Antimicrobial peptides: mechanism of action, activity and clinical potential
Antimicrobial peptides: mechanism of action, activity and clinical potential
- 解放军医学杂志（英文版） 2022年9卷第2期 页码：231-258
- Affiliations：
1.Zhejiang Provincial Key Laboratory of Silkworm Bioreactor and Biomedicine, College of Life Sciences and Medicine, Zhejiang Sci-Tech University, No. 928, Street 2, Xiasha Higher Education Zone, Hangzhou 310018, China
2.Department of Oncology, The 903rd Hospital of PLA, Hangzhou 310013, China
3.Department of Pharmaceutical Chemistry and the Cardiovascular Research Institute, University of California San Francisco, 555 Mission Bay Blvd. South, San Francisco, CA 94158, USA
4.Oncogenic Signaling and Growth Control Program, Peter MacCallum Cancer Centre, 305 Grattan Street, Melbourne, VIC 3000, Australia
5.Sir Peter MacCallum Department of Oncology, University of Melbourne, Parkville, VIC 3010, Australia
- Author bio：
* fucy03@zstu.edu.cn
- Funds：grants from the National Natural Science Foundation of China(81770176);the special support plan for Zhejiang Province High-Level Talents(2019R52011)
DOI：10.1186/s40779-021-00343-2
中图分类号：-
纸质出版：2022-04
- Accepted：
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Antimicrobial peptides: mechanism of action, activity and clinical potential[J]. 解放军医学杂志（英文版）, 2022,9(2):231-258.
Zhang et al.: Antimicrobial peptides: mechanism of action, activity and clinical potential. Mil Med Res, 2021, 8: 48.
Antimicrobial peptides: mechanism of action, activity and clinical potential[J]. 解放军医学杂志（英文版）, 2022,9(2):231-258. DOI： 10.1186/s40779-021-00343-2.
Zhang et al.: Antimicrobial peptides: mechanism of action, activity and clinical potential. Mil Med Res, 2021, 8: 48. DOI： 10.1186/s40779-021-00343-2.
摘要
Abstract
The management of bacterial infections is becoming a major clinical challenge due to the rapid evolution of antibiotic resistant bacteria. As an excellent candidate to overcome antibiotic resistance
antimicrobial peptides (AMPs) that are produced from the synthetic and natural sources demonstrate a broad-spectrum antimicrobial activity with the high specificity and low toxicity. These peptides possess distinctive structures and functions by employing sophisticated mechanisms of action. This comprehensive review provides a broad overview of AMPs from the origin
structural characteristics
mechanisms of action
biological activities to clinical applications. We finally discuss the strategies to optimize and develop AMP-based treatment as the potential antimicrobial and anticancer therapeutics.
关键词
Keywords
references
Wang J , Dou X , Song J , Lyu Y , Zhu X , Xu L , et al . Antimicrobial peptides: promising alternatives in the post feeding antibiotic era . Med Res Rev . 2019 ; 39 ( 3 ): 831 - 59 .
Mohammed I , Said DG , Dua HS . Human antimicrobial peptides in ocular surface defense . Prog Retin Eye Res . 2017 ; 61 : 1 - 22 .
Kang HK , Kim C , Seo CH , Park Y . The therapeutic applications of antimicrobial peptides (AMPs): a patent review . J Microbiol . 2017 ; 55 ( 1 ): 1 - 12 .
Lei J , Sun L , Huang S , Zhu C , Li P , He J , et al . The antimicrobial peptides and their potential clinical applications . Am J Transl Res . 2019 ; 11 ( 7 ): 3919 - 31 .
Kang X , Dong F , Shi C , Liu S , Sun J , Chen J , et al . DRAMP 2.0, an updated data repository of antimicrobial peptides . Sci Data . 2019 ; 6 ( 1 ): 148 .
Mookherjee N , Anderson MA , Haagsman HP , Davidson DJ . Antimicrobial host defence peptides: functions and clinical potential . Nat Rev Drug Discov . 2020 ; 19 ( 5 ): 311 - 32 .
Roudi R , Syn NL , Roudbary M . Antimicrobial peptides as biologic and immunotherapeutic agents against cancer: a comprehensive overview . Front Immunol . 2017 ; 8 : 1320 .
Zhang LJ , Gallo RL . Antimicrobial peptides . Curr Biol . 2016 ; 26 ( 1 ): R14 - 9 .
Pfalzgraff A , Brandenburg K , Weindl G . Antimicrobial peptides and their therapeutic potential for bacterial skin infections and wounds . Front Pharmacol . 2018 ; 9 : 281 .
Munita JM , Arias CA . Mechanisms of antibiotic resistance . Microbiol Spectr . 2016 . https://doi.org/10.1128/microbiolspec.VMBF-0016-2015 https://doi.org/10.1128/microbiolspec.VMBF-0016-2015 .
Hiltunen T , Virta M , Laine AL . Antibiotic resistance in the wild: an eco-evolutionary perspective . Philos Trans R Soc Lond B Biol Sci . 2017 ; 372 ( 1712 ): 20160039 .
Chung PY , Khanum R . Antimicrobial peptides as potential anti-biofilm agents against multidrug-resistant bacteria . J Microbiol Immunol Infect . 2017 ; 50 ( 4 ): 405 - 10 .
Mwangi J , Hao X , Lai R , Zhang ZY . Antimicrobial peptides: new hope in the war against multidrug resistance . Zool Res . 2019 ; 40 ( 6 ): 488 - 505 .
Costa F , Teixeira C , Gomes P , Martins MCL . Clinical application of AMPs . Adv Exp Med Biol . 2019 ; 1117 : 281 - 98 .
Mahlapuu M , Håkansson J , Ringstad L , Björn C . Antimicrobial peptides: an emerging category of therapeutic agents . Front Cell Infect Microbiol . 2016 ; 6 : 194 .
Groisman EA . How bacteria resist killing by host-defense peptides . Trends Microbiol . 1994 ; 2 ( 11 ): 444 - 9 .
Yazici A , Ortucu S , Taskin M , Marinelli L . Natural-based antibiofilm and antimicrobial peptides from microorganisms . Curr Top Med Chem . 2018 ; 18 ( 24 ): 2102 - 7 .
Moyer TB , Heil LR , Kirkpatrick CL , Goldfarb D , Lefever WA , Parsley NC , et al . PepSAVI-MS reveals a proline-rich antimicrobial peptide in Amaranthus tricolor . J Nat Prod . 2019 ; 82 ( 10 ): 2744 - 53 .
Lee JH , Seo M , Lee HJ , Baek M , Kim IW , Kim SY , et al . Anti-inflammatory activity of antimicrobial peptide allomyrinasin derived from the Dynastid Beetle, Allomyrina dichotoma . J Microbiol Biotechnol . 2019 ; 29 ( 5 ): 687 - 95 .
Kim SY , Zhang F , Gong W , Chen K , Xia K , Liu F , et al . Copper regulates the interactions of antimicrobial piscidin peptides from fish mast cells with formyl peptide receptors and heparin . J Biol Chem . 2018 ; 293 ( 40 ): 15381 - 96 .
Li B , Lyu P , Xie S , Qin H , Pu W , Xu H , et al . LFB: a novel antimicrobial brevinin-like peptide from the skin secretion of the Fujian Large Headed Frog, Limnonectes fujianensi . Biomolecules . 2019 ; 9 ( 6 ): 242 .
van Hoek ML , Prickett MD , Settlage RE , Kang L , Michalak P , Vliet KA , et al . The Komodo dragon (Varanus komodoensis) genome and identification of innate immunity genes and clusters . BMC Genomics . 2019 ; 20 ( 1 ): 684 .
Braun MS , Sporer F , Zimmermann S , Wink M . Birds, feather-degrading bacteria and preen glands: the antimicrobial activity of preen gland secretions from turkeys (Meleagris gallopavo) is amplified by keratinase . FEMS Microbiol Ecol . 2018 . https://doi.org/10.1093/femsec/fiy117 https://doi.org/10.1093/femsec/fiy117 .
Wang X , Sun Y , Wang F , You L , Cao Y , Tang R , et al . A novel endogenous antimicrobial peptide CAMP211-225 derived from casein in human milk . Food Funct . 2020 ; 11 ( 3 ): 2291 - 8 .
Mattick AT , Hirsch A . Further observations on an inhibitory substance (nisin) from lactic streptococci . Lancet . 1947 ; 2 ( 6462 ): 5 - 8 .
Gharsallaoui A , Oulahal N , Joly C , Degraeve P . Nisin as a food preservative: part 1: physicochemical properties, antimicrobial activity, and main uses . Crit Rev Food Sci Nutr . 2016 ; 56 ( 8 ): 1262 - 74 .
Shin JM , Gwak JW , Kamarajan P , Fenno JC , Rickard AH , Kapila YL . Biomedical applications of nisin . J Appl Microbiol . 2016 ; 120 ( 6 ): 1449 - 65 .
Kitagawa N , Otani T , Inai T . Nisin, a food preservative produced by Lactococcus lactis, affects the localization pattern of intermediate filament protein in HaCaT cells . Anat Sci Int . 2019 ; 94 ( 2 ): 163 - 71 .
Alkotaini B , Anuar N , Kadhum AAH , Sani AA . Detection of secreted antimicrobial peptides isolated from cell-free culture supernatant of Paenibacillus alvei AN5 . J Ind Microbiol Biotechnol . 2013 ; 40 ( 6 ): 571 - 9 .
Yi T , Huang Y , Chen Y . Production of an antimicrobial peptide AN5-1 in Escherichia coli and its dual mechanisms against bacteria . Chem Biol Drug Des . 2015 ; 85 ( 5 ): 598 - 607 .
Garcia-Gutierrez E , Mayer MJ , Cotter PD , Narbad A . Gut microbiota as a source of novel antimicrobials . Gut Microbes . 2019 ; 10 ( 1 ): 1 - 21 .
Pushpanathan P , Mathew GS , Selvarajan S , Seshadri KG , Srikanth P . Gut microbiota and its mysteries . Indian J Med Microbiol . 2019 ; 37 ( 2 ): 268 - 77 .
Essig A , Hofmann D , Münch D , Gayathri S , Kunzler M , Kallio PT , et al . Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis . J Biol Chem . 2014 ; 289 ( 50 ): 34953 - 64 .
Srivastava S , Dashora K , Ameta KL , Singh NP , El-Enshasy HA , Pagano MC , et al . Cysteine-rich antimicrobial peptides from plants: the future of antimicrobial therapy . Phytother Res . 2021 ; 35 ( 1 ): 256 - 77 .
Höng K , Austerlitz T , Bohlmann T , Bohlmann H . The thionin family of antimicrobial peptides . PLoS ONE . 2021 ; 16 ( 7 ): e0254549 .
Li J , Hu S , Jian W , Xie C , Yang X . Plant antimicrobial peptides: structures, functions, and applications . Bot Stud . 2021 ; 62 ( 1 ): 5 .
Taveira GB , Mello EO , Souza SB , Monteiro RM , Ramos AC , Carvalho AO , et al . Programmed cell death in yeast by thionin-like peptide from Capsicum annuum fruits involving activation of caspases and extracellular H + flux . Biosci Rep . 2018 ; 38 ( 2 ): BSR20180119 .
Hao G , Bakker MG , Kim HS . Enhanced resistance to Fusarium graminearum in transgenic arabidopsis plants expressing a modified plant thionin . Phytopathology . 2020 ; 110 ( 5 ): 1056 - 66 .
Tang SS , Prodhan ZH , Biswas SK , Le CF , Sekaran SD . Antimicrobial peptides from different plant sources: isolation, characterisation, and purification . Phytochemistry . 2018 ; 154 : 94 - 105 .
Gourbal B , Pinaud S , Beckers GJM , Van Der Meer JWM , Conrath U , Netea MG . Innate immune memory: an evolutionary perspective . Immunol Rev . 2018 ; 283 ( 1 ): 21 - 40 .
Wu Q , Patočka J , Kuča K . Insect antimicrobial peptides, a mini review . Toxins (Basel) . 2018 ; 10 ( 11 ): 461 .
Loch G , Zinke I , Mori T , Carrera P , Schroer J , Takeyama H , et al . Antimicrobial peptides extend lifespan in Drosophila . PLoS ONE . 2017 ; 12 ( 5 ): e0176689 .
Hanson MA , Lemaitre B . New insights on Drosophila antimicrobial peptide function in host defense and beyond . Curr Opin Immunol . 2020 ; 62 : 22 - 30 .
