S , et al . Structural insights into assembly, operation and inhibition of a type I restriction-modification system . Nat Microbiol . 2020 ; 5 ( 9 ): 1107 - 18 .

Belogurov AA , Delver EP , Rodzevich OV . Plasmid pKM101 encodes two nonhomologous antirestriction proteins (ArdA and ArdB) whose expression is controlled by homologous regulatory sequences . J Bacteriol . 1993 ; 175 ( 15 ): 4843 - 50 .

Serfiotis-Mitsa D , Herbert AP , Roberts GA , Soares DC , White JH , Blakely GW , et al . The structure of the KlcA and ArdB proteins reveals a novel fold and antirestriction activity against type I DNA restriction systems in vivo but not in vitro . Nucleic Acids Res . 2010 ; 38 ( 5 ): 1723 - 37 .

Kamachi K , Sota M , Tamai Y , Nagata N , Konda T , Inoue T , et al . Plasmid pBP136 from Bordetella pertussis represents an ancestral form of IncP-1beta plasmids without accessory mobile elements . Microbiology (Reading) . 2006 ; 152 ( Pt 12 ): 3477 - 84 .

Liang W , Xie Y , Xiong W , Tang Y , Li G , Jiang X , et al . Anti-restriction protein, KlcAHS, promotes dissemination of carbapenem resistance . Front Cell Infect Microbiol . 2017 ; 7 : 150 .

Liang W , Tang Y , Li G , Shen P , Tian Y , Jiang H , et al . KlcAHS genes are ubiquitous in clinical, blaKPC-2-positive Klebsiella pneumoniae isolates . Infect Genet Evol . 2019 ; 70 : 84 - 9 .

Belogurov AA , Delver EP , Agafonova OV , Belogurova NG , Lee LY , Kado CI . Antirestriction protein Ard (Type C) encoded by IncW plasmid pSa has a high similarity to the “protein transport” domain of TraC1 primase of promiscuous plasmid RP4 . J Mol Biol . 2000 ; 296 ( 4 ): 969 - 77 .

González-Montes L , Del Campo I , Garcillán-Barcia MP , De La Cruz F , Moncalian G . ArdC, a ssDNA-binding protein with a metalloprotease domain, overpasses the recipient hsdRMS restriction system broadening conjugation host range . PLoS Genet . 2020 ; 16 ( 4 ): e1008750 .

Rees CE , Wilkins BM . Protein transfer into the recipient cell during bacterial conjugation studies with F and RP4 . Mol Microbiol . 1990 ; 4 ( 7 ): 1199 - 205 .

Marinus MG , Casadesus J . Roles of DNA adenine methylation in hostpathogen interactions: mismatch repair, transcriptional regulation, and more . FEMS Microbiol Rev . 2009 ; 33 ( 3 ): 488 - 503 .

Blow MJ , Clark TA , Daum CG , Deutschbauer AM , Fomenkov A , Fries R , et al . The epigenomic landscape of prokaryotes . PLoS Genet . 2016 ; 12 ( 2 ): e1005854 .

Fang G , Munera D , Friedman DI , Mandlik A , Chao MC , Banerjee O , et al . Genome-wide mapping of methylated adenine residues in pathogenic Escherichia coli using single-molecule real-time sequencing . Nat Biotechnol . 2012 ; 30 ( 12 ): 1232 - 9 .

Yamaichi Y , Chao MC , Sasabe J , Clark L , Davis BM , Yamamoto N , et al . High-resolution genetic analysis of the requirements for horizontal transmission of the ESBL plasmid from Escherichia coli O104:H4 . Nucleic Acids Res . 2015 ; 43 ( 1 ): 348 - 60 .

Sampei GI , Furuya N , Tachibana K , Saitou Y , Suzuki T , Mizobuchi K , et al . Complete genome sequence of the incompatibility group I1 plasmid R64 . Plasmid . 2010 ; 64 ( 2 ): 92 - 103 .

Holden MT , Seth-Smith HM , Crossman LC , Sebaihia M , Bentley SD , Cerdeno-Tarraga AM , et al . The genome of Burkholderia cenocepacia J2315, an epidemic pathogen of cystic fibrosis patients . J Bacteriol . 2009 ; 191 ( 1 ): 261 - 77 .

