Hemostatic agents for prehospital hemorrhage control: a narrative review
Hemostatic agents for prehospital hemorrhage control: a narrative review
- MMR 2020年7卷第4期 页码：444-463
- Affiliations：
Defence Research and Development Canada, Toronto Research Centre, 1133 Sheppard Avenue West, Toronto, ON M3K 2C9, Canada
- Author bio：
henry.peng@drdc-rddc.gc.ca
- Funds：
DOI：10.1186/s40779-020-00241-z
中图分类号：-
纸质出版：2020-12
- Accepted：
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Hemostatic agents for prehospital hemorrhage control: a narrative review[J]. MMR, 2020,7(4):444-463.
Peng: Hemostatic agents for prehospital hemorrhage control: a narrative review. Mil Med Res,2020, 7: 13.
Hemostatic agents for prehospital hemorrhage control: a narrative review[J]. MMR, 2020,7(4):444-463. DOI： 10.1186/s40779-020-00241-z.
Peng: Hemostatic agents for prehospital hemorrhage control: a narrative review. Mil Med Res,2020, 7: 13. DOI： 10.1186/s40779-020-00241-z.
摘要
Abstract
Hemorrhage is the leading cause of preventable death in combat trauma and the secondary cause of death in civilian trauma. A significant number of deaths due to hemorrhage occur before and in the first hour after hospital arrival. A literature search was performed through PubMed
Scopus
and Institute of Scientific Information databases for English language articles using terms relating to hemostatic agents
prehospital
battlefield or combat dressings
and prehospital hemostatic resuscitation
followed by cross-reference searching. Abstracts were screened to determine relevance and whether appropriate further review of the original articles was warranted. Based on these findings
this paper provides a review of a variety of hemostatic agents ranging from clinically approved products for human use to newly developed concepts with great potential for use in prehospital settings. These hemostatic agents can be administered either systemically or locally to stop bleeding through different mechanisms of action. Comparisons of current hemostatic products and further directions for prehospital hemorrhage control are also discussed.
关键词
Keywords
references
Stannard A , Morrison JJ , Scott DJ , Ivatury RA , Ross JD , Rasmussen TE . The epidemiology of noncompressible torso hemorrhage in the wars in Iraq and Afghanistan . J Trauma Acute Care Surg . 2013 ; 74 ( 3 ): 830 - 4 .
Eastridge BJ , Hardin M , Cantrell J , Oetjen-Gerdes L , Zubko T , Mallak C , et al . Died of wounds on the battlefield: causation and implications for improving combat casualty care . J Trauma . 2011 ; 71 ( 1 ): S4 - 8 .
Eastridge BJ , Mabry RL , Seguin P , Cantrell J , Tops T , Uribe P , et al . Death on the battlefield (2001–2011): implications for the future of combat casualty care . J Trauma Acute Care Surg . 2012 ; 73 ( 6 ): S431 - 7 .
Norton R , Kobusingye O . Injuries . N Engl J Med . 2013 ; 368 ( 18 ): 1723 - 30 .
U. S. Burden of Disease Collaborators . The state of US health, 1990–2010: Burden of diseases, injuries, and risk factors . JAMA . 2013 ; 310 ( 6 ): 591 – 606 .
National Academies of Sciences Engineering and Medicine . A national trauma care system: integrating military and civilian trauma systems to achieve zero preventable deaths after injury . Washington, DC : The National Academies Press ; 2016 . p. 530 .
Hess JR , Brohi K , Dutton RP , Hauser CJ , Holcomb JB , Kluger Y , et al . The coagulopathy of trauma: a review of mechanisms . J Trauma Acute Care Surg . 2008 ; 65 ( 4 ): 748 - 54 .
Davenport RA , Brohi K . Cause of trauma-induced coagulopathy . Curr Opin Anesthesiol . 2015 ; 29 ( 2 ): 212 - 9 .
Stephens CT , Gumbert S , Holcomb JB . Trauma-associated bleeding: management of massive transfusion . Curr Opin Anesthesiol . 2016 ; 29 ( 2 ): 250 - 5 .
Martin M , Oh J , Currier H , Tai N , Beekley A , Eckert M , et al . An analysis of in-hospital deaths at a modern combat support hospital . J Trauma . 2009 ; 66 ( 4 ): S51 - 61 .
Pidcoke HF , Spinella PC . RDCR symposium fifth-year anniversary edition: global prehospital care rooted in a history of military innovation . Transfusion . 2016 ; 56 ( Suppl 2 ): S107 - 9 .
Chang R , Eastridge BJ , Holcomb JB . Remote damage control resuscitation in austere environments . Wilderness Environ Med . 2017 ; 28 ( 2 ): S124 - 34 .
MacGoey P , Lamb CM , Navarro AP , Brooks AJ . Damage control: the modern paradigm . Trauma . 2016 ; 18 ( 3 ): 165 - 77 .
Smith IM , James RH , Dretzke J , Midwinter MJ . Pre-hospital blood product resuscitation for trauma: a systematic review . Shock . 2016 ; 46 ( 1 ): 3 - 16 .
Shand S , Curtis K , Dinh M , Burns B . What is the impact of prehospital blood product administration for patients with catastrophic haemorrhage: an integrative review . Injury . 2019 ; 50 ( 2 ): 226 - 34 .
Rijnhout TWH , Wever KE , Marinus R , Hoogerwerf N , Jr Geeraedts LMG , Tan E . Is prehospital blood transfusion effective and safe in haemorrhagic trauma patients? A systematic review and meta-analysis . Injury . 2019 ; 50 ( 5 ): 1017 - 27 .
Fenger-Eriksen C , Fries D , David J-S , Bouzat P , Lance MD , Grottke O , et al . Pre-hospital plasma transfusion: a valuable coagulation support or an expensive fluid therapy ? Crit Care . 2019 ; 23 ( 1 ): 238 .
van Oostendorp SE , Tan ECTH , Geeraedts LMG . Prehospital control of lifethreatening truncal and junctional haemorrhage is the ultimate challenge in optimizing trauma care; a review of treatment options and their applicability in the civilian trauma setting . Scand J Trauma Res Emerg Med . 2016 ; 24 ( 1 ): 1 - 13 .
Rappold JF , Bochicchio GV . Surgical adjuncts to noncompressible torso hemorrhage as tools for patient blood management . Transfusion . 2016 ; 56 ( Suppl 2 ): 203 - 7 .
Smith AH , Laird C , Porter K , Bloch M . Haemostatic dressings in prehospital care . J Emerg Med . 2013 ; 30 ( 10 ): 784 - 9 .
Sigal A , Martin A , Ong A . Availability and use of hemostatic agents in prehospital trauma patients in Pennsylvania translation from the military to the civilian setting . Open Access Emerg Med . 2017 ; 9 : 47 - 52 .
Neuffer MC , McDivitt J , Rose D , King K , Cloonan CC , Vayer JS . Hemostatic dressings for the first responder: a review . Mil Med . 2004 ; 169 ( 9 ): 716 - 20 .
Pusateri AE , Delgado AV , Jr Dick EJ , Martinez RS , Holcomb JB , Ryan KL . Application of a granular mineral-based hemostatic agent (QuikClot) to reduce blood loss after grade V liver injury in swine . J Trauma . 2004 ; 57 ( 3 ): 555 - 62 .
Peng T . Biomaterials for hemorrhage control . Trends Biomater Artif Organs . 2010 ; 24 ( 1 ): 27 - 68 .