Chowdhury M , Li CF , He Z , Lu Y , Liu XS , Wang YF , et al . Toll family members bind multiple Spatzle proteins and activate antimicrobial peptide gene expression in Drosophila . J Biol Chem . 2019 ; 294 ( 26 ): 10172 - 81 .
Yang D , Biragyn A , Kwak LW , Oppenheim JJ . Mammalian defensins in immunity: more than just microbicidal . Trends Immunol . 2002 ; 23 ( 6 ): 291 - 6 .
Ageitos JM , Sánchez-Pérez A , Calo-Mata P , Villa TG . Antimicrobial peptides (AMPs): ancient compounds that represent novel weapons in the fight against bacteria . Biochem Pharmacol . 2017 ; 133 : 117 - 38 .
Avila EE . Functions of antimicrobial peptides in vertebrates . Curr Protein Pept Sci . 2017 ; 18 ( 11 ): 1098 - 119 .
Muncaster S , Kraakman K , Gibbons O , Mensink K , Forlenza M , Jacobson G , et al . Antimicrobial peptides within the Yellowtail Kingfish (Seriola lalandi) . Dev Comp Immunol . 2018 ; 80 : 67 - 80 .
van Harten RM , van Woudenbergh E , van Dijk A , Haagsman HP . Cathelicidins: immunomodulatory antimicrobials . Vaccines (Basel) . 2018 ; 6 ( 3 ): 63 .
Chen C , Wang A , Zhang F , Zhang M , Yang H , Li J , et al . The protective effect of fish-derived cathelicidins on bacterial infections in zebrafish, Danio rerio . Fish Shellfish Immunol . 2019 ; 92 : 519 - 27 .
Patocka J , Nepovimova E , Klimova B , Wu Q , Kuca K . Antimicrobial peptides: amphibian host defense peptides . Curr Med Chem . 2019 ; 26 ( 32 ): 5924 - 46 .
Wei L , Yang J , He X , Mo G , Hong J , Yan X , et al . Structure and function of a potent lipopolysaccharide-binding antimicrobial and anti-inflammatory peptide . J Med Chem . 2013 ; 56 ( 9 ): 3546 - 56 .
Perez-Peinado C , Dias SA , Domingues MM , Benfield AH , Freire JM , Radis-Baptista G , et al . Mechanisms of bacterial membrane permeabilization by crotalicidin (Ctn) and its fragment Ctn(15–34), antimicrobial peptides from rattlesnake venom . J Biol Chem . 2018 ; 293 ( 5 ): 1536 - 49 .
Rajasekaran G , Kumar SD , Yang S , Shin SY . The design of a cell-selective fowlicidin-1-derived peptide with both antimicrobial and anti-inflammatory activities . Eur J Med Chem . 2019 ; 182 : 111623 .
Young-Speirs M , Drouin D , Cavalcante PA , Barkema HW , Cobo ER . Host defense cathelicidins in cattle: types, production, bioactive functions and potential therapeutic and diagnostic applications . Int J Antimicrob Agents . 2018 ; 51 ( 6 ): 813 - 21 .
Harman RM , Yang S , He MK , Van de Walle GR . Antimicrobial peptides secreted by equine mesenchymal stromal cells inhibit the growth of bacteria commonly found in skin wounds . Stem Cell Res Ther . 2017 ; 8 ( 1 ): 157 .
Huynh E , Penney J , Caswell J , Li J . Protective effects of protegrin in dextran sodium sulfate-induced murine colitis . Front Pharmacol . 2019 ; 10 : 156 .
Reczyńska D , Zalewska M , Czopowicz M , Kaba J , Zwierzchowski L , Bagnicka E . Small ruminant lentivirus infection influences expression of acute phase proteins and cathelicidin genes in milk somatic cells and peripheral blood leukocytes of dairy goats . Vet Res . 2018 ; 49 ( 1 ): 113 .
Panteleev PV , Bolosov IA , Kalashnikov AA , Kokryakov VN , Shamova OV , Emelianova AA , et al . Combined antibacterial effects of goat cathelicidins with different mechanisms of action . Front Microbiol . 2018 ; 9 : 2983 .
Tedde V , Bronzo V , Puggioni GMG , Pollera C , Casula A , Curone G , et al . Milk cathelicidin and somatic cell counts in dairy goats along the course of lactation . J Dairy Res . 2019 ; 86 ( 2 ): 217 - 21 .
de Lima M , da Silva RA , da Silva MF , da Silva PAB , Costa R , Teixeira JAC , et al . Brazilian kefir-fermented Sheep’s milk, a source of antimicrobial and antioxidant peptides . Probiotics Antimicrob Proteins . 2018 ; 10 ( 3 ): 446 - 55 .
Coorens M , Schneider VAF , de Groot AM , van Dijk A , Meijerink M , Wells JM , et al . Cathelicidins inhibit Escherichia coli-induced TLR2 and TLR4 activation in a viability-dependent manner . J Immunol . 2017 ; 199 ( 4 ): 1418 - 28 .
Schneider VA , Coorens M , Ordonez SR , Tjeerdsma-van Bokhoven JL , Posthuma G , van Dijk A , et al . Imaging the antimicrobial mechanism(s) of cathelicidin-2 . Sci Rep . 2016 ; 6 : 32948 .
Nakazawa M , Maeda S , Omori M , Kaji K , Yokoyama N , Nakagawa T , et al . Duodenal expression of antimicrobial peptides in dogs with idiopathic inflammatory bowel disease and intestinal lymphoma . Vet J . 2019 ; 249 : 47 - 52 .
Peng H , Purkerson JM , Schwaderer AL , Schwartz GJ . Metabolic acidosis stimulates the production of the antimicrobial peptide cathelicidin in rabbit urine . Am J Physiol Renal Physiol . 2017 ; 313 ( 5 ): F1061 - 7 .
Nagaoka I , Tamura H , Reich J . Therapeutic potential of cathelicidin peptide LL-37, an antimicrobial agent, in a murine sepsis model . Int J Mol Sci . 2020 ; 21 ( 17 ): 5973 .
Fruitwala S , El-Naccache DW , Chang TL . Multifaceted immune functions of human defensins and underlying mechanisms . Semin Cell Dev Biol . 2019 ; 88 : 163 - 72 .
Pace BT , Lackner AA , Porter E , Pahar B . The role of defensins in HIV pathogenesis . Mediators Inflamm . 2017 ; 2017 : 5186904 .
Contreras G , Shirdel I , Braun MS , Wink M . Defensins: transcriptional regulation and function beyond antimicrobial activity . Dev Comp Immunol . 2020 ; 104 : 103556 .
Pasupuleti M , Schmidtchen A , Malmsten M . Antimicrobial peptides: key components of the innate immune system . Crit Rev Biotechnol . 2012 ; 32 ( 2 ): 143 - 71 .
Gurao A , Kashyap SK , Singh R . Beta-defensins: an innate defense for bovine mastitis . Vet World . 2017 ; 10 ( 8 ): 990 - 8 .
Tang KY , Wang X , Wan QH , Fang SG . A crucial role of paralogous betadefensin genes in the Chinese alligator innate immune system revealed by the first determination of a Crocodilia defensin cluster . Dev Comp Immunol . 2018 ; 81 : 193 - 203 .
Wang R , Ma D , Lin L , Zhou C , Han Z , Shao Y , et al . Identification and characterization of an avian beta-defensin orthologue, avian betadefensin 9, from quails . Appl Microbiol Biotechnol . 2010 ; 87 ( 4 ): 1395 - 405 .
Pei J , Jiang L . Antimicrobial peptide from mucus of Andrias davidianus: screening and purification by magnetic cell membrane separation technique . Int J Antimicrob Agents . 2017 ; 50 ( 1 ): 41 - 6 .
Li T , Liu Q , Wang D , Li J . Characterization and antimicrobial mechanism of CF-14, a new antimicrobial peptide from the epidermal mucus of catfish . Fish Shellfish Immunol . 2019 ; 92 : 881 - 8 .
Chang YL , Wang Z , Igawa S , Choi JE , Werbel T , Di Nardo A . Lipocalin 2: a new antimicrobial in mast cells . Int J Mol Sci . 2019 ; 20 ( 10 ): 2380 .
Schneider JJ , Unholzer A , Schaller M , Schafer-Korting M , Korting HC . Human defensins . J Mol Med (Berl) . 2005 ; 83 ( 8 ): 587 - 95 .
Sørense O , Arnljots K , Cowland JB , Bainton DF , Borregaard N . The human antibacterial cathelicidin, hCAP-18, is synthesized in myelocytes and metamyelocytes and localized to specific granules in neutrophils . Blood . 1997 ; 90 ( 7 ): 2796 - 803 .
Pinheiro da Silva F , Machado MC . The dual role of cathelicidins in systemic inflammation . Immunol Lett . 2017 ; 182 : 57 - 60 .
Varga JFA , Bui-Marinos MP , Katzenback BA . Frog skin innate immune defences: sensing and surviving pathogens . Front Immunol . 2018 ; 9 : 3128 .
Pei J , Feng Z , Ren T , Sun H , Han H , Jin W , et al . Purification, characterization and application of a novel antimicrobial peptide from Andrias davidianus blood . Lett Appl Microbiol . 2018 ; 66 ( 1 ): 38 - 43 .
Hui CY , Guo Y , Zhang W , Yang XQ , Gao CX , Yang XY . Isolation and characterization of antimicrobial peptides from healthy male urine . Pak J Pharm Sci . 2017 ; 30 ( 2 ): 363 - 7 .
Wu CX , Liu ZF . Proteomic profiling of sweat exosome suggests its involvement in skin immunity . J Invest Dermatol . 2018 ; 138 ( 1 ): 89 - 97 .
Correia A , Weimann A . Protein antibiotics: mind your language . Nat Rev Microbiol . 2021 ; 19 ( 1 ): 7 .
Di Somma A , Moretta A , Canè C , Cirillo A , Duilio A . Antimicrobial and antibiofilm peptides . Biomolecules . 2020 ; 10 ( 4 ): 652 .
Pirtskhalava M , Amstrong AA , Grigolava M , Chubinidze M , Alimbarashvili E , Vishnepolsky B , et al . DBAASP v3: database of antimicrobial/cytotoxic activity and structure of peptides as a resource for development of new therapeutics . Nucleic Acids Res . 2021 ; 49 ( D1 ): D288 - 97 .
Dennison SR , Harris F , Mura M , Phoenix DA . An atlas of anionic antimicrobial peptides from amphibians . Curr Protein Pept Sci . 2018 ; 19 ( 8 ): 823 - 38 .
Almarwani B , Phambu N , Hamada YZ , Sunda-Meya A . Interactions of an anionic antimicrobial peptide with Zinc(II): application to bacterial mimetic membranes . Langmuir . 2020 ; 36 ( 48 ): 14554 - 62 .
de Haën C , Neurath H , Teller DC . The phylogeny of trypsin-related serine proteases and their zymogens. New methods for the investigation of distant evolutionary relationships . J Mol Biol . 1975 ; 92 ( 2 ): 225 - 59 .
Miller A , Matera-Witkiewicz A , Mikolajczyk A , Watly J , Wilcox D , Witkowska D , et al . Zn-enhanced Asp-rich antimicrobial peptides: N-terminal coordination by Zn(II) and Cu(II), which distinguishes Cu(II) binding to different peptides . Int J Mol Sci . 2021 ; 22 ( 13 ): 6971 .
Teixeira V , Feio MJ , Bastos M . Role of lipids in the interaction of antimicrobial peptides with membranes . Prog Lipid Res . 2012 ; 51 ( 2 ): 149 - 77 .
Gennaro R , Zanetti M . Structural features and biological activities of the cathelicidin-derived antimicrobial peptides . Biopolymers . 2000 ; 55 ( 1 ): 31 - 49 .
Lewies A , Wentzel JF , Jacobs G , Du Plessis LH . The potential use of natural and structural analogues of antimicrobial peptides in the fight against neglected tropical diseases . Molecules . 2015 ; 20 ( 8 ): 15392 - 433 .
Aidoukovitch A , Dahl S , Falt F , Nebel D , Svensson D , Tufvesson E , et al . Antimicrobial peptide LL-37 and its pro-form, hCAP18, in desquamated epithelial cells of human whole saliva . Eur J Oral Sci . 2020 ; 128 ( 1 ): 1 - 6 .
