Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma

Ying Sun

doi:10.1186/s40779-019-0224-7

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Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma

EDITORIAL | Updated：2023-06-05

- Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma
- Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma
- MMR 2020年7卷第2期页码：239-241
- Affiliations：
  
  Department of Radiation Oncology, Sun Yat-sen University Cancer Center, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine, Guangdong Key Laboratory of Nasopharyngeal Carcinoma Diagnosis and Therapy, Guangzhou 510060, China
- Author bio：
  
  sunying@sysucc.org.cn
- Funds：
- DOI：10.1186/s40779-019-0224-7
  中图分类号：
- 纸质出版：2020-06
- Accepted：
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Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma[J]. MMR, 2020,7(2):239-241.

Cite this article as: Sun: Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma. Mil Med Res, 2019, 6: 32
Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma[J]. MMR, 2020,7(2):239-241. DOI： 10.1186/s40779-019-0224-7.

Cite this article as: Sun: Boron neutron capture therapy: moving towards targeted therapy for locally recurrent head and neck squamous cell carcinoma. Mil Med Res, 2019, 6: 32 DOI： 10.1186/s40779-019-0224-7.

摘要

Abstract

Locally recurrent head and neck squamous cell carcinoma (HNSCC) is often unresectable

and a repeat course of radiotherapy is associated with incremental toxicities. Boron neutron capture therapy (BNCT) is a novel targeted radiotherapy modality that can achieve a high dose gradient between cancerous and adjacent normal tissues. However

the relationships among the dose resulting from BNCT

tumor response to BNCT

and survival are not completely understood. Recently

a study published in Radiotherapy and Oncology investigated the efficacy of BNCT in the treatment of patients with locally recurrent HNSCC and the factors associated with favorable treatment response and survival. In this article

the findings

strengths and limitations of this study are discussed in depth

and the significance of the study and motivations for future research are highlighted.

关键词

Keywords

references

Bourhis J , Le Maitre A , Baujat B , Audry H , Pignon JP . Individual patients’ data meta-analyses in head and neck cancer . Curr Opin Oncol. 2007 ; 19 ( 3 ): 188 – 94 . https://doi.org/10.1097/CCO.0b013e3280f01010 https://doi.org/10.1097/CCO.0b013e3280f01010 .

Chang JH , Wu CC , Yuan KS , Wu ATH , Wu SY . Locoregionally recurrent head and neck squamous cell carcinoma: incidence, survival, prognostic factors, and treatment outcomes . Oncotarget. 2017 ; 8 ( 33 ): 55600 – 12 . https://doi.org/10.18632/oncotarget.16340 https://doi.org/10.18632/oncotarget.16340 .

Rwigema JC , Heron DE , Ferris RL , Andrade RS , Gibson MK , Yang Y , et al . The impact of tumor volume and radiotherapy dose on outcome in previously irradiated recurrent squamous cell carcinoma of the head and neck treated with stereotactic body radiation therapy . Am J Clin Oncol. 2011 ; 34 ( 4 ): 372 – 9 . https://doi.org/10.1097/COC.0b013e3181e84dc0 https://doi.org/10.1097/COC.0b013e3181e84dc0 .

Vargo JA , Ward MC , Caudell JJ , Riaz N , Dunlap NE , Isrow D , et al . A multiinstitutional comparison of SBRT and IMRT for definitive reirradiation of recurrent or second primary head and neck cancer . Int J Radiat Oncol Biol Phys. 2018 ; 100 ( 3 ): 595 – 605 . https://doi.org/10.1016/j.ijrobp.2017.04.017 https://doi.org/10.1016/j.ijrobp.2017.04.017 .

Ohnleiter T , Truntzer P , Antoni D , Guihard S , Elgard AM , Noel G . Prognostic factors for head and neck cancer reirradiation: a systematic review . Cancer Radiother. 2017 ; 21 ( 4 ): 316 – 38 . https://doi.org/10.1016/j.canrad.2017.02.004 https://doi.org/10.1016/j.canrad.2017.02.004 .

