Differential roles of RIG-I like receptors in SARS-CoV-2 infection

Duo-Meng Yang; Ting-Ting Geng; Andrew G. Harrison; Peng-Hua Wang

doi:10.1186/s40779-021-00340-5

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Differential roles of RIG-I like receptors in SARS-CoV-2 infection

LETTER TO THE EDITOR | Updated：2023-02-28

- Differential roles of RIG-I like receptors in SARS-CoV-2 infection
- Differential roles of RIG-I like receptors in SARS-CoV-2 infection
- 解放军医学杂志（英文版） 2022年9卷第2期页码：262-264
- Affiliations：
  
  Department of Immunology, School of Medicine, University of Connecticut Health Center, Farmington, CT 06030, USA
- Author bio：
  
  * pewang@uchc.edu
- Funds：
  
  a National Institutes of Health grant(R01AI132526);a UConn Health Startup fund to Wang P
- DOI：10.1186/s40779-021-00340-5
  中图分类号：
- 纸质出版：2022-04
- Accepted：
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Differential roles of RIG-I like receptors in SARS-CoV-2 infection[J]. 解放军医学杂志（英文版）, 2022,9(2):262-264.

Yang et al.: Differential roles of RIG-I like receptors in SARS-CoV-2 infection. Mil Med Res, 2021, 8: 49.
Differential roles of RIG-I like receptors in SARS-CoV-2 infection[J]. 解放军医学杂志（英文版）, 2022,9(2):262-264. DOI： 10.1186/s40779-021-00340-5.

Yang et al.: Differential roles of RIG-I like receptors in SARS-CoV-2 infection. Mil Med Res, 2021, 8: 49. DOI： 10.1186/s40779-021-00340-5.

摘要

Abstract

Retinoic acid-inducible gene I (RIG-I) and melanoma differentiation-associated protein 5 (MDA5) sense viral RNA and activate antiviral immune responses. Herein we investigate their functions in human epithelial cells

the primary and initial target of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). A deficiency in MDA5

RIG-I or mitochondrial antiviral signaling protein (MAVS) enhanced viral replication. The expression of the type I/III interferon (IFN) during infection was impaired in

MDA5

–/–

and

MAVS

–/–

but not in

RIG-I

–/–

when compared to wild type (WT) cells. The mRNA level of full-length angiotensin-converting enzyme 2 (ACE2)

the cellular entry receptor for SARS-CoV-2

was approximately 2.5-fold higher in

RIG-I

–/–

than WT cells. These data demonstrate MDA5 as the predominant SARS-CoV-2 sensor

IFN-independent induction of ACE2 and anti-SARS-CoV-2 role of RIG-I in epithelial cells.

关键词

Keywords

references

Tan X , Sun L , Chen J , Chen ZJ . Detection of microbial infections through innate immune sensing of nucleic acids . Annu Rev Microbiol . 2018 ; 72 : 447 - 78 .

Hayn M , Hirschenberger M , Koepke L , Nchioua R , Straub JH , Klute S , et al . Systematic functional analysis of SARS-CoV-2 proteins uncovers viral innate immune antagonists and remaining vulnerabilities . Cell Rep . 2021 ; 35 ( 7 ): 109126 .

Geng T , Lin T , Yang D , Harrison AG , Vella AT , Fikrig E , et al . A critical role for STING signaling in limiting pathogenesis of Chikungunya virus . J Infect Dis . 2021 ; 223 ( 12 ): 2186 - 96 .

Yin X , Riva L , Pu Y , Martin-Sancho L , Kanamune J , Yamamoto Y , et al . MDA5 governs the innate immune response to SARS-CoV-2 in lung epithelial cells . Cell Rep . 2021 ; 34 ( 2 ): 108628 .

Yamada T , Sato S , Sotoyama Y , Orba Y , Sawa H , Yamauchi H , et al . RIG-I triggers a signaling-abortive anti-SARS-CoV-2 defense in human lung cells . Nat Immunol . 2021 ; 22 ( 7 ): 820 - 8 .

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