Fabisiak A , Murawska N , Fichna J . LL-37: cathelicidin-related antimicrobial peptide with pleiotropic activity . Pharmacol Rep . 2016 ; 68 ( 4 ): 802 - 8 .
Johansson J , Gudmundsson GH , Rottenberg ME , Berndt KD , Agerberth B . Conformation-dependent antibacterial activity of the naturally occurring human peptide LL-37 . J Biol Chem . 1998 ; 273 ( 6 ): 3718 - 24 .
Koehbach J , Craik DJ . The vast structural diversity of antimicrobial peptides . Trends Pharmacol Sci . 2019 ; 40 ( 7 ): 517 - 28 .
Zhao H . Mode of action of antimicrobial peptides [academic dissertation] . Helsinki: University of Helsinki . 2003 ; 47 ( 3 ): 965 - 71 .
Klüver E , Schulz-Maronde S , Scheid S , Meyer B , Forssmann WG , Adermann K . Structure-activity relation of human beta-defensin 3: influence of disulfide bonds and cysteine substitution on antimicrobial activity and cytotoxicity . Biochemistry . 2005 ; 44 ( 28 ): 9804 - 16 .
Mattar EH , Almehdar HA , Yacoub HA , Uversky VN , Redwan EM . Antimicrobial potentials and structural disorder of human and animal defensins . Cytokine Growth Factor Rev . 2016 ; 28 : 95 - 111 .
Lehrer RI , Lu W . Alpha-defensins in human innate immunity . Immunol Rev . 2012 ; 245 ( 1 ): 84 - 112 .
Tai KP , Le VV , Selsted ME , Ouellette AJ . Hydrophobic determinants of α-defensin bactericidal activity . Infect Immun . 2014 ; 82 ( 6 ): 2195 - 202 .
Koehbach J . Structure-activity relationships of insect defensins . Front Chem . 2017 ; 5 : 45 .
Guyot N , Meudal H , Trapp S , Iochmann S , Silvestre A , Jousset G , et al . Structure, function, and evolution of Gga-AvBD11, the archetype of the structural avian-double-beta-defensin family . Proc Natl Acad Sci U S A . 2020 ; 117 ( 1 ): 337 - 45 .
Sitaram N . Antimicrobial peptides with unusual amino acid compositions and unusual structures . Curr Med Chem . 2006 ; 13 ( 6 ): 679 - 96 .
Selsted ME . Theta-defensins: cyclic antimicrobial peptides produced by binary ligation of truncated alpha-defensins . Curr Protein Pept Sci . 2004 ; 5 ( 5 ): 365 - 71 .
Conibear AC , Rosengren KJ , Daly NL , Henriques ST , Craik DJ . The cyclic cystine ladder in theta-defensins is important for structure and stability, but not antibacterial activity . J Biol Chem . 2013 ; 288 ( 15 ): 10830 - 40 .
Holani R , Shah C , Haji Q , Inglis GD , Uwiera RRE , Cobo ER . Prolinearginine rich (PR-39) cathelicidin: structure, expression and functional implication in intestinal health . Comp Immunol Microbiol Infect Dis . 2016 ; 49 : 95 - 101 .
Hernandez-Flores JL , Rodriguez MC , Gastelum Arellanez A , Alvarez-Morales A , Avila EE . Effect of recombinant prophenin 2 on the integrity and viability of Trichomonas vaginalis . Biomed Res Int . 2015 ; 2015 : 430436 .
Smirnova MP , Kolodkin NI , Kolobov AA , Afonin VG , Afonina IV , Stefanenko LI , et al . Indolicidin analogs with broad-spectrum antimicrobial activity and low hemolytic activity . Peptides . 2020 ; 132 : 170356 .
Khurshid Z , Najeeb S , Mali M , Moin SF , Raza SQ , Zohaib S , et al . Histatin peptides: pharmacological functions and their applications in dentistry . Saudi Pharm J . 2017 ; 25 ( 1 ): 25 - 31 .
Starling S . Innate immunity: a new way out for lysozyme . Nat Rev Gastroenterol Hepatol . 2017 ; 14 ( 10 ): 567 .
Ragland SA , Criss AK . From bacterial killing to immune modulation: recent insights into the functions of lysozyme . PLoS Pathog . 2017 ; 13 ( 9 ): e1006512 .
Zhang C , Zhang J , Liu M , Huang M . Molecular cloning, expression and antibacterial activity of goose-type lysozyme gene in Microptenus salmoides . Fish Shellfish Immunol . 2018 ; 82 : 9 - 16 .
Ibrahim HR , Thomas U , Pellegrini A . A helix-loop-helix peptide at the upper lip of the active site cleft of lysozyme confers potent antimicrobial activity with membrane permeabilization action . J Biol Chem . 2001 ; 276 ( 47 ): 43767 - 74 .
Toda H , Williams JA , Gulledge M , Sehgal A . A sleep-inducing gene, nemuri, links sleep and immune function in Drosophila . Science . 2019 ; 363 ( 6426 ): 509 - 15 .
Harford C , Sarkar B . Amino terminal Cu(II)- and Ni(II)-binding (ATCUN) motif of proteins and peptides: metal binding, DNA cleavage, and other properties . Acc Chem Res . 1997 ; 30 : 123 - 30 .
Portelinha J , Duay SS , Yu SI , Heilemann K , Libardo MDJ , Juliano SA , et al . Antimicrobial peptides and copper(II) ions: novel therapeutic opportunities . Chem Rev . 2021 ; 121 ( 4 ): 2648 - 712 .
Wende C , Kulak N . Fluorophore ATCUN complexes: combining agent and probe for oxidative DNA cleavage . Chem Commun (Camb) . 2015 ; 51 ( 62 ): 12395 - 8 .
Heinrich J , König NF , Sobottka S , Sarkar B , Kulak N . Flexible vs . rigid bis(2-benzimidazolyl) ligands in Cu(II) complexes: impact on redox chemistry and oxidative DNA cleavage activity . J Inorg Biochem . 2019 ; 194 : 223 - 32 .
Lin TY , Weibel DB . Organization and function of anionic phospholipids in bacteria . Appl Microbiol Biotechnol . 2016 ; 100 ( 10 ): 4255 - 67 .
Enoki TA , Moreira-Silva I , Lorenzon EN , Cilli EM , Perez KR , Riske KA , et al . Antimicrobial peptide K0-W6-Hya1 induces stable structurally modified lipid domains in anionic membranes . Langmuir . 2018 ; 34 ( 5 ): 2014 - 25 .
Vance JE . Phospholipid synthesis and transport in mammalian cells . Traffic . 2015 ; 16 ( 1 ): 1 - 18 .
Florek OB , Clifton LA , Wilde M , Arnold T , Green RJ , Frazier RA . Lipid composition in fungal membrane models: effect of lipid fluidity . Acta Crystallogr D Struct Biol . 2018 ; 74 ( Pt 12 ): 1233 - 44 .
Renne MF , de Kroon A . The role of phospholipid molecular species in determining the physical properties of yeast membranes . FEBS Lett . 2018 ; 592 ( 8 ): 1330 - 45 .
Baxter AA , Lay FT , Poon IKH , Kvansakul M , Hulett MD . Tumor cell membrane-targeting cationic antimicrobial peptides: novel insights into mechanisms of action and therapeutic prospects . Cell Mol Life Sci . 2017 ; 74 ( 20 ): 3809 - 25 .
Groux-Degroote S , Guérardel Y , Delannoy P . Gangliosides: structures, biosynthesis, analysis, and roles in cancer . ChemBioChem . 2017 ; 18 ( 13 ): 1146 - 54 .
Vicente CM , da Silva DA , Sartorio PV , Silva TD , Saad SS , Nader HB , et al . Heparan sulfate proteoglycans in human colorectal cancer . Anal Cell Pathol (Amst) . 2018 ; 2018 : 8389595 .
Riedl S , Zweytick D , Lohner K . Membrane-active host defense peptides–challenges and perspectives for the development of novel anticancer drugs . Chem Phys Lipids . 2011 ; 164 ( 8 ): 766 - 81 .
Rajagopal M , Walker S . Envelope structures of gram-positive bacteria . Curr Top Microbiol Immunol . 2017 ; 404 : 1 - 44 .
Baek MH , Kamiya M , Kushibiki T , Nakazumi T , Tomisawa S , Abe C , et al . Lipopolysaccharide-bound structure of the antimicrobial peptide cecropin P1 determined by nuclear magnetic resonance spectroscopy . J Pept Sci . 2016 ; 22 ( 4 ): 214 - 21 .
Malanovic N , Lohner K . Gram-positive bacterial cell envelopes: the impact on the activity of antimicrobial peptides . Biochim Biophys Acta . 2016 ; 1858 ( 5 ): 936 - 46 .
Bechinger B , Gorr SU . Antimicrobial peptides: mechanisms of action and resistance . J Dent Res . 2017 ; 96 ( 3 ): 254 - 60 .
Hong J , Lu X , Deng Z , Xiao S , Yuan B , Yang K . How melittin inserts into cell membrane: conformational changes, inter-peptide cooperation, and disturbance on the membrane . Molecules . 2019 ; 24 ( 9 ): 1775 .
Oliva R , Del Vecchio P , Grimaldi A , Notomista E , Cafaro V , Pane K , et al . Membrane disintegration by the antimicrobial peptide (P)GKY20: lipid segregation and domain formation . Phys Chem Chem Phys . 2019 ; 21 ( 7 ): 3989 - 98 .
Queme-Pena M , Juhasz T , Mihaly J , Cs Szigyarto I , Horvati K , Bosze S , et al . Manipulating active structure and function of cationic antimicrobial peptide CM15 with the polysulfonated drug suramin: a step closer to in vivo complexity . ChemBioChem . 2019 ; 20 ( 12 ): 1578 - 90 .
Lee TH , Hall KN , Aguilar MI . Antimicrobial peptide structure and mechanism of action: a focus on the role of membrane structure . Curr Top Med Chem . 2016 ; 16 ( 1 ): 25 - 39 .
Abrunhosa F , Faria S , Gomes P , Tomaz I , Pessoa JC , Andreu D , et al . Interaction and lipid-induced conformation of two cecropin-melittin hybrid peptides depend on peptide and membrane composition . J Phys Chem B . 2005 ; 109 ( 36 ): 17311 - 9 .
Strandberg E , Wadhwani P , Tremouilhac P , Durr UH , Ulrich AS . Solid-state NMR analysis of the PGLa peptide orientation in DMPC bilayers: structural fidelity of 2H-labels versus high sensitivity of 19F-NMR . Biophys J . 2006 ; 90 ( 5 ): 1676 - 86 .
Silva JP , Appelberg R , Gama FM . Antimicrobial peptides as novel antituberculosis therapeutics . Biotechnol Adv . 2016 ; 34 ( 5 ): 924 - 40 .
Kumar P , Kizhakkedathu JN , Straus SK . Antimicrobial peptides: diversity, mechanism of action and strategies to improve the activity and biocompatibility in vivo . Biomolecules . 2018 ; 8 ( 1 ): 4 .
Hale JD , Hancock RE . Alternative mechanisms of action of cationic antimicrobial peptides on bacteria . Expert Rev Anti Infect Ther . 2007 ; 5 ( 6 ): 951 - 9 .
Hancock RE , Patrzykat A . Clinical development of cationic antimicrobial peptides: from natural to novel antibiotics . Curr Drug Targets Infect Disord . 2002 ; 2 ( 1 ): 79 - 83 .
Dennison SR , Morton LH , Harris F , Phoenix DA . Low pH enhances the action of maximin H5 against Staphylococcus aureus and helps mediate lysylated phosphatidylglycerol-induced resistance . Biochemistry . 2016 ; 55 ( 27 ): 3735 - 51 .
Li S , Hao L , Bao W , Zhang P , Su D , Cheng Y , et al . A novel short anionic antibacterial peptide isolated from the skin of Xenopus laevis with broad antibacterial activity and inhibitory activity against breast cancer cell . Arch Microbiol . 2016 ; 198 ( 5 ): 473 - 82 .
Sowa-Jasilek A , Zdybicka-Barabas A , Staczek S , Pawlikowska-Pawlega B , Grygorczuk-Planeta K , Skrzypiec K , et al . Antifungal activity of anionic defense peptides: insight into the action of galleria mellonella anionic peptide 2 . Int J Mol Sci . 2020 ; 21 ( 6 ): 1912 .
