Repair cell first, then regenerate the tissues and organs

Xiao-Bing Fu

doi:10.1186/s40779-021-00297-5

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Repair cell first, then regenerate the tissues and organs

COMMENTARY | Updated：2023-02-28

- Repair cell first, then regenerate the tissues and organs
- Repair cell first, then regenerate the tissues and organs
- 解放军医学杂志（英文版） 2021年8卷第4期页码：579-580
- Affiliations：
  
  Wound Healing Unit, Medical Innovation Department and the Fourth Medical Center, Chinese PLA General Hospital and PLA Medical College, Beijing 100853, China
- Author bio：
  
  fuxiaobing@vip.sina.com
- Funds：
- DOI：10.1186/s40779-021-00297-5
  中图分类号：
- 纸质出版：2021-12
- Accepted：
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Repair cell first, then regenerate the tissues and organs[J]. 解放军医学杂志（英文版）, 2021,8(4):579-580.

Fu: Repair cell first, then regenerate the tissues and organs. Mil Med Res,2021, 8: 2.
Repair cell first, then regenerate the tissues and organs[J]. 解放军医学杂志（英文版）, 2021,8(4):579-580. DOI： 10.1186/s40779-021-00297-5.

Fu: Repair cell first, then regenerate the tissues and organs. Mil Med Res,2021, 8: 2. DOI： 10.1186/s40779-021-00297-5.

摘要

Abstract

Wound healing

tissue repair and regenerative medicine are in great demand

and great achievements in these fields have been made. The traditional strategy of tissue repair and regeneration has focused on the level of tissues and organs directly; however

the basic process of repair at the cell level is often neglected. Because the cell is the basic unit of organism structure and function; cell damage is caused first by ischemia or ischemia-reperfusion after severe trauma and injury. Then

damage to tissues and organs occurs with massive cell damage

apoptosis and even cell death. Thus

how to achieve the aim of perfect repair and regeneration? The basic process of tissue or organ repair and regeneration should involve repair of cells first

then tissues and organs. In this manuscript

it is my consideration about how to repair the cell first

then regenerate the tissues and organs.

关键词

Keywords

references

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Fu XB , Shen ZY , Chen YL , et al . Recombinant bovine basic fibroblast growth factor accelerates wound healing in patients with burns, donor sites and chronic dermal ulcers . Chin Med J . 2000 ; 113 ( 4 ): 367 - 71 .

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Zhao AD , Qin H , Sun ML , Ma K , Fu XB . Efficient and rapid conversion of human astrocytes and ALS mouse model spinal cord astrocytes into motor neuron-like cells by defined small molecules . Mil Med Res . 2020 ; 7 ( 1 ): 42 . https://doi.org/10.1186/s40779-020-00271-7 https://doi.org/10.1186/s40779-020-00271-7 .

Xiao J , Lin ZF , Qin H , Zheng ZL , Gong FH , et al . Growth factor regulatory system: a new system for not truly recognized organisms . Sci China Life Sci . 2020 ; 63 ( 3 ): 443 - 6 . https://doi.org/10.1007/s11427-019-1590-x https://doi.org/10.1007/s11427-019-1590-x .

Li XK . The FGF metabolic axis . Front Med . 2019 ; 13 ( 5 ): 511 - 30 . https://doi.org/10.1007/s11684-019-0711-y https://doi.org/10.1007/s11684-019-0711-y .

Nagappan PG , Chen H , Wang DY . Neuroregeneration and plasticity: a review of the physiological mechanisms for achieving functional recovery postinjury . Mil Med Res . 2020 ; 7 ( 1 ): 30 . https://doi.org/10.1186/s40779-020-00259-3 https://doi.org/10.1186/s40779-020-00259-3 .

Wei S , Ma JX , Xu L , Gu XS , Ma XL . Biodegradable materials for bone defect repair . Mil Med Res . 2020 ; 7 ( 1 ): 54 . https://doi.org/10.1186/s40779-020-00280-6 https://doi.org/10.1186/s40779-020-00280-6 .

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