Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review

Diana A. Kimono

doi:10.1186/s40779-021-00341-4

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Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review

REVIEW | Updated：2023-02-28

- Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review
- Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review
- 解放军医学杂志（英文版） 2022年9卷第1期页码：98-105
- Affiliations：
  
  NYU Langone Medical Center, New York, NY 10016, USA
- Author bio：
  
  * Diana.Kimono@nyulangone.org
- Funds：
- DOI：10.1186/s40779-021-00341-4
  中图分类号：
- 纸质出版：2022-02
- Accepted：
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Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review[J]. 解放军医学杂志（英文版）, 2022,9(1):98-105.

Kimono: Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review. Mil Med Res, 2021, 8: 50.
Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review[J]. 解放军医学杂志（英文版）, 2022,9(1):98-105. DOI： 10.1186/s40779-021-00341-4.

Kimono: Gastrointestinal problems, mechanisms and possible therapeutic directions in Gulf war illness: a mini review. Mil Med Res, 2021, 8: 50. DOI： 10.1186/s40779-021-00341-4.

摘要

Abstract

By its nature

Gulf war illness (GWI) is multi-symptomatic and affects several organ systems in the body. Along with other symptoms

veterans who suffer from GWI commonly report chronic gastrointestinal issues such as constipation

pain

indigestion

etc. However

until recently

most attention has been focused on neurological disturbances such as cognitive impairments

chronic fatigue

and chronic pain among affected veterans. With such high prevalence of gastrointestinal problems among Gulf war (GW) veterans

it is surprising that there is little research to investigate the mechanisms behind these issues. This review summarizes all the available works on the mechanisms behind gastrointestinal problems in GWI that have been published to date in various databases. Generally

these studies

which were done in rodent models

in vitro

and human cohorts propose that an altered microbiome

a reactive enteric nervous system or a leaky gut among other possible mechanisms are the major drivers of gastrointestinal problems reported in GWI. This review aims to draw attention to the gastrointestinal tract as an important player in GWI disease pathology and a potential therapeutic target.

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references

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