Effects and mechanisms of a microcurrent dressing on skin wound healing: a review
Effects and mechanisms of a microcurrent dressing on skin wound healing: a review
- MMR 2014年1卷第3期 页码：177-185
- Affiliations：
Beijing Institute of Radiation Medicine, Beijing 100850, China
- Author bio：
*: huzongqian@gmail.com;
pengry@bmi.ac.cn
- Funds：
DOI：10.1186/2054-9369-1-24
中图分类号：-
纸质出版：2014-09
- Accepted：
Scan QR Code
Effects and mechanisms of a microcurrent dressing on skin wound healing: a review[J]. MMR, 2014,1(3):177-185.
Yu et al.: Effects and mechanisms of a microcurrent dressing on skin wound healing: a review. Mil Med Res 2014, 1: 24
Effects and mechanisms of a microcurrent dressing on skin wound healing: a review[J]. MMR, 2014,1(3):177-185. DOI： 10.1186/2054-9369-1-24.
Yu et al.: Effects and mechanisms of a microcurrent dressing on skin wound healing: a review. Mil Med Res 2014, 1: 24 DOI： 10.1186/2054-9369-1-24.
摘要
Abstract
The variety of wound types has resulted in a wide range of wound dressings
with new products frequently being introduced to target different aspects of the wound healing process. The ideal wound dressing should achieve rapid healing at a reasonable cost
with minimal inconvenience to the patient. Microcurrent dressing
a novel wound dressing with inherent electric activity
can generate low-level microcurrents at the device-wound contact surface in the presence of moisture and can provide an advanced wound healing solution for managing wounds. This article offers a review of the effects and mechanisms of the microcurrent dressing on the healing of skin wounds.
关键词
Keywords
references
Reid B , Zhao M : The electrical response to injury: Molecular mechanisms and wound healing . Adv Wound Care 2014 , 3 : 184 - 201 .
Vieira AC , Reid B , Cao L , Mannis MJ , Schwab IR , Zhao M : Ionic components of electric current at rat corneal wounds . PLoS One 2011 , 6 : e17411 .
Ly M , Poole-Warren L : Acceleration of wound healing using electrical fields: Time for a stimulating discussion . Wound Pract Res 2008 , 16 : 138 .
Feedar JA , Kloth LC , Gentzkow GD : Chronic dermal ulcer healing enhanced with monophasic pulsed electrical stimulation . Phys Ther 1991 , 71 : 639 - 649 .
Franek A , Kostur R , Polak A , Taradaj J , Szlachta Z , Blaszczak E , Dolibog P , Dolibog P , Koczy B , Kucio C : Using high voltage electrical stimulation in the treatment of recalcitrant pressure ulcers: results of a randomized, controlled clinical study . Ostomy Wound Manage 2012 , 58 : 30 - 44 .
Polak A , Franek A , Taradaj J : High voltage pulsed current electrical stimulation in wound treatment . Adv Wound Care 2014 , 3 : 104 - 117 .
Houghton PE : Clinical trials involving biphasic pulsed current, microcurrent, and/or low-intensity direct current . Adv Wound Care 2014 , 3 : 166 - 183 .
Department of Health and Human Services (DHHS) : Centers for Medicare and Medicaid Services, CMS Manual System. Pub. 100-03 Medicare national coverage determinations. 1/270. 1/Electrical stimulation (ES) and electromagnetic therapy for the treatment of wounds . Baltimore, MD : Centers for Medicare and Medicaid services . 2004 .
Levin M : Bioelectric mechanisms in regeneration: Unique aspects and future perspectives . Semin Cell Dev Biol 2009 , 20 : 543 - 556 .
Isseroff RR , Dahle SE : Electrical stimulation therapy and wound healing: Where are we now? Adv Wound Care 2012 , 1 : 238 - 243 .
Kloth LC : Electrical stimulation technologies for wound healing . Adv Wound Care (New Rochelle) 2014 , 3 : 81 - 90 .
Barnes R , Shahin Y , Gohil R , Chetter I : Electrical stimulation vs. standard care for chronic ulcer healing: A systematic review and meta-analysis of randomised controlled trials . Eur J Clin Invest 2014 , 44 : 429 - 440 .
de Gd GFO , Foglio MA , de Carvalho JE , Santos GM , Testa M , Passarini JR , de Moraes CP , Esquisatto MA , Mendonca JS , Mendonca FA : Effects of the topical application of hydroalcoholic leaf extract of Oncidium flexuosum Sims. (Orchidaceae) and microcurrent on the healing of wounds surgically induced in Wistar rats . Evid Based Complement Alternat Med 2011 , 2011 : 950347 .
