Cell fusion in the pathogenesis of COVID-19

You Zheng; Lu-Lin Zhou; Yan Su; Qiang Sun

doi:10.1186/s40779-021-00348-x

Your Location：

Home >

Browse articles >

Cell fusion in the pathogenesis of COVID-19

LETTER TO THE EDITO | Updated：2023-02-28

- Cell fusion in the pathogenesis of COVID-19
- Cell fusion in the pathogenesis of COVID-19
- 解放军医学杂志（英文版） 2022年9卷第3期页码：387-388
- Affiliations：
  
  Laboratory of Cell Engineering, Institute of Biotechnology; Research Unit of Cell Death Mechanism, Chinese Academy of Medical Science, 2021RU008, 20 Dongda Street, Beijing 100071, China
- Author bio：
  
  * sunq@bmi.ac.cn
- Funds：
  
  the National Key Research & Development Program of China(2018YFA0900804;2019YFA0903801);the National Natural Science Foundation of China(31970685)
- DOI：10.1186/s40779-021-00348-x
  中图分类号：
- 纸质出版：2022-06
- Accepted：
Scan QR Code
Cell fusion in the pathogenesis of COVID-19[J]. 解放军医学杂志（英文版）, 2022,9(3):387-388.

Zheng et al.: Cell fusion in the pathogenesis of COVID-19. Mil Med Res, 2021, 8: 68.
Cell fusion in the pathogenesis of COVID-19[J]. 解放军医学杂志（英文版）, 2022,9(3):387-388. DOI： 10.1186/s40779-021-00348-x.

Zheng et al.: Cell fusion in the pathogenesis of COVID-19. Mil Med Res, 2021, 8: 68. DOI： 10.1186/s40779-021-00348-x.

摘要

Abstract

关键词

Keywords

references

Wu F , Zhao S , Yu B , Chen YM , Wang W , Song ZG , et al . A new coronavirus associated with human respiratory disease in China . Nature . 2020 ; 579 ( 7798 ): 265 - 9 .

Zhang Z , Zheng Y , Niu Z , Zhang B , Wang C , Yao X , et al . SARS-CoV-2 spike protein dictates syncytium-mediated lymphocyte elimination . Cell Death Differ . 2021 ; 28 ( 9 ): 2765 - 77 .

Shang J , Wan Y , Luo C , Ye G , Geng Q , Auerbach A , et al . Cell entry mechanisms of SARS-CoV-2 . Proc Natl Acad Sci U S A . 2020 ; 117 ( 21 ): 11727 - 34 .

Buchrieser J , Dufloo J , Hubert M , Monel B , Planas D , Rajah MM , et al . Syncytia formation by SARS-CoV-2-infected cells . EMBO J . 2020 ; 39 ( 23 ): e106267 .

Jiang X , Zhang Z , Wang C , Ren H , Gao L , Peng H , et al . Bimodular effects of D614G mutation on the spike glycoprotein of SARS-CoV-2 enhance protein processing, membrane fusion, and viral infectivity . Signal Transduct Target Ther . 2020 ; 5 ( 1 ): 268 .

Braga L , Ali H , Secco I , Chiavacci E , Neves G , Goldhill D , et al . Drugs that inhibit TMEM16 proteins block SARS-CoV-2 spike-induced syncytia . Nature . 2021 ; 594 ( 7861 ): 88 - 93 .

Zeng C , Evans JP , King T , Zheng YM , Oltz EM , Whelan SPJ , et al . SARS-CoV-2 Spreads through Cell-to-Cell Transmission . bioRxiv [Preprint] . 2021 . https://doi.org/10.1101/2021.06.01.446579 https://doi.org/10.1101/2021.06.01.446579 .

Xia S , Liu M , Wang C , Xu W , Lan Q , Feng S , et al . Inhibition of SARS-CoV-2 (previously 2019-nCoV) infection by a highly potent pan-coronavirus fusion inhibitor targeting its spike protein that harbors a high capacity to mediate membrane fusion . Cell Res . 2020 ; 30 ( 4 ): 343 - 55 .

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

暂无数据