Mandal SM , Khan J , Mahata D , Saha S , Sengupta J , Silva ON , et al . A self-assembled clavanin A-coated amniotic membrane scaffold for the prevention of biofilm formation by ocular surface fungal pathogens . Biofouling . 2017 ; 33 ( 10 ): 881 - 91 .
Fiorentino F , Sauer JB , Qiu X , Corey RA , Cassidy CK , Mynors-Wallis B , et al . Dynamics of an LPS translocon induced by substrate and an antimicrobial peptide . Nat Chem Biol . 2021 ; 17 ( 2 ): 187 - 95 .
Cardoso MH , Meneguetti BT , Costa BO , Buccini DF , Oshiro KGN , Preza SLE , et al . Non-lytic antibacterial peptides that translocate through bacterial membranes to act on intracellular targets . Int J Mol Sci . 2019 ; 20 ( 19 ): 4877 .
Uyterhoeven ET , Butler CH , Ko D , Elmore DE . Investigating the nucleic acid interactions and antimicrobial mechanism of buforin II . FEBS Lett . 2008 ; 582 ( 12 ): 1715 - 8 .
Zhang Y , Liu S , Li S , Cheng Y , Nie L , Wang G , et al . Novel short antimicrobial peptide isolated from Xenopus laevis skin . J Pept Sci . 2017 ; 23 ( 5 ): 403 - 9 .
Chen X , Li L . Non-membrane mechanisms of antimicrobial peptide P7 against Escherichia coli . Wei Sheng Wu Xue Bao . 2016 ; 56 ( 11 ): 1737 - 45 .
Kang HK , Seo CH , Luchian T , Park Y . Pse-T2, an antimicrobial peptide with high-level, broad-spectrum antimicrobial potency and skin biocompatibility against multidrug-resistant Pseudomonas aeruginosa infection . Antimicrob Agents Chemother . 2018 ; 62 ( 12 ): e01493 - e1518 .
Wu C , Biswas S , Garcia De Gonzalo CV , van der Donk WA . Investigations into the mechanism of action of sublancin . ACS Infect Dis . 2019 ; 5 ( 3 ): 454 - 9 .
Boman HG , Agerberth B , Boman A . Mechanisms of action on Escherichia coli of cecropin P1 and PR-39, two antibacterial peptides from pig intestine . Infect Immun . 1993 ; 61 ( 7 ): 2978 - 84 .
Graf M , Mardirossian M , Nguyen F , Seefeldt AC , Guichard G , Scocchi M , et al . Proline-rich antimicrobial peptides targeting protein synthesis . Nat Prod Rep . 2017 ; 34 ( 7 ): 702 - 11 .
Roy RN , Lomakin IB , Gagnon MG , Steitz TA . The mechanism of inhibition of protein synthesis by the proline-rich peptide oncocin . Nat Struct Mol Biol . 2015 ; 22 ( 6 ): 466 - 9 .
Florin T , Maracci C , Graf M , Karki P , Klepacki D , Berninghausen O , et al . An antimicrobial peptide that inhibits translation by trapping release factors on the ribosome . Nat Struct Mol Biol . 2017 ; 24 ( 9 ): 752 - 7 .
Mardirossian M , Barriere Q , Timchenko T , Muller C , Pacor S , Mergaert P , et al . Fragments of the nonlytic proline-rich antimicrobial peptide Bac5 Kill Escherichia coli cells by inhibiting protein synthesis . Antimicrob Agents Chemother . 2018 ; 62 ( 8 ): e00534 - e618 .
Otvos L Jr , Rogers ME , Consolvo PJ , Condie BA , Lovas S , et al . Interaction between heat shock proteins and antimicrobial peptides . Biochemistry . 2000 ; 39 ( 46 ): 14150 - 9 .
Kragol G , Lovas S , Varadi G , Condie BA , Hoffmann R , Otvos L Jr . The antibacterial peptide pyrrhocoricin inhibits the ATPase actions of DnaK and prevents chaperone-assisted protein folding . Biochemistry . 2001 ; 40 ( 10 ): 3016 - 26 .
Braffman NR , Piscotta FJ , Hauver J , Campbell EA , Link AJ , Darst SA . Structural mechanism of transcription inhibition by lasso peptides microcin J25 and capistruin . Proc Natl Acad Sci U S A . 2019 ; 116 ( 4 ): 1273 - 8 .
Yang H , Fu J , Zhao Y , Shi H , Hu H , Wang H . Escherichia coli PagP enzyme-based de novo design and in vitro activity of antibacterial peptide LL-37 . Med Sci Monit . 2017 ; 23 : 2558 - 64 .
Hou X , Feng C , Li S , Luo Q , Shen G , Wu H , et al . Mechanism of antimicrobial peptide NP-6 from Sichuan pepper seeds against E. coli and effects of different environmental factors on its activity . Appl Microbiol Biotechnol . 2019 ; 103 ( 16 ): 6593 - 604 .
Lehrer RI , Barton A , Daher KA , Harwig SS , Ganz T , Selsted ME . Interaction of human defensins with Escherichia coli. Mechanism of bactericidal activity . J Clin Invest . 1989 ; 84 ( 2 ): 553 - 61 .
de Leeuw E , Li C , Zeng P , Li C , Diepeveen-de Buin M , Lu WY , et al . Functional interaction of human neutrophil peptide-1 with the cell wall precursor lipid II . FEBS Lett . 2010 ; 584 ( 8 ): 1543 - 8 .
Ling LL , Schneider T , Peoples AJ , Spoering AL , Engels I , Conlon BP , et al . A new antibiotic kills pathogens without detectable resistance . Nature . 2015 ; 517 ( 7535 ): 455 - 9 .
Manabe T , Kawasaki K . D-form KLKLLLLLKLK-NH2 peptide exerts higher antimicrobial properties than its L-form counterpart via an association with bacterial cell wall components . Sci Rep . 2017 ; 7 : 43384 .
Wilmes M , Stockem M , Bierbaum G , Schlag M , Gotz F , Tran DQ , et al . Killing of Staphylococci by theta-defensins involves membrane impairment and activation of autolytic enzymes . Antibiotics (Basel) . 2014 ; 3 ( 4 ): 617 - 31 .
Yasir M , Dutta D , Willcox MDP . Mode of action of the antimicrobial peptide Mel4 is independent of Staphylococcus aureus cell membrane permeability . PLoS ONE . 2019 ; 14 ( 7 ): e0215703 .
Lv Y , Shao G , Zhang Q , Wang X , Meng Y , Wang L , et al . The antimicrobial peptide PFR induces necroptosis mediated by ER stress and elevated cytoplasmic calcium and mitochondrial ROS levels: cooperation with Ara-C to act against acute myeloid leukemia . Signal Transduct Target Ther . 2019 ; 4 : 38 .
Kurpe SR , Grishin SY , Surin AK , Panfilov AV , Slizen MV , Chowdhury SD , et al . Antimicrobial and amyloidogenic activity of peptides. Can antimicrobial peptides be used against SARS-CoV-2? Int J Mol Sci . 2020 ; 21 ( 24 ): 9552 .
Zhang M , Zhao J , Zheng J . Molecular understanding of a potential functional link between antimicrobial and amyloid peptides . Soft Matter . 2014 ; 10 ( 38 ): 7425 - 51 .
Kurpe SR , Grishin SY , Surin AK , Selivanova OM , Fadeev RS , Dzhus UF , et al . Antimicrobial and amyloidogenic activity of peptides synthesized on the basis of the ribosomal S1 protein from Thermus thermophilus . Int J Mol Sci . 2020 ; 21 ( 17 ): 6382 .
Mokoena MP . Lactic acid bacteria and their bacteriocins: classification, biosynthesis and applications against uropathogens: a mini-review . Molecules . 2017 ; 22 ( 8 ): 1255 .
Wang S , Fang Q , Lu Z , Gao Y , Trembleau L , Ebel R , et al . Discovery and biosynthetic investigation of a new antibacterial dehydrated nonribosomal tripeptide . Angew Chem Int Ed Engl . 2021 ; 60 ( 6 ): 3229 - 37 .
Galvan Marquez IJ , McKay B , Wong A , Cheetham JJ , Bean C , Golshani A , et al . Mode of action of nisin on Escherichia coli . Can J Microbiol . 2020 ; 66 ( 2 ): 161 - 8 .
Tong Z , Zhang Y , Ling J , Ma J , Huang L , Zhang L . An in vitro study on the effects of nisin on the antibacterial activities of 18 antibiotics against Enterococcus faecalis . PLoS ONE . 2014 ; 9 ( 2 ): e89209 .
Li C , Hong PP , Yang MC , Zhao XF , Wang JX . FOXO regulates the expression of antimicrobial peptides and promotes phagocytosis of hemocytes in shrimp antibacterial immunity . PLoS Pathog . 2021 ; 17 ( 4 ): e1009479 .
Rodríguez-Rojas A , Baeder DY , Johnston P , Regoes RR , Rolff J . Bacteria primed by antimicrobial peptides develop tolerance and persist . PLoS Pathog . 2021 ; 17 ( 3 ): e1009443 .
Liang X , Zhang X , Lian K , Tian X , Zhang M , Wang S , et al . Antiviral effects of Bovine antimicrobial peptide against TGEV in vivo and in vitro . J Vet Sci . 2020 ; 21 ( 5 ): e80 .
Yasin B , Wang W , Pang M , Cheshenko N , Hong T , Waring AJ , et al . Theta defensins protect cells from infection by herpes simplex virus by inhibiting viral adhesion and entry . J Virol . 2004 ; 78 ( 10 ): 5147 - 56 .
Yasin B , Pang M , Turner JS , Cho Y , Dinh NN , Waring AJ , et al . Evaluation of the inactivation of infectious Herpes simplex virus by host-defense peptides . Eur J Clin Microbiol Infect Dis . 2000 ; 19 ( 3 ): 187 - 94 .
Barlow PG , Svoboda P , Mackellar A , Nash AA , York IA , Pohl J , et al . Antiviral activity and increased host defense against influenza infection elicited by the human cathelicidin LL-37 . PLoS One . 2011 ; 6 ( 10 ): e25333 .
Bergman P , Walter-Jallow L , Broliden K , Agerberth B , Soderlund J . The antimicrobial peptide LL-37 inhibits HIV-1 replication . Curr HIV Res . 2007 ; 5 ( 4 ): 410 - 5 .
Tripathi S , Tecle T , Verma A , Crouch E , White M , Hartshorn KL . The human cathelicidin LL-37 inhibits influenza A viruses through a mechanism distinct from that of surfactant protein D or defensins . J Gen Virol . 2013 ; 94 ( Pt 1 ): 40 - 9 .
Howell MD , Jones JF , Kisich KO , Streib JE , Gallo RL , Leung DY . Selective killing of vaccinia virus by LL-37: implications for eczema vaccinatum . J Immunol . 2004 ; 172 ( 3 ): 1763 - 7 .
Howell MD , Wollenberg A , Gallo RL , Flaig M , Streib JE , Wong C , et al . Cathelicidin deficiency predisposes to eczema herpeticum . J Allergy Clin Immunol . 2006 ; 117 ( 4 ): 836 - 41 .
Ahmed A , Siman-Tov G , Hall G , Bhalla N , Narayanan A . Human antimicrobial peptides as therapeutics for viral infections . Viruses . 2019 ; 11 ( 8 ): 704 .
Yu J , Dai Y , Fu Y , Wang K , Yang Y , Li M , et al . Cathelicidin antimicrobial peptides suppress EV71 infection via regulating antiviral response and inhibiting viral binding . Antiviral Res . 2021 ; 187 : 105021 .
LeMessurier KS , Lin Y , McCullers JA , Samarasinghe AE . Antimicrobial peptides alter early immune response to influenza A virus infection in C57BL/6 mice . Antiviral Res . 2016 ; 133 : 208 - 17 .
Vilas Boas LC , de Lima LM , Migliolo L , Mendes GD , de Jesus MG , Franco OL , et al . Linear antimicrobial peptides with activity against herpes simplex virus 1 and Aichi virus . Biopolymers . 2017 . https://doi.org/10.1002/bip.22871 https://doi.org/10.1002/bip.22871 .
Marcocci ME , Amatore D , Villa S , Casciaro B , Aimola P , Franci G , et al . The amphibian antimicrobial peptide temporin B inhibits in vitro herpes simplex virus 1 infection . Antimicrob Agents Chemother . 2018 ; 62 ( 5 ): e02367 - 417 .
