Cooper GS , Bynum ML , Somers EC . Recent insights in the epidemiology of autoimmune diseases: improved prevalence estimates and understanding of clustering of diseases . J Autoimmun . 2009 ; 33 ( 3-4 ): 197 - 207 .

Lee J , Taneja V , Vassallo R . Cigarette smoking and inflammation: cellular and molecular mechanisms . J Dent Res . 2012 ; 91 ( 2 ): 142 - 9 .

Wipfli H . The tobacco atlas . 4th ed . New York : Oxford University Press ; 2012 . https://doi.org/10.1093/aje/kws389 https://doi.org/10.1093/aje/kws389 .

Oberg M , Jaakkola MS , Woodward A , Peruga A , Pruss-Ustun A . Worldwide burden of disease from exposure to second-hand smoke: a retrospective analysis of data from 192 countries . Lancet . 2011 ; 377 ( 9760 ): 139 - 46 .

Mathers CD , Loncar D . Projections of global mortality and burden of disease from 2002 to 2030 . PLoS Med . 2006 ; 3 ( 11 ): e442 .

Thun MJ , DeLancey JO , Center MM , Jemal A , Ward EM . The global burden of cancer: priorities for prevention . Carcinogenesis . 2010 ; 31 ( 1 ): 100 - 10 .

Ezzati M , Lopez AD . Estimates of global mortality attributable to smoking in 2000 . Lancet . 2003 ; 362 ( 9387 ): 847 - 52 .

Cramer T , Yamanishi Y , Clausen BE , Förster I , Pawlinski R , Mackman N , et al . HIF-1α is essential for myeloid cell-mediated inflammation . Cell . 2003 ; 112 ( 5 ): 645 - 57 .

Nathan C . Immunology: Oxygen and the inflammatory cell . Nature . 2003 ; 422 ( 6933 ): 675 - 6 .

Taylor CT , Colgan SP . Hypoxia and gastrointestinal disease . J Mol Med . 2007 ; 85 ( 12 ): 1295 - 300 .

Bluhm AL , Weinstein J , Sousa JA . Free radicals in tobacco smoke . Nature . 1971 ; 229 ( 5285 ): 500 .

Ding YS , Zhang L , Jain RB , Jain N , Wang RY , Ashley DL , et al . Levels of tobacco-specific nitrosamines and polycyclic aromatic hydrocarbons in main stream smoke from different tobacco varieties . Cancer Epidemiol Biomarkers Prev . 2008 ; 17 ( 12 ): 3366 - 71 .

Talhout R , Schulz T , Florek E , Van Benthem J , Wester P , Opperhuizen A . Hazardous compounds in tobacco smoke . Int J Environ Res Public Health . 2011 ; 8 ( 2 ): 613 - 28 .

IARC , World Health Organization . Tobacco smoke and involuntary smoking . Iarc ; 2004 .

Hoffmann D , Hoffmann I . The changing cigarette: chemical studies and bioassays . In: Burns DM , Benowitz NL , editors . Risks associated with smoking cigarettes with low machine-measured yields of tar and nicotine , vol. 13 . Bethesda : US Department of Health and Human Services, Public Health Service, National Institute of Health, National Cancer Institute (NCI) Monograph ; 2001 . p. 159 - 91 .

Swauger JE , Steichen TJ , Murphy PA , Kinsler S . An analysis of the mainstream smoke chemistry of samples of the US cigarette market acquired between 1995 and 2000 . Regul Toxicol Pharmacol . 2002 ; 35 ( 2 ): 142 - 56 .

US Department of Health Human Services . Reducing the health consequences of smoking. 25 years of progress . A report of the Surgeon General . 1989 : 140 – 161 .

Mehta H , Nazzal K , Sadikot RT . Cigarette smoking and innate immunity . Inflamm Res . 2008 ; 57 ( 11 ): 497 - 503 .

Comer DM , Elborn JS , Inflammatory EM . cytotoxic effects of acrolein, nicotine, acetylaldehyde and cigarette smoke extract on human nasal epithelial cells . BMC Pulm Med . 2014 ; 14 ( 1 ): 32 .

SCENIHR (Scientific Committee on Emerging and Newly Identified Health Risks) , Addictiveness and Attractiveness of Tobacco Additives . 2010 . https://ec.europa.eu/health/scientific_committees/emerging/docs/scenihr_o_029.pdf https://ec.europa.eu/health/scientific_committees/emerging/docs/scenihr_o_029.pdf . Accessed 15 Dec 2017 .

Talhout R , Opperhuizen A , van Amsterdam JG . Role of acetaldehyde in tobacco smoke addiction. Eur . Neuropsychopharmacol . 2007 ; 17 ( 10 ): 627 - 36 .

Cao J , Belluzzi JD , Loughlin SE , Keyler DE , Pentel PR , Leslie FM . Acetaldehyde, a major constituent of tobacco smoke, enhances behavioral, endocrine, and neuronal responses to nicotine in adolescent and adult rats . Neuropsychopharmacology . 2007 ; 32 ( 9 ): 2025 - 35 .

Caron L , Karkazis K , Raffin TA , Koenig BA , Swan G . Nicotine addiction through a neurogenomic prism: ethics, public health, and smoking . Nicotine Tob Res . 2005 ; 7 ( 2 ): 181 - 97 .

Heliovaara M , Aho K , Aromaa A , Knekt P , Reunanen A . Smoking and risk of rheumatoid arthritis . J Rheumatol . 1993 ; 20 ( 11 ): 1830 - 5 .

Silman AJ , Newman J , Macgregor AJ . Cigarette smoking increases the risk of rheumatoid arthritis. Results from a nationwide study of disease-discordant twins . Arthritis Rheum . 1996 ; 39 ( 5 ): 732 - 5 .

