Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results

Biao Xu; Bo Tu; Fang Chu; Mohamed Jalloh; Jin-Song Mu; Jun-Jie Zheng; Wei-Wei Chen

doi:10.1186/s40779-021-00345-0

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Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results

LETTER TO THE EDITOR | Updated：2023-02-28

- Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results
- Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results
- 解放军医学杂志（英文版） 2022年9卷第3期页码：379-381
- Affiliations：
  
  1.Chinese Military Medical Expert Group in Sierra Leone, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China
  2.the 34Th Military Hospital, Wilberforce Barracks, Freetown, Sierra Leone
- Author bio：
  
  * cww302@126.com
- Funds：
  
  the National Grand Program on Key Infectious Disease(2018ZX10103002-001-007);the Biosafety Special Program(19SWAQ 13)
- DOI：10.1186/s40779-021-00345-0
  中图分类号：
- 纸质出版：2022-06
- Accepted：
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Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results[J]. 解放军医学杂志（英文版）, 2022,9(3):379-381.

Xu et al.: Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results. Mil Med Res, 2021, 8: 52.
Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results[J]. 解放军医学杂志（英文版）, 2022,9(3):379-381. DOI： 10.1186/s40779-021-00345-0.

Xu et al.: Secondary analysis of malaria rapid diagnostic tests from rounds 5–8 of WHO product testing with a focus on false-negative results. Mil Med Res, 2021, 8: 52. DOI： 10.1186/s40779-021-00345-0.

摘要

Abstract

Despite the widespread use of malaria rapid diagnostic test (RDT) in clinical practice

there are a lot of challenges. We conducted a secondary analysis of 129 malaria RDT data from rounds 5–8 of the World Health Organization (WHO) product testing summary and discuss the causes of false-negative (FN) results with a focus on low parasite density

improper RDT storage

operation and interpretation

and

Plasmodium falciparum

with a

pfhrp2/3

gene deletion. The results demonstrated that the malaria RDTs currently commercially available might cause FN results in practice.

关键词

Keywords

references

World Health Organization ( 2018 ). Malaria rapid diagnostic test performance: results of WHO product testing of malaria RDTs: round 8 (2016–2018) . https://apps.who.int/iris/handle/10665/276190 https://apps.who.int/iris/handle/10665/276190

Kavanaugh MJ , Azzam SE , Rockabrand DM . Malaria rapid diagnostic tests: literary review and recommendation for a quality assurance, quality control algorithm . Diagnostics (Basel) . 2021 ; 11 ( 5 ): 768 .

World Health Organization ( 2018 ). Malaria rapid diagnostic test performance: summary results of WHO product testing of malaria RDTs: round 1–8 (2008–2018) . https://apps.who.int/iris/handle/10665/276193 https://apps.who.int/iris/handle/10665/276193

Plucinski MM , Dimbu PR , Fortes F , Murphy SC , Smith NT , Cruz KR , et al . Malaria parasite density in individuals with different rapid diagnostic test results and concentrations of HRP2 antigen . Am J Trop Med Hyg . 2019 ; 100 : 1202 - 3 .

Seidahmed OM , Mohamedein MM , Elsir AA , Ali FT , el Malik FM , Ahmed ES . End-user errors in applying two malaria rapid diagnostic tests in a remote area of Sudan . Trop Med Int Health . 2008 ; 13 : 406 - 9 .

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