Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community acquired pneumonia

Hongseok Yoo; Jimi Oh; Chul Park

doi:10.1186/s40779-020-00235-x

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Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community acquired pneumonia

RESEARCH | Updated：2023-06-05

- Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community acquired pneumonia
- Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community acquired pneumonia
- MMR 2020年7卷第3期页码：324-334
- Affiliations：
  
  1.Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul 06351, South Korea.
  2.Department of Anesthesiology and Pain Medicine, Asan Medical Center, University of Ulsan College of Medicine, Seoul 05505, South Korea.
  3.Division of Pulmonary Medicine, Department of Internal Medicine, Wonkwang University Hospital, Iksan 54538, South Korea.
- Author bio：
  
  * cholssak21@gmail.com
- Funds：
- DOI：10.1186/s40779-020-00235-x
  中图分类号：
- 纸质出版：2020-09
- Accepted：
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Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community acquired pneumonia[J]. MMR, 2020,7(3):324-334.

Yoo et al.: Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community acquired pneumonia. Mil Med Res, 2020, 7: 6
Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community acquired pneumonia[J]. MMR, 2020,7(3):324-334. DOI： 10.1186/s40779-020-00235-x.

Yoo et al.: Characteristics of fever and response to antipyretic therapy in military personnel with adenovirus-positive community acquired pneumonia. Mil Med Res, 2020, 7: 6 DOI： 10.1186/s40779-020-00235-x.

摘要

Abstract

Background:

In 2014

an outbreak of adenoviral pneumonia occurred in the Korean military training center. However

there are limited data on the characteristics of the fever and its response to antipyretic therapy in immunocompetent adults with adenovirus-positive community-acquired pneumonia (CAP).

Methods:

The medical records of the patients who were admitted to the Armed Forces Chuncheon Hospital for the treatment of CAP between January 2014 and December 2016 were retrospectively analyzed. The patients were divided into three groups

namely

the adenovirus-positive (Adv) group

the adenovirus-negative (Non-Adv) group and the unknown pathogen group

according to the results of a polymerase chain reaction (PCR) test and sputum culture used to measure adenovirus and other bacteria or viruses in respiratory specimens. We evaluated and compared the demographics

clinicolaboratory findings and radiological findings upon admission between the two groups.

Results:

Out of the 251 military personnel with CAP during the study periods

67 were classified into the Adv group

while 134 were classified into the Non-Adv group and 50 were classified into the unknown pathogen group. The patients in the Adv group had a longer duration of fever after admission ((3.2±1.6) d

. (1.9±1.2) d

. (2.2±1.5) d

=0.018) and symptom onset ((5.8±2.2) d

. (3.9±2.5) d

. (3.7±2.0) d

=0.006) than patients in the Non-Adv and unknown pathogen groups

respectively. The patients in the Adv group had a higher mean temperature at admission(37.8±0.3

. 37.3±0.3

=0.005)

and more patients were observed over 40 and 39 to 40(14.9%

. 2.2%

. 4.0%

35.8%

. 3.7%

. 6.0%

0.001) than those in the Non-Adv and unknown pathogen groups

respectively. The Adv group more commonly had no response or exhibited adverse events after antipyretic treatment compared to the Non-Adv group (17.9%

. 1.5%

35.0%

. 4.3%

0.001

=0.05

respectively). In addition

the time from admission to overall clinical stabilization was significantly longer in the patients in the Adv group than in those in the Non-Adv group ((4.3±2.8) d

. (2.9±1.8) d

=0.034

respectively). Furthermore

no significant difference in the length of hospital stay was observed between the two groups

and no patient died in either group.

Conclusions:

In this study

Adv-positive CAP in immunocompetent military personnel patients had distinct fever characteristics and responses to antipyretic treatment.

关键词

Keywords

references

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