De Angelis M , Casciaro B , Genovese A , Brancaccio D , Marcocci ME , Novellino E , et al . Temporin G, an amphibian antimicrobial peptide against influenza and parainfluenza respiratory viruses: insights into biological activity and mechanism of action . FASEB J . 2021 ; 35 ( 2 ): e21358 .
Boffert R , Businger R , Preiss H , Ehmann D , Truffault V , Simon C , et al . The human alpha-defensin-derived peptide HD5(1–9) inhibits cellular attachment and entry of human cytomegalovirus . Antiviral Res . 2020 ; 177 : 104779 .
He M , Zhang H , Li Y , Wang G , Tang B , Zhao J , et al . Cathelicidinderived antimicrobial peptides inhibit Zika virus through direct inactivation and interferon pathway . Front Immunol . 2018 ; 9 : 722 .
Monteiro JMC , Oliveira MD , Dias RS , Nacif-Marcal L , Feio RN , Ferreira SO , et al . The antimicrobial peptide HS-1 inhibits dengue virus infection . Virology . 2018 ; 514 : 79 - 87 .
Hu H , Guo N , Chen S , Guo X , Liu X , Ye S , et al . Antiviral activity of Piscidin 1 against pseudorabies virus both in vitro and in vivo . Virol J . 2019 ; 16 ( 1 ): 95 .
Uchio E , Inoue H , Kadonosono K . Anti-adenoviral effects of human cationic antimicrobial protein-18/LL-37, an antimicrobial peptide, by quantitative polymerase chain reaction . Korean J Ophthalmol . 2013 ; 27 ( 3 ): 199 - 203 .
Sousa FH , Casanova V , Findlay F , Stevens C , Svoboda P , Pohl J , et al . Cathelicidins display conserved direct antiviral activity towards rhinovirus . Peptides . 2017 ; 95 : 76 - 83 .
Chessa C , Bodet C , Jousselin C , Wehbe M , Leveque N , Garcia M . Antiviral and immunomodulatory properties of antimicrobial peptides produced by human keratinocytes . Front Microbiol . 2020 ; 11 : 1155 .
Holly MK , Diaz K , Smith JG . Defensins in viral infection and pathogenesis . Annu Rev Virol . 2017 ; 4 ( 1 ): 369 - 91 .
Grant WB , Lahore H , McDonnell SL , Baggerly CA , French CB , Aliano JL , et al . Evidence that vitamin D supplementation could reduce risk of influenza and COVID-19 infections and deaths . Nutrients . 2020 ; 12 ( 4 ): 988 .
Ash MM , Phillips CM . Parasitic diseases with cutaneous manifestations . N C Med J . 2016 ; 77 ( 5 ): 350 - 4 .
Theel ES , Pritt BS . Parasites. Microbiol Spectr . 2016 . https://doi.org/10.1128/microbiolspec.DMIH2-0013-2015 https://doi.org/10.1128/microbiolspec.DMIH2-0013-2015 .
Parise ME , Hotez PJ , Slutsker L . Neglected parasitic infections in the United States: needs and opportunities . Am J Trop Med Hyg . 2014 ; 90 ( 5 ): 783 - 5 .
Uraki S , Sugimoto K , Shiraki K , Tameda M , Inagaki Y , Ogura S , et al . Human beta-defensin-3 inhibits migration of colon cancer cells via downregulation of metastasis-associated 1 family, member 2 expression . Int J Oncol . 2014 ; 45 ( 3 ): 1059 - 64 .
Pitale DM , Kaur G , Baghel M , Kaur KJ , Shaha C . Halictine-2 antimicrobial peptide shows promising anti-parasitic activity against Leishmania spp . Exp Parasitol . 2020 ; 218 : 107987 .
Tinoco-Nunes B , Telleria EL , da Silva-Neves M , Marques C , Azevedo-Brito DA , Pitaluga AN , et al . The sandfly Lutzomyia longipalpis LL5 embryonic cell line has active Toll and Imd pathways and shows immune responses to bacteria, yeast and Leishmania . Parasit Vectors . 2016 ; 9 : 222 .
Fang Y , He X , Zhang P , Shen C , Mwangi J , Xu C , et al . In vitro and in vivo antimalarial activity of LZ1, a peptide derived from snake cathelicidin . Toxins (Basel) . 2019 ; 11 ( 7 ): 379 .
Kuckelhaus SA , Leite JR , Muniz-Junqueira MI , Sampaio RN , Bloch C Jr , Tosta CE . Antiplasmodial and antileishmanial activities of phylloseptin-1, an antimicrobial peptide from the skin secretion of Phyllomedusa azurea (Amphibia) . Exp Parasitol . 2009 ; 123 ( 1 ): 11 - 6 .
Hancock RE , Haney EF , Gill EE . The immunology of host defence peptides: beyond antimicrobial activity . Nat Rev Immunol . 2016 ; 16 ( 5 ): 321 - 34 .
Mack MR , Kim BS . Superficial immunity: antimicrobial responses are more than skin deep . Immunity . 2016 ; 45 ( 1 ): 6 - 8 .
Kang HK , Lee HH , Seo CH , Park Y . Antimicrobial and immunomodulatory properties and applications of marine-derived proteins and peptides . Mar Drugs . 2019 ; 17 ( 6 ): 350 .
Jirillo E , Magrone T . Editorial: antimicrobial peptides as mediators of innate immunity . Curr Pharm Des . 2018 ; 24 ( 10 ): 1041 - 2 .
Neumann A , Vollger L , Berends ET , Molhoek EM , Stapels DA , Midon M , et al . Novel role of the antimicrobial peptide LL-37 in the protection of neutrophil extracellular traps against degradation by bacterial nucleases . J Innate Immun . 2014 ; 6 ( 6 ): 860 - 8 .
Tjabringa GS , Ninaber DK , Drijfhout JW , Rabe KF , Hiemstra PS . Human cathelicidin LL-37 is a chemoattractant for eosinophils and neutrophils that acts via formyl-peptide receptors . Int Arch Allergy Immunol . 2006 ; 140 ( 2 ): 103 - 12 .
Yang D , Chen Q , Schmidt AP , Anderson GM , Wang JM , Wooters J , et al . LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1 (FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells . J Exp Med . 2000 ; 192 ( 7 ): 1069 - 74 .
Agier J , Brzezińska-Błaszczyk E . Cathelicidins and defensins regulate mast cell antimicrobial activity . Postepy Hig Med Dosw (Online) . 2016 ; 70 : 618 - 36 .
Lishko VK , Moreno B , Podolnikova NP , Ugarova TP . Identification of human cathelicidin peptide LL-37 as a ligand for macrophage integrin αMβ2 (Mac-1, CD11b/CD18) that promotes phagocytosis by opsonizing bacteria . Res Rep Biochem . 2016 ; 2016 ( 6 ): 39 - 55 .
Cao Y , Chen F , Sun Y , Hong H , Wen Y , Lai Y , et al . LL-37 promotes neutrophil extracellular trap formation in chronic rhinosinusitis with nasal polyps . Clin Exp Allergy . 2019 ; 49 ( 7 ): 990 - 9 .
Yoon SH , Hwang I , Lee E , Cho HJ , Ryu JH , Kim TG , et al . Antimicrobial peptide Ll-37 drives rosacea-like skin inflammation in an Nlrp3-dependent manner . J Invest Dermatol . 2021 ; S0022-202X(21)01009-5 .
Schiffmann S , Gunne S , Henke M , Ulshofer T , Steinhilber D , Sethmann A , et al . Sodium bituminosulfonate used to treat rosacea modulates generation of inflammatory mediators by primary human neutrophils . J Inflamm Res . 2021 ; 14 : 2569 - 82 .
Bąbolewska E , Brzezińska-Błaszczyk E . Human-derived cathelicidin LL-37 directly activates mast cells to proinflammatory mediator synthesis and migratory response . Cell Immunol . 2015 ; 293 ( 2 ): 67 - 73 .
Agier J , Brzezińska-Błaszczyk E , Żelechowska P , Wiktorska M , Pietrzak J , Różalska S . Cathelicidin LL-37 affects surface and intracellular Toll-like receptor expression in tissue mast cells . J Immunol Res . 2018 ; 2018 : 7357162 .
Bowdish DM , Davidson DJ , Speert DP , Hancock RE . The human cationic peptide LL-37 induces activation of the extracellular signal-regulated kinase and p38 kinase pathways in primary human monocytes . J Immunol . 2004 ; 172 ( 6 ): 3758 - 65 .
Nakamura K , Sakuragi N , Takakuwa A , Ayabe T . Paneth cell α-defensins and enteric microbiota in health and disease . Biosci Microbiota Food Health . 2016 ; 35 ( 2 ): 57 - 67 .
Takakuwa A , Nakamura K , Kikuchi M , Sugimoto R , Ohira S , Yokoi Y , et al . Butyric acid and leucine induce alpha-defensin secretion from small intestinal paneth cells . Nutrients . 2019 ; 11 ( 11 ): 2817 .
Xu D , Lu W . Defensins: a double-edged sword in host immunity . Front Immunol . 2020 ; 11 : 764 .
Soehnlein O , Kai-Larsen Y , Frithiof R , Sorensen OE , Kenne E , Scharffetter-Kochanek K , et al . Neutrophil primary granule proteins HBP and HNP1-3 boost bacterial phagocytosis by human and murine macrophages . J Clin Invest . 2008 ; 118 ( 10 ): 3491 - 502 .
Niyonsaba F , Ushio H , Nakano N , Ng W , Sayama K , Hashimoto K , et al . Antimicrobial peptides human beta-defensins stimulate epidermal keratinocyte migration, proliferation and production of proinflammatory cytokines and chemokines . J Invest Dermatol . 2007 ; 127 ( 3 ): 594 - 604 .
Medina Santos CE , Lopez Hurtado CN , Rivas Santiago B , Gonzalez-Amaro R , Catano Canizales YG , Martinez Fierro ML , et al . LL-37, HNP-1, and HBD2/3 modulate the secretion of cytokines TNF-alpha, IL-6, IFN-gamma, IL-10 and MMP1 in human primary cell cultures . Eur Cytokine Netw . 2016 ; 27 ( 3 ): 68 - 74 .
Burgey C , Kern WV , Römer W , Sakinc T , Rieg S . The innate defense antimicrobial peptides hBD3 and RNase7 are induced in human umbilical vein endothelial cells by classical inflammatory cytokines but not Th17 cytokines . Microbes Infect . 2015 ; 17 ( 5 ): 353 - 9 .
Huang C , Yang X , Huang J , Liu X , Yang X , Jin H , et al . Porcine betadefensin 2 provides protection against bacterial infection by a direct bactericidal activity and alleviates inflammation via interference with the TLR4/NF-kappaB pathway . Front Immunol . 2019 ; 10 : 1673 .
Sechet E , Telford E , Bonamy C , Sansonetti PJ , Sperandio B . Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3 . Proc Natl Acad Sci U S A . 2018 ; 115 ( 42 ): E9869 - 78 .
Xu D , Liao C , Zhang B , Tolbert WD , He W , Dai Z , et al . Human enteric α-defensin 5 promotes Shigella infection by enhancing bacterial adhesion and invasion . Immunity . 2018 ; 48 ( 6 ): 1233 - 44 .
Xu D , Liao C , Xiao J , Fang K , Zhang W , Yuan W , et al . Human enteric defensin 5 promotes Shigella infection of macrophages . Infect Immun . 2019 ; 88 ( 1 ): e00769 - e819 .
Prasad SV , Fiedoruk K , Daniluk T , Piktel E , Bucki R . Expression and function of host defense peptides at inflammation sites . Int J Mol Sci . 2019 ; 21 ( 1 ): 104 .
Hosoda H , Nakamura K , Hu Z , Tamura H , Reich J , Kuwahara-Arai K , et al . Antimicrobial cathelicidin peptide LL37 induces NET formation and suppresses the inflammatory response in a mouse septic model . Mol Med Rep . 2017 ; 16 ( 4 ): 5618 - 26 .
Zhang Z , Le K , La Placa D , Armstrong B , Miller MM , Shively JE . CXCR2 specific endocytosis of immunomodulatory peptide LL-37 in human monocytes and formation of LL-37 positive large vesicles in differentiated monoosteophils . Bone Rep . 2020 ; 12 : 100237 .
Alalwani SM , Sierigk J , Herr C , Pinkenburg O , Gallo R , Vogelmeier C , et al . The antimicrobial peptide LL-37 modulates the inflammatory and host defense response of human neutrophils . Eur J Immunol . 2010 ; 40 ( 4 ): 1118 - 26 .
