Application of stem cells in tissue engineering for defense medicine
Application of stem cells in tissue engineering for defense medicine
- MMR 2018年5卷第2期 页码：140-158
- Affiliations：
1.Bio-artifical Organ and Regenerative Medicine Unit, National Defence University of Malaysia, Sungai Besi Camp, 57000 Kuala Lumpur, Malaysia
2.Department of Physiology, Pre-clinical Block, National University of Malaysia Medical Centre, Jalan Yaacob Latif, Bandar Tun Razak, 56000 Kuala Lumpur, Malaysia
- Author bio：
*: azizimis@gmail.com; azizimiskon@upnm.edu.my
- Funds：
DOI：10.1186/s40779-018-0154-9
中图分类号：-
纸质出版：2018-06
- Accepted：
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Application of stem cells in tissue engineering for defense medicine[J]. MMR, 2018,5(2):140-158.
Ude et al.: Application of stem cells in tissue engineering for defense medicine. Mil Med Res, 2018, 5: 7
Application of stem cells in tissue engineering for defense medicine[J]. MMR, 2018,5(2):140-158. DOI： 10.1186/s40779-018-0154-9.
Ude et al.: Application of stem cells in tissue engineering for defense medicine. Mil Med Res, 2018, 5: 7 DOI： 10.1186/s40779-018-0154-9.
摘要
Abstract
The dynamic nature of modern warfare
including threats and injuries faced by soldiers
necessitates the development of countermeasures that address a wide variety of injuries. Tissue engineering has emerged as a field with the potential to provide contemporary solutions. In this review
discussions focus on the applications of stem cells in tissue engineering to address health risks frequently faced by combatants at war. Human development depends intimately on stem cells
the mysterious precursor to every kind of cell in the body that
with proper instruction
can grow and differentiate into any new tissue or organ. Recent reports have suggested the greater therapeutic effects of the anti-inflammatory
trophic
paracrine and immune-modulatory functions associated with these cells
which induce them to restore normal healing and tissue regeneration by modulating immune reactions
regulating inflammation
and suppressing fibrosis. Therefore
the use of stem cells holds significant promise for the treatment of many battlefield injuries and their complications. These applications include the treatment of injuries to the skin
sensory organs
nervous system tissues
the musculoskeletal system
circulatory/pulmonary tissues and genitals/testicles and of acute radiation syndrome and the development of novel biosensors. The new research developments in these areas suggest that solutions are being developed to reduce critical consequences of wounds and exposures suffered in warfare. Current military applications of stem cell-based therapies are already saving the lives of soldiers who would have died in previous conflicts. Injuries that would have resulted in deaths previously now result in wounds today; similarly
today’s permanent wounds may be reduced to tomorrow’s bad memories with further advances in stem cell-based therapies.
关键词
Keywords
references
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