Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer?

Your Location：

Home >

Browse articles >

Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer?

RESEARCH | Updated：2023-06-05

- Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer?
- Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer?
- MMR 2020年7卷第4期页码：384-390
- Affiliations：
  
  1.Department of Intensive Care Unit, Ankara Eğitim ve Araştırma Şehir Hastanesi, 06800 Ankara, PA, Turkey.
  2.Department of Gastrointestinal Surgery, Ankara Eğitim ve Araştırma Şehir Hastanesi, 06800 Ankara, PA, Turkey.
- Author bio：
  
  * imungan@gmail.com
- Funds：
- DOI：10.1186/s40779-020-00234-y
  中图分类号：
- 纸质出版：2020-12
- Accepted：
Scan QR Code
Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer?[J]. MMR, 2020,7(4):384-390.

Mungan et al.: Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer?. Mil Med Res, 2020, 7: 9.
Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer?[J]. MMR, 2020,7(4):384-390. DOI： 10.1186/s40779-020-00234-y.

Mungan et al.: Does the preoperative platelet-tolymphocyte ratio and neutrophil-tolymphocyte ratio predict morbidity after gastrectomy for gastric cancer?. Mil Med Res, 2020, 7: 9. DOI： 10.1186/s40779-020-00234-y.

摘要

Abstract

Background:

2

Gastric cancer is the 2nd most common cause of cancer-related deaths

and the morbidity rate after surgery is reported to be as high as 46%. The estimation of possible complications

morbidity

and mortality and the ability to specify patients at high risk have become substantial for an intimate follow-up and for proper management in the intensive care unit. This study aimed to determine the prognostic value of the preoperative platelet-to-lymphocyte ratio (PLR) and neutrophil-to-lymphocyte ratio (NLR) and their relations with clinical outcomes and complications after gastrectomy for gastric cancer.

Methods:

2

This single-center

retrospective cohort study evaluated the data of 292 patients who underwent gastrectomy with curative intent between January 2015 and June 2018 in a tertiary state hospital in Ankara

Turkey. A receiver operating characteristic curve was generated to evaluate the ability of laboratory values to predict clinically relevant postoperative complications. The area under the curve was computed to compare the predictive power of the NLR and PLR. Then

the cutoff points were selected as the stratifying values for the PLR and NLR.

Results:

2

The area under the curve values of the PLR (0.60

95% CI 0.542–0.657) and NLR (0.556

95% CI 0.497–0.614) were larger than those of the other preoperative laboratory values. For the PLR

the diagnostic sensitivity and specificity were 50.00% and 72.22%

respectively

whereas for the NLR

the diagnostic sensitivity and specificity were 37.50% and 80.16%

respectively. The PLR was related to morbidity

whereas the relation of the NLR with mortality was more prominent. This study demonstrated that the PLR and NLR may predict mortality and morbidity

via

the Clavien-Dindo classification in gastric cancer patients. The variable was grade ≥3 in the Clavien-Dindo classification

including complications requiring surgical or endoscopic interventions

life-threatening complications

and death. Both the PLR and NLR differed significantly according to Clavien-Dindo grade ≥3. In this analysis

the PLR was related to morbidity

while the NLR relation with mortality was more intense.

Conclusion:

2

Based on the results of the study

the PLR and NLR could be used as independent predictive factors for mortality and morbidity in patients with gastric cancer.

关键词

Keywords

references

Takahashi T , Saikawa Y , Kitagawa Y . Gastric cancer: current status of diagnosis and treatment . Cancers . 2013 ; 5 ( 1 ): 48 - 63 .

Hamilton TD , Mahar AL , Haas B , Beyfuss K , Law CHL , Karanicolas PJ , et al . The impact of advanced age on short-term outcomes following gastric cancer resection: an ACS-NSQIP analysis . Gastric Cancer . 2018 ; 21 ( 4 ): 710 - 9 .

Inaoka K , Kanda M , Uda H , Tanaka Y , Tanaka C , Kobayashi D , et al . Clinical utility of the platelet-lymphocyte ratio as a predictor of postoperative complications after radical gastrectomy for clinical T2–4 gastric cancer . World J Gastroenterol . 2017 ; 23 ( 14 ): 2519 - 26 .

Chen XD , Mao CC , Wu RS , Zhang WT , Lin J , Sun XW , et al . Use of the combination of the preoperative platelet-to-lymphocyte ratio and tumor characteristics to predict peritoneal metastasis in patients with gastric cancer . PLoS One . 2017 ; 12 ( 4 ): e0175074 .