Borba GC , Hochman B , Liebano RE , Enokihara MM , Ferreira LM : Does preoperative electrical stimulation of the skin alter the healing process? J Surg Res 2011 , 166 : 324 - 329 .
Sundelacruz S , Li C , Choi YJ , Levin M , Kaplan DL : Bioelectric modulation of wound healing in a 3D in vitro model of tissue-engineered bone . Biomaterials 2013 , 34 : 6695 - 6705 .
Li L , Gu W , Du J , Reid B , Deng X , Liu Z , Zong Z , Wang H , Yao B , Yang C , Yan J , Zeng L , Chalmers L , Zhao M , Jiang J : Electric fields guide migration of epidermal stem cells and promote skin wound healing . Wound Repair Regen 2012 , 20 : 840 - 851 .
Zhao Z , Qin L , Reid B , Pu J , Hara T , Zhao M : Directing migration of endothelial progenitor cells with applied DC electric fields . Stem Cell Res 2012 , 8 : 38 - 48 .
Schreml S , Klein SM , Babilas P , Karrer S : Wound dressings in chronic wound therapy . Phlebologie 2013 , 42 : 189 - 196 .
Gurtner GC , Werner S , Barrandon Y , Longaker MT : Wound repair and regeneration . Nature 2008 , 453 : 314 - 321 .
Kaur S , Lyte P , Garay M , Liebel F , Sun Y , Liu JC , Southall MD : Galvanic zinc-copper microparticles produce electrical stimulation that reduces the inflammatory and immune responses in skin . Arch Dermatol Res 2011 , 303 : 551 - 562 .
Cook HA , Morales M , La Rosa EM , Dean J , Donnelly MK , McHugh P , Otradovec A , Wright KS , Kula T , Tepper SH : Effects of electrical stimulation on lymphatic flow and limb volume in the rat . Phys Ther 1994 , 74 : 1040 - 1046 .
Daeschlein G , Assadian O , Kloth LC , Meinl C , Ney F , Kramer A : Antibacterial activity of positive and negative polarity low-voltage pulsed current (LVPC) on six typical Gram-positive and Gram-negative bacterial pathogens of chronic wounds . Wound Repair Regen 2007 , 15 : 399 - 403 .
Demir H , Balay H , Kirnap M : A comparative study of the effects of electrical stimulation and laser treatment on experimental wound healing in rats . J Rehabil Res Dev 2004 , 41 : 147 - 154 .
Lee JW , Yoon SW , Kim TH , Park SJ : The effects of microcurrents on inflammatory reaction induced by ultraviolet irradiation . J Phys Ther Sci 2011 , 23 : 693 - 696 .
Blount AL , Foster S , Rapp DA , Wilcox R : The use of bioelectric dressings in skin graft harvest sites: A prospective case series . J Burn Care Res 2012 , 33 : 354 - 357 .
Kondo T : Timing of skin wounds . Legal Med 2007 , 9 : 109 - 114 .
Demidova-Rice TN , Durham JT , Herman IM : Wound healing angiogenesis: Innovations and challenges in acute and chronic wound healing . Adv Wound Care 2012 , 1 : 17 - 22 .
Jung M , Lord MS , Cheng B , Lyons JG , Alkhouri H , Hughes JM , McCarthy SJ , Iozzo RV , Whitelock JM : Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: A role in angiogenesis and wound healing . J Bio Chem 2013 , 288 : 3289 - 3304 .
Zhao M , Bai H , Wang E , Forrester JV , McCaig CD : Electrical stimulation directly induces pre-angiogenic responses in vascular endothelial cells by signaling through VEGF receptors . J Cell Sci 2004 , 117 : 397 - 405 .
Park RJ , Son H , Kim K , Kim S , Oh T : The effect of microcurrent electrical stimulation on the foot blood circulation and pain of diabetic neuropathy . J Phys Ther Sci 2011 , 23 : 515 - 518 .
Clarke Moloney M , Lyons G , Breen P , Burke P , Grace P : Haemodynamic study examining the response of venous blood flow to electrical stimulation of the gastrocnemius muscle in patients with chronic venous disease . Eur J Vasc Endovasc 2006 , 31 : 300 - 305 .
McDougall S , Dallon J , Sherratt J , Maini P : Fibroblast migration and collagen deposition during dermal wound healing: mathematical modelling and clinical implications . Philos T R Soc A 2006 , 364 : 1385 - 1405 .