Baylis JR , Chan KYT , Kastrup CJ . Halting hemorrhage with self-propelling particles and local drug delivery . Thromb Res . 2016 ; 141 ( Suppl 2 ): 36 - 9 .
Chaturvedi A , Dowling MB , Gustin JP , Scalea TM , Raghavan SR , Pasley JD , et al . Hydrophobically modified chitosan gauze: a novel topical hemostat . J Surg Res . 2017 ; 207 : 45 - 52 .
Peng H , Shek P . Development of in situ-forming hydrogels for hemorrhage control . J Mater Sci Mater Med . 2009 ; 20 ( 8 ): 1753 - 62 .
Peng HT , Blostein MD , Shek PN . Experimental optimization of an in situ forming hydrogel for hemorrhage control . J Biomed Mater Res B . 2009 ; 89 ( 1 ): 199 - 209 .
Rago AP , Duggan MJ , Beagle J , Peev MP , Marini J , Hwabejire JO , et al . Selfexpanding foam for prehospital treatment of intra-abdominal hemorrhage: 28-day survival and safety . J Trauma Acute Care Surg . 2014 ; 77 ( 3 ): S127 - 33 .
Otrocka-Domagała I , Jastrzębski P , Adamiak Z , Paździor-Czapula K , Gesek M , Mikiewicz M , et al . Safety of the long-term application of QuikClot combat gauze, ChitoGauze PRO and Celox gauze in a femoral artery injury model in swine–the preliminary study . Pol J Vet Sci . 2016 ; 19 ( 2 ): 337 - 43 .
Kheirabadi BS , Mace JE , Terrazas IB , Fedyk CG , Estep JS , Dubick MA , et al . Safety evaluation of new hemostatic agents, smectite granules, and kaolincoated gauze in a vascular injury wound model in swine . J Trauma Acute Care Surg . 2010 ; 68 ( 2 ): 269 - 78 .
Liberati A , Altman DG , Tetzlaff J , Mulrow C , Gøtzsche PC , Ioannidis JP , et al . The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration . PLoS Med . 2009 ; 6 ( 7 ): e1000100 .
Maegele M . Coagulation factor concentrate-based therapy for remote damage control resuscitation (RDCR): a reasonable alternative ? Transfusion . 2016 ; 56 ( Suppl 2 ): 157 - 65 .
Matsushima K , Benjamin E , Demetriades D . Prothrombin complex concentrate in trauma patients . Am J Surg . 2015 ; 209 ( 2 ): 413 - 7 .
Nascimento B , Callum J , Tien H , Peng H , Rizoli S , Karanicolas P , et al . Fibrinogen in the initial resuscitation of severe trauma (FiiRST):a randomized feasibility trial . Br J Anaesth . 2016 ; 117 ( 6 ): 775 - 82 .
Sanders S , Tien H , Callum J , Nascimento B , Peng H , Funk C , et al . Fibrinogen concentrate in the special operations forces environment . Mil Med . 2018 ; 183 ( 1–2 ): e45 - 50 .
Pusateri AE , Given MB , Schreiber MA , Spinella PC , Pati S , Kozar RA , et al . Dried plasma: state of the science and recent developments . Transfusion . 2016 ; 56 ( Suppl 2 ): 128 - 39 .
Shlaifer A , Siman-Tov M , Radomislensky I , Peleg K , Klein Y , Glassberg E , et al . The impact of pre pospital administration of freeze dried plasma on casualty outcome . J Trauma Acute Care Surg . 2018 ; 86 ( 1 ): 108 - 15 .
Heier HE , Badloe J , Bohonek M , Cap A , Doughty H , Korsak J , et al . Use of Tranexamic acid in bleeding combat casualties . Mil Med . 2015 ; 180 ( 8 ): 844 - 6 .
Ausset S , Glassberg E , Nadler R , Sunde G , Cap AP , Hoffmann C , et al . Tranexamic acid as part of remote damage-control resuscitation in the prehospital setting: a critical appraisal of the medical literature and available alternatives . J Trauma Acute Care Surg . 2015 ; 78 ( 6 ): S70 - 5 .
El-Menyar A , Sathian B , Asim M , Latifi R , Al-Thani H . Efficacy of prehospital administration of tranexamic acid in trauma patients: a meta-analysis of the randomized controlled trials . Am J Emerg Med . 2018 ; 36 ( 6 ): 1079 - 87 .
Huebner BR , Dorlac WC , Cribari C . Tranexamic acid use in prehospital uncontrolled hemorrhage . Wilderness Environ Med . 2017 ; 28 ( 2 ): S50 - 60 .
Fitzpatrick GM , Cliff R , Tandon N . Thrombosomes: a platelet-derived hemostatic agent for control of noncompressible hemorrhage . Transfusion . 2013 ; 53 ( Suppl 1 ): 100S - 6 .
Macko AR , Crossland RF , Cap AP , Fryer DM , Mitchell TA , Pusateri AE , et al . Control of severe intra-abdominal hemorrhage with an infusible plateletderived hemostatic agent in a nonhuman primate (rhesus macaque) model . J Trauma Acute Care Surg . 2016 ; 80 ( 4 ): 617 - 24 .
Hawksworth JS , Elster EA , Fryer D , Sheppard F , Morthole V , Krishnamurthy G , et al . Evaluation of lyophilized platelets as an infusible hemostatic agent in experimental non-compressible hemorrhage in swine . J Thromb Haemost . 2009 ; 7 ( 10 ): 1663 - 71 .
Bertram JP , Williams CA , Robinson R , Segal SS , Flynn NT , Lavik EB . Synthetic platelets: nanotechnology to halt bleeding . Sci Transl Med . 2009 ; 1 ( 11 ): 11ra22 .
Anselmo AC , Modery-Pawlowski CL , Menegatti S , Kumar S , Vogus DR , Tian LL , et al . Platelet-like nanoparticles: mimicking shape, flexibility, and surface biology of platelets to target vascular injuries . ACS Nano . 2014 ; 8 ( 11 ): 11243 - 53 .
Modery-Pawlowski CL , Tian LL , Pan V , McCrae KR , Mitragotri S , Sen GA . Approaches to synthetic platelet analogs . Biomaterials . 2013 ; 34 ( 2 ): 526 - 41 .
Chan LW , White NJ , Pun SH . Synthetic strategies for engineering intravenous hemostats . Bioconjug Chem . 2015 ; 26 ( 7 ): 1224 - 36 .
Chan LW , White NJ , Pun SH . A fibrin cross-linking polymer enhances clot formation similar to factor concentrates and tranexamic acid in an in vitro model of coagulopathy . ACS Biomater Sci Eng . 2016 ; 2 ( 3 ): 403 - 8 .
Lamm RJ , Lim EB , Weigandt KM , Pozzo LD , White NJ , Pun SH . Peptide valency plays an important role in the activity of a synthetic fibrincrosslinking polymer . Biomaterials . 2017 ; 132 : 96 - 104 .
Bennett BL , Littlejohn LF , Kheirabadi BS , Butler FK , Kotwal RS , Dubick MA , et al . Management of external hemorrhage in tactical combat casualty care: chitosan-based hemostatic gauze dressings. TCCC guidelines change 13-05 . J Spec Oper Med . 2014 ; 14 ( 3 ): 12 - 29 .
Bennett BL . Bleeding control using hemostatic dressings: lessons learned . Wilderness Environ Med . 2017 ; 28 ( 2 ): S39 - 49 .
