Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study

Lan Wu; Bing-Hui Li; Yun-Yun Wang; Chao-Yang Wang; Hao Zi; Hong Weng; Qiao Huang; You-Jia Zhu; Xian-Tao Zeng

doi:10.1186/s40779-019-0223-8

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Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study

RESEARCH | Updated：2023-06-05

- Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study
- Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study
- MMR 2020年7卷第2期页码：157-165
- Affiliations：
  
  1.Center for Evidence-Based and Translational Medicine, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  2.Department of Stomatology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
  3.Center for Evidence-Based Medicine, Institute of Evidence-Based Medicine and Knowledge Translation, Henan University, Kaifeng 475000, China
  4.Department of Urology, Zhongnan Hospital of Wuhan University, Wuhan 430071, China
- Author bio：
  
  * Zhuyoujia1954@sina.com;
  zengxiantao1128@163.com; zengxiantao1128@gmail.com
- Funds：
  
  the Nature Science Foundation of Hubei Province(2019CFB760);the Health Commission of Hubei Province Scientific Research Project(WJ2019H035);the Technical Innovation Major Program of Hubei province(2016ACA152);the National Key Research and Development Plan of China (Technology helps Economy 2020)(2016YFC0106300);The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. The authors declare that there are no conflicts of interest in this study
- DOI：10.1186/s40779-019-0223-8
  中图分类号：
- 纸质出版：2020-06
- Accepted：
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Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study[J]. MMR, 2020,7(2):157-165.

Cite this article as: Wu et al.: Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study. Mil Med Res, 2019, 6: 34
Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study[J]. MMR, 2020,7(2):157-165. DOI： 10.1186/s40779-019-0223-8.

Cite this article as: Wu et al.: Periodontal disease and risk of benign prostate hyperplasia: a cross-sectional study. Mil Med Res, 2019, 6: 34 DOI： 10.1186/s40779-019-0223-8.

摘要

Abstract

Background:

Both periodontal disease and benign prostatic hyperplasia are age-related diseases that affect millions of people worldwide. Hence

this study aimed to investigate the association between periodontal disease and the risk of benign prostatic hyperplasia.

Methods:

A total of 4930 participants were selected from an available health examination that was carried out in 2017

only males were considered for further analysis. All eligible males were divided into benign prostatic hyperplasia and normal groups

the benign prostatic hyperplasia group was then divided into prostate volume ≤60 g and >60 g subgroups; all their periodontal status was extracted and then into normal (CPI score of 0)

periodontal disease (CPI score between 1 and 4)

and periodontitis (CPI score between 3 and 4) groups. The correlation between periodontal disease and benign prostatic hyperplasia was investigated using logistic regression analyses and greedy matching case-control analysis. Subgroup analysis based on prostate volume was also performed. All analyses were conducted with SAS 9.4 software.

Results:

A total of 2171 males were selected for this analysis. The presence of periodontal disease significantly increased the risk of benign prostatic hyperplasia by 1.68 times (

=1.68

95% CI: 1.26–2.24)

and individuals with periodontitis showed a higher risk (

=4.18

95% CI: 2.75–6.35). In addition

among matched cases and controls

this association remained robust (periodontal disease:

=1.85

95% CI: 1.30–2.64; periodontitis:

=4.83

95% CI: 2.57–9.07). Subgroup analysis revealed that periodontal disease significantly increased benign prostate hyperplasia risk as well (for prostate volume ≤60 g:

=1.64

95% CI: 1.22–2.20; for volume

60 g:

=2.17

95% CI: 1.04–4.53)

and there was a higher risk in the group with a prostate volume greater than 60 g.

Conclusions:

Periodontal disease is significantly and positively associated with an increased risk of benign prostatic hyperplasia. Further validation studies should be performed to explore the relationship between periodontal treatment and benign prostate hyperplasia.

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references

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