Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation

Zheng-Gang Wang; Hao Tan; Lian-Yang Zhang; Dao-Cheng Liu; Hua-Liang Xiao; Wen-Hua Du

doi:10.1186/2054-9369-1-4

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Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation

RESEARCH | Updated：2026-03-12

- Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation
- Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation
- MMR 2014年1卷第1期页码：37-43
- Affiliations：
  
  State Key Laboratory of Trauma, Burns and Combined Injury, Trauma Center, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing 400042, China
- Author bio：
  
  *: dpzhangly@163.com
- Funds：
- DOI：10.1186/2054-9369-1-4
  中图分类号：
- 纸质出版：2014-03
- Accepted：
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Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation[J]. MMR, 2014,1(1):37-43.

Wang et al.: Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation. Military Medical Research 2014, 1: 4
Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation[J]. MMR, 2014,1(1):37-43. DOI： 10.1186/2054-9369-1-4.

Wang et al.: Effect of intra-abdominal volume increment on kidneys in minipigs with intra-abdominal hypertension after hemorrhagic shock and resuscitation. Military Medical Research 2014, 1: 4 DOI： 10.1186/2054-9369-1-4.

摘要

Abstract

Background:

To investigate the effect of intra-abdominal volume increment (IAVI) on intra-abdominal hypertension (IAH) in the kidneys.

Methods:

Eight minipigs were successfully established as IAH models and were randomly divided into two groups: the IAVI group and the sham-operated group. The intravesical pressure

inferior vena cava pressure and urine volume were measured before shock

2 h after IAH

and 22 h after surgery

respectively. The following indices were measured: serum creatinine

urea nitrogen

renal cortical thickness

ratio of abdominal anteroposterior diameter/transverse diameter

renal thickness

diameter of the renal sinus and the wet/dry ratio of renal tissues.

Results:

The intravesical pressure (IVP) of the 8 minipig IAH models was calculated to be 21.16±4.63 mmHg. There was a significant increase in the abdominal anteroposterior diameter/transverse diameter ratio. The minipigs in the IAVI group survived during the observational period

whereas 2 minipigs died at 18 h and 20 h in the sham-operated group. Twenty-two hours after surgery

the animals in the IAVI group displayed increased urinary volume (UV) and decreased Cr and Ur and remarkable decreases of VP and IVCP. After IAH

the renal cortical thickness and the renal thickness increased significantly. The renal wet/dry ratio in the sham-operated group was higher than that in the IAVI group.

Conclusion:

IAVI helps to control renal dysfunction after IAH

which may be related to lowering the intra-abdominal pressure

thus alleviating renal edema and blood stasis.

关键词

Keywords

references

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