Boulton AJ , Lewis CT , Naumann DN , Midwinter MJ . Prehospital haemostatic dressings for trauma: a systematic review . J Emerg Med . 2018 ; 35 ( 7 ): 449 - 57 .
Sims K , Montgomery HR , Dituro P , Kheirabadi BS , Butler FK . Management of external hemorrhage in tactical combat casualty care: the adjunctive use of XStat™ compressed hemostatic sponges: TCCC guidelines change 15-03 . J Spec Oper Med . 2016 ; 16 ( 1 ): 19 - 28 .
Chang JC , Holloway BC , Zamisch M , Hepburn MJ , Ling GS . ResQFoam for the treatment of non-compressible hemorrhage on the front line . Mil Med . 2015 ; 180 ( 9 ): 932 - 3 .
Holcomb J , Nunez T . Damage control resuscitation . In: Martin M , Beekley A , editors. Front Line Surgery : Springer New York ; 2011 . p 47 - 58 .
Klages M , Zacharowski K , Weber CF . Coagulation management in traumaassociated coagulopathy: allogenic blood products versus coagulation factor concentrates in trauma care . Curr Opin Anesthesiol . 2016 ; 29 ( 2 ): 245 - 9 .
Sperry JL , Guyette FX , Brown JB , Yazer MH , Triulzi DJ , Early-Young BJ , et al . Prehospital plasma during air medical transport in trauma patients at risk for hemorrhagic shock . N Engl J Med . 2018 ; 379 ( 4 ): 315 - 26 .
Moore HB , Moore EE , Chapman MP , McVaney K , Bryskiewicz G , Blechar R , et al . Plasma-first resuscitation to treat haemorrhagic shock during emergency ground transportation in an urban area: a randomised trial . Lancet . 2018 ; 392 ( 10144 ): 283 - 91 .
Glassberg E , Nadler R , Gendler S , Abramovich A , Spinella PC , Gerhardt RT , et al . Freeze-dried plasma at the point of injury: from concept to doctrine . Shock . 2013 ; 40 ( 6 ): 444 - 50 .
Aubron C , Reade MC , Fraser JF , Cooper DJ . Efficacy and safety of fibrinogen concentrate in trauma patients—a systematic review . J Crit Care . 2014 ; 29 ( 3 ): 471 e11 - 7 .
Curry NS , Davenport R . Transfusion strategies for major haemorrhage in trauma . Br J Haematol . 2019 ; 184 ( 4 ): 508 - 23 .
Kalina U , Bickhard H , Schulte S . Biochemical comparison of seven commercially available prothrombin complex concentrates . Int J Clin Pract . 2008 ; 62 ( 10 ): 1614 - 22 .
Grottke O , Levy JH . Prothrombin complex concentrates in trauma and perioperative bleeding . Anesthesiology . 2015 ; 122 ( 4 ): 923 - 31 .
Peralta MR , Chowdary P . The use of new procoagulants in blunt and penetrating trauma . Curr Opin Anesthesiol . 2019 ; 32 ( 2 ): 200 - 5 .
Buckley L , Gonzales R . Challenges to producing novel therapies- dried plasma for use in trauma and critical care . Transfusion . 2019 ; 59 ( Suppl 1 ): 837 - 45 .
Shlaifer A , Siman-Tov M , Radomislensky I , Peleg K , Shina A , Baruch EN , et al . Prehospital administration of freeze-dried plasma, is it the solution for trauma casualties ? J Trauma Acute Care Surg . 2017 ; 83 ( 4 ): 675 - 82 .
Sunde GA , Vikenes B , Strandenes G , Flo KC , Hervig TA , Kristoffersen EK , et al . Freeze dried plasma and fresh red blood cells for civilian prehospital hemorrhagic shock resuscitation . J Trauma Acute Care Surg . 2015 ; 78 ( 6 ): S26 - 30 .
Oakeshott JE , Griggs JE , Wareham GM , Lyon RM . Feasibility of prehospital freeze-dried plasma administration in a UK helicopter emergency medical service . Eur J Emerg Med . 2019 ; 26 ( 5 ): 373 - 8 .
Garrigue D , Godier A , Glacet A , Labreuche J , Kipnis E , Paris C , et al . French lyophilized plasma versus fresh frozen plasma for the initial management of trauma induced coagulopathy: a randomized open-label trial . J Thromb Haemost . 2017 ; 16 ( 3 ): 481 - 9 .
Nguyen C , Bordes J , Cungi PJ , Esnault P , Cardinale M , Mathais Q , et al . Use of French lyophilized plasma transfusion in severe trauma patients is associated with an early plasma transfusion and early transfusion ratio improvement . J Trauma Acute Care Surg . 2018 ; 84 ( 5 ): 780 - 5 .
Rottenstreich M , Malka I , Glassberg E , Schwartz O , Tarif B . Pre-hospital intraosseous freeze dried plasma transfusion: a case report . Disaster Mil Med . 2015 ; 1 : 8 .
Sailliol A , Martinaud C , Cap AP , Civadier C , Clavier B , Deshayes AV , et al . The evolving role of lyophilized plasma in remote damage control resuscitation in the French armed forces health service . Transfusion . 2013 ; 53 ( Suppl 1 ): 65S - 71 .
Martinaud C , Ausset S , Deshayes AV , Cauet A , Demazeau N , Sailliol A . Use of freeze-dried plasma in French intensive care unit in Afghanistan . J Trauma Acute Care Surg . 2011 ; 71 ( 6 ): 1761 - 5 .
Pusateri AE , Given MB , Macdonald VW , Homer MJ . Comprehensive US government program for dried plasma development . Transfusion . 2016 ; 56 ( Suppl 1 ): S16 - 23 .
Levy JH , Szlam F , Tanaka KA , Sniecienski RM . Fibrinogen and hemostasis: a primary hemostatic target for the management of acquired bleeding . Anesth Analg . 2012 ; 114 ( 2 ): 261 - 74 .
Fries D , Martini WZ . Role of fibrinogen in trauma-induced coagulopathy . Br J Anaesth . 2010 ; 105 ( 2 ): 116 - 21 .
Rourke C , Curry N , Khan S , Taylor R , Raza I , Davenport R , et al . Fibrinogen levels during trauma hemorrhage, response to replacement therapy, and association with patient outcomes . J Thromb Haemost . 2012 ; 10 ( 7 ): 1342 - 51 .
Kimura Y , Kimura S , Sumita S , Yamakage M . Predictors of hypofibrinogenemia in blunt trauma patients on admission . J Anesth . 2015 ; 29 ( 2 ): 242 - 8 .
Inaba K , Karamanos E , Lustenberger T , Schöchl H , Shulman I , Nelson J , et al . Impact of fibrinogen levels on outcomes after acute injury in patients requiring a massive transfusion . J Am Coll Surg . 2013 ; 216 ( 2 ): 290 - 7 .
Franchini M , Lippi G . Fibrinogen replacement therapy: a critical review of the literature . Blood Transfus . 2012 ; 10 ( 1 ): 23 - 7 .
Schulz PM , Gehringer W , Nöhring S , Müller S , Schmidt T , Kekeiss-Schertler S , et al . Biochemical characterization, stability, and pathogen safety of a new fibrinogen concentrate (fibryga®) . Biologicals . 2018 ; 52 ( 1 ): 72 - 7 .