Fomenkov A , Sun Z , Murray IA , Ruse C , Mcclung C , Yamaichi Y , et al . Plasmid replication-associated single-strand-specific methyltransferases . Nucleic Acids Res . 2020 ; 48 ( 22 ): 12858 - 73 .

Smith J . Superinfection drives virulence evolution in experimental populations of bacteria and plasmids . Evolution . 2011 ; 65 ( 3 ): 831 - 41 .

Subbiah M , Top EM , Shah DH , Call DR . Selection pressure required for long-term persistence of blaCMY-2-positive IncA/C plasmids . Appl Environ Microbiol . 2011 ; 77 ( 13 ): 4486 - 93 .

Harrison E , Brockhurst MA . Plasmid-mediated horizontal gene transfer is a coevolutionary process . Trends Microbiol . 2012 ; 20 ( 6 ): 262 - 7 .

Carroll AC , Wong A . Plasmid persistence: costs, benefits, and the plasmid paradox . Can J Microbiol . 2018 ; 64 ( 5 ): 293 - 304 .

Brockhurst MA , Harrison E . Ecological and evolutionary solutions to the plasmid paradox . Trends Microbiol . 2021 . https://doi.org/10.1016/j.tim.2021.11.001 https://doi.org/10.1016/j.tim.2021.11.001 .

Salje J , Gayathri P , Löwe J . The ParMRC system: molecular mechanisms of plasmid segregation by actin-like filaments . Nat Rev Microbiol . 2010 ; 8 ( 10 ): 683 - 92 .

Pilla G , Tang CM . Going around in circles: virulence plasmids in enteric pathogens . Nat Rev Microbiol . 2018 ; 16 ( 8 ): 484 - 95 .

Gerdes K , Howard M , Szardenings F . Pushing and pulling in prokaryotic DNA segregation . Cell . 2010 ; 141 ( 6 ): 927 - 42 .

Harms A , Brodersen DE , Mitarai N , Gerdes K . Toxins, targets, and triggers: an overview of toxin-antitoxin biology . Mol Cell . 2018 ; 70 ( 5 ): 768 - 84 .

Schumacher MA . Bacterial plasmid partition machinery: a minimalist approach to survival . Curr Opin Struct Biol . 2012 ; 22 ( 1 ): 72 - 9 .

Garcillán-Barcia MP , de la Cruz F . Why is entry exclusion an essential feature of conjugative plasmids? Plasmid . 2008 ; 60 ( 1 ): 1 - 18 .

Humbert M , Huguet KT , Coulombe F , Burrus V . Entry exclusion of conjugative plasmids of the IncA, IncC, and related untyped incompatibility groups . J Bacteriol . 2019 ; 201 ( 10 ): e00731 - 818 .

Frost LS , Ippen-Ihler K , Skurray RA . Analysis of the sequence and gene products of the transfer region of the F sex factor . Microbiol Rev . 1994 ; 58 ( 2 ): 162 - 210 .

Achtman M , Kennedy N , Skurray R . Cell-cell interactions in conjugating Escherichia coli: role of traT protein in surface exclusion . Proc Natl Acad Sci U S A . 1977 ; 74 ( 11 ): 5104 - 8 .

Firth N , Skurray R . Characterization of the F plasmid bifunctional conjugation gene, traG . Mol Gen Genet . 1992 ; 232 ( 1 ): 145 - 53 .

Audette GF , Manchak J , Beatty P , Klimke WA , Frost LS . Entry exclusion in F-like plasmids requires intact TraG in the donor that recognizes its cognate TraS in the recipient . Microbiology (Reading) . 2007 ; 153 ( Pt 2 ): 442 - 51 .

Achtman M , Manning PA , Kusecek B , Schwuchow S , Neil W . A genetic analysis of F sex factor cistrons needed for surface exclusion in Escherichia coli . J Mol Biol . 1980 ; 138 ( 4 ): 779 - 95 .

Skurray RA , Reeves P . Characterization of lethal zygosis associated with conjugation in Escherichia coli K-12 . J Bacteriol . 1973 ; 113 ( 1 ): 58 - 70 .

