Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data

Jian-Hua Cheng; Ding Nie; Bin Li; Song-Bai Gui; Chu-Zhong Li; Ya-Zhuo Zhang; Luigi Maria Cavallo; Peng Zhao

doi:10.1186/s40779-021-00332-5

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Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data

RESEARCH | Updated：2023-02-28

- Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data
- Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data
- 解放军医学杂志（英文版） 2022年9卷第3期页码：277-285
- Affiliations：
  
  1.Neurosurgical Department, Beijing Tiantan Hospital, Capital Medical University, No. 119 South Fourth Ring West Road, Fengtai District, Beijing 100070, China
  2.Department of Cell and Biology, Beijing Neurosurgical Institute, Beijing 100070, China
  3.Division of Neurosurgery, Universitá Degli Studi di Napoli Federico II, 80142 Naples, Italy
- Author bio：
  
  * zhaopeng@ccmu.edu.cn
- Funds：
- DOI：10.1186/s40779-021-00332-5
  中图分类号：
- 纸质出版：2022-06
- Accepted：
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Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data[J]. 解放军医学杂志（英文版）, 2022,9(3):277-285.

Cheng et al.: Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data. Mil Med Res, 2021, 8: 39.
Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data[J]. 解放军医学杂志（英文版）, 2022,9(3):277-285. DOI： 10.1186/s40779-021-00332-5.

Cheng et al.: Clinical features, radiological profiles, pathological features and surgical outcomes of pituicytomas: a report of 11 cases and a pooled analysis of individual patient data. Mil Med Res, 2021, 8: 39. DOI： 10.1186/s40779-021-00332-5.

摘要

Abstract

Background:

Pituicytoma is an extremely rare low-grade glial tumor that is closely related to the neurohypophysis axis. Most studies of pituicytomas include only several cases. To better understand this disease

we reviewed a series of cases of pituicytomas. The diagnosis and treatment of pituicytoma must be further elucidated.

Methods:

Eleven patients with pituicytoma admitted to Beijing Tiantan Hospital from 2012 to 2019 were selected. The clinical features

including radiological and histological examination

surgical records and prognosis were reviewed. Sixty-eight other previously published cases of pituicytoma also were used to analyze the predictive factors for the results. The Cox regression model was used for univariate and multivariate analyses.

Results:

Our patients included 5 males (45.5%) and 6 females (54.5%)

with a mean age of 49.3 years. The tumor was located in the suprasellar region in 5 patients (45.5%)

intrasellar region in 4 patients (36.4%)

and intrasellar-suprasellar region in 2 patients (18.2%). All patients were misdiagnosed with other common tumors in the sellar region before the operation. During the operation

gross total resection (GTR) of the tumor was achieved in 6 patients (54.5%)

and subtotal resection (STR) was achieved in 5 patients (45.5%). The mean progression-free survival (PFS) time was 29.82 months. Tumor progression after surgical resection occurred in 4 patients (36.4%). Among them

60.0% of the patients (cases 4

7) with STR experienced progression

while 16.7% of the patients (case 2) with GTR experienced progression. Combined with the 68 cases in the literature

GTR was an independent risk factor for PFS time (

0.05).

Conclusions:

Pituicytomas are more common in middle-aged people and the sellar region. The clinical manifestations of pituicytomas are different

but no diagnostic clinical features have been identified other than an abnormally abundant blood supply. Currently

GTR is the best approach for the treatment of pituicytomas. More patients and longer follow-up periods were needed to further elucidate the biological features of pituicytomas.

关键词

Keywords

references

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