Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma

Li-Bo Zhang; Rong-Rong Pang; Qing-Hua Qiao; Zhi-Hua Wang; Xin-Yi Xia; Chang-Jun Wang; Xiao-Li Xu

doi:10.1186/s40779-020-00273-5

Your Location：

Home >

Browse articles >

Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma

CASE REPORT | Updated：2023-02-28

- Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma
- Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma
- 解放军医学杂志（英文版） 2021年8卷第1期页码：132-137
- Affiliations：
  
  1.COVID-19 Research Center, Institute of Laboratory Medicine, Jinling Hospital, Nanjing University School of Medicine, the First School of Clinical Medicine, Southern Medical University, Nanjing 210002, Jiangsu, China
  2.Department of Laboratory Medicine, Nanjing Red Cross Blood Center, Nanjing 210003, Jiangsu, China
  3.Medical and Technical Support Department, Pingdingshan Medical District, the 989th Hospital, Pingdingshan 467000, Henan, China
  4.Department of Laboratory Medicine & Blood Transfusion, Wuhan Huoshenshan Hospital, Wuhan 430100, Hubei, China
  5.Department of Laboratory Medicine & Blood Transfusion, the 907th Hospital, Nanping 350702, Fujian, China
  6.Joint Expert Group for COVID-19, Wuhan Huoshenshan Hospital, Wuhan 430100, Hubei, China
  7.Center for Disease Control and Prevention of PLA, No. 20 Dongda Street, Fengtai District, Beijing 100071, China
  8.Department of Medical Administration, Jinling Hospital, Nanjing University School of Medicine, No. 305 East Zhongshan Road, Nanjing 210002, Jiangsu, China
- Author bio：
  
  * xinyixia@nju.edu.cn;
  science2008@hotmail.com;
  xxl2019kt@sina.com
- Funds：
  
  the Key Foundation of Wuhan Huoshenshan Hospital(2020 [18]);Key Research & Development Program of Jiangsu Province(BE2018713);Medical Innovation Project of Logistics Service(18JS005);the Foundation of Jiangsu Population Association(JSPA2019017);Medical Science and Technology Development Foundation, Nanjing Department of Health(YKK18179)
- DOI：10.1186/s40779-020-00273-5
  中图分类号：
- 纸质出版：2021-03
- Accepted：
Scan QR Code
Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma[J]. 解放军医学杂志（英文版）, 2021,8(1):132-137.

Zhang et al.: Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma. Mil Med Res, 2020, 7: 45.
Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma[J]. 解放军医学杂志（英文版）, 2021,8(1):132-137. DOI： 10.1186/s40779-020-00273-5.

Zhang et al.: Successful recovery of COVID-19-associated recurrent diarrhea and gastrointestinal hemorrhage using convalescent plasma. Mil Med Res, 2020, 7: 45. DOI： 10.1186/s40779-020-00273-5.

摘要

Abstract

Background:

Gastrointestinal symptoms are not rare among coronavirus disease 2019 (COVID-19) patients

but there have been no reports regarding convalescent plasma therapy for the recovery of gastrointestinal problems in COVID-19 patients.

Case presentation:

We present two cases of patients with COVID-19-associated recurrent diarrhea and positive fecal occult blood who successfully recovered after a one-time convalescent plasma administration.

Conclusion:

When COVID-19 patients develop recurrent or refractory gastrointestinal symptoms and fail to respond to the available treatment

alternative therapy with convalescent plasma administration may be considered.

关键词

Keywords

references

Bedford J , Enria D , Giesecke J , Heymann DL , Ihekweazu C , Kobinger G , et al . COVID-19: towards controlling of a pandemic . Lancet. 2020 ; 395 ( 10229 ): 1015 – 8 .

Baj J , Karakula-Juchnowicz H , Teresinski G , Buszewicz G , Ciesielka M , Sitarz E , et al . COVID-19: specific and non-specific clinical manifestations and symptoms: the current state of knowledge . J Clin Med. 2020 ; 9 ( 6 ): 1753 . https://doi.org/10.3390/jcm9061753 https://doi.org/10.3390/jcm9061753 .

Chen Y , Chen L , Deng Q , Zhang G , Wu K , Ni L , et al . The presence of SARSCoV-2 RNA in the feces of COVID-19 patients . J Med Virol. 2020 ; 92 ( 7 ): 833 – 40 .

Wang W , Xu Y , Gao R , Lu R , Han K , Wu G , et al . Detection of SARS-CoV-2 in different types of clinical specimens . JAMA. 2020 ; 323 ( 18 ): 1843 – 4 .

Zhang T , Cui X , Zhao X , Wang J , Zheng J , Zheng G , et al . Detectable SARSCoV-2 viral RNA in feces of three children during recovery period of COVID-19 pneumonia . J Med Virol. 2020 ; 92 ( 7 ): 909 – 14 . https://doi.org/10.1002/jmv.25795 https://doi.org/10.1002/jmv.25795 .

Lin L , Jiang X , Zhang Z , Huang S , Zhang Z , Fang Z , et al . Gastrointestinal symptoms of 95 cases with SARS-CoV-2 infection . Gut. 2020 ; 69 ( 6 ): 997 – 1001 .