Luo XL , Li JX , Huang HR , Duan JL , Dai RX , Tao RJ , et al . LL37 Inhibits Aspergillus fumigatus infection via directly binding to the fungus and preventing excessive inflammation . Front Immunol . 2019 ; 10 : 283 .
Zhang C , Yang M , Ericsson AC . Antimicrobial peptides: potential application in liver cancer . Front Microbiol . 2019 ; 10 : 1257 .
Jin G , Weinberg A . Human antimicrobial peptides and cancer . Semin Cell Dev Biol . 2019 ; 88 : 156 - 62 .
Niemirowicz K , Prokop I , Wilczewska AZ , Wnorowska U , Piktel E , Watek M , et al . Magnetic nanoparticles enhance the anticancer activity of cathelicidin LL-37 peptide against colon cancer cells . Int J Nanomedicine . 2015 ; 10 : 3843 - 53 .
Kuroda K , Fukuda T , Isogai H , Okumura K , Krstic-Demonacos M , Isogai E . Antimicrobial peptide FF/CAP18 induces apoptotic cell death in HCT116 colon cancer cells via changes in the metabolic profile . Int J Oncol . 2015 ; 46 ( 4 ): 1516 - 26 .
Piktel E , Niemirowicz K , Wnorowska U , Watek M , Wollny T , Gluszek K , et al . The role of cathelicidin LL-37 in cancer development . Arch Immunol Ther Exp (Warsz) . 2016 ; 64 ( 1 ): 33 - 46 .
Ren SX , Cheng AS , To KF , Tong JH , Li MS , Shen J , et al . Host immune defense peptide LL-37 activates caspase-independent apoptosis and suppresses colon cancer . Cancer Res . 2012 ; 72 ( 24 ): 6512 - 23 .
Wang J , Cheng M , Law IKM , Ortiz C , Sun M , Koon HW . Cathelicidin suppresses colon cancer metastasis via a P2RX7-dependent mechanism . Mol Ther Oncolytics . 2019 ; 12 : 195 - 203 .
Hayashi M , Kuroda K , Ihara K , Iwaya T , Isogai E . Suppressive effect of an analog of the antimicrobial peptide of LL37 on colon cancer cells via exosome-encapsulated miRNAs . Int J Mol Med . 2018 ; 42 ( 6 ): 3009 - 16 .
Wu WK , Sung JJ , To KF , Yu L , Li HT , Li ZJ , et al . The host defense peptide LL-37 activates the tumor-suppressing bone morphogenetic protein signaling via inhibition of proteasome in gastric cancer cells . J Cell Physiol . 2010 ; 223 ( 1 ): 178 - 86 .
Maraming P , Klaynongsruang S , Boonsiri P , Peng SF , Daduang S , Leelayuwat C , et al . The cationic cell-penetrating KT2 peptide promotes cell membrane defects and apoptosis with autophagy inhibition in human HCT 116 colon cancer cells . J Cell Physiol . 2019 ; 234 ( 12 ): 22116 - 29 .
Maijaroen S , Jangpromma N , Daduang J , Klaynongsruang S . KT2 and RT2 modified antimicrobial peptides derived from Crocodylus siamensis Leucrocin I show activity against human colon cancer HCT-116 cells . Environ Toxicol Pharmacol . 2018 ; 62 : 164 - 76 .
Dia VP , Krishnan HB . BG-4, a novel anticancer peptide from bitter gourd (Momordica charantia), promotes apoptosis in human colon cancer cells . Sci Rep . 2016 ; 6 : 33532 .
Chen YC , Tsai TL , Ye XH , Lin TH . Anti-proliferative effect on a colon adenocarcinoma cell line exerted by a membrane disrupting antimicrobial peptide KL15 . Cancer Biol Ther . 2015 ; 16 ( 8 ): 1172 - 83 .
Chen X , Zou X , Qi G , Tang Y , Guo Y , Si J , et al . Roles and mechanisms of human cathelicidin LL-37 in cancer . Cell Physiol Biochem . 2018 ; 47 ( 3 ): 1060 - 73 .
Chen J , Shin VY , Ho JC , Siu MT , Cheuk IW , Kwong A . Functional implications of cathelicidin antimicrobial protein in breast cancer and tumor-associated macrophage microenvironment . Biomolecules . 2020 ; 10 ( 5 ): 688 .
Habes C , Weber G , Goupille C . Sulfated glycoaminoglycans and proteoglycan syndecan-4 are involved in membrane fixation of LL-37 and its pro-migratory effect in breast cancer cells . Biomolecules . 2019 ; 9 ( 9 ): 481 .
Lu Q , Quan W , Wu J , Zhang X , Ma W , Pang L , et al . Effect of antibacterial peptide hCAP18/LL-37 on ovarian cancer microenvironment and the regulatory mechanism of its expression . Zhonghua Zhong Liu Za Zhi . 2015 ; 37 ( 10 ): 725 - 30 .
Jia J , Zheng Y , Wang W , Shao Y , Li Z , Wang Q , et al . Antimicrobial peptide LL-37 promotes YB-1 expression, and the viability, migration and invasion of malignant melanoma cells . Mol Med Rep . 2017 ; 15 ( 1 ): 240 - 8 .
Ji P , Zhou Y , Yang Y , Wu J , Zhou H , Quan W , et al . Myeloid cell-derived LL-37 promotes lung cancer growth by activating Wnt/beta-catenin signaling . Theranostics . 2019 ; 9 ( 8 ): 2209 - 23 .
Lee J , Shin KO , Kim Y , Cho J , Lim HW , Yoon SI , et al . Cathelicidin-related antimicrobial peptide regulates CD73 expression in mouse Th17 cells via p38 . Cells . 2020 ; 9 ( 6 ): 1561 .
Rabjerg M , Bjerregaard H , Halekoh U , Jensen BL , Walter S , Marcussen N . Molecular characterization of clear cell renal cell carcinoma identifies CSNK2A1, SPP1 and DEFB1 as promising novel prognostic markers . APMIS . 2016 ; 124 ( 5 ): 372 - 83 .
Albrethsen J , Bøgebo R , Gammeltoft S , Olsen J , Winther B , Raskov H . Upregulated expression of human neutrophil peptides 1, 2 and 3 (HNP 1–3) in colon cancer serum and tumours: a biomarker study . BMC Cancer . 2005 ; 5 : 8 .
Jeong D , Kim H , Kim D , Ban S , Oh S , Ji S , et al . Defensin alpha 6 (DEFA6) is a prognostic marker in colorectal cancer . Cancer Biomark . 2019 ; 24 ( 4 ): 485 - 95 .
Xu N , Wang YS , Pan WB , Xiao B , Wen YJ , Chen XC , et al . Human alphadefensin-1 inhibits growth of human lung adenocarcinoma xenograft in nude mice . Mol Cancer Ther . 2008 ; 7 ( 6 ): 1588 - 97 .
Wang YS , Li D , Shi HS , Wen YJ , Yang L , Xu N , et al . Intratumoral expression of mature human neutrophil peptide-1 mediates antitumor immunity in mice . Clin Cancer Res . 2009 ; 15 ( 22 ): 6901 - 11 .
Li D , Qin Q , Wang XY , Shi HS , Luo M , Guo FC , et al . Intratumoral expression of mature human neutrophil peptide-1 potentiates the therapeutic effect of doxorubicin in a mouse 4T1 breast cancer model . Oncol Rep . 2014 ; 31 ( 3 ): 1287 - 95 .
Lundy FT , Orr DF , Gallagher JR , Maxwell P , Shaw C , Napier SS , et al . Identification and overexpression of human neutrophil alpha-defensins (human neutrophil peptides 1, 2 and 3) in squamous cell carcinomas of the human tongue . Oral Oncol . 2004 ; 40 ( 2 ): 139 - 44 .
Semlali A , Al Amri A , Azzi A , Al Shahrani O , Arafah M , Kohailan M , et al . Expression and new exon mutations of the human Beta defensins and their association on colon cancer development . PLoS ONE . 2015 ; 10 ( 6 ): e0126868 .
Abiko Y , Suraweera AK , Nishimura M , Arakawa T , Takuma T , Mizoguchi I , et al . Differential expression of human beta-defensin 2 in keratinized and non-keratinized oral epithelial lesions; immunohistochemistry and in situ hybridization . Virchows Arch . 2001 ; 438 ( 3 ): 248 - 53 .
Joly S , Compton LM , Pujol C , Kurago ZB , Guthmiller JM . Loss of human beta-defensin 1, 2, and 3 expression in oral squamous cell carcinoma . Oral Microbiol Immunol . 2009 ; 24 ( 5 ): 353 - 60 .
Sawaki K , Mizukawa N , Yamaai T , Yoshimoto T , Nakano M , Sugahara T . High concentration of beta-defensin-2 in oral squamous cell carcinoma . Anticancer Res . 2002 ; 22 ( 4 ): 2103 - 7 .
Donald CD , Sun CQ , Lim SD , Macoska J , Cohen C , Amin MB , et al . Cancer-specific loss of beta-defensin 1 in renal and prostatic carcinomas . Lab Invest . 2003 ; 83 ( 4 ): 501 - 5 .
Sun CQ , Arnold R , Fernandez-Golarz C , Parrish AB , Almekinder T , He J , et al . Human beta-defensin-1, a potential chromosome 8p tumor suppressor: control of transcription and induction of apoptosis in renal cell carcinoma . Cancer Res . 2006 ; 66 ( 17 ): 8542 - 9 .
Ling YM , Chen JY , Guo L , Wang CY , Tan WT , Wen Q , et al . Beta-defensin 1 expression in HCV infected liver/liver cancer: an important role in protecting HCV progression and liver cancer development . Sci Rep . 2017 ; 7 ( 1 ): 13404 .
Bonamy C , Sechet E , Amiot A , Alam A , Mourez M , Fraisse L , et al . Expression of the human antimicrobial peptide beta-defensin-1 is repressed by the EGFR-ERK-MYC axis in colonic epithelial cells . Sci Rep . 2018 ; 8 ( 1 ): 18043 .
Liu WJ , Liu XJ , Xu J , Li L , Li Y , Zhang SH , et al . EGFR-targeting, betadefensin-tailored fusion protein exhibits high therapeutic efficacy against EGFR-expressed human carcinoma via mitochondria-mediated apoptosis . Acta Pharmacol Sin . 2018 ; 39 ( 11 ): 1777 - 86 .
Sun CQ , Arnold RS , Hsieh CL , Dorin JR , Lian F , Li Z , et al . Discovery and mechanisms of host defense to oncogenesis: targeting the β defensin-1 peptide as a natural tumor inhibitor . Cancer Biol Ther . 2019 ; 20 ( 6 ): 774 - 86 .
Salem A , Almahmoudi R , Hagstrom J , Stark H , Nordstrom D , Salo T , et al . Human beta-defensin 2 expression in oral epithelium: potential therapeutic targets in oral lichen planus . Int J Mol Sci . 2019 ; 20 ( 7 ): 1780 .
Li D , Wang W , Shi HS , Fu YJ , Chen X , Chen XC , et al . Gene therapy with beta-defensin 2 induces antitumor immunity and enhances local antitumor effects . Hum Gene Ther . 2014 ; 25 ( 1 ): 63 - 72 .
Sun T , Luo Y , Wang M , Xie T , Yan H . Recombinant oncolytic vaccinia viruses expressing human β-defensin 2 enhance anti-tumor immunity . Mol Ther Oncolytics . 2019 ; 13 : 49 - 57 .
Wang K , Wang JH , Baskaran H , Wang R , Jurevic R . Effect of human beta-defensin-3 on head and neck cancer cell migration using microfabricated cell islands . Head Neck Oncol . 2012 ; 4 : 41 .
Hanaoka Y , Yamaguchi Y , Yamamoto H , Ishii M , Nagase T , Kurihara H , et al . In vitro and in vivo anticancer activity of human beta-defensin-3 and its mouse homolog . Anticancer Res . 2016 ; 36 ( 11 ): 5999 - 6004 .
Xu D , Zhang B , Liao C , Zhang W , Wang W , Chang Y , et al . Human betadefensin 3 contributes to the carcinogenesis of cervical cancer via activation of NF-kappaB signaling . Oncotarget . 2016 ; 7 ( 46 ): 75902 - 13 .
Gomez Hernandez MP , Bates AM , Starman EE , Lanzel EA , Comnick C , Xie XJ , et al . HBD3 induces PD-L1 expression on head and neck squamous cell carcinoma cell lines . Antibiotics (Basel) . 2019 ; 8 ( 4 ): 161 .