Hutchinson D , Shepstone L , Moots R , Lear JT , Lynch MP . Heavy cigarette smoking is strongly associated with rheumatoid arthritis (RA), particularly in patients without a family history of RA . Ann Rheum Dis . 2001 ; 60 ( 3 ): 223 - 7 .

Vessey MP , Villard-Mackintosh L , Yeates D . Oral contraceptives, cigarette smoking and other factors in relation to arthritis . Contraception . 1987 ; 35 ( 5 ): 457 - 64 .

Stolt P , Källberg H , Lundberg I , Sjögren B , Klareskog L , Alfredsson L . Silica exposure is associated with increased risk of developing rheumatoid arthritis: results from the Swedish EIRA study . Ann Rheum Dis . 2005 ; 64 ( 4 ): 582 - 6 .

Karlson EW , Lee I , Cook NR , Manson JE , Buring JE , Hennekens CH . A retrospective cohort study of cigarette smoking and risk of rheumatoid arthritis in female health professionals . Arthritis Rheumatol . 1999 ; 42 ( 5 ): 910 - 7 .

Criswell LA , Merlino LA , Cerhan JR , Mikuls TR , Mudano AS , Burma M , et al . Cigarette smoking and the risk of rheumatoid arthritis among postmenopausal women: Results from the Iowa Women’s Health Study . Am J Med . 2002 ; 112 ( 6 ): 465 - 71 .

Uhlig T , Hagen KB , Kvien TK . Current tobacco smoking, formal education, and the risk of rheumatoid arthritis . J Rheumatol . 1999 ; 26 ( 1 ): 47 - 54 .

Voigt LF , Koepsell TD , Nelson JL , Dugowson CE , Daling JR . Smoking, obesity, alcohol consumption, and the risk of rheumatoid arthritis . Epidemiology . 1994 ; 5 ( 5 ): 525 - 32 .

Symmons DP , Bankhead CR , Harrison BJ , Brennan P , Silman AJ , Barrett EM , et al . Blood transfusion, smoking, and obesity as risk factors for the development of rheumatoid arthritis. Results from a primary care-based incident case-control study in Norfolk, England . Arthritis Rheumatol . 1997 ; 40 ( 11 ): 1955 - 61 .

Padyukov L , Silva C , Stolt P , Alfredsson L , Klareskog L . A gene-environment interaction between smoking and shared epitope genes in HLA-DR provides a high risk of seropositive rheumatoid arthritis . Arthritis Rheumatol . 2004 ; 50 ( 10 ): 3085 - 92 .

Avila MH , Liang MH , Willett WC , Stampfer MJ , Colditz GA , Rosner B , et al . Reproductive factors, smoking, and the risk for rheumatoid arthritis . Epidemiology . 1990 ; 1 ( 4 ): 285 - 91 .

Hazes JM , Dijkmans BA , Vandenbroucke JP , De Vries RR , Cats A . Lifestyle and the risk of rheumatoid arthritis: cigarette smoking and alcohol consumption . Ann Rheum Dis . 1990 ; 49 ( 12 ): 980 - 2 .

Krishnan E , Sokka T , Hannonen P . Smoking-gender interaction and risk for rheumatoid arthritis . Arthritis Res Ther . 2003 ; 5 ( 3 ): R158 .

Klareskog L , Stolt P , Lundberg K , Kallberg H , Bengtsson C , Grunewald J , et al . A new model for an etiology of rheumatoid arthritis: smoking may trigger HLA-DR (shared epitope) - restricted immune reactions to auto-antigens modified by citrullination . Arthritis Rheumatol . 2006 ; 54 ( 1 ): 38 - 46 .

Olsson AR , Skogh T , Wingren G . Comorbidity and lifestyle, reproductive factors, and environmental exposures associated with rheumatoid arthritis . Ann Rheum Dis . 2001 ; 60 ( 10 ): 934 - 9 .

Costenbader KH , Feskanich D , Mandl LA , Karlson EW . Smoking intensity, duration, and cessation, and the risk of rheumatoid arthritis in women . Am J Med . 2006 ; 119 ( 6 ): e501–3. e509

Sugiyama D , Nishimura K , Tamaki K , Tsuji G , Nakazawa T , Morinobu A , et al . Impact of smoking as a risk factor for developing rheumatoid arthritis: a meta-analysis of observational studies . Ann Rheum Dis . 2010 ; 69 ( 01 ): 70 - 81 .

Freemer MM , King Jr TE , Criswell LA . Association of smoking with dsDNA autoantibody production in systemic lupus erythematosus . Ann Rheum Dis . 2006 ; 65 ( 5 ): 581 - 4 .

Afridi HI , Kazi TG , Talpur FN , Naher S , Brabazon D . Relationship between toxic metals exposure via cigarette smoking and rheumatoid arthritis . Clin Lab . 2014 ; 60 ( 10 ): 1735 - 45 .

Villard-Mackintosh L , Vessey MP . Oral contraceptives and reproductive factors in multiple sclerosis incidence . Contraception . 1993 ; 47 ( 2 ): 161 - 8 .

Thorogood M , Hannaford PC . The influence of oral contraceptives on the risk of multiple sclerosis . BJOG . 1998 ; 105 ( 12 ): 1296 - 9 .

Ghadirian P , Dadgostar B , Azani R , Maisonneuve PA . case-control study of the association between socio-demographic, lifestyle and medical history factors and multiple sclerosis . Can J Public Health . 2001 ; 92 ( 4 ): 281 .

Hernan MA , Oleky MJ , Ascherio A . Cigarette smoking and incidence of multiple sclerosis . Am J Epidemiol . 2001 ; 154 ( 1 ): 69 - 74 .