Haas T , Cushing MM , Asmis LM . Comparison of the efficacy of two human fibrinogen concentrates to treat dilutional coagulopathy in vitro . Scand J Clin Lab Invest . 2018 ; 78 ( 3 ): 230 - 5 .
Ross C , Rangarajan S , Karimi M , Toogeh G , Apte S , Lissitchkov T , et al . Pharmacokinetics, clot strength and safety of a new fibrinogen concentrate: randomized comparison with active control in congenital fibrinogen deficiency . J Thromb Haemost . 2018 ; 16 ( 2 ): 253 - 61 .
Djambas Khayat C , El Khorassani M , Lambert T , Gay V , Barthez-Toullec M , Lamazure J , et al . Clinical pharmacology, efficacy and safety study of a triple-secured fibrinogen concentrate in adults and adolescent patients with congenital fibrinogen deficiency . J Thromb Haemost . 2019 ; 17 ( 4 ): 635 - 44 .
González-Guerrero C , Lozano-Andreu T , Roch-Santed M , Rivera-Sánchez L , Brandariz-Núñez D , Pastó-Cardona L , et al . Evaluation of the efficiency under current use of human fibrinogen concentrate in trauma patients with lifethreatening hemorrhagic disorders . Blood Coagul Fibrinolysis . 2017 ; 28 ( 1 ): 66 - 71 .
Ozier Y , Hunt BJ . Fibrinogen concentrate for management of bleeding: against indiscriminate use . J Thromb Haemost . 2011 ; 9 ( 1 ): 6 - 8 .
Kozek-Langenecker S , Fries D , Spahn DR , Zacharowski K . Fibrinogen concentrate: clinical reality and cautious Cochrane recommendation . Br J Anaesth . 2014 ; 112 ( 5 ): 784 - 7 .
Bolliger D , Tanaka KA . Fibrinogen—is it a universal haemostatic agent ? Br J Anaesth . 2016 ; 117 ( 5 ): 548 - 50 .
Maegele M , Zinser M , Schlimp C , Schöchl H , Fries D . Injectable hemostatic adjuncts in trauma: fibrinogen and the FIinTIC study . J Trauma Acute Care Surg . 2015 ; 78 ( 6 ): S76 - 82 .
Steinmetz J , Sørensen MA , Henriksen HH , Lange T , Larsen CF , Johansson PI , et al . Pilot randomized trial of fibrinogen in trauma Haemorrhage (PRooFiTH): study protocol for a randomized controlled trial . Trials . 2016 ; 17 ( 1 ): 1 - 8 .
Innerhofer P , Fries D , Mittermayr M , Innerhofer N , von Langen D , Hell T , et al . Reversal of trauma-induced coagulopathy using first-line coagulation factor concentrates or fresh frozen plasma (RETIC): a single-Centre, parallel group, open-label, randomised trial . Lancet Haematol . 2017 ; 4 ( 6 ): e258 - 71 .
Hayakawa M , Gando S , Ono Y , Wada T , Yanagida Y , Sawamura A . Fibrinogen level deteriorates before other routine coagulation parameters and massive transfusion in the early phase of severe trauma: a retrospective observational study . Semin Thromb Hemost . 2015 ; 41 ( 1 ): 35 - 42 .
Ziegler B , Bachler M , Haberfellner H , Innerhofer P , Hell T , Kaufmann M , et al . Efficacy of pre-Hospital administration of fibrinogen concentrate (Clottafact®) in trauma patients presumed to bleed (FIinTIC): Results from a multicentre double-blind, placebo-controlled, randomised, pilot trial . 2019 . https://ssrn.com/abstract=3377525 https://ssrn.com/abstract=3377525 . Accessed 12 May 2019 .
Sharma V , Fan J , Jerath A , Pang K , Bojko B , Pawliszyn J , et al . Pharmacokinetics of tranexamic acid in patients undergoing cardiac surgery with use of cardiopulmonary bypass . Anaesthesia . 2012 ; 67 ( 11 ): 1242 - 50 .
Moore EE , Moore HB , Gonzalez E , Sauaia A , Banerjee A , Silliman CC . Rationale for the selective administration of tranexamic acid to inhibit fibrinolysis in the severely injured patient . Transfusion . 2016 ; 56 : S110 - 4 .
Godier A , Parmar K , Manandhar K , Hunt BJ . An in vitro study of the effects of t-PA and tranexamic acid on whole blood coagulation and fibrinolysis . J Clin Pathol . 2017 ; 70 ( 2 ): 154 - 61 .
Roberts I , Shakur H , Afolabi A , Brohi K , Coats T , Dewan Y , et al . The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial . Lancet . 2011 ; 377 ( 9771 ): 1096 - 101 .
Lipsky AM , Abramovich A , Nadler R , Feinstein U , Shaked G , Kreiss Y , et al . Tranexamic acid in the prehospital setting: Israel defense forces' initial experience . Injury . 2014 ; 45 ( 1 ): 66 - 70 .
Wright C . Battlefield administration of tranexamic acid by combat troops: a feasibility analysis . J R Army Med Corps . 2014 ; 160 ( 4 ): 271 - 2 .
Aedo-Martín D , García-Cañas R , Navarro-Suay R , Martínez-Roldán M , Baños-Turza R , Tamburri-Bariain R . Use of tranexamic acid in combat casualties. Experience of the Spanish medical corps. Clinical series and literature review . Rev Esp Cir Ortop Traumatol . 2016 ; 60 ( 3 ): 200 - 5 .
CRASH trial collaborators , Shakur H , Roberts I , Bautista R , Caballero J , Coats T , et al . Effects of tranexamic acid on death, vascular occlusive events, and blood transfusion in trauma patients with significant haemorrhage (CRASH-2): a randomised, placebo-controlled trial . Lancet . 2010 ; 376 ( 9734 ): 23 - 32 .
Shakur H , Roberts I , Fawole B , Chaudhri R , El-Sheikh M , Akintan A , et al . Effect of early tranexamic acid administration on mortality, hysterectomy, and other morbidities in women with post-partum haemorrhage (WOMAN): an international, randomised, double-blind, placebo-controlled trial . Lancet . 2017 ; 389 ( 10084 ): 2105 - 16 .
Roberts I . Fibrinolytic shutdown: fascinating theory but randomized controlled trial data are needed . Transfusion . 2016 ; 56 ( Suppl 2 ): 115 - 8 .
Jansen JA , Lameijer JRC , Snoeker BAM . Combined intravenous, topical and oral tranexamic acid administration in total knee replacement: evaluation of safety in patients with previous thromboembolism and effect on hemoglobin level and transfusion rate . Knee . 2017 ; 24 ( 5 ): 1206 - 12 .
Ker K , Beecher D , Roberts I . Topical application of tranexamic acid for the reduction of bleeding . Cochrane Database Syst Rev . 2013 ; 7 : CD010562 .
Montroy J , Hutton B , Moodley P , Fergusson NA , Cheng W , Tinmouth A , et al . The efficacy and safety of topical tranexamic acid: a systematic review and meta-analysis . Transfus Med Rev . 2018 ; 32 ( 3 ): 165 - 78 .
Picetti R , Shakur-Still H , Medcalf RL , Standing JF , Roberts I . What concentration of tranexamic acid is needed to inhibit fibrinolysis?A systematic review of pharmacodynamics studies . Blood Coagul Fibrinolysis . 2019 ; 30 ( 1 ): 1 - 10 .
Schöchl H , Schlimp CJ , Maegele M . Tranexamic acid, fibrinogen concentrate, and prothrombin complex concentrate: data to support prehospital use ? Shock . 2014 ; 41 : 44 - 6 .