Nevo Y , Goldes Y , Barda L , Nadler R , Gutman M , Nevler A . Risk factors for complications of total/subtotal gastrectomy for gastric cancer: prospectively collected, based on the Clavien-Dindo classification system . Isr Med Assoc J . 2018 ; 5 ( 20 ): 277 - 80 .

Min KW , Kwon MJ , Kim DH , Son BK , Kim EK , Oh YH , et al . Persistent elevation of postoperative neutrophil-to-lymphocyte ratio: A better predictor of survival in gastric cancer than elevated preoperative neutrophilto-lymphocyte ratio . Sci Rep . 2017 ; 7 ( 1 ): 13967 .

Zhang Y , Lu JJ , Du YP , Feng CX , Wang LQ , Chen MB . Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio in gastric cancer . Medicine . 2018 ; 97 ( 12 ): e0144 .

Matowicka-Karna J , Kamocki Z , Polińska B , Osada J , Kemona H . Platelets and inflammatory markers in patients with gastric cancer . Clin Dev Immunol . 2013 ; 2013 : 401623 .

Voutsadakis IA . Thrombocytosis as a prognostic marker in gastrointestinal cancers . World J Gastrointest Oncol . 2014 ; 6 ( 2 ): 34 - 40 .

Zheng CF , Liu WY , Zeng FF , Zheng MH , Shi HY , Zhou Y , et al . Prognostic value of platelet-to-lymphocyte ratios among critically ill patients with acute kidney injury . Crit Care . 2017 ; 21 ( 1 ): 238 .

Seropian IM , Romeo FJ , Pizarro R , Vulcano NO , Posatini RA , Marenchino RG , et al . Neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio as predictors of survival after heart transplantation . ESC Heart Fail . 2018 ; 5 ( 1 ): 149-56 . doi: 10.1002/ehf2.12199 http://doi.org/10.1002/ehf2.12199 .

Edge SB , Compton CC . The American Joint Committee on Cancer: the 7th edition of the AJCC cancer staging manual and the future of TNM . Ann Surg Oncol . 2010 ; 17 ( 6 ): 1471 - 4 .

Kim JH , Lee JY , Kim HK , Lee JW , Jung SG , Jung K , et al . Prognostic significance of the neutrophil-to-lymphocyte ratio and platelet-tolymphocyte ratio in patients with stage III and IV colorectal cancer . World J Gastroenterol . 2017 ; 23 ( 3 ): 505 - 15 .

Oh D , Pyo JS , Son BK . Prognostic roles of inflammatory markers in pancreatic cancer: comparison between the Neutrophil-to-Lymphocyte ratio and Platelet-to-Lymphocyte ratio . Gastroenterol Res Pract . 2018 ; 2018 : 9745601 .

Zhang X , Zhang W , Feng LJ . Prognostic significance of neutrophil lymphocyte ratio in patients with gastric cancer: a meta-analysis . PLoS One . 2014 ; 9 ( 11 ): e111906 .

Shimada H , Takiguchi N , Kainuma O , Soda H , Ikeda A , Cho A , et al . High preoperative neutrophil-lymphocyte ratio predicts poor survival in patients with gastric cancer . Gastric Cancer . 2010 ; 13 ( 3 ): 170 - 6 . doi: 10.1007/s10120-010-0554-3 http://doi.org/10.1007/s10120-010-0554-3 .

Sun X , Liu X , Liu J , Chen S , Xu D , Li W , et al . Preoperative neutrophil-tolymphocyte ratio plus platelet-to-lymphocyte ratio in predicting survival for patients with stage I-II gastric cancer . Chin J Cancer . 2016 ; 35 ( 1 ): 57 .

Kim EY , Lee JW , Yoo HM , Park CH , Song KY . The platelet-to-lymphocyte ratio versus neutrophil-to- lymphocyte ratio: which is better as a prognostic factor in gastric cancer ? Ann Surg Oncol . 2015 ; 22 ( 13 ): 4363 - 70 .

Guo YH , Sun HF , Zhang YB , Liao ZJ , Zhao L , Cui J , et al . The clinical use of the platelet/lymphocyte ratio and lymphocyte/monocyte ratio as prognostic predictors in colorectal cancer: a meta-analysis . Oncotarget . 2017 ; 8 ( 12 ): 20011 - 24 .

Huang XZ , Chen WJ , Zhang X , Wu CC , Zhang CY , Sun SS , et al . An elevated platelet/lymphocyte ratio predicts poor prognosis and clinicopathological characteristics in patients with colorectal cancer: a meta-analysis . Dis Markers . 2017 ; 2017 : 1053125 .

0

浏览量

1

Downloads

0

CSCD

文章被引用时，请邮件提醒。

Submit

工具集

关联资源

相关文章

暂无数据

相关作者

暂无数据

相关机构

暂无数据

⁰