Riise T , Nortvedt MW , Ascherio A . Smoking is a risk factor for multiple sclerosis . Neurology . 2003 ; 61 ( 8 ): 1122 - 4 .

Ghaussy NO , Sibbitt WL , Qualls CR . Cigarette smoking, alcohol consumption, and the risk of systemic lupus erythematosus: a casecontrol study . J Rheumatol . 2001 ; 28 ( 11 ): 2449 - 53 .

Hardy CJ , Palmer BP , Muir KR , Sutton AJ , Powell RJ . Smoking history, alcohol consumption, and systemic lupus erythematosus: a case-control study . Ann Rheum Dis . 1998 ; 57 ( 8 ): 451 - 5 .

Nagata C , Fujita S , Iwata H , Kurosawa Y , Kobayashi K , Kobayashi M , et al . Systemic lupus erythematosus: a case-control epidemiologic study in Japan . Int J Dermatol . 1995 ; 34 ( 5 ): 333 - 7 .

Petri M , Thompson E , Abusuwwa R , Huang J , Garrett E . Bales: The Baltimore Lupus Environmental Study . Arthritis Rheumatol . 2001 ; 44 ( 9 ): S331 .

Cooper GS , Dooley MA , Treadwell EL , St Clair EW , Gilkeson GS . Smoking and use of hair treatments in relation to risk of developing systemic lupus erythematosus . J Rheumatol . 2001 ; 28 ( 12 ): 2653 - 6 .

Reidenberg MM , Drayer DE , Lorenzo B , Strom BL , West SL , Snyder ES , et al . Acetylation phenotypes and environmental chemical exposure of people with idiopathic systemic lupus erythematosus . Arthritis Rheumatol . 1993 ; 36 ( 7 ): 971 - 3 .

Benoni C , Nilsson Å , Nived O . Smoking and inflammatory bowel disease: Comparison with systemic lupus erythematosus: a case-control study . Scand J Gastroenterol . 1990 ; 25 ( 7 ): 751 - 5 .

Bengtsson AA , Rylander L , Hagmar L , Nived O , Sturfelt G . Risk factors for developing systemic lupus erythematosus: a case-control study in southern Sweden . Rheumatology . 2002 ; 41 ( 5 ): 563 - 71 .

Sanchez-Guerrero J , Karlson EW , Colditz GA , Hunter DJ , Speizer FE , Liang MH . Hair dye use and the risk of developing systemic lupus erythematosus: a cohort study . Arthritis Rheumatol . 1996 ; 39 ( 4 ): 657 - 62 .

Formica MK , Palmer JR , Rosenberg L , McAlindon TE . Smoking, alcohol consumption, and risk of systemic lupus erythematosus in the Black Women’s Health Study . J Rheumatol . 2003 ; 30 ( 6 ): 1222 - 6 .

Vestergaard P , Rejnmark L , Weeke J , Hoeck HC , Nielsen HK , Rungby J , et al . Smoking as a risk factor for Graves’ disease, toxic nodular goiter, and autoimmune hypothyroidism . Thyroid . 2002 ; 12 ( 1 ): 69 - 75 .

Chen YL , Chang TC , Chen CJ . Influence of smoking on Graves’ disease with or without ophthalmopathy and nontoxic nodular goiter in Taiwan . J Formos Med Assoc . 1994 ; 93 ( 1 ): 40 - 4 .

Winsa B , Mandahl A , Karlsson FA . Graves’ disease, endocrine ophthalmopathy and smoking . Acta Endocrinol . 1993 ; 128 ( 2 ): 156 - 60 .

Yoshiuchi K , Kumano H , Nomura S , Yoshimura H , Ito K , Kanaji Y , et al . Stressful life events and smoking were associated with Graves’ disease in women, but not in men . Psychosom Med . 1998 ; 60 ( 2 ): 182 - 5 .

Brix TH , Hansen PS , Kyvik KO , Hegedüs L . Cigarette smoking and risk of clinically overt thyroid disease: a population-based twin case-control study . Arch Intern Med . 2000 ; 160 ( 5 ): 661 - 6 .

Bartalena L , Martino E , Marcocci C , Bogazzi F , Panicucci M , Velluzzi F , et al . More on smoking habits and Graves’ ophthalmopathy . J Endocrinol Invest . 1989 ; 12 ( 10 ): 733 - 7 .

Pfeilschifter J , Ziegler R . Smoking and endocrine ophthalmopathy: impact of smoking severity and current vs lifetime cigarette consumption . Clin Endocrinol . 1996 ; 45 ( 4 ): 477 - 81 .

Holm IA , Manson JE , Michels KB , Alexander EK , Willett WC , Utiger RD . Smoking and other lifestyle factors and the risk of Graves’ hyperthyroidism . Arch Intern Med . 2005 ; 165 ( 14 ): 1606 - 11 .

Howel D , Fischbacher CM , Bhopal RS , Gray J , Metcalf JV , James OF . An exploratory population-based case-control study of primary biliary cirrhosis . Hepatology . 2000 ; 31 ( 5 ): 1055 - 60 .

Gershwin ME , Selmi C , Worman HJ , Gold EB , Watnik M , Utts J , et al . Risk factors and comorbidities in primary biliary cirrhosis: a controlled interviewbased study of 1032 patients . Hepatology . 2005 ; 42 ( 5 ): 1194 - 202 .

Ross KA . Evidence for somatic gene conversion and deletion in bipolar disorder, Crohn’s disease, coronary artery disease, hypertension, rheumatoid arthritis, type-1 diabetes, and type-2 diabetes . BMC Med . 2011 ; 9 ( 1 ): 12 .