Boudreau RM , Deshpande KK , Day GM , Hinckley WR , Harger N , Pritts TA , et al . Prehospital tranexamic acid administration during aeromedical transport after injury . J Surg Res . 2019 ; 233 : 132 - 8 .
Etchill EW , Myers SP , Raval JS , Hassoune A , SenGupta A , Neal MD . Platelet transfusion in critical care and surgery: evidence-based review of contemporary practice and future directions . Shock . 2017 ; 47 ( 5 ): 537 - 49 .
Klein E , Farber S , Djerassi I , Toch R , Freeman G , Arnold P . The preparation and clinical administration of lyophilized platelet material to children with acute leukemia and aplastic anemia . J Pediatr . 1956 ; 49 ( 5 ): 517 - 22 .
Stefanini M , Kistner SA . Platelets, platelet factors and platelet substitutes in the management of thrombocytopenic states . Bibl Haematol . 1958 ; 7 : 378 - 81 .
Barroso J , Osborne B , Teramura G , Pellham E , Fitzpatrick M , Biehl R , et al . Safety evaluation of a lyophilized platelet-derived hemostatic product . Transfusion . 2018 ; 58 ( 12 ): 2969 - 77 .
Inaba K , Barmparas G , Rhee P , Branco BC , Fitzpatrick M , Okoye OT , et al . Dried platelets in a swine model of liver injury . Shock . 2014 ; 41 ( 5 ): 429 - 34 .
Burdette AJ , III Andrew Pratt G , Campagna MV , Sheppard FR . Evaluation of a new generation platelet-derived hemostatic agent in a rabbit thrombocytopenic model . Thromb Res . 2017 ; 158 : 79 - 82 .
Chan V , Sarkari M , Sunderland R , St. John AE , White NJ , Kastrup CJ . Platelets loaded with liposome-encapsulated thrombin have increased coagulability . J Thromb Haemost . 2018 ; 16 ( 6 ): 1226 - 35 .
Lashof-Sullivan M , Shoffstall A , Lavik E . Intravenous hemostats: challenges in translation to patients . Nanoscale . 2013 ; 5 ( 22 ): 10719 - 28 .
Modery-Pawlowski CL , Tian LL , Ravikumar M , Wong TL , Gupta AS . In vitro and in vivo hemostatic capabilities of a functionally integrated platelet-mimetic liposomal nanoconstruct . Biomaterials . 2013 ; 34 ( 12 ): 3031 - 41 .
Dyer MR , Hickman D , Luc N , Haldeman S , Loughran P , Pawlwoski C , et al . Intravenous administration of synthetic platelets(SynthoPlate™) in a mouse liver injury model of uncontrolled hemorrhage improves hemostasis . J Trauma Acute Care Surg . 2018 ; 84 ( 6 ): 917 - 23 .
Lashof-Sullivan M , Holland M , Groynom R , Campbell D , Shoffstall A , Lavik E . Hemostatic nanoparticles improve survival following blunt trauma even after 1 week incubation at 50℃ . ACS Biomater Sci Eng . 2016 ; 2 ( 3 ): 385 - 92 .
Lashof-Sullivan MM , Shoffstall E , Atkins KT , Keane N , Bir C , VandeVord P , et al . Intravenously administered nanoparticles increase survival following blast trauma . Proc Natl Acad Sci U S A . 2014 ; 111 ( 28 ): 10293 - 8 .
Onwukwe C , Maisha N , Holland M , Varley M , Groynom R , Hickman D , et al . Engineering intravenously administered nanoparticles to reduce infusion reaction and stop bleeding in a large animal model of trauma . Bioconjug Chem . 2018 ; 29 ( 7 ): 2436 - 47 .
Welsch N , Brown AC , Barker TH , Lyon LA . Enhancing clot properties through fibrin-specific self-cross-linked PEG side-chain microgels . Colloids Surf B Biointerfaces . 2018 ; 166 : 89 - 97 .
Chan LW , Wang X , Wei H , Pozzo LD , White NJ , Pun SH . A synthetic fibrin cross-linking polymer for modulating clot properties and inducing hemostasis . Sci Transl Med . 2015 ; 7 ( 277 ): 277ra29 .
Chan LW , Kim CH , Wang X , Pun SH , White NJ , Kim TH . PolySTAT-modified chitosan gauzes for improved hemostasis in external hemorrhage . Acta Biomater . 2016 ; 31 : 178 - 85 .
Chan KYT , Zhao C , Siren EMJ , Chan JCY , Boschman J , Kastrup CJ . Adhesion of blood clots can be enhanced when copolymerized with a macromer that is crosslinked by coagulation factor XIIIa . Biomacromolecules . 2016 ; 17 ( 6 ): 2248 - 52 .
Morgan CE , Dombrowski AW , Rubert Pérez CM , Bahnson ESM , Tsihlis ND , Jiang W , et al . Tissue-factor targeted peptide amphiphile nanofibers as an injectable therapy to control hemorrhage . ACS Nano . 2015 ; 10 ( 1 ): 899 - 909 .
Hansen CE , Myers DR , Baldwin WH , Sakurai Y , Meeks SL , Lyon LA , et al . Platelet–microcapsule hybrids leverage contractile force for targeted delivery of hemostatic agents . ACS Nano . 2017 ; 11 ( 6 ): 5579 - 89 .
Behrens AM , Sikorski MJ , Kofinas P . Hemostatic strategies for traumatic and surgical bleeding . J Biomed Mater Res A . 2014 ; 102 ( 11 ): 4182 - 94 .
Grissom TE , Fang R . Topical hemostatic agents and dressings in the prehospital setting . Curr Opin Anesthesiol . 2015 ; 28 ( 2 ): 210 - 6 .
Güven HE . Topical hemostatics for bleeding control in pre-hospital setting–then and now . Ulus Travma Acil Cerrahi Derg . 2017 ; 23 ( 5 ): 357 - 61 .
Chiara O , Cimbanassi S , Bellanova G , Chiarugi M , Mingoli A , Olivero G , et al . A systematic review on the use of topical hemostats in trauma and emergency surgery . BMC Surg . 2018 ; 18 ( 1 ): 68 .
Khoshmohabat H , Paydar S , Kazemi HM , Dalfardi B . Overview of agents used for emergency hemostasis . Trauma Mon . 2016 ; 21 ( 1 ): e26023 .
Bennett BL , Littlejohn L . Review of new topical hemostatic dressings for combat casualty care . Mil Med . 2014 ; 179 ( 5 ): 497 - 514 .
Schauer SG , April MD , Naylor JF , Maddry JK , Arana AA , Dubick MA , et al . Prehospital application of hemostatic agents in Iraq and Afghanistan . Prehosp Emerg Care . 2018 ; 22 ( 5 ): 1 - 10 .
Baylis JR , Yeon JH , Thomson MH , Kazerooni A , Wang X , St. John AE , et al . Self-propelled particles that transport cargo through flowing blood and halt hemorrhage . Sci Adv . 2015 ; 1 ( 9 ): e1500379 .
Mueller GR , Pineda TJ , Xie HX , Teach JS , Barofsky AD , Schmid JR , et al . A novel sponge-based wound stasis dressing to treat lethal noncompressible hemorrhage . J Trauma Acute Care Surg . 2012 ; 73 ( 2 ): S134 - 9 .
