The roles of exosomal immune checkpoint proteins in tumors
The roles of exosomal immune checkpoint proteins in tumors
- 解放军医学杂志（英文版） 2022年9卷第3期 页码：365-375
- Affiliations：
- Author bio：
* wangzhihuazsc@csu.edu.cn;
penghongling@csu.edu.cn
- Funds：the National Natural Science Foundation of China(81670160;82070175;81800198;81600183;81700168);the Natural Science Foundation of Changsha Municipal(kq2014234)
DOI：10.1186/s40779-021-00350-3
中图分类号：-
纸质出版：2022-06
- Accepted：
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The roles of exosomal immune checkpoint proteins in tumors[J]. 解放军医学杂志（英文版）, 2022,9(3):365-375.
Xing et al.: The roles of exosomal immune checkpoint proteins in tumors. Mil Med Res, 2021, 8: 56.
The roles of exosomal immune checkpoint proteins in tumors[J]. 解放军医学杂志（英文版）, 2022,9(3):365-375. DOI： 10.1186/s40779-021-00350-3.
Xing et al.: The roles of exosomal immune checkpoint proteins in tumors. Mil Med Res, 2021, 8: 56. DOI： 10.1186/s40779-021-00350-3.
摘要
Abstract
Targeting immune checkpoints has achieved great therapeutic effects in the treatment of early-stage tumors. However
most patients develop adaptive resistance to this therapy. The latest evidence demonstrates that tumor-derived exosomes may play a key role in systemic immune suppression and tumor progression. In this article
we highlight the role of exosomal immune checkpoint proteins in tumor immunity
with an emphasis on programmed death ligand 1 (PD-L1) and cytotoxic T lymphocyte-associated antigen 4 (CTLA-4)
as well as emerging evidence on roles of T cell immunoglobulin-3 (TIM-3)
arginase 1 (ARG1)
and estrogen receptor binding fragment-associated antigen 9 (EBAG9) expressed by exosomes.
关键词
Keywords
references
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