Advances in single-cell sequencing: insights from organ transplantation

Ying Wang; Jian-Ye Wang; Angelika Schnieke; Konrad Fischer

doi:10.1186/s40779-021-00336-1

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Advances in single-cell sequencing: insights from organ transplantation

REVIEW | Updated：2023-02-28

- Advances in single-cell sequencing: insights from organ transplantation
- Advances in single-cell sequencing: insights from organ transplantation
- 解放军医学杂志（英文版） 2022年9卷第1期页码：86-97
- Affiliations：
  
  1.Chair of Livestock Biotechnology, School of Life Sciences Weihenstephan, Technical University of Munich, Liesel Beckman Str 1, 85354 Freising, Germany
  2.Department of Surgery, School of Medicine, Technical University of Munich, 81675 Munich, Germany
- Author bio：
  
  * konrad.fischer@wzw.tum.de
- Funds：
- DOI：10.1186/s40779-021-00336-1
  中图分类号：
- 纸质出版：2022-02
- Accepted：
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Advances in single-cell sequencing: insights from organ transplantation[J]. 解放军医学杂志（英文版）, 2022,9(1):86-97.

Wang et al.: Advances in single-cell sequencing: insights from organ transplantation. Mil Med Res, 2021, 8: 45.
Advances in single-cell sequencing: insights from organ transplantation[J]. 解放军医学杂志（英文版）, 2022,9(1):86-97. DOI： 10.1186/s40779-021-00336-1.

Wang et al.: Advances in single-cell sequencing: insights from organ transplantation. Mil Med Res, 2021, 8: 45. DOI： 10.1186/s40779-021-00336-1.

摘要

Abstract

Single-cell RNA sequencing (scRNA-seq) is a comprehensive technical tool to analyze intracellular and intercellular interaction data by whole transcriptional profile analysis. Here

we describe the application in biomedical research

focusing on the immune system during organ transplantation and rejection. Unlike conventional transcriptome analysis

this method provides a full map of multiple cell populations in one specific tissue and presents a dynamic and transient unbiased method to explore the progression of allograft dysfunction

starting from the stress response to final graft failure. This promising sequencing technology remarkably improves individualized organ rejection treatment by identifying decisive cellular subgroups and cell-specific interactions.

关键词

Keywords

references

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