Bois PR . Hyper mutable minisatellites, a human affair? Genomics . 2003 ; 81 ( 4 ): 349 - 55 .

Ellegren H . Microsatellites: simple sequences with complex evolution . Nature Rev Genet . 2004 ; 5 ( 6 ): 435 .

Holmes R , Chang Y , Soloway PD . Timing and sequence requirements defined for embryonic maintenance of imprinted DNA methylation at Rasgrf1 . Mol Cell Biol . 2006 ; 26 ( 24 ): 9564 - 70 .

Yauk CL , Polyzos A , Rowan-Carroll A , Kortubash I , Williams A , Kovalchuk O . Tandem repeat mutation, global DNA methylation, and regulation of DNA methyltransferases in cultured mouse embryonic fibroblast cells chronically exposed to chemicals with different modes of action . Environ Mol Mutagen . 2008 ; 49 ( 1 ): 26 - 35 .

Shukla S , Kavak E , Gregory M , Imashimizu M , Shutinoski B , Kashlev M , et al . CTCF-promoted RNA polymerase II pausing links DNA methylation to splicing . Nature . 2011 ; 479 ( 7371 ): 74 .

Renaudineau Y , Youinou P . Epigenetics and autoimmunity, with special emphasis on methylation . Keio J Med . 2011 ; 60 ( 1 ): 10 - 6 .

Ross KA . Coherent somatic mutation in autoimmune disease . PloS one . 2014 ; 9 ( 7 ): e101093 .

Fiorillo E , Orrú V , Stanford SM , Liu Y , Salek M , Rapini N , et al . Autoimmuneassociated PTPN22 R620W variation reduces phosphorylation of lymphoid phosphatase on an inhibitory tyrosine residue . J Biol Chem . 2010 ; 285 ( 34 ): 26506 - 18 .

Criswell LA , Pfeiffer KA , Lum RF , Gonzales B , Novitzke J , Kern M , et al . Analysis of families in the multiple autoimmune disease genetics consortium (MADGC) collection: the PTPN22 620W allele associates with multiple autoimmune phenotypes . Am J Hum Genet . 2005 ; 76 ( 4 ): 561 - 71 .

Menard L , Saadoun D , Isnardi I , Ng YS , Meyers G , Massad C , et al . The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans . J Clin Invest . 2011 ; 121 ( 9 ): 3635 .

Arechiga AF , Habib T , He Y , Zhang X , Zhang ZY , Funk A , et al . Cutting edge: the PTPN22 allelic variant associated with autoimmunity impairs B cell signaling . J Immunol . 2009 ; 182 ( 6 ): 3343 - 7 .

Zhang J , Zahir N , Jiang Q , Miliotis H , Heyraud S , Meng X , et al . The autoimmune disease-associated PTPN22 variant promotes calpain-mediated Lyp/Pep degradation associated with lymphocyte and dendritic cell hyperresponsiveness . Nature Genet . 2011 ; 43 ( 9 ): 902 - 7 .

DeMarini DM . Genotoxicity of tobacco smoke and tobacco smoke condensate: a review . Mutat Res Rev Mutat Res . 2004 ; 567 ( 2 ): 447 - 74 .

Roemer E , Schramke H , Weiler H , Buettner A , Kausche S , Weber S , et al . Mainstream smoke chemistry and in vitro and in vivo toxicity of the reference cigarettes 3R4F and 2R4F . Beitragezur Tab Int Contrib Tob Res . 2012 ; 25 ( 1 ): 316 - 35 .

Pryor WA , Stone K , Zang LY , Bermúdez E . Fractionation of aqueous cigarette tar extracts: fractions that contain the tar radical cause DNA damage . Chem Res Toxicol . 1998 ; 11 ( 5 ): 441 - 8 .

DeMarini DM . Genotoxicity of tobacco smoke and tobacco smoke condensate . Mutat Res Rev Genet Toxicol . 1983 ; 114 ( 1 ): 59 - 89 .

International Agency for Research on Cancer . Tobacco smoking (IARC Monographs on the Evaluation of the Carcinogenic Risk of Chemicals to Humans, Vol. 38) . Lyon : International Agency for Research on Cancer (IARC Press) ; 1986 .

Husgafvel-Pursiainen K . Genotoxicity of environmental tobacco smoke: a review . Mutat Res Rev Mutat Res . 2004 ; 567 ( 2 ): 427 - 45 .

Podlutsky A , Hou SM , Nyberg F , Pershagen G , Lambert B . Influence of smoking and donor age on the spectrum of in vivo mutation at the HPRTlocus in T lymphocytes of healthy adults . Mutat Res Fund Mol Mech Mut . 1999 ; 431 ( 2 ): 325 - 39 .

Keohavong P , Xi L , Day RD , Zhang L , Grant SG , Day BW , et al . HPRT gene alterations in umbilical cord blood T-lymphocytes in newborns of mothers exposed to tobacco smoke during pregnancy . Mutat Res Fund Mol Mech Mut . 2005 ; 572 ( 1 ): 156 - 66 .

Mahdi H , Fisher BA , Källberg H , Plant D , Malmström V , Rönnelid J , et al . Specific interaction between genotype, smoking and autoimmunity to citrullinated α-enolase in the etiology of rheumatoid arthritis . Nat Genet . 2009 ; 41 ( 12 ): 1319 - 24 .

van der Woude D , Alemayehu WG , Verduijn W , de Vries RR , Houwing-Duistermaat JJ , Huizinga TW , et al . Gene-environment interaction influences the reactivity of autoantibodies to citrullinated antigens in rheumatoid arthritis . Nat Genet . 2010 ; 42 ( 10 ): 814 - 6 .

