Targeting PPARα in low ambient temperature exposure- induced cardiac dysfunction and remodeling

Xi-Yao Chen; Yang Jiao; Fu-Yang Zhang

doi:10.1186/s40779-021-00347-y

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Targeting PPARα in low ambient temperature exposure- induced cardiac dysfunction and remodeling

LETTER TO THE EDITOR | Updated：2023-02-28

- Targeting PPARα in low ambient temperature exposure- induced cardiac dysfunction and remodeling
- Targeting PPARα in low ambient temperature exposure- induced cardiac dysfunction and remodeling
- 解放军医学杂志（英文版） 2022年9卷第3期页码：382-384
- Affiliations：
  
  1.Department of Geriatrics, Xijing Hospital, Air Force Medical University, Xi’an 710032, China
  2.Department of Stomatology, the 7th Medical Center of Chinese, PLA General Hospital, Beijing 100700, China
  3.Department of Cardiology, Xijing Hospital, Air Force Medical University, Xi’an 710032, China
- Author bio：
  
  * plazhangfuyang@163.com
- Funds：
  
  the National Natural Science Foundation of China(81800326);the Innovation and Cultivation Fund of the 7th Medical Center of Chinese PLA General Hospital, the Open Project of State Key Laboratory of Military Stomatology(2018KA02);the Military Medical Science and Technology Youth Training Program(21QNPY116)
- DOI：10.1186/s40779-021-00347-y
  中图分类号：
- 纸质出版：2022-06
- Accepted：
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Targeting PPARα in low ambient temperature exposure- induced cardiac dysfunction and remodeling[J]. 解放军医学杂志（英文版）, 2022,9(3):382-384.

Chen et al.: Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling. Mil Med Res, 2021, 8: 53.
Targeting PPARα in low ambient temperature exposure- induced cardiac dysfunction and remodeling[J]. 解放军医学杂志（英文版）, 2022,9(3):382-384. DOI： 10.1186/s40779-021-00347-y.

Chen et al.: Targeting PPARα in low ambient temperature exposure-induced cardiac dysfunction and remodeling. Mil Med Res, 2021, 8: 53. DOI： 10.1186/s40779-021-00347-y.

摘要

Abstract

The present study demonstrates that the down-regulation of peroxisome proliferator-activated receptor-α (PPARα) results in chronic low ambient temperature (LT) exposure-induced cardiac dysfunction and remodeling

emphasizing the therapeutic potential of PPARα activation strategies (e.g.

fenofibrate treatment) in LT-associated cardiac injury.

关键词

Keywords

references

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