Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial <italic style="font-style: italic">Acinetobacter baumannii</italic> infection after trauma: a case report and review of the literature

Li Zhong; Xue-Zhi Shi; Lei Su; Zhi-Feng Liu

doi:10.1186/s40779-020-00253-9

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Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature

CASE REPORT | Updated：2023-06-05

- Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature
- Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature
- MMR 2020年7卷第4期页码：497-502
- Affiliations：
  
  1.Second Clinical College of Guangzhou University of Chinese Medicine, Guangzhou 510515, China.
  2.Department of Critical Care Medicine, the First Affiliated Hospital of Guizhou University of Chinese Medicine, Guiyang 550001, China.
  3.Department of Critical Care Medicine, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China.
  4.Key Laboratory of Hot Zone Trauma Care and Tissue Repair of PLA, General Hospital of Southern Theater Command of PLA, Guangzhou 510010, China.
- Author bio：
  
  * Zhifengliu7797@163.com
- Funds：
  
  National Natural Science Foundation of China(81571940;81741125);Guangzhou Science and Technology Planning Project of China(201504281714528);PLA Logistics Research Project of China(CWH17L020;17CXZ008;18CXZ030)
- DOI：10.1186/s40779-020-00253-9
  中图分类号：
- 纸质出版：2020-12
- Accepted：
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Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature[J]. MMR, 2020,7(4):497-502.

Zhong et al.: Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature. Mil Med Res, 2020, 7: 23.
Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature[J]. MMR, 2020,7(4):497-502. DOI： 10.1186/s40779-020-00253-9.

Zhong et al.: Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature. Mil Med Res, 2020, 7: 23. DOI： 10.1186/s40779-020-00253-9.

摘要

Abstract

Background:

Intracranial infection after craniotomy is one of the most serious postoperative complications

especially multidrug-resistant (MDR) or extensively drug-resistant (XDR) bacterial meningitis

and strongly affects the prognosis of patients. Current treatment experience regarding these infections is scarce.

Case presentation:

We report a case of severe intracranial infection of XDR

Acinetobacter baumannii

(

A. baumannii

) that was treated by intravenous (IV) injection

sequential intraventricular (IVT) injection of tigecycline and polymyxin B

and other anti-infective drugs. Good results were obtained

and the patient was eventually discharged from the hospital. This case is characterized by intracranial infection.

Conclusions:

The polymyxin B IV+IVT pathway is an ideal treatment strategy for XDR

A. baumannii

. The tigecycline IVT pathway is also a safe treatment option.

关键词

Keywords

references

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Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature

Sequential intraventricular injection of tigecycline and polymyxin B in the treatment of intracranial Acinetobacter baumannii infection after trauma: a case report and review of the literature

DOI：10.1186/s40779-020-00253-9

摘要

Abstract

关键词

Keywords

references