Robbins WA , Elashoff DA , Xun L , Jia J , Li N , Wu G , et al . Effect of lifestyle exposures on sperm aneuploidy . Cytogenet Genome Res . 2005 ; 111 ( 3–4 ): 371 - 7 .

Yauk CL , Berndt ML , Williams A , Rowan-Carroll A , Douglas GR , Stämpfli MR . Mainstream tobacco smoke causes paternal germ-line DNA mutation . Cancer Res . 2007 ; 67 ( 11 ): 5103 - 6 .

Hruba D , Sikolova V , Kunzova S , Kasikova K . The role of smoking in the epigenetic modification of phenotype: the latest knowledge about smoking-induced pathways . Cas Lek Cesk . 2013 ; 152 ( 1 ): 31 - 5 .

Rajendrasozhan S , Yao H , Rahman I . Current perspectives on role of chromatin modifications and deacetylases in lung inflammation of COPD . COPD . 2009 ; 6 ( 4 ): 291 - 7 .

Lengfeld J , Cutforth T , Agalliu D . The role of angiogenesis in the pathology of multiple sclerosis . Vascular Cell . 2014 ; 6 ( 1 ): 23 .

Sternglanz R . Histone acetylation: a gateway to transcriptional activation . Trends Biochem Sci . 1996 ; 21 ( 10 ): 357 - 8 .

Brown CE , Lechner T , Howe LE , Workman JL . The many HATs of transcription coactivators . Trends Biochem Sci . 2000 ; 25 ( 1 ): 15 - 9 .

Wu C . Chromatin remodeling and the control of gene expression . J Biol Chem . 1997 ; 272 : 28171 - 4 .

deRuijter AJ , van Gennip AH , Caron HN , Kemp S , van Kuilenburg AB . Histone deacetylases (HDACs):characterization of the classical HDAC family . Biochem J . 2003 ; 370 ( 3 ): 737 - 49 .

Yang XJ , Gregoire S . Class II histone deacetylases:fromsequence to function, regulation, and clinicalimplication . Mol Cell Biol . 2005 ; 25 ( 8 ): 2873 - 84 .

Yang XJ , Seto E . The Rpd3/Hda1 family of lysine deacetylases: from bacteria and yeast to mice and men . Nat Rev Mol Cell Biol . 2008 ; 9 ( 3 ): 206 - 18 .

Wang Z , Zang C , Cui K , Schones DE , Barski A , Peng W , et al . Genome-wide mapping of HATs and HDACs reveals distinct functions in active and inactive genes . Cell . 2009 ; 138 ( 5 ): 1019 - 31 .

Haery L , Thompson RC , Gilmore TD . Histone acetyl transferases and histone deacetylases in B-and T-cell development, physiology and malignancy . Genes Cancer . 2015 ; 6 ( 5-6 ): 184 - 213 .

Sun XJ , Man N , Tan Y , Nimer SD , Wang L . The role of histone acetyl transferases in normal and malignant hematopoiesis . Front Oncol . 2015 ; 5 ( 108 ): 1 - 11 .

Moodie FM , Marwick JA , Anderson CS , Szulakowski P , Biswas SK , Bauter MR , et al . Oxidative stress and cigarette smoke alter chromatin remodeling but differentially regulate NF-κB activation and proinflammatory cytokine release in alveolar epithelial cells . FASEB J . 2004 ; 18 ( 15 ): 1897 - 9 .

Rajendrasozhan S , Yang SR , Caito S , Rahman I . Nucleocytoplasmic shuttling and posttranslational modifications of sirtuin in response to cigarette smoke lead to increased acetylation of NF-κB and FOXO3 . Am J Respir Crit Care Med . 2008 ; 177 : A266 .

Somers EC , Richardson BC . Environmental exposures, epigenetic changes and the risk of lupus . Lupus . 2014 ; 23 ( 6 ): 568 - 76 .

Walters MJ , Paul-Clark MJ , McMaster SK , Ito K , Adcock IM , Mitchell JA . Cigarette smoke activates human monocytes by an oxidant- AP-1 signaling pathway: implications for steroid resistance . Mol Pharmacol . 2005 ; 68 ( 5 ): 1343 - 53 .

Yang SR , Chida AS , Bauter MR , Shafiq N , Seweryniak K , Maggirwar SB , et al . Cigarette smoke induces pro-inflammatory cytokine release by activation of NF-kappaB and posttranslational modifications of histone deacetylase in macrophages . Am J Physiol Lung Cell Mol Physiol . 2006 ; 291 ( 11 ): L46 - 57 .

Adenuga D , Yao H , March TH , Seagrave J , Rahman I . Histone deacetylase 2 is phosphorylated, ubiquitinated and degraded by cigarette smoke . Am J Respir Cell Mol Biol . 2009 ; 40 ( 4 ): 464 - 73 .

Yao H , Edirisinghe I , Rajendrasozhan S , Yang SR , Caito S , Adenuga D , et al . Cigarette smoke mediated inflammatory and oxidative responses are straindependent in mice . Am J Physiol Lung Cell Mol Physiol . 2008 ; 294 ( 6 ): L1174 - 86 .

Yao H , Yang SR , Kode A , Rajendrasozhan S , Caito S , Adenuga D , et al . Redox regulation of lung inflammation: role of NADPH oxidase and NF-kappaB signalling . Biochem Soc Trans . 2007 ; 35 ( 5 ): 1151 - 5 .

Ito K , Barnes PJ , Adcock IM . Glucocorticoid receptor recruitment of histone deacetylase 2 inhibits interleukin-1beta-induced histone H4 acetylation on lysines 8 and 12 . Mol Cell Biol . 2000 ; 20 ( 18 ): 6891 - 903 .

