Biomarkers for patients with trauma associated acute respiratory distress syndrome

Wu-Jian Xu; Yong Song

doi:10.1186/s40779-017-0134-5

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Biomarkers for patients with trauma associated acute respiratory distress syndrome

REVIEW | Updated：2026-03-12

- Biomarkers for patients with trauma associated acute respiratory distress syndrome
- Biomarkers for patients with trauma associated acute respiratory distress syndrome
- MMR 2018年5卷第1期页码：72-78
- Affiliations：
  
  1.Department of Respiratory Medicine, Jinling Hospital, 305 Zhongshan Road, Nanjing 210002, China
  2.Nanjing University Institute of Respiratory Medicine, Nanjing 210002, China
- Author bio：
  
  *: yong_song6310@yahoo.com
- Funds：
  
  the National Natural Science Foundation of China(81370172;81570078);China Postdoctoral Science Foundation(2016 T1015)
- DOI：10.1186/s40779-017-0134-5
  中图分类号：
- 纸质出版：2018-03
- Accepted：
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Biomarkers for patients with trauma associated acute respiratory distress syndrome[J]. MMR, 2018,5(1):72-78.

Xu et al.: Biomarkers for patients with trauma associated acute respiratory distress syndrome. Mil Med Res, 2017, 4: 25
Biomarkers for patients with trauma associated acute respiratory distress syndrome[J]. MMR, 2018,5(1):72-78. DOI： 10.1186/s40779-017-0134-5.

Xu et al.: Biomarkers for patients with trauma associated acute respiratory distress syndrome. Mil Med Res, 2017, 4: 25 DOI： 10.1186/s40779-017-0134-5.

摘要

Abstract

Trauma is a major factor that contributes to the risk for acute respiratory distress syndrome (ARDS). Biomarkers that predict the risk

diagnosis

treatment response and prognosis of ARDS after trauma have been widely investigated. In addition to their applications in clinical diagnosis and treatment

these biomarkers provide important insights into our understanding of the pathogenesis of ARDS. This review begins with a brief introduction regarding the incidence and pathogenesis of trauma-associated ARDS. Then

we focus on reviewing the clinical trials that have been designed to investigate the value of biomarkers in ARDS after trauma. Biomarkers with a confirmed value in ARDS have been organized on the basis of key pathogenic processes that are central to ARDS and are described in detail. Among these

angiopoietin 2 (Ang-2)

L-selectin

Clara cell protein 16 (CC16)

soluable receptor for advanced glycation end products (sRAGE)

Surfactant protein D (SP-D)

histones

mtDNAs and some biomarker panels had a certain association with the diagnosis and prognosis of trauma-related ARDS. Further investigations are needed regarding the design of trials

the best sampling approaches and the optimal combinations of the biomarker panels.

关键词

Keywords

references

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