Siddiqui F , Patel M , Khan M , McLean S , Dragovic J , Jin JY , et al . Stereotactic body radiation therapy for primary, recurrent, and metastatic tumors in the head-and-neck region . Int J Radiat Oncol Biol Phys. 2009 ; 74 ( 4 ): 1047 – 53 . https://doi.org/10.1016/j.ijrobp.2008.09.022 https://doi.org/10.1016/j.ijrobp.2008.09.022 .

Ward MC , Riaz N , Caudell JJ , Dunlap NE , Isrow D , Zakem SJ , et al . Refining patient selection for reirradiation of head and neck squamous carcinoma in the IMRT era: a multi-institution cohort study by the MIRI collaborative . Int J Radiat Oncol Biol Phys. 2018 ; 100 ( 3 ): 586 – 94 . https://doi.org/10.1016/j.ijrobp.2017.06.012 https://doi.org/10.1016/j.ijrobp.2017.06.012 .

Barth RF , Mi P , Yang W . Boron delivery agents for neutron capture therapy of cancer . Cancer Commun. 2018 ; 38 ( 1 ): 35 . https://doi.org/10.1186/s40880-018-0299-7 https://doi.org/10.1186/s40880-018-0299-7 .

Barth RF , Coderre JA , Vicente MG , Blue TE . Boron neutron capture therapy of cancer: current status and future prospects . Clin Cancer Res. 2005 ; 11 ( 11 ): 3987 – 4002 . https://doi.org/10.1158/1078-0432.CCR-05-0035 https://doi.org/10.1158/1078-0432.CCR-05-0035 .

Barth RF , Zhang Z , Liu T . A realistic appraisal of boron neutron capture therapy as a cancer treatment modality . Cancer Commun. 2018 ; 38 ( 1 ): 36 . https://doi.org/10.1186/s40880-018-0280-5 https://doi.org/10.1186/s40880-018-0280-5 .

Wang LW , Liu YH , Chou FI , Jiang SH . Clinical trials for treating recurrent head and neck cancer with boron neutron capture therapy using the Tsing-Hua open Pool reactor . Cancer Commun. 2018 ; 38 ( 1 ): 37 . https://doi.org/10.1186/s40880-018-0295-y https://doi.org/10.1186/s40880-018-0295-y .

Miyatake SI , Kawabata S , Hiramatsu R , Kuroiwa T , Suzuki M , Ono K . Boron neutron capture therapy of malignant Gliomas . Prog Neurol Surg. 2018 ; 32 : 48 – 56 . https://doi.org/10.1159/000469679 https://doi.org/10.1159/000469679 .

Hiratsuka J , Kamitani N , Tanaka R , Yoden E , Tokiya R , Suzuki M , et al . Boron neutron capture therapy for vulvar melanoma and genital extramammary Paget's disease with curative responses . Cancer Commun. 2018 ; 38 ( 1 ): 38 . https://doi.org/10.1186/s40880-018-0297-9 https://doi.org/10.1186/s40880-018-0297-9 .

Coderre JA , Morris GM . The radiation biology of boron neutron capture therapy . Radiat Res. 1999 ; 151 ( 1 ): 1 – 18 . https://doi.org/10.2307/3579742 https://doi.org/10.2307/3579742 .

Gonzalez SJ , Santa Cruz GA . The photon-isoeffective dose in boron neutron capture therapy . Radiat Res. 2012 ; 178 ( 6 ): 609 – 21 . https://doi.org/10.1667/RR2944.1 https://doi.org/10.1667/RR2944.1 .

Koivunoro H , Kankaanranta L , Seppala T , Haapaniemi A , Makitie A , Joensuu H . Boron neutron capture therapy for locally recurrent head and neck squamous cell carcinoma: an analysis of dose response and survival . Radiother Oncol. 2019 ; 137 : 153 – 8 . https://doi.org/10.1016/j.radonc.2019.04.033 https://doi.org/10.1016/j.radonc.2019.04.033 .

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