Mercado N , Thimmulappa R , Thomas CMR , Fenwick PS , Chana KK , Donnelly LE , et al . Decreased histone deacetylase2 impairs Nrf2 activation by oxidative stress . Biochem Biophys Res Commun . 2011 ; 406 ( 2 ): 292 - 8 .

Li YP , Gorelik G , Strickland FM , Richardson BC . Oxidative Stress, T Cell DNA Methylation, and Lupus . Arthritis Rheumatol . 2014 ; 66 ( 6 ): 1574 - 82 .

Fujii J , Kurahashi T , Konno T , Homma T , Iuchi Y . Oxidative stress as a potential causal factor for autoimmune hemolytic anemia and systemic lupus erythematosus . World J Nephrol . 2015 ; 4 ( 2 ): 213 - 22 .

Yang SR , Valvo S , Yao H , Kode A , Rajendrasozhan S , Edirisinghe I , et al . IKK alpha causes chromatin modification on pro-inflammatory genes by cigarette smoke in mouse lung . Am J Respir Cell Mol Biol . 2008 ; 38 ( 6 ): 689 - 98 .

Lunec J , Herbert K , Blount S , Griffiths HR , Emery P . 8-Hydroxy deoxyguanosine: a marker of oxidative DNA damage in systemic lupus erythematosus . FEBS Lett . 1994 ; 348 ( 2 ): 131 - 8 .

Ohsawa M . Heavy metal induced immunotoxicity and its mechanisms . Yakugaku Zasshi . 2009 ; 129 ( 3 ): 305 - 19 .

Tsai CP , Lee CT . Multiple sclerosis incidence associated with the soil lead and arsenic concentrations in Taiwan . PLoS One . 2013 ; 8 ( 6 ): e65911 .

Freitas M , Fernandes E . Zinc, cadmium and nickel increase the activation of NF-κB and the release of cytokines from THP-1 monocytic cells . Metallomics . 2011 ; 3 ( 11 ): 1238 - 43 .

Vassallo R , Tamada K , Lau JS , Kroening PR , Chen L . Cigarette smoke extract suppresses human dendritic cell function leading to preferential induction of Th-2 priming . J Immunol . 2005 ; 175 ( 4 ): 2684 - 91 .

Robays LJ , Lanckacker EA , Moerloose KB , Maes T , Bracke KR , Brusselle GG , et al . Concomitant inhalation of cigarette smoke andaerosolized protein activates airway dendritic cells and induces allergic airwayinflam-mationin a TLR-independent way . J Immunol . 2009 ; 183 ( 4 ): 2758 - 66 .

Lee SH , Goswami S , Grudo A , Song LZ , Bandi V , Goodnight-White S , et al . Antielastin autoimmunity in tobacco smoking-induced emphysema . Nat Med . 2007 ; 13 ( 5 ): 567 - 9 .

Mian MF , Lauzon NM , Stampfli MR , Mossman KL , Ashkar AA . Impairment of human NK cell cytotoxic activity and cytokine release by cigarette smoke . J Leukoc Biol . 2008 ; 83 ( 3 ): 774 - 84 .

Smeltz RB , Wolf NA , Swanborg RH . Inhibition of autoimmune T cell responses in the DA Rat by bone marrow-derived NK cells in vitro : Implications for autoimmunity . J Immunol . 1999 ; 163 ( 3 ): 1390 - 7 .

Prummel MF , Strieder T , Wiersinga WM . The environment and autoimmune thyroid diseases . Eur J Endocrinol . 2004 ; 150 ( 5 ): 605 - 18 .

Zhou L , Chong MM , Littman DR . Plasticity of CD4 + T cell lineage differentiation . Immunity . 2009 ; 30 ( 5 ): 646 - 55 .

Byron KA , Varigos GA , Wootton AM . IL-4 production is increased in cigarette smokers . Clin Exp Immunol . 1994 ; 95 ( 2 ): 333 - 6 .

Nakamura Y , Miyata M , Ohba T , Ando T , Hatsushika K , Suenaga F , et al . Cigarette smoke extract induces thymic stromal lymphopoietin expression, leading to T (H) 2-type immune responses and airway inflammation . J Allergy Clin Immunol . 2008 ; 122 ( 6 ): 1208 - 14 .

Van Hove CL , Moerloose K , Maes T , Joos GF , Tournoy KG . Cigarette smoke enhances Th-2 driven airway inflammation and delays inhalational tolerance . Respir Res . 2008 ; 9 ( 1 ): 42 .

deHeens GL , van der Velden U , Loos BG . Cigarette smoking enhances T cell activation and a Th2 immune response; an aspect of the pathophysiology in periodontal disease . Cytokine . 2009 ; 47 ( 3 ): 157 - 61 .

Smelter DF , Sathish V , Thompson MA , Pabelick CM , Vassallo R , Prakash YS . Thymic stromal lymphopoietin in cigarette smoke-exposed human airway smooth muscle . J Immunol . 2010 ; 185 ( 5 ): 3035 - 40 .

Shan M , Cheng HF , Song LZ , Roberts L , Green L , Hacken-Bitar J , et al . Lung myeloid dendritic cells coordinately induce TH1and TH17 responses in human emphysema . Sci Transl Med . 2009 ; 1 ( 4 ): 4ra10 .

Zivadinov R , Weinstock-Guttman B , Hashmi K , Abdelrahman N , Stosic M , Dwyer M , et al . Smoking is associated with increased lesion volumes and brain atrophy in multiple sclerosis . Neurology . 2009 ; 73 ( 7 ): 504 - 10 .

Bakonyi T , Radák Z . High altitude and free radicals . J Sports Sci Med . 2004 ; 3 ( 2 ): 64 - 9 .