Jennings J , Chen D , Feldman D : Transcriptional response of dermal fibroblasts in direct current electric fields . Bioelectromagnetics 2008 , 29 : 394 - 405 .
Alvarez OM , Mertz PM , Smerbeck RV , Eaglstein WH : The healing of superficial skin wounds is stimulated by external electrical current . J Invest Dermatol 1983 , 81 : 144 - 148 .
Sugimoto M , Maeshige N , Honda H , Yoshikawa Y , Uemura M , Yamamoto M , Terashi H : Optimum microcurrent stimulation intensity for galvanotaxis in human fibroblasts . J Wound Care 2012 , 21 : 5 - 10 .
Tandon N , Cimetta E , Villasante A , Kupferstein N , Southall MD , Fassih A , Xie J , Sun Y , Vunjak-Novakovic G : Galvanic microparticles increase migration of human dermal fibroblasts in a wound-healing model via reactive oxygen species pathway . Exp Cell Res 2014 , 320 : 79 - 91 .
Nishimura KY , Isseroff RR , Nuccitelli R : Human keratinocytes migrate to the negative pole in direct current electric fields comparable to those measured in mammalian wounds . J Cell Sci 1996 , 109 : 199 - 207 .
Banerjee J , Das Ghatak P , Roy S , Khanna S , Sequin EK , Bellman K , Dickinson BC , Suri P , Subramaniam VV , Chang CJ , Sen CK : Improvement of human keratinocyte migration by a redox active bioelectric dressing . PLoS One 2014 , 9 : e89239 .
Varhus JD : A novel bioelectric device enhances wound healing: An equine case series . J Equine Vet Sci 2014 , 34 : 421 - 430 .
Harding AC , Gil J , Valdes J , Solis M , Davis SC : Efficacy of a bio-electric dressing in healing deep, partial-thickness wounds using a porcine model . Ostomy Wound Manage 2012 , 58 : 50 - 55 .
Obradovic Wagner D , Sieber C , Bhushan R , Borgermann JH , Graf D , Knaus P : BMPs: from bone to body morphogenetic proteins . Sci Signal 2010 , 3 : mr1 .
Botchkarev VA : Bone morphogenetic proteins and their antagonists in skin and hair follicle biology . J Invest Dermatol 2003 , 120 : 36 - 47 .
Camaschella C : BMP6 orchestrates iron metabolism . Nature genetics 2009 , 41 : 386 - 388 .
Miyazono K , Kamiya Y , Morikawa M : Bone morphogenetic protein receptors and signal transduction . J Biochem 2010 , 147 : 35 - 51 .
Owens P , Han G , Li AG , Wang X-J : The role of Smads in skin development . J Invest Dermatol 2008 , 128 : 783 - 790 .
Rotzer D , Krampert M , Sulyok S , Braun S , Stark H , Boukamp P , Werner S : Id proteins: novel targets of activin action, which regulate epidermal homeostasis . Oncogene 2005 , 25 : 2070 - 2081 .
Han G , Li F , ten Dijke P , Wang X-J : Temporal smad7 transgene induction in mouse epidermis accelerates skin wound healing . Am J Pathol 2011 , 179 : 1768 - 1779 .
Hayden MS , Ghosh S : NF-κB in immunobiology . Cell Res 2011 , 21 : 223 - 244 .
Mulero MC , Bigas A , Espinosa L : IκBα beyond the NF-kB dogma . Oncotarget 2013 , 4 : 1550 .
Liu S , Chen ZJ : Expanding role of ubiquitination in NF-κB signaling . Cell Res 2010 , 21 : 6 - 21 .
Shah V , Ferguson J , Hunsaker L , Deck L , Vander Jagt D : Cardiac glycosides inhibit LPS-induced activation of pro-inflammatory cytokines in whole blood through an NF-kB-dependent mechanism . Int J App Res Natural Products 2011 , 4 : 11 - 19 .
Kitamura M : Control of NF-κB and inflammation by the unfolded protein response . Int Rev Immunol 2011 , 30 : 4 - 15 .
Iglesias PA , Devreotes PN : Navigating through models of chemotaxis . Curr Opin Cell Biol 2008 , 20 : 35 - 40 .
Jin T : Gradient sensing during chemotaxis . Curr Opin Cell Biol 2013 , 25 : 532 - 537 .
Zhao M , Song B , Pu J , Wada T , Reid B , Tai G , Wang F , Guo A , Walczysko P , Gu Y , Sasaki T , Suzuki A , Forrester JV , Bourne HR , Devreotes