Strzelecka P , Czaplinska D , Sadej R , Wardowska A , Pikula M , Lesner A . Simplified, serine-rich theta-defensin analogues as antitumour peptides . Chem Biol Drug Des . 2017 ; 90 ( 1 ): 52 - 63 .
Ye Z , Dong H , Li Y , Ma T , Huang H , Leong HS , et al . Prevalent homozygous deletions of type i interferon and defensin genes in human cancers associate with immunotherapy resistance . Clin Cancer Res . 2018 ; 24 ( 14 ): 3299 - 308 .
Skalska J , Oliveira FD , Figueira TN , Mello EO , Gomes VM , McNaughton-Smith G , et al . Plant defensin PvD1 modulates the membrane composition of breast tumour-derived exosomes . Nanoscale . 2019 ; 11 ( 48 ): 23366 - 81 .
Dong Z , Hu H , Yu X , Tan L , Ma C , Xi X , et al . Novel frog skin-derived peptide dermaseptin-PP for lung cancer treatment: in vitro /vivo evaluation and anti-tumor mechanisms study . Front Chem . 2020 ; 8 : 476 .
Li X , Wang Y , Zou Z , Yang M , Wu C , Su Y , et al . OM-LV20, a novel peptide from odorous frog skin, accelerates wound healing in vitro and in vivo . Chem Biol Drug Des . 2018 ; 91 ( 1 ): 126 - 36 .
Wu J , Yang J , Wang X , Wei L , Mi K , Shen Y , et al . A frog cathelicidin peptide effectively promotes cutaneous wound healing in mice . Biochem J . 2018 ; 475 ( 17 ): 2785 - 99 .
Pfalzgraff A , Barcena-Varela S , Heinbockel L , Gutsmann T , Brandenburg K , Martinez-de-Tejada G , et al . Antimicrobial endotoxin-neutralizing peptides promote keratinocyte migration via P2X7 receptor activation and accelerate wound healing in vivo . Br J Pharmacol . 2018 ; 175 ( 17 ): 3581 - 93 .
Werner S , Krieg T , Smola H . Keratinocyte-fibroblast interactions in wound healing . J Invest Dermatol . 2007 ; 127 ( 5 ): 998 - 1008 .
Wang PH , Huang BS , Horng HC , Yeh CC , Chen YJ . Wound healing . J Chin Med Assoc . 2018 ; 81 ( 2 ): 94 - 101 .
Takeo M , Lee W , Ito M . Wound healing and skin regeneration . Cold Spring Harb Perspect Med . 2015 ; 5 ( 1 ): a023267 - 71 .
Moravvej H , Memariani M , Memariani H , Robati RM , Gheisari M . Can antimicrobial peptides be repurposed as a novel therapy for keloids? Dermatology . 2021 ; 237 ( 2 ): 293 - 5 .
Alencar-Silva T , Braga MC , Santana GOS , Saldanha-Araujo F , Pogue R , Dias SC , et al . Breaking the frontiers of cosmetology with antimicrobial peptides . Biotechnol Adv . 2018 ; 36 ( 8 ): 2019 - 31 .
Yoo JH , Ho S , Tran DH , Cheng M , Bakirtzi K , Kukota Y , et al . Anti-fibrogenic effects of the anti-microbial peptide cathelicidin in murine colitisassociated fibrosis . Cell Mol Gastroenterol Hepatol . 2015 ; 1 ( 1 ): 55 - 74 .
Gauglitz GG , Bureik D , Zwicker S , Ruzicka T , Wolf R . The antimicrobial peptides psoriasin (S100A7) and koebnerisin (S100A15) suppress extracellular matrix production and proliferation of human fibroblasts . Skin Pharmacol Physiol . 2015 ; 28 ( 3 ): 115 - 23 .
Yan Z , Wang D , An C , Xu H , Zhao Q , Shi Y , et al . The antimicrobial peptide YD attenuates inflammation via miR-155 targeting CASP12 during liver fibrosis . Acta Pharm Sin B . 2021 ; 11 ( 1 ): 100 - 11 .
Ramos R , Silva JP , Rodrigues AC , Costa R , Guardao L , Schmitt F , et al . Wound healing activity of the human antimicrobial peptide LL37 . Peptides . 2011 ; 32 ( 7 ): 1469 - 76 .
Conlon JM , Mechkarska M , Abdel-Wahab YH , Flatt PR . Peptides from frog skin with potential for development into agents for type 2 diabetes therapy . Peptides . 2018 ; 100 : 275 - 81 .
Zainab AJAA , Ashish N , Ragnath V . Salivary levels of antimicrobial peptides in chronic periodontitis patients with type 2 diabetes . J Int Acad Periodontol . 2019 ; 21 ( 1 ): 36 - 44 .
Meguro S , Tomita M , Katsuki T , Kato K , Oh H , Ainai A , et al . Plasma antimicrobial peptide LL-37 level is inversely associated with HDL cholesterol level in patients with type 2 diabetes mellitus . Int J Endocrinol . 2014 ; 2014 : 703696 .
Sun J , Furio L , Mecheri R , van der Does AM , Lundeberg E , Saveanu L , et al . Pancreatic β-cells limit autoimmune diabetes via an immunoregulatory antimicrobial peptide expressed under the influence of the gut microbiota . Immunity . 2015 ; 43 ( 2 ): 304 - 17 .
Hu Z , Murakami T , Suzuki K , Tamura H , Kuwahara-Arai K , Iba T , et al . Antimicrobial cathelicidin peptide LL-37 inhibits the LPS/ATPinduced pyroptosis of macrophages by dual mechanism . PLoS ONE . 2014 ; 9 ( 1 ): e85765 .
Hu Z , Murakami T , Suzuki K , Tamura H , Reich J , Kuwahara-Arai K , et al . Antimicrobial cathelicidin peptide LL-37 inhibits the pyroptosis of macrophages and improves the survival of polybacterial septic mice . Int Immunol . 2016 ; 28 ( 5 ): 245 - 53 .
Yoshimura T , McLean MH , Dzutsev AK , Yao X , Chen K , Huang J , et al . The antimicrobial peptide CRAMP is essential for colon homeostasis by maintaining microbiota balance . J Immunol . 2018 ; 200 ( 6 ): 2174 - 85 .
Zhang M , Liang W , Gong W , Yoshimura T , Chen K , Wang JM . The critical role of the antimicrobial peptide LL-37/ CRAMP in protection of colon microbiota balance, mucosal homeostasis, anti-inflammatory responses, and resistance to carcinogenesis . Crit Rev Immunol . 2019 ; 39 ( 2 ): 83 - 92 .
Rathinam VAK , Chan FK . Inflammasome, inflammation, and tissue homeostasis . Trends Mol Med . 2018 ; 24 ( 3 ): 304 - 18 .
Nejman D , Livyatan I , Fuks G , Gavert N , Zwang Y , Geller LT , et al . The human tumor microbiome is composed of tumor type-specific intracellular bacteria . Science . 2020 ; 368 ( 6494 ): 973 - 80 .
Nguyen LT , Chau JK , Perry NA , de Boer L , Zaat SA , Vogel HJ . Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs . PLoS ONE . 2010 ; 5 ( 9 ): e12684 .
Schweizer F . Cationic amphiphilic peptides with cancer-selective toxicity . Eur J Pharmacol . 2009 ; 625 ( 1–3 ): 190 - 4 .
Vlieghe P , Lisowski V , Martinez J , Khrestchatisky M . Synthetic therapeutic peptides: science and market . Drug Discov Today . 2010 ; 15 ( 1–2 ): 40 - 56 .
Li W , Separovic F , O’Brien-Simpson NM , Wade JD . Chemically modified and conjugated antimicrobial peptides against superbugs . Chem Soc Rev . 2021 ; 50 ( 8 ): 4932 - 73 .
Malins LR . Peptide modification and cyclization via transition-metal catalysis . Curr Opin Chem Biol . 2018 ; 46 : 25 - 32 .
Lei M , Jayaraman A , Van Deventer JA , Lee K . Engineering selectively targeting antimicrobial peptides . Annu Rev Biomed Eng . 2021 ; 23 : 339 - 57 .
Schmidtchen A , Pasupuleti M , Malmsten M . Effect of hydrophobic modifications in antimicrobial peptides . Adv Colloid Interface Sci . 2014 ; 205 : 265 - 74 .
Porter SL , Coulter SM , Pentlavalli S , Thompson TP , Laverty G . Self-assembling diphenylalanine peptide nanotubes selectively eradicate bacterial biofilm infection . Acta Biomater . 2018 ; 77 : 96 - 105 .
Pedron CN , de Oliveira CS , da Silva AF , Andrade GP , da Silva Pinhal MA , Cerchiaro G , et al . The effect of lysine substitutions in the biological activities of the scorpion venom peptide VmCT1 . Eur J Pharm Sci . 2019 ; 136 : 104952 .
Torres MDT , Pedron CN , Higashikuni Y , Kramer RM , Cardoso MH , Oshiro KGN , et al . Structure-function-guided exploration of the antimicrobial peptide polybia-CP identifies activity determinants and generates synthetic therapeutic candidates . Commun Biol . 2018 ; 1 : 221 .
Fjell CD , Hiss JA , Hancock RE , Schneider G . Designing antimicrobial peptides: form follows function . Nat Rev Drug Discov . 2011 ; 11 ( 1 ): 37 - 51 .
Molhoek EM , van Dijk A , Veldhuizen EJ , Haagsman HP , Bikker FJ . Improved proteolytic stability of chicken cathelicidin-2 derived peptides by D-amino acid substitutions and cyclization . Peptides . 2011 ; 32 ( 5 ): 875 - 80 .
Hilchie AL , Haney EF , Pinto DM , Hancock RE , Hoskin DW . Enhanced killing of breast cancer cells by a d-amino acid analog of the winter flounder-derived pleurocidin NRC-03 . Exp Mol Pathol . 2015 ; 99 ( 3 ): 426 - 34 .
Li Y , Liu T , Liu Y , Tan Z , Ju Y , Yang Y , et al . Antimicrobial activity, membrane interaction and stability of the D-amino acid substituted analogs of antimicrobial peptide W3R6 . J Photochem Photobiol B . 2019 ; 200 : 111645 .
Chen HL , Su PY , Shih C . Improvement of in vivo antimicrobial activity of HBcARD peptides by D-arginine replacement . Appl Microbiol Biotechnol . 2016 ; 100 ( 21 ): 9125 - 32 .
Zhang L , Carmichael R . Short antimicrobial lipopeptides . WO 2013142088 A1 . 2013 .
Eckert Randal H , Yarbrough Daniel K , Shi W , Anderson Maxwell H , Qi F , He J , et al . Selectively targeted antimicrobial peptides and the use thereof . WO 2008030988 A2 . 2008 .
Gunasekera S , Muhammad T , Strömstedt AA , Rosengren KJ , Göransson U . Backbone cyclization and dimerization of LL-37-derived peptides enhance antimicrobial activity and proteolytic stability . Front Microbiol . 2020 ; 11 : 168 .
Ting DSJ , Beuerman RW , Dua HS , Lakshminarayanan R , Mohammed I . Strategies in translating the therapeutic potentials of host defense peptides . Front Immunol . 2020 ; 11 : 983 .
Dathe M , Nikolenko H , Klose J , Bienert M . Cyclization increases the antimicrobial activity and selectivity of arginine- and tryptophancontaining hexapeptides . Biochemistry . 2004 ; 43 ( 28 ): 9140 - 50 .
Thomsen TT , Mendel HC , Al-Mansour W , Oddo A , Lobner-Olesen A , Hansen PR . Analogues of a cyclic antimicrobial peptide with a flexible linker show promising activity against Pseudomonas aeruginosa and Staphylococcus aureus . Antibiotics (Basel) . 2020 ; 9 ( 7 ): 366 .
Scudiero O , Nigro E , Cantisani M , Colavita I , Leone M , Mercurio FA , et al . Design and activity of a cyclic mini-beta-defensin analog: a novel antimicrobial tool . Int J Nanomed . 2015 ; 10 : 6523 - 39 .
Moiola M , Memeo MG , Quadrelli P . Stapled peptides—a useful improvement for peptide-based drugs . Molecules . 2019 ; 24 ( 20 ): 3654 .
Hirano M , Saito C , Yokoo H , Goto C , Kawano R , Misawa T , et al . Development of antimicrobial stapled peptides based on magainin 2 sequence . Molecules . 2021 ; 26 ( 2 ): 444 .