Dosek A , Ohno H , Acs Z , Taylor AW , Radak Z . High altitude and oxidative stress . Respir Physiol Neurobiol . 2007 ; 158 ( 2 ): 128 - 31 .

Karakucuk S . Effects of High Altitude Related Oxidative Stress on Intraocular Pressure and Central Corneal Thickness-A Research Model for the Etiology of Glaucoma . In: Rumelt S , editor . Glaucoma-Basic and Clinical Concepts . Europe : In Tech ; 2011 . p. 271 - 90 .

Jefferson JA , Simoni J , Escudero E , Hurtado ME , Swenson ER , Wesson DE , et al . Increased oxidative stress following acute and chronic high altitude exposure . High Alt Med Biol . 2004 ; 5 ( 1 ): 61 - 9 .

Semenza GL , Wang GL . A nuclear factor induced by hypoxia via de novo protein synthesis binds to the human erythropoietin gene enhancer at a site required for transcriptional activation . Mol Cell Biol . 1992 ; 12 ( 12 ): 5447 - 54 .

Patel SA , Simon MC . Biology of hypoxia-inducible factor-2alpha in development and disease . Cell Death Differ . 2008 ; 15 ( 4 ): 628 - 34 .

Huh YH , Lee G , Lee KB , Koh JT , Chun JS , Ryu JH . HIF-2α-induced chemokines stimulate motility of fibroblast-like synoviocytes and chondrocytes into the cartilage-pannus interface in experimental rheumatoid arthritis mouse models . Arthritis Res Ther . 2015 ; 17 ( 1 ): 302 .

Pan F , Barbi J , Pardoll DM . Hypoxia-inducible factor1: a link between metabolism and T cell differentiation and a potential therapeutic target . Oncoimmunology . 2012 ; 1 ( 4 ): 510 - 5 .

Biddlestone J , Bandarra D , Rocha S . The role of hypoxia in inflammatory disease . Int J Mol Med . 2015 ; 35 ( 4 ): 859 - 69 .

Kaelin WG , Ratcliffe PJ . Oxygen sensing by metazoans: the central role of the HIF hydroxylase pathway . Mol Cell . 2008 ; 30 ( 4 ): 393 - 402 .

Mahon PC , Hirota K , Semenza GL . FIH-1: a novel protein that interacts with HIF-1alpha and VHL to mediate repression of HIF-1 transcriptional activity . Genes Dev . 2001 ; 15 ( 20 ): 2675 - 86 .

Lando D , Peet DJ , Gorman JJ , Whelan DA , Whitelaw ML , Bruick RK . FIH-1 is an asparaginyl hydroxylase enzyme that regulates the transcriptional activity of hypoxia-inducible factor . Genes Dev . 2002 ; 16 ( 12 ): 1466 - 71 .

Lando D , Peet DJ , Whelan DA , Gorman JJ , Whitelaw ML . Asparagine hydroxylation of the HIF transactivation domain a hypoxic switch . Science . 2002 ; 295 ( 5556 ): 858 - 61 .

Bollinger T , Gies S , Naujoks J , Feldhoff L , Bollinger A , Solbach W , et al . HIF-1a-and hypoxia-dependent immune responses in human CD4 + CD25 high Tcells and T helper 17cells . J Leukoc Biol . 2014 ; 96 ( 2 ): 305 - 12 .

Hu F , Shi L , Mu R , Zhu J , Li Y , Ma X , et al . Hypoxia-inducible factor-1α and interleukin 33 form a regulatory circuit to perpetuate the inflammation in rheumatoid arthritis . PLoS One . 2013 ; 8 ( 8 ): e72650 .

Shi LZ , Wang R , Huang G , Vogel P , Neale G , Green DR , et al . HIF1adependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells . J Exp Med . 2011 ; 208 ( 7 ): 1367 - 76 .

Geng H , Harvey CT , Pittsenbarger J , Liu Q , Beer TM , Xue C , et al . HDAC4 Protein regulates HIF1α protein lysine acetylation and cancer cell response to hypoxia . J Biol Chem . 2011 ; 286 ( 44 ): 38095 - 102 .

Maltzman JS , Haase VH . Low oxygen stimulates the immune system . Kidney Int . 2008 ; 73 ( 7 ): 797 - 9 .

Imig JD , Ryan MJ . Immune and inflammatory role in renal disease . Compr Physiol . 2013 ; 3 ( 2 ): 957 - 76 .

Cummins EP , Taylor CT . Hypoxia-responsive transcription factors . Pflugers Arch . 2005 ; 450 ( 6 ): 363 - 71 .

Koong AC , Chen EY , Giaccia AJ . Hypoxia causes the activation of nuclear factor κB through the phosphorylation of IκBα on tyrosine residues . Cancer Res . 1994 ; 54 ( 6 ): 1425 - 30 .

Simmonds RE , Foxwell BM . Signalling, inflammation and arthritis: NF-kappa B and its relevance to arthritis and inflammation . Rheumatol Oxf Engl . 2008 ; 47 ( 5 ): 584 - 90 .

Benito MJ , Murphy E , Murphy EP , vanden Berg WB , Fitz Gerald O , Bresnihan B . Increased synovial tissue NF-kappa B1 expression at sites adjacent to the cartilage-pannus junction in rheumatoid arthritis . Arthritis Rheum . 2004 ; 50 ( 6 ): 1781 - 7 .

Handel ML , McMorrow LB , Gravallese EM . Nuclear factor- kappa B in rheumatoid synovium. Localization of p50 and p65 . Arthritis Rheum . 1995 ; 38 ( 12 ): 1762 - 70 .

Müller-Ladner U , Pap T , Gay RE , Neidhart M , Gay S . Mechanisms of disease: The molecular and cellular basis of joint destruction in rheumatoid arthritis . Nat Clin Pract Rheumatol . 2005 ; 1 ( 2 ): 102 - 10 .

