Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers
Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers
- 解放军医学杂志（英文版） 2021年8卷第4期 页码：564-578
- Affiliations：
1.Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
2.Department of Stomatology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, China
3.Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
4.Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
5.Department of Pathology, Duke University School of Medicine, Durham, NC 27710, USA
6.School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong, China
- Author bio：
* wangxinghuan1695@163.com;
huhl@sustech.edu.cn;
zengxiantao1128@whu.edu.cn; zengxiantao1128@163.com
- Funds：the Zhongnan Hospital of Wuhan University Science, Technology and Innovation Seed Fund(znpy2019011);the Fundamental Research Funds for the Central Universities(2042020kf0130);the Nature Science Foundation of Hubei Province(2019FFB03902);the Health Commission of Hubei Province Scientific Research Project(WJ2019H035)
DOI：10.1186/s40779-021-00344-1
中图分类号：-
纸质出版：2021-12
- Accepted：
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Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers[J]. 解放军医学杂志（英文版）, 2021,8(4):564-578.
Yuan et al.: Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers. Mil Med Res, 2021, 8: 54.
Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers[J]. 解放军医学杂志（英文版）, 2021,8(4):564-578. DOI： 10.1186/s40779-021-00344-1.
Yuan et al.: Oral microbiota in the oral-genitourinary axis: identifying periodontitis as a potential risk of genitourinary cancers. Mil Med Res, 2021, 8: 54. DOI： 10.1186/s40779-021-00344-1.
摘要
Abstract
Periodontitis has been proposed as a novel risk factor of genitourinary cancers: although periodontitis and genitourinary cancers are two totally distinct types of disorders
epidemiological and clinical studies
have established associations between them. Dysbiosis of oral microbiota has already been established as a major factor contributing to periodontitis. Recent emerging epidemiological evidence and the detection of oral microbiota in genitourinary organs indicate the presence of an oral-genitourinary axis and oral microbiota may be involved in the pathogenesis of genitourinary cancers. Therefore
oral microbiota provides the bridge between periodontitis and genitourinary cancers. We have carried out this narrative review which summarizes epidemiological studies exploring the association between periodontitis and genitourinary cancers. We have also highlighted the current evidence demonstrating the capacity of oral microbiota to regulate almost all hallmarks of cancer
and proposed the potential mechanisms of oral microbiota in the development of genitourinary cancers.
关键词
Keywords
references
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