Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019

Cong Zhu; Dan-Qi Wang; Hao Zi; Qiao Huang; Jia-Min Gu; Lu-Yao Li; Xing-Pei Guo; Fei Li; Cheng Fang; Xiao-Dong Li; Xian-Tao Zeng

doi:10.1186/s40779-021-00359-8

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Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019

RESEARCH | Updated：2023-02-28

- Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019
- Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019
- 解放军医学杂志（英文版） 2022年9卷第4期页码：432-443
- Affiliations：
  
  1.Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  2.Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  3.Department of Evidence-Based Medicine and Clinical Epidemiology, Second School of Clinical Medicine, Wuhan University, Wuhan 430071, China
  4.Institutes of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng 475000, Henan, China
  5.Department of Urology, Huaihe Hospital of Henan University, Kaifeng 475000, Henan, China
- Author bio：
  
  * vitsippa@whu.edu.cn;
  hndxhhyylxd@126.com;
  zengxiantao1128@whu.edu.cn; zengxiantao1128@163.com
- Funds：
  
  the National Key Research and Development Plan of China(Technology helps Economy 2020);the Fundamental Research Funds for the Central Universities(2042020kf1081);the Nature Science Foundation of Hubei Province(2019CFB760);the Translational Medicine and Interdisciplinary Research Joint Fund of Zhongnan Hospital of Wuhan University(ZNJC201917);the Health Commission of the Hubei Province Scientific Research Project(WJ2019H035)
- DOI：10.1186/s40779-021-00359-8
  中图分类号：
- 纸质出版：2022-08
- Accepted：
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Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019[J]. 解放军医学杂志（英文版）, 2022,9(4):432-443.

Zhu C, Wang DQ, Zi H, Huang Q, Gu JM, Li LY, et al. Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019. Mil Med Res. 2021;8(1):64.
Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019[J]. 解放军医学杂志（英文版）, 2022,9(4):432-443. DOI： 10.1186/s40779-021-00359-8.

Zhu C, Wang DQ, Zi H, Huang Q, Gu JM, Li LY, et al. Epidemiological trends of urinary tract infections, urolithiasis and benign prostatic hyperplasia in 203 countries and territories from 1990 to 2019. Mil Med Res. 2021;8(1):64. DOI： 10.1186/s40779-021-00359-8.

摘要

Abstract

Background:

Urinary tract infections (UTI)

urolithiasis

and benign prostatic hyperplasia (BPH) are three of the most common nonmalignant conditions in urology. However

there is still a lack of comprehensive and updated epidemiological data. This study aimed to investigate the disease burden of UTI

urolithiasis

and BPH in 203 countries and territories from 1990 to 2019.

Methods:

Data were extracted from the Global Burden of Disease 2019

including incident cases

deaths

disability-adjusted life-years (DALYs) and corresponding age-standardized rate (ASR) from 1990 to 2019. Estimated annual percentage changes (EAPC) were calculated to evaluate the trends of ASR. The associations between disease burden and social development degrees were analyzed using a sociodemographic index (SDI).

Results:

Compared with 1990

the incident cases of UTI

urolithiasis

and BPH increased by 60.40%

48.57%

and 105.70% in 2019

respectively. The age-standardized incidence rate (ASIR) of UTI increased (EAPC=0.08)

while urolithiasis (EAPC=–0.83) and BPH (EAPC=–0.03) decreased from 1990 to 2019. In 2019

the age-standardized mortality rate (ASMR) of UTI and urolithiasis were 3.13/100

000 and 0.17/100

000

respectively. BPH had the largest increase (110.56%) in DALYs in the past three decades

followed by UTI (68.89%) and urolithiasis (16.95%). The burden of UTI was mainly concentrated in South Asia and Tropical Latin America

while the burden of urolithiasis and BPH was recorded in Asia and Eastern Europe. Moreover

the ASIR and SDI of urolithiasis in high-SDI regions from 1990 to 2019 were negatively correlated

while the opposite trend was seen in low-SDI regions. In 2019

the ASIR of UTI in females was 3.59 times that of males

while the ASIR of urolithiasis in males was 1.96 times higher than that in females. The incidence was highest in the 30–34

55–59

and 65–69 age groups among the UTI

urolithiasis

and BPH groups

respectively.

Conclusions:

Over the past three decades

the disease burden has increased for UTI but decreased for urolithiasis and BPH. The allocation of medical resources should be based more on the epidemiological characteristics and geographical distribution of diseases.

关键词

Keywords

references

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