Aggarwal BB , Takada Y , Shishodia S , Gutierrez AM , Oommen OV , Ichikawa H , et al . Nuclear transcription factor NF-kappa B: role in biology and medicine . Indian J Exp Biol . 2004 ; 42 ( 4 ): 341 - 53 .

Lund-Olesen K . Oxygen tension in synovial fluids . Arthritis Rheum . 1970 ; 13 ( 6 ): 769 - 76 .

Falchuk KH , Goetzl EJ , Kulka JP . Respiratory gases of synovial fluids. An approach to synovial tissue circulatory-metabolic imbalance in rheumatoid arthritis . Am J Med . 1970 ; 49 ( 2 ): 223 - 31 .

Sivakumar B , Akhavani MA , Winlove CP , Taylor PC , Paleolog EM , Kang N . Synovial hypoxia as a cause of tendon rupture in rheumatoid arthritis . J Hand Surg . 2008 ; 33 ( 1 ): 49 - 58 .

Ng CT , Biniecka M , Kennedy A , McCormick J , Fitzgerald O , Bresnihan B , et al . Synovial tissue hypoxia and inflammation in vivo . Ann Rheum Dis . 2010 ; 69 ( 7 ): 1389 - 95 .

Jeon CH , Ahn J-K , Chai J-Y , Kim HJ , Bae E-K , Park SH , et al . Hypoxia appears at pre-arthritic stage and shows co-localization with early synovial inflammation in collagen induced arthritis . Clin Exp Rheumatol . 2008 ; 26 ( 4 ): 646 - 8 .

Quinonez-Flores CM , Gonzalez-Chayez SA , Pacheco-Tena C . Hypoxia and its implications in rheumatoid arthritis . J Biomed sci . 2016 ; 23 ( 1 ): 62 .

Li G , Zhang Y , Qian Y , Zhang H , Guo S , Sunagawa M , et al . Interleukin-17A promotes rheumatoid arthritis synoviocytes migration and invasion under hypoxia by increasing MMP2 and MMP9 expression through NF-kB/HIF-1α pathway . Mol Immunol . 2013 ; 53 ( 3 ): 227 - 36 .

Ahn JK , Koh E-M , Cha H-S , Lee YS , Kim J , Bae EK , et al . Role of hypoxiainducible factor-1alpha in hypoxia-induced expressions of IL-8, MMP-1 and MMP-3 in rheumatoid fibroblast-like synoviocytes . Rheumatol Oxf Engl . 2008 ; 47 ( 6 ): 834 - 9 .

Cha HS , Ahn KS , Jeon CH , Kim J , Song YW , Koh EM . Influence of hypoxia on the expression of matrix metalloproteinase-1, -3 and tissue inhibitor of metalloproteinase-1 in rheumatoid synovial fibroblasts . Clin Exp Rheumatol . 2003 ; 21 ( 5 ): 593 - 8 .

Oikawa M , Abe M , Kurosawa H , Hida W , Shirato K , Sato Y . Hypoxia induces transcription factor ETS-1 via the activity of hypoxia-inducible factor-1 . Biochem Biophys Res Commun . 2001 ; 289 ( 1 ): 39 - 43 .

Behrens P , Mathiak M , Mangold E , Kirdorf S , Wellmann A , Fogt F , et al . Stromal expression of invasion-promoting, matrix-degrading proteases MMP-1 and -9 and the Ets 1 transcription factor in HNPCC carcinomas and sporadic colorectal cancers . Int J Cancer . 2003 ; 107 ( 2 ): 183 - 8 .

Belaiba RS , Bonello S , Zähringer C , Schmidt S , Hess J , Kietzmann T , et al . Hypoxia up-regulates hypoxia-inducible factor-1α transcription by involving phosphatidyl inositol 3-kinase and nuclear factor κB in pulmonary artery smooth muscle cells . Mol Biol Cell . 2007 ; 18 ( 12 ): 4691 - 7 .

Rius J , Guma M , Schachtrup C , Akassoglou K , Zinkernagel AS , Nizet V , et al . NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α . Nature . 2008 ; 453 ( 7196 ): 807 - 11 .

Van Uden P , Kenneth NS , Rocha S . Regulation of hypoxia-inducible factor-1α by NF-κB . Biochem J . 2008 ; 412 ( 3 ): 477 - 84 .

Scortegagna M , Cataisson C , Martin RJ , Hicklin DJ , Schreiber RD , Yuspa SH , et al . HIF-1α regulates epithelial inflammation by cell autonomous NFκB activation and paracrine stromal remodeling . Blood . 2008 ; 111 ( 7 ): 3343 - 54 .

Karhausen J , Furuta GT , Tomaszewski JE , Johnson RS , Colgan SP , Haase VH . Epithelial hypoxia-inducible factor-1 is protective in murine experimental colitis . J Clin Invest . 2004 ; 114 ( 8 ): 1098 - 106 .

Donohoe DR , Collins LB , Wali A , Bigler R , Sun W , Bultman SJ . The Warburg effect dictates the mechanism of butyrate-mediated histone acetylation and cell proliferation . Mol Cell . 2012 ; 48 ( 4 ): 612 - 26 .

Chang X , Wei C . Glycolysis and rheumatoid arthritis . Int J Rheum Dis . 2011 ; 14 ( 3 ): 217 - 22 .

Dang EV , Barbi J , Yang H-Y , Jinasena D , Yu H , Zheng Y , et al . Control of T(H)17/T (reg) balance by hypoxia-inducible factor 1 . Cell . 2011 ; 146 ( 5 ): 772 - 84 .