Shina A , Lipsky AM , Nadler R , Levi M , Benov A , Ran Y , et al . Prehospital use of hemostatic dressings by the Israel Defence forces medical corps: a case series of 122 patients . J Trauma Acute Care Surg . 2015 ; 79 ( 4 ): S204 - 9 .
Leonard J , Zietlow J , Morris D , Berns K , Eyer S , Martinson K , et al . A multi-institutional study of hemostatic gauze and tourniquets in rural civilian trauma . J Trauma Acute Care Surg . 2016 ; 81 ( 3 ): 441 - 4 .
Travers S , Lefort H , Ramdani E , Lemoine S , Jost D , Bignand M , et al . Hemostatic dressings in civil prehospital practice: 30 uses of QuikClot combat gauze . Eur J Emerg Med . 2016 ; 23 ( 5 ): 391 - 4 .
Sena MJ , Douglas G , Gerlach T , Grayson JK , Pichakron KO , Zierold D . A pilot study of the use of kaolin-impregnated gauze (combat gauze) for packing high-grade hepatic injuries in a hypothermic coagulopathic swine model . J Surg Res . 2013 ; 183 ( 2 ): 704 - 9 .
Schauer S , April M , Naylor J , Fisher A , Cunningham C , Ryan K , et al . QuikClot® combat gauze® use by ground forces in Afghanistan the prehospital trauma registry experience . J Spec Oper Med . 2017 ; 17 ( 2 ): 101 - 6 .
Choron RL , Hazelton JP , Hunter K , Capano-Wehrle L , Gaughan J , Chovanes J , et al . Intra-abdominal packing with laparotomy pads and QuikClot™ during damage control laparotomy: a safety analysis . Injury . 2017 ; 48 ( 1 ): 158 - 64 .
Gegel BT , Austin PN , Johnson A . An evidence-based review of the use of a combat gauze (QuikClot) for hemorrhage control . AANA J . 2013 ; 81 ( 6 ): 453 - 8 .
Cheng N , Cao X , Peng HT . Chitosan: a promising biomaterial for tissue engineering and hemorrhage control . In: Ferguson AN , O'Neill AG , editors. Focus on chitosan research . Hauppauge : USA Nova Science Publishers, Inc. ; 2011 . p. 49 - 82 .
Khan MA , Mujahid M . A review on recent advances in chitosan based composite for hemostatic dressings . Int J Biol Macromol . 2019 ; 124 : 138 - 47 .
Conley SP , Littlejohn LF , Henao J , DeVito SS , Zarow GJ . Control of junctional hemorrhage in a consensus swine model with hemostatic gauze products following minimal training . Mil Med . 2015 ; 180 ( 11 ): 1189 - 95 .
Pozza M , Millner RW . Celox (chitosan) for haemostasis in massive traumatic bleeding: experience in Afghanistan . Eur J Emerg Med . 2011 ; 18 ( 1 ): 31 - 3 .
Hatamabadi HR , Asayesh Zarchi F , Kariman H , Arhami Dolatabadi A , Tabatabaey A , Amini A . Celox-coated gauze for the treatment of civilian penetrating trauma: a randomized clinical trial . Trauma Mon . 2015 ; 20 ( 1 ): e23862 .
te Grotenhuis R , van Grunsven PM , Heutz WM , Tan EC . Prehospital use of hemostatic dressings in emergency medical services in the Netherlands: a prospective study of 66 cases . Injury . 2016 ; 47 ( 5 ): 1007 - 11 .
Rall JM , Cox JM . Evaluation of Xstat and combat gauze in a swine model of lethal junctional hemorrhate in coagulopathic swine . 2017 . https://apps.dtic.mil/docs/citations/AD1037122 https://apps.dtic.mil/docs/citations/AD1037122 . Accessed 12 Mar 2019 .
Warriner Z , Lam L , Matsushima K , Benjamin E , Strumwasser A , Demetriades D , et al . Initial evaluation of the efficacy and safety of in-hospital expandable hemostatic minisponge use in penetrating trauma . J Trauma Acute Care Surg . 2019 ; 86 ( 3 ): 424 - 30 .
Genyk Y , Kato T , Pomposelli JJ , Wright JK , Sher LS , Tetens V , et al . Fibrin sealant patch (TachoSil) vs oxidized regenerated cellulose patch (Surgicel original) for the secondary treatment of local bleeding in patients undergoing hepatic resection: a randomized controlled trial . J Am Coll Surg . 2016 ; 222 ( 3 ): 261 - 8 .
Erdogan D , Van Gulik TM . Evolution of fibrinogen-coated collagen patch for use as a topical hemostatic agent . J Biomed Mater Res B . 2008 ; 85 ( 1 ): 272 - 8 .
Jackson M , Taher M , Burge J , Krishnamurti C , Reid T , Alving B . Hemostatic efficacy of a fibrin sealant dressing in an animal model of kidney injury . J Trauma . 1998 ; 45 : 662 - 5 .
Fischer CP , Bochicchio G , Shen J , Patel B , Batiller J , Hart JC . A prospective, randomized, controlled trial of the efficacy and safety of fibrin pad as an adjunct to control soft tissue bleeding during abdominal, retroperitoneal, pelvic, and thoracic surgery . J Am Coll Surg . 2013 ; 217 ( 3 ): 385 - 93 .
Koea JB , Batiller J , Patel B , Shen J , Hammond J , Hart J , et al . A phase III, randomized, controlled, superiority trial evaluating the fibrin pad versus standard of care in controlling parenchymal bleeding during elective hepatic surgery . HPB . 2013 ; 15 ( 1 ): 61 - 70 .
Pusateri AE , Kheirabadi BS , Delgado AV , Doyle JW , Kanellos J , Uscilowicz JM , et al . Structural design of the dry fibrin sealant dressing and its impact on the hemostatic efficacy of the product . J Biomed Mater Res B . 2004 ; 70 ( 1 ): 114 - 21 .
Kheirabadi BS , Acheson EM , Deguzman R , Crissey JM , Delgado AV , Estep SJ , et al . The potential utility of fibrin sealant dressing in repair of vascular injury in swine . J Trauma . 2007 ; 62 ( 1 ): 94 - 103 .
Pusateri AE , Holcomb JB , Harris RA , MacPhee MJ , Charles NC , Beall LD , et al . Effect of fibrin bandage fibrinogen concentration on blood loss after grade V liver injury in swine . Mil Med . 2001 ; 166 ( 3 ): 217 - 22 .
Holcomb J , MacPhee M , Hetz S , Harris R , Pusateri A , Hess J . Efficacy of a dry fibrin sealant dressing for hemorrhage control after ballistic injury . Arch Surg . 1998 ; 133 ( 1 ): 32 - 5 .
Jackson MR , Friedman SA , Carter AJ , Bayer V , Burge JR , MacPhee MJ , et al . Hemostatic efficacy of a fibrin sealant-based topical agent in a femoral artery injury model: a randomized, blinded, placebo-controlled study . J Vasc Surg . 1997 ; 26 ( 2 ): 274 - 80 .
Baker JE , Goodman MD , Makley AT , Stevens-Topie SM , Veile RA , Mahoney EJ , et al . Evaluation of a novel fibrin sealant patch in hemorrhage control after vascular or hepatic injury . Mil Med . 2019 ; 184 ( 3/4 ): e290 - 6 .
Cheng CM , Meyer-Massetti C , Kayser SR . A review of three stand-alone topical thrombins for surgical hemostasis . Clin Ther . 2009 ; 31 ( 1 ): 32 - 41 .