Bertozzi Silva J , Storms Z , Sauvageau D . Host receptors for bacteriophage adsorption . FEMS Microbiol Lett . 2016 ; 363 ( 4 ): fnw002 .

Getino M , de la Cruz F . Natural and artificial strategies to control the conjugative transmission of plasmids . Microbiol Spectr . 2018 . https://doi.org/10.1128/microbiolspec.MTBP-0015-2016 https://doi.org/10.1128/microbiolspec.MTBP-0015-2016 .

Dionisio F , Zilhão R , Gama JA . Interactions between plasmids and other mobile genetic elements affect their transmission and persistence . Plasmid . 2019 ; 102 : 29 - 36 .

Gama JA , Zilhão R , Dionisio F . Impact of plasmid interactions with the chromosome and other plasmids on the spread of antibiotic resistance . Plasmid . 2018 ; 99 : 82 - 8 .

Gasson MJ , Willetts NS . Five control systems preventing transfer of Escherichia coli K-12 sex factor F . J Bacteriol . 1975 ; 122 ( 2 ): 518 - 25 .

Wong JJW , Lu J , Edwards RA , Frost LS , Glover JNM . Structural basis of cooperative DNA recognition by the plasmid conjugation factor . TraM Nucleic Acids Res . 2011 ; 39 ( 15 ): 6775 - 88 .

Peng Y , Lu J , Wong JJW , Edwards RA , Frost LS , Mark Glover JN . Mechanistic basis of plasmid-specific DNA binding of the F plasmid regulatory protein . TraM J Mol Biol . 2014 ; 426 ( 22 ): 3783 - 95 .

Ham LM , Skurray R . Molecular analysis and nucleotide sequence of finQ, a transcriptional inhibitor of the F plasmid transfer genes . Mol Gen Genet . 1989 ; 216 ( 1 ): 99 - 105 .

Close SM , Kado CI . The Osa gene of pSa encodes a 211-kilodalton protein that suppresses Agrobacterium tumefaciens oncogenicity . J Bacteriol . 1991 ; 173 ( 17 ): 5449 - 56 .

Getino M , Palencia-Gándara C , Garcillán-Barcia MP , De La Cruz F . PifC and Osa, plasmid weapons against rival conjugative coupling proteins . Front Microbiol . 2017 ; 8 : 2260 .

Maindola P , Raina R , Goyal P , Atmakuri K , Ojha A , Gupta S , et al . Multiple enzymatic activities of ParB/Srx superfamily mediate sexual conflict among conjugative plasmids . Nat Commun . 2014 ; 5 : 5322 .

Willetts N . Interactions between the F conjugal transfer system and CloDF13: TnA plasmids . Mol Gen Genet . 1980 ; 180 ( 1 ): 213 - 7 .

Zhong L , Shi XZ , Su L , Liu ZF . Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature . Mil Med Res . 2020 ; 7 ( 1 ): 23 .

Botelho J , Grosso F , Peixe L . Antibiotic resistance in Pseudomonas aeruginosa-Mechanisms, epidemiology and evolution . Drug Resist Updat . 2019 ; 44 : 100640 .

Navon-Venezia S , Kondratyeva K , Carattoli A . Klebsiella pneumoniae: a major worldwide source and shuttle for antibiotic resistance . FEMS Microbiol Rev . 2017 ; 41 ( 3 ): 252 - 75 .

Asif M , Alvi IA , Rehman SU . Insight into Acinetobacter baumannii: pathogenesis, global resistance, mechanisms of resistance, treatment options, and alternative modalities . Infect Drug Resist . 2018 ; 11 : 1249 - 60 .

Stalder T , Top E . Plasmid transfer in biofilms: a perspective on limitations and opportunities . NPJ Biofilms Microbiomes . 2016 ; 2 : 16022 .

Li C , Chen J , Li SC . Understanding Horizontal Gene Transfer network in human gut microbiota . Gut Pathog . 2020 ; 12 : 33 .

Shi N , Li N , Duan X , Niu H . Interaction between the gut microbiome and mucosal immune system . Mil Med Res . 2017 ; 4 : 14 .

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