Liu Q , Wang RS , Qu GQ , Wang YY , Liu P , Zhu YZ , et al . Gross examination report of a COVID-19 death autopsy . Fa Yi Xue Za Zhi. 2020 ; 36 ( 1 ): 21 – 3 . https://doi.org/10.12116/j.issn.1004-5619.2020.01.005 https://doi.org/10.12116/j.issn.1004-5619.2020.01.005 .

Zhang H , Li HB , Lyu JR , Lei XM , Li W , Wu G , et al . Specific ACE2 expression in small intestinal enterocytes may cause gastrointestinal symptoms and injury after 2019-nCoV infection . Int J Infect Dis. 2020 ; 96 : 19 – 24 . https://doi.org/10.1016/j.ijid.2020.04.027 https://doi.org/10.1016/j.ijid.2020.04.027 .

Chen N , Zhou M , Dong X , Qu J , Gong F , Han Y , et al . Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study . Lancet. 2020 ; 395 ( 10223 ): 507 – 13 .

Guan WJ , Ni ZY , Hu Y , Liang WH , Ou CQ , He JX , et al . Clinical characteristics of coronavirus disease 2019 in China . N Engl J Med. 2020 ; 382 ( 18 ): 1708 – 20 .

Huang C , Wang Y , Li X , Ren L , Zhao J , Hu Y , et al . Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China . Lancet. 2020 ; 395 ( 10223 ): 497 – 506 .

Wang D , Hu B , Hu C , Zhu F , Liu X , Zhang J , et al . Clinical characteristics of 138 hospitalized patients with 2019 novel coronavirus-infected pneumonia in Wuhan, China . JAMA. 2020 ; 323 ( 11 ): 1061 – 9 . https://doi.org/10.1001/jama.2020.1585 https://doi.org/10.1001/jama.2020.1585 .

Zhu N , Zhang D , Wang W , Li X , Yang B , Song J , et al . A novel coronavirus from patients with pneumonia in China, 2019 . N Engl J Med. 2020 ; 382 ( 8 ): 727 – 33 .

Xiao F , Tang M , Zheng X , Liu Y , Li X , Shan H . Evidence for gastrointestinal infection of SARS-CoV-2 . Gastroenterology. 2020 ; 158 ( 6 ): 1831 – 3 .

Ye M , Fu D , Ren Y , Wang F , Wang D , Zhang F , et al . Treatment with convalescent plasma for COVID-19 patients in Wuhan, China . J Med Virol. 2020 . https://doi.org/10.1002/jmv.25882 https://doi.org/10.1002/jmv.25882 .

Zhang L , Pang R , Xue X , Bao J , Ye S , Dai Y , et al . Anti-SARS-CoV-2 virus antibody levels in convalescent plasma of six donors who have recovered from COVID-19 . Aging (Albany NY). 2020 ; 12 ( 8 ): 6536 – 42 .

Nobel YR , Phipps M , Zucker J , Lebwohl B , Wang TC , Sobieszczyk ME , et al . Gastrointestinal symptoms and COVID-19: case-control study from the United States . Gastroenterology. 2020 ; 159 ( 1 ): 373 – 5 .

Long QX , Liu BZ , Deng HJ , Wu GC , Deng K , Chen YK , et al . Antibody responses to SARS-CoV-2 in patients with COVID-19 . Nat Med. 2020 ; 26 ( 6 ): 845 – 8 .

To KK , Tsang OT , Leung WS , Tam AR , Wu TC , Lung DC , et al . Temporal profiles of viral load in posterior oropharyngeal saliva samples and serum antibody responses during infection by SARS-CoV-2: an observational cohort study . Lancet Infect Dis. 2020 ; 20 ( 5 ): 565 – 74 .

Tian Y , Rong L , Nian W , He Y . Review article: gastrointestinal features in COVID-19 and the possibility of faecal transmission . Aliment Pharmacol Ther. 2020 ; 51 ( 9 ): 843 – 51 .

Hosoda T , Sakamoto M , Shimizu H , Okabe N . SARS-CoV-2 enterocolitis with persisting to excrete the virus for approximately two weeks after recovering from diarrhea: a case report . Infect Control Hosp Epidemiol. 2020 ; 41 ( 6 ): 753 – 4 .

Blanco-Colino R , Vilallonga R , Martin R , Petrola C , Armengol M . Suspected acute abdomen as an extrapulmonary manifestation of Covid-19 infection . Cir Esp. 2020 ; 98 ( 5 ): 295 – 6 .

Tullie L , Ford K , Bisharat M , Watson T , Thakkar H , Mullassery D , et al . Gastrointestinal features in children with COVID-19: an observation of varied presentation in eight children . Lancet Child Adolesc Health. 2020 ; 4 ( 7 ): e19 – 20 .

浏览量

Downloads

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

Monkeypox outbreak in the age of COVID-19: a new global health emergency

Neuroinflammation in mild respiratory COVID-19: insights into cognitive impairment in milder cases

Pushing the frontiers of military medical excellence: updates, progress and future needs

Characterization of oral and gut microbiome and plasma metabolomics in COVID-19 patients after 1-year follow-up

Understanding neutralising antibodies against SARS-CoV-2 and their implications in clinical practice