Izumi Y , Gika M , Shinya N , Miyabashira S , Imamura T , Nozaki C , et al . Hemostatic efficacy of a recombinant thrombin-coated polyglycolic acid sheet coupled with liquid fibrinogen, evaluated in a canine model of pulmonary arterial hemorrhage . J Trauma . 2007 ; 63 : 783 - 7 .
Spotnitz W . Fibrin sealant patches: powerful and easy-to-use hemostats . Open Access Surg . 2014 ; 4 : 71 - 9 .
Navarro A , Brooks A . Use of local pro-coagulant haemostatic agents for intra-cavity control of haemorrhage after trauma . Eur J Trauma Emerg Surg . 2015 ; 41 ( 5 ): 493 - 500 .
Rickenbacher A , Breitenstein S , Lesurtel M , Frilling A . Efficacy of TachoSil a fibrin-based haemostat in different fields of surgery - a systematic review . Expert Opin Biol Ther . 2009 ; 9 ( 7 ): 897 - 907 .
Watters JM , Van PY , Hamilton GJ , Sambasivan C , Differding JA , Schreiber MA . Advanced hemostatic dressings are not superior to gauze for care under fire scenarios . J Trauma . 2011 ; 70 ( 6 ): 1413 - 8 .
Morrison JJ . Noncompressible torso hemorrhage . Crit Care Clin . 2017 ; 33 ( 1 ): 37 - 54 .
Lewis KM , Atlee H , Mannone A , Lin L , Goppelt A . Efficacy of hemostatic matrix and microporous polysaccharide hemospheres . J Surg Res . 2015 ; 193 ( 2 ): 825 - 30 .
Tackett SM , Calcaterra D , Magee G , Lattouf OM . Real-world outcomes of hemostatic matrices in cardiac surgery . J Cardiothorac Vasc Anesth . 2014 ; 28 ( 6 ): 1558 - 65 .
Pursifull NF , Morris MS , Harris RA , Morey AF . Damage control management of experimental grade 5 renal injuries: further evaluation of FloSeal gelatin matrix . J Trauma . 2006 ; 60 : 346 - 50 .
Izzo F , Di Giacomo R , Falco P , Piccirillo M , Iodice R , Orlando AP , et al . Efficacy of a haemostatic matrix for the management of bleeding in patients undergoing liver resection: results from 237 cases . Curr Med Res Opin . 2008 ; 24 ( 4 ): 1011 - 5 .
Jameson M , Gross CW , Kountakis SE . FloSeal use in endoscopic sinus surgery: effect on postoperative bleeding and synechiae formation . Otolaryngol Head Neck Surg . 2006 ; 27 ( 2 ): 86 - 90 .
Stacey MJ , Rampaul RS , Rengaragan A , Duffy JP , MacMillan RD . Use of FloSeal matrix hemostatic agent in partial splenectomy after penetrating trauma . J Trauma . 2008 ; 64 ( 2 ): 507 - 8 .
Klemcke HG . Evaluation of FloSeal as a potential intracavitary hemostatic agent . J Trauma . 2006 ; 60 ( 2 ): 385 - 9 .
Su H , Wei S , Chen F , Cui R , Liu C . Tranexamic acid-loaded starch hemostatic microspheres . RSC Adv . 2019 ; 9 ( 11 ): 6245 - 53 .
Gupta N , Chetter I , Hayes P , Albert HY , Moneta GL , Shenoy S , et al . Randomized trial of a dry-powder, fibrin sealant in vascular procedures . J Vasc Surg . 2015 ; 62 ( 5 ): 1288 - 95 .
Verhoef C , Singla N , Moneta G , Muir W , Rijken A , Lockstadt H , et al . Fibrocaps for surgical hemostasis: two randomized, controlled phase II trials . J Surg Res . 2015 ; 194 ( 2 ): 679 - 87 .
Bochicchio GV , Gupta N , Porte RJ , Renkens KL , Pattyn P , Topal B , et al . The FINISH-3 trial: a phase 3, international, randomized, single-blind, controlled trial of topical Fibrocaps in intraoperative surgical hemostasis . J Am Coll Surg . 2015 ; 220 ( 1 ): 70 - 81 .
Kumar VA , Wickremasinghe NC , Shi S , Hartgerink JD . Nanofibrous snake venom hemostat . ACS Biomater Sci Eng . 2015 ; 1 ( 12 ): 1300 - 5 .
Ruan L , Zhang H , Luo H , Liu J , Tang F , Shi YK , et al . Designed amphiphilic peptide forms stable nanoweb, slowly releases encapsulated hydrophobic drug, and accelerates animal hemostasis . Proc Natl Acad Sci U S A . 2009 ; 106 ( 13 ): 5105 - 10 .
Ellis-Behnke RG , Liang YX , Tay DKC , Kau PWF , Schneider GE , Zhang S , et al . Nano hemostat solution: immediate hemostasis at the nanoscale . Nanomedicine . 2006 ; 2 ( 4 ): 207 - 15 .
Hsu BB , Conway W , Tschabrunn CM , Mehta M , Perez-Cuevas MB , Zhang S , et al . Clotting mimicry from robust hemostatic bandages based on self-assembling peptides . ACS Nano . 2015 ; 9 ( 9 ): 9394 - 406 .
Zhao X , Guo B , Wu H , Liang Y , Ma PX . Injectable antibacterial conductive nanocomposite cryogels with rapid shape recovery for noncompressible hemorrhage and wound healing . Nat Commun . 2018 ; 9 ( 1 ): 2784 .
Rago AP , Sharma U , Duggan M , King DR . Percutaneous damage control with self-expanding foam: pre-hospital rescue from abdominal exsanguination . Trauma . 2016 ; 18 ( 2 ): 85 - 91 .
Peev MP , Rago A , Hwabejire JO , Duggan MJ , Beagle J , Marini J , et al . Self-expanding foam for prehospital treatment of severe intra-abdominal hemorrhage: dose finding study . J Trauma Acute Care Surg . 2014 ; 76 ( 3 ): 619 - 24 .
Duggan MJ , Mejaddam AY , Beagle J , deMoya MA , Velmahosa GC , Alam HB , et al . Development of a lethal, closed-abdomen grade V hepato-portal injury model in non-coagulopathic swine . J Surg Res . 2013 ; 182 ( 1 ): 101 - 7 .
Mesar T , Martin D , Lawless R , Podbielski J , Cook M , Underwood S , et al . Human dose confirmation for self-expanding intra-abdominal foam: a translational, adaptive, multicenter trial in recently deceased human subjects . J Trauma Acute Care Surg . 2015 ; 79 ( 1 ): 39 - 47 .
Falus G . Tissue sealant for use in non-compressible hemorrhage . US Patent . 2012 ; 8 : 314,211 .
Bochicchio G , Falus G . ClotFoam as an adjunct to hemostasis in abdominal surgery - liver bleeding is encountered . https://clinicaltrials.gov/ct2/show/NCT02264730 https://clinicaltrials.gov/ct2/show/NCT02264730 . Accessed 12 Mar 2019 .
Filips D , Logsetty S , Tan J , Atkinson I , Mottet K . The iTClamp controls junctional bleeding in a lethal swine exsanguination model . Prehosp Emerg Care . 2013 ; 17 ( 4 ): 526 - 32 .