Grassi L , Maisetta G , Esin S , Batoni G . Combination strategies to enhance the efficacy of antimicrobial peptides against bacterial biofilms . Front Microbiol . 2017 ; 8 : 2409 .
Almaaytah A , Qaoud MT , Abualhaijaa A , Al-Balas Q , Alzoubi KH . Hybridization and antibiotic synergism as a tool for reducing the cytotoxicity of antimicrobial peptides . Infect Drug Resist . 2018 ; 11 : 835 - 47 .
Wang C , Yang C , Chen YC , Ma L , Huang K . Rational design of hybrid peptides: a novel drug design approach . Curr Med Sci . 2019 ; 39 ( 3 ): 349 - 55 .
Fox MA , Thwaite JE , Ulaeto DO , Atkins TP , Atkins HS . Design and characterization of novel hybrid antimicrobial peptides based on cecropin A, LL-37 and magainin II . Peptides . 2012 ; 33 ( 2 ): 197 - 205 .
David AA , Park SE , Parang K , Tiwari RK . Antibiotics-peptide conjugates against multidrug-resistant bacterial pathogens . Curr Top Med Chem . 2018 ; 18 ( 22 ): 1926 - 36 .
Schnaider L , Rosenberg A , Kreiser T , Kolusheva S , Gazit E , Berman J . Peptide self-assembly is linked to antibacterial, but not antifungal, activity of histatin 5 derivatives . mSphere . 2020 ; 5 ( 2 ): e00021 - e120 .
Nel AE , Mädler L , Velegol D , Xia T , Hoek EM , Somasundaran P , et al . Understanding biophysicochemical interactions at the nano-bio interface . Nat Mater . 2009 ; 8 ( 7 ): 543 - 57 .
Hancock RE , Sahl HG . Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies . Nat Biotechnol . 2006 ; 24 ( 12 ): 1551 - 7 .
Carratalá JV , Serna N , Villaverde A , Vázquez E , Ferrer-Miralles N . Nanostructured antimicrobial peptides: the last push towards clinics . Biotechnol Adv . 2020 ; 44 : 107603 .
Umerska A , Cassisa V , Matougui N , Joly-Guillou ML , Eveillard M , Saulnier P . Antibacterial action of lipid nanocapsules containing fatty acids or monoglycerides as co-surfactants . Eur J Pharm Biopharm . 2016 ; 108 : 100 - 10 .
Radaic A , de Jesus MB , Kapila YL . Bacterial anti-microbial peptides and nano-sized drug delivery systems: the state of the art toward improved bacteriocins . J Control Release . 2020 ; 321 : 100 - 18 .
Lam SJ , O’Brien-Simpson NM , Pantarat N , Sulistio A , Wong EHH , Chen YY , et al . Combating multidrug-resistant Gram-negative bacteria with structurally nanoengineered antimicrobial peptide polymers . Nat Microbiol . 2016 ; 1 ( 11 ): 16162 .
Falciani C , Zevolini F , Brunetti J , Riolo G , Gracia R , Marradi M , et al . Antimicrobial peptide-loaded nanoparticles as inhalation therapy for Pseudomonas aeruginosa infections . Int J Nanomedicine . 2020 ; 15 : 1117 - 28 .
Taylor EN , Webster TJ . The use of superparamagnetic nanoparticles for prosthetic biofilm prevention . Int J Nanomed . 2009 ; 4 : 145 - 52 .
Liu Y , Sun Y , Li S , Liu M , Qin X , Chen X , et al . Tetrahedral framework nucleic acids deliver antimicrobial peptides with improved effects and less susceptibility to bacterial degradation . Nano Lett . 2020 ; 20 ( 5 ): 3602 - 10 .
Rajchakit U , Sarojini V . Recent developments in antimicrobial-peptideconjugated gold nanoparticles . Bioconjug Chem . 2017 ; 28 ( 11 ): 2673 - 86 .
Nyström L , Strömstedt AA , Schmidtchen A , Malmsten M . Peptideloaded microgels as antimicrobial and anti-inflammatory surface coatings . Biomacromol . 2018 ; 19 ( 8 ): 3456 - 66 .
Martin-Serrano Á , Gómez R , Ortega P , de la Mata FJ . Nanosystems as vehicles for the delivery of antimicrobial peptides (AMPs) . Pharmaceutics . 2019 ; 11 ( 9 ): 448 .
Teixeira MC , Carbone C , Sousa MC , Espina M , Garcia ML , Sanchez-Lopez E , et al . Nanomedicines for the delivery of antimicrobial peptides (AMPs) . Nanomaterials (Basel) . 2020 ; 10 ( 3 ): 560 .
Dusinska M , Tulinska J , El Yamani N , Kuricova M , Liskova A , Rollerova E , et al . Immunotoxicity, genotoxicity and epigenetic toxicity of nanomaterials: new strategies for toxicity testing? Food Chem Toxicol . 2017 ; 109 ( Pt 1 ): 797 - 811 .
Makowski M , Silva ÍC , Pais do Amaral C , Gonçalves S , Santos NC . Advances in lipid and metal nanoparticles for antimicrobial peptide delivery . Pharmaceutics . 2019 ; 11 ( 11 ): 588 .
Kim GC , Cheon DH , Lee Y . Challenge to overcome current limitations of cell-penetrating peptides . Biochim Biophys Acta Proteins Proteom . 2021 ; 1869 ( 4 ): 140604 .
Bahnsen JS , Franzyk H , Sayers EJ , Jones AT , Nielsen HM . Cell-penetrating antimicrobial peptides—prospectives for targeting intracellular infections . Pharm Res . 2015 ; 32 ( 5 ): 1546 - 56 .
Lee H , Lim SI , Shin SH , Lim Y , Koh JW , Yang S . Conjugation of cellpenetrating peptides to antimicrobial peptides enhances antibacterial activity . ACS Omega . 2019 ; 4 ( 13 ): 15694 - 701 .
Hansen A , Schäfer I , Knappe D , Seibel P , Hoffmann R . Intracellular toxicity of proline-rich antimicrobial peptides shuttled into mammalian cells by the cell-penetrating peptide penetratin . Antimicrob Agents Chemother . 2012 ; 56 ( 10 ): 5194 - 201 .
Budagavi DP , Chugh A . Antibacterial properties of Latarcin 1 derived cell-penetrating peptides . Eur J Pharm Sci . 2018 ; 115 : 43 - 9 .
Drexelius M , Reinhardt A , Grabeck J , Cronenberg T , Nitsche F , Huesgen PF , et al . Multistep optimization of a cell-penetrating peptide towards its antimicrobial activity . Biochem J . 2021 ; 478 ( 1 ): 63 - 78 .
Hao X , Yan Q , Zhao J , Wang W , Huang Y , Chen Y . TAT Modification of alpha-helical anticancer peptides to improve specificity and efficacy . PLoS ONE . 2015 ; 10 ( 9 ): e0138911 .
Mathur H , Field D , Rea MC , Cotter PD , Hill C , Ross RP . Bacteriocinantimicrobial synergy: a medical and food perspective . Front Microbiol . 2017 ; 8 : 1205 .
Lee H , Lee DG . Novel approaches for efficient antifungal drug action . J Microbiol Biotechnol . 2018 ; 28 ( 11 ): 1771 - 81 .
Dosler S , Mataraci E . In vitro pharmacokinetics of antimicrobial cationic peptides alone and in combination with antibiotics against methicillin resistant Staphylococcus aureus biofilms . Peptides . 2013 ; 49 : 53 - 8 .
Mataraci E , Dosler S . In vitro activities of antibiotics and antimicrobial cationic peptides alone and in combination against methicillin-resistant Staphylococcus aureus biofilms . Antimicrob Agents Chemother . 2012 ; 56 ( 12 ): 6366 - 71 .
Li S , She P , Zhou L , Zeng X , Xu L , Liu Y , et al . High-throughput identification of antibacterials against Pseudomonas aeruginosa . Front Microbiol . 2020 ; 11 : 591426 .
Chen Y , Wu J , Cheng H , Dai Y , Wang Y , Yang H , et al . Anti-infective effects of a fish-derived antimicrobial peptide against drug-resistant bacteria and its synergistic effects with antibiotic . Front Microbiol . 2020 ; 11 : 602412 .
Lin L , Nonejuie P , Munguia J , Hollands A , Olson J , Dam Q , et al . Azithromycin synergizes with cationic antimicrobial peptides to exert bactericidal and therapeutic activity against highly multidrug-resistant gram-negative bacterial pathogens . EBioMedicine . 2015 ; 2 ( 7 ): 690 - 8 .
Vriens K , Cools TL , Harvey PJ , Craik DJ , Spincemaille P , Cassiman D , et al . Synergistic activity of the plant defensin HsAFP1 and caspofungin against Candida albicans biofilms and planktonic cultures . PLoS ONE . 2015 ; 10 ( 8 ): e0132701 .
Casciaro B , Loffredo MR , Luca V , Verrusio W , Cacciafesta M , Mangoni ML . Esculentin-1a derived antipseudomonal peptides: limited induction of resistance and synergy with aztreonam . Protein Pept Lett . 2018 ; 25 ( 12 ): 1155 - 62 .
Magana M , Pushpanathan M , Santos AL , Leanse L , Fernandez M , Ioannidis A , et al . The value of antimicrobial peptides in the age of resistance . Lancet Infect Dis . 2020 ; 20 ( 9 ): e216 - 30 .
Glattard E , Salnikov ES , Aisenbrey C , Bechinger B . Investigations of the synergistic enhancement of antimicrobial activity in mixtures of magainin 2 and PGLa . Biophys Chem . 2016 ; 210 : 35 - 44 .
Zerweck J , Strandberg E , Kukharenko O , Reichert J , Burck J , Wadhwani P , et al . Molecular mechanism of synergy between the antimicrobial peptides PGLa and magainin 2 . Sci Rep . 2017 ; 7 ( 1 ): 13153 .
Ma W , Sun S , Li W , Zhang Z , Lin Z , Xia Y , et al . Individual roles of peptides PGLa and magainin 2 in synergistic membrane poration . Langmuir . 2020 ; 36 ( 26 ): 7190 - 9 .
Remington JM , Liao C , Sharafi M , Ste Marie EJ , Ferrell JB , Hondal RJ , et al . Aggregation state of synergistic antimicrobial peptides . J Phys Chem Lett . 2020 ; 11 ( 21 ): 9501 - 6 .
Ilyas H , Kim J , Lee D , Malmsten M , Bhunia A . Structural insights into the combinatorial effects of antimicrobial peptides reveal a role of aromatic-aromatic interactions in antibacterial synergism . J Biol Chem . 2019 ; 294 ( 40 ): 14615 - 33 .
Zhao X , Zhen Z , Wang X , Guo N . Synergy of a combination of nisin and citric acid against Staphylococcus aureus and Listeria monocytogenes . Food Addit Contam A Chem Anal Control Expo Risk Assess . 2017 ; 34 ( 12 ): 2058 - 68 .
Ahn KB , Kim AR , Kum KY , Yun CH , Han SH . The synthetic human beta-defensin-3 C15 peptide exhibits antimicrobial activity against Streptococcus mutans, both alone and in combination with dental disinfectants . J Microbiol . 2017 ; 55 ( 10 ): 830 - 6 .
Badaoui Najjar M , Kashtanov D , Chikindas ML . Epsilon-poly-L-lysine and nisin A act synergistically against Gram-positive food-borne pathogens Bacillus cereus and Listeria monocytogenes . Lett Appl Microbiol . 2007 ; 45 ( 1 ): 13 - 8 .
Namivandi-Zangeneh R , Wong EHH , Boyer C . Synthetic antimicrobial polymers in combination therapy: tackling antibiotic resistance . ACS Infect Dis . 2021 ; 7 ( 2 ): 215 - 53 .
Tian J , Zhang J , Yang J , Du L , Geng H , Cheng Y . Conjugated polymers act synergistically with antibiotics to combat bacterial drug resistance . ACS Appl Mater Interfaces . 2017 ; 9 ( 22 ): 18512 - 20 .
Thappeta KRV , Vikhe YS , Yong AMH , Chan-Park MB , Kline KA . Combined efficacy of an antimicrobial cationic peptide polymer with conventional antibiotics to combat multidrug-resistant pathogens . ACS Infect Dis . 2020 ; 6 ( 5 ): 1228 - 37 .
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