Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study

Yue Yu; Ren-Qi Yao; Yu-Feng Zhang; Su-Yu Wang; Wang Xi; Jun-Nan Wang; Xiao-Yi Huang; Yong-Ming Yao; Zhi-Nong Wang

doi:10.1186/s40779-021-00330-7

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Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study

RESEARCH | Updated：2023-02-28

- Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study
- Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study
- 解放军医学杂志（英文版） 2022年9卷第3期页码：265-276
- Affiliations：
  
  1.Department of Cardiothoracic Surgery, Changzheng Hospital, Naval Medical University, 415 Fengyang Road, Huangpu District, Shanghai 200003, China
  2.Trauma Research Center, Fourth Medical Center and Medical Innovation Research Department of the Chinese PLA General Hospital, 51 Fucheng Road, Haidian District, Beijing 100048, China
  3.Department of Burn Surgery, Changhai Hospital, Naval Medical University, Shanghai 200433, China
  4.Medical Research Center of War Injuries and Trauma, Changzheng Hospital, Naval Medical University, Shanghai 200003, China
  5.Department of Pathology, Changhai Hospital, Naval Medical University, Shanghai 200433, China
- Author bio：
  
  * c_ff@sina.com;
  wangzn007@smmu.edu.cn
- Funds：
  
  the National Nature Science Foundation of China(81770244);Medical Science and Technology Youth Cultivation Plan(17QNP013;20QNPY038);Naval Military University Foreign Student Teaching Research and Reform Project(WJYA2018005);Shanghai Municipal Commission of Science and Technology(17ZR1439100)
- DOI：10.1186/s40779-021-00330-7
  中图分类号：
- 纸质出版：2022-06
- Accepted：
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Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study[J]. 解放军医学杂志（英文版）, 2022,9(3):265-276.

Yu et al.: Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study. Mil Med Res, 2021, 8: 38.
Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study[J]. 解放军医学杂志（英文版）, 2022,9(3):265-276. DOI： 10.1186/s40779-021-00330-7.

Yu et al.: Is oxygen therapy beneficial for normoxemic patients with acute heart failure? A propensity score matched study. Mil Med Res, 2021, 8: 38. DOI： 10.1186/s40779-021-00330-7.

摘要

Abstract

Background:

The clinical efficiency of routine oxygen therapy is uncertain in patients with acute heart failure (AHF) who do not have hypoxemia. The aim of this study was to investigate the association between oxygen therapy and clinical outcomes in normoxemic patients hospitalized with AHF using real-world data.

Methods:

Normoxemic patients diagnosed with AHF on intensive care unit (ICU) admission from the electronic ICU (eICU) Collaborative Research Database were included in the current study

in which the study population was divided into the oxygen therapy group and the ambient air group. Propensity score matching (PSM) was applied to create a balanced covariate distribution between patients receiving supplemental oxygen and those exposed to ambient air. Linear regression and logistic regression models were performed to assess the associations between oxygen therapy and length of stay (LOS)

and all-cause in-hospital as well as ICU mortality rates

respectively. A series of sensitivity and subgroup analyses were conducted to further validate the robustness of our findings.

Results:

A total of 2922 normoxemic patients with AHF were finally included in the analysis. Overall

42.1% (1230/2922) patients were exposed to oxygen therapy

and 57.9% (1692/2922) patients did not receive oxygen therapy (defined as the ambient air group). After PSM analysis

1122 pairs of patients were matched: each patient receiving oxygen therapy was matched with a patient without receiving supplemental oxygen. The multivariable logistic model showed that there was no significant interaction between the ambient air and oxygen therapy for all-cause in-hospital mortality [odds ratio (

)=1.30; 95% confidence interval (CI) 0.92–1.82;

=0.138] or ICU mortality (

=1.39; 95%CI 0.83–2.32;

=0.206) in the post-PSM cohorts. In addition

linear regression analysis revealed that oxygen therapy was associated with prolonged ICU LOS (

=1.11; 95%CI 1.06–1.15;

0.001) and hospital LOS (

=1.06; 95%CI 1.01–1.10;

=0.009) after PSM. Furthermore

the absence of an effect of supplemental oxygen on mortality was consistent in all subgroups.

Conclusions:

Routine use of supplemental oxygen in AHF patients without hypoxemia was not found to reduce all cause in-hospital mortality or ICU mortality.

关键词

Keywords

references

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