Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls

Beatrice Alexandra Golomb; Sridevi Devaraj; Alexis K. Messner; Hayley Jean Koslik; Jun Hee Han; Barnabas Yik

doi:10.1186/s40779-021-00337-0

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Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls

RESEARCH | Updated：2023-02-28

- Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls
- Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls
- 解放军医学杂志（英文版） 2022年9卷第2期页码：205-214
- Affiliations：
  
  1.Department of Medicine, School of Medicine, University of California, San Diego, La Jolla, CA 92093, USA
  2.Department of Pathology and Immunology, Baylor College of Medicine, Houston, TX 77030, USA
  3.Swedish Medical Center, Seattle, WA 98109, USA
  4.Henry M. Jackson Foundation for the Advancement of Military Medicine, San Diego, CA 92134, USA
  5.Santa Clara Valley Medical Center, San Jose, CA 95128, USA
- Author bio：
  
  * bgolomb@ucsd.edu
- Funds：
  
  The parent study was funded by the Department of Defense Congressionally Directed Medical Research Program(GW093063);The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. No additional external funding was received
- DOI：10.1186/s40779-021-00337-0
  中图分类号：
- 纸质出版：2022-04
- Accepted：
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Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls[J]. 解放军医学杂志（英文版）, 2022,9(2):205-214.

Golomb et al.: Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls. Mil Med Res, 2021, 8: 46.
Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls[J]. 解放军医学杂志（英文版）, 2022,9(2):205-214. DOI： 10.1186/s40779-021-00337-0.

Golomb et al.: Lower blood malondialdehyde is associated with past pesticide exposure: findings in Gulf War illness and healthy controls. Mil Med Res, 2021, 8: 46. DOI： 10.1186/s40779-021-00337-0.

摘要

Abstract

Background:

Malondialdehyde (MDA) is a candidate general marker of oxidative stress (OS). We sought to assess the relation of MDA to Gulf War illness (GWI) and to a variety of exposures.

Methods:

This is an observational study involving subjects from Southern California recruited from October 2011 to May 2014. MDA was assessed in 81 participants (41 GWI-cases

40 controls). General and Gulf-specific exposures were elicited. MDA case–control comparison was restricted to 40 matched pairs. The potential association between MDA and exposures was assessed using regression analyses. Gulf-specific exposures were incorporated into a case-specific model.

Results:

Plasma MDA was significantly lower in GWI-cases than controls. Composite pesticide and fuel-solvent exposures negatively predicted MDA in the total sample

as well as in the analyses that included either GWI-cases or controls only. Self-reported exposure to organophosphate (OP) nerve gas was a strong predictor for lower MDA level in veterans with GWI.

Conclusions:

Past pesticide exposures predicted lower MDA in both veterans with GWI and in healthy controls.

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references

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