A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia

Jean-François Magnaval; Guy Laurent; Noémie Gaudré; Judith Fillaux; Antoine Berry

doi:10.1186/s40779-017-0124-7

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A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia

RESEARCH | Updated：2026-03-12

- A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia
- A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia
- MMR 2017年4卷第4期页码：181-192
- Affiliations：
  
  1.Department of Medical Parasitology, Faculty of Medicine, Toulouse University, 37 allees Jules-Guesde, Toulouse, France
  2.Purpan Center for Pathophysiology, INSERM UMR U1043, CNRS UMR 5282, Toulouse University, Toulouse, France
  3.Department of Hematology, Toulouse University Hospitals, Toulouse, France
  4.Cancer Institute, Toulouse University and Oncopole, Toulouse, France
  5.Department of Parasitology and Mycology, Toulouse University Hospitals, Toulouse, France
  6.PharmaDev, IRD UMR 152, Toulouse University, Toulouse, France
- Author bio：
  
  *: jean-francois.magnaval@univ-tlse3.fr
- Funds：
- DOI：10.1186/s40779-017-0124-7
  中图分类号：
- 纸质出版：2017-12
- Accepted：
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A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia[J]. MMR, 2017,4(4):181-192.

Magnaval et al.: A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia. Mil Med Res, 2017, 4: 15
A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia[J]. MMR, 2017,4(4):181-192. DOI： 10.1186/s40779-017-0124-7.

Magnaval et al.: A diagnostic protocol designed for determining allergic causes in patients with blood eosinophilia. Mil Med Res, 2017, 4: 15 DOI： 10.1186/s40779-017-0124-7.

摘要

Abstract

Background:

Blood eosinophilia is a common laboratory abnormality

and its characterization frequently represents a quandary for primary care physicians. Consequently

in France

specialists and particularly hematologists

often must investigate patients who present with blood eosinophilia that often

but not always

occurs because of allergic causes. Both the Departments of Hematology and Parasitology at Toulouse University Hospitals established a collaboration to rule out allergic causes of eosinophilia

particularly helminthiases

prior to initiating more sophisticated investigations.

Methods:

Since 2004

the authors employed the same protocol to investigate eosinophilic outpatients who attended the clinic of Parasitology at Toulouse University Hospitals

and they reported the performance of this diagnostic procedure that was designed to be rapid (no hospitalization required) and only moderately expensive.

Results:

A total of 406 patients who presented with blood eosinophilia greater than 0.5(×10

giga cells per litter

G/L) had an allergic etiology in 350(86.2%) cases. Among the remaining 56 subjects

17 did not undergo a follow-up and 39 were referred to another specialized department

mostly Hematology. However

only 21 patients attended then were subsequently investigated. Non-allergic causes of eosinophilia

including 3 cases of the lymphoid variant of hypereosinophilic syndrome and 2 cases of myeloproliferative disorder

were identified in 14 patients

whereas 7 remained diagnosed as having idiopathic eosinophilia.

Conclusion:

This study underlines the need to investigate patients presenting with even moderate blood eosinophilia. The work-up that was employed appears to be efficient and versatile and may be used by any medical specialist

such as in hematology

infectious disease

or internal medicine departments

who needs to investigate eosinophilic patients and should initially rule out any etiology of allergic eosinophilia.

关键词

Keywords

references

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