Walchak A , Zarow G , McLean J , Stuart SM , Roszko P . Pilot study of a novel swine model for controlling junctional hemorrhage using the iTClamp in conjunction with hemostatic agents . Mil Med . 2019 ; 184 ( Suppl 1 ): 367 - 73 .
Morrison JJ , Galgon RE , Jansen JO , Cannon JW , Rasmussen TE , Eliason JL . A systematic review of the use of resuscitative endovascular balloon occlusion of the aorta in the management of hemorrhagic shock . J Trauma Acute Care Surg . 2016 ; 80 ( 2 ): 324 - 34 .
Inoue J , Shiraishi A , Yoshiyuki A , Haruta K , Matsui H , Otomo Y . Resuscitative endovascular balloon occlusion of the aorta might be dangerous in patients with severe torso trauma: a propensity score analysis . J Trauma Acute Care Surg . 2016 ; 80 ( 4 ): 559 - 67 .
Campion EM , Fox CJ . Prehospital hemorrhage control and REBOA . Curr Trauma Rep . 2019 ; 5 ( 3 ): 129 - 36 .
Drew B , Bennett BL , Littlejohn L . Application of current hemorrhage control techniques for backcountry care: part one, tourniquets and hemorrhage control adjuncts . Wilderness Environ Med . 2015 ; 26 ( 2 ): 236 - 45 .
Jensen NHL , Stensballe J , Afshari A . Comparing efficacy and safety of fibrinogen concentrate to cryoprecipitate in bleeding patients: a systematic review . Acta Anaesthesiol Scand . 2016 ; 60 ( 8 ): 1033 - 42 .
Akbari E , Safari S , Hatamabadi H . The effect of fibrinogen concentrate and fresh frozen plasma on the outcome of patients with acute traumatic coagulopathy: a quasi-experimental study . Am J Emerg Med . 2018 ; 36 ( 11 ): 1947 - 50 .
Zhang YJ , Gao B , Liu XW . Topical and effective hemostatic medicines in the battlefield . Int J Clin Exp Med . 2015 ; 8 ( 1 ): 10 - 9 .
Welch M , Barratt J , Peters A , Wright C . Systematic review of prehospital haemostatic dressings . J R Army Med Corps . 2019 . Published Online First: 2 February 2019 . doi: 10.1136/jramc-2018-001066 http://doi.org/10.1136/jramc-2018-001066 .
Granville-Chapman J , Jacobs N , Midwinter MJ . Pre-hospital haemostatic dressings: a systematic review . Injury . 2011 ; 42 ( 5 ): 447 - 59 .
Pusateri AE , Holcomb JB , Kheirabadi BS , Alam HB , Wade CE , Ryan KL . Making sense of the preclinical literature on advanced hemostatic products . J Trauma . 2006 ; 60 ( 3 ): 674 - 82 .
Sondeen JL , Hanson MA , Prince MD , de Guzman R , Polykratis IA , Aden JKI , et al . Double-blinded, placebo-controlled study of early tranexamic acid treatment in swine uncontrolled hemorrhage model . J Trauma Acute Care Surg . 2016 ; 80 ( 1 ): 81 - 8 .
Arnaud F , Teranishi K , Tomori T , Carr W , McCarron R . Comparison of 10 hemostatic dressings in a groin puncture model in swine . J Vasc Surg . 2009 ; 50 ( 3 ): 632 - 9 .
Devlin JJ , Kircher S , Kozen BG , Littlejohn LF , Johnson AS . Comparison of ChitoFlex®, CELOX™, and QuikClot® in control of hemorrhage . J Emerg Med . 2011 ; 41 ( 3 ): 237 - 45 .
Satterly S , Nelson D , Zwintscher N , Oguntoye M , Causey W , Theis B , et al . Hemostasis in a noncompressible hemorrhage model: an end-user evaluation of hemostatic agents in a proximal arterial injury . J Surg Educ . 2013 ; 70 ( 2 ): 206 - 11 .
Rall JM , Cox JM , Songer AG , Cestero RF , Ross JD . Comparison of novel hemostatic dressings with QuikClot combat gauze in a standardized swine model of uncontrolled hemorrhage . J Trauma Acute Care Surg . 2013 ; 75 ( 2 ): S150 - 6 .
Cox J , Rall J . Evaluation of XSTAT® and QuickClot® combat gauze® in a swine model of lethal junctional hemorrhage in coagulopathic swine . J Spec Oper Med . 2017 ; 17 ( 3 ): 64 - 7 .
Kheirabadi BS , MacE JE , Terrazas IB , Fedyk CG , Valdez KK , MacPhee MJ , et al . Clot-inducing minerals versus plasma protein dressing for topical treatment of external bleeding in the presence of coagulopathy . J Trauma . 2010 ; 69 ( 5 ): 1062 - 72 .
Kheirabadi B . Evaluation of topical hemostatic agents for combat wound treatment . US Army Med Dep J . 2011 ; 37 : 25 - 37 .
Kheirabadi BS , Arnaud F , McCarron R , Murdock AD , Hodge DL , Ritter B , et al . Development of a standard swine hemorrhage model for efficacy assessment of topical hemostatic agents . J Trauma Acute Care Surg . 2011 ; 71 ( 1 ): S139 - 46 .
van Zyl N , Reade MC , Fraser JF . Experimental animal models of traumatic coagulopathy: a systematic review . Shock . 2015 ; 44 ( 1 ): 16 - 24 .
Butler FK , Bennett B , Wedmore CI . Tactical combat casualty care and wilderness medicine: advancing trauma care in austere environments . Emerg Med Clin North Am . 2017 ; 35 ( 2 ): 391 - 407 .
Ofosu FA , Freedman J , Semple JW . Plasma-derived biological medicines used to promote haemostasis . Thromb Haemost . 2008 ; 99 ( 5 ): 851 - 62 .
Solomon C , Groner A , Ye J , Pendrak I . Safety of fibrinogen concentrate: analysis of more than 27 years of pharmacovigilance data . Thromb Haemost . 2015 ; 113 ( 4 ): 759 - 71 .
Kheirabadi BS , Edens JW , Terrazas IB , Estep JS , Klemcke HG , Dubick MA , et al . Comparison of new hemostatic granules/powders with currently deployed hemostatic products in a lethal model of extremity arterial hemorrhage in swine . J Trauma . 2009 ; 66 ( 2 ): 316 - 28 .
Tomizawa Y . Clinical benefits and risk analysis of topical hemostats: a review . J Artificial Organs . 2005 ; 8 ( 3 ): 137 - 42 .
Hangge P , Stone J , Albadawi H , Zhang YS , Khademhosseini A , Oklu R . Hemostasis and nanotechnology . Cardiovasc Diagn Ther . 2017 ; 7 ( Suppl 3 ): 267 - 75 .
Gaston E , Fraser JF , Xu ZP , Ta HT . Nano- and micro-materials in the treatment of internal bleeding and uncontrolled hemorrhage . Nanomed Nanotechnol Biol Med . 2018 ; 14 ( 2 ): 507 - 19 .
Medina-Sánchez M , Xu H , Schmidt OG . Micro- and nano-motors: the new generation of drug carriers . Ther Deliv . 2018 ; 9 ( 4 ): 303 - 16 .
Girish A , Hickman DA , Banerjee A , Luc N , Ma Y , Miyazawa K , et al . Traumatargeted delivery of tranexamic acid improves hemostasis and survival in rat liver hemorrhage model . J Thromb Haemost . 2019 ; 17 ( 10 ): 1632 - 44 .
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