Radiation-induced inflammation and autoimmune diseases

Rasoul Yahyapour; Peyman Amini; Saeed Rezapour; Mohsen Cheki; Abolhasan Rezaeyan; Bagher Farhood; Dheyauldeen Shabeeb; Ahmed Eleojo Musa; Hengameh Fallah; Masoud Najafi

doi:10.1186/s40779-018-0156-7

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Radiation-induced inflammation and autoimmune diseases

REVIEW | Updated：2026-03-12

- Radiation-induced inflammation and autoimmune diseases
- Radiation-induced inflammation and autoimmune diseases
- MMR 2018年5卷第1期页码：62-71
- Affiliations：
  
  1.School of Medicine, Jiroft University of Medical Sciences, Jiroft Zip code: 8813833435, Iran
  2.Department of Radiology, Faculty of Paramedical, Tehran University of Medical Sciences, Tehran Zip code: 1417613151, Iran
  3.Department of Radiologic Technology, Faculty of Paramedicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz Zip code: 6135715794, Iran
  4.Department of Medical Physics, School of Medicine, Iran University of Medical Sciences, Tehran Zip code: 1449614535, Iran
  5.Departments of Medical Physics and Radiology, Faculty of Paramedical Sciences, Kashan University of Medical Sciences, Kashan Zip code: 3715835155, Iran
  6.Department of Medical Physics and Biomedical Engineering, Faculty of Medicine, Tehran University of Medical Sciences (International Campus), Tehran Zip code: 1417613151, Iran
  7.Department of Physiology, College of Medicine, University of Misan, Misan, Iraq
  8.Research center for molecular and cellular imaging, Tehran University of Medical Sciences, Tehran Zip code: 1417613151, Iran
  9.Department of Chemistry, Faculty of Science, Islamic Azad University, Arak Zip code: 3836119131, Iran
  10.Radiology and Nuclear Medicine Department, School of Paramedical Sciences, Kermanshah University of Medical Science, Kermanshah Zip code: 6714869914, Iran
- Author bio：
  
  *: masoudnajafi67@yahoo.com
- Funds：
- DOI：10.1186/s40779-018-0156-7
  中图分类号：
- 纸质出版：2018-03
- Accepted：
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Radiation-induced inflammation and autoimmune diseases[J]. MMR, 2018,5(1):62-71.

Yahyapour et al.: Radiation-induced inflammation and autoimmune diseases. Mil Med Res, 2018, 5: 9
Radiation-induced inflammation and autoimmune diseases[J]. MMR, 2018,5(1):62-71. DOI： 10.1186/s40779-018-0156-7.

Yahyapour et al.: Radiation-induced inflammation and autoimmune diseases. Mil Med Res, 2018, 5: 9 DOI： 10.1186/s40779-018-0156-7.

摘要

Abstract

Currently

ionizing radiation (IR) plays a key role in the agricultural and medical industry

while accidental exposure resulting from leakage of radioactive sources or radiological terrorism is a serious concern. Exposure to IR has various detrimental effects on normal tissues. Although an increased risk of carcinogenesis is the best-known long-term consequence of IR

evidence has shown that other diseases

particularly diseases related to inflammation

are common disorders among irradiated people. Autoimmune disorders are among the various types of immune diseases that have been investigated among exposed people. Thyroid diseases and diabetes are two autoimmune diseases potentially induced by IR. However

the precise mechanisms of IR-induced thyroid diseases and diabetes remain to be elucidated

and several studies have shown that chronic increased levels of inflammatory cytokines after exposure play a pivotal role. Thus

cytokines

including interleukin-1(IL-1)

tumor necrosis factor (TNF-α) and interferon gamma (IFN-α)

play a key role in chronic oxidative damage following exposure to IR. Additionally

these cytokines change the secretion of insulin and thyroid-stimulating hormone(TSH). It is likely that the management of inflammation and oxidative damage is one of the best strategies for the amelioration of these diseases after a radiological or nuclear disaster. In the present study

we reviewed the evidence of radiation-induced diabetes and thyroid diseases

as well as the potential roles of inflammatory responses. In addition

we proposed that the mitigation of inflammatory and oxidative damage markers after exposure to IR may reduce the incidence of these diseases among individuals exposed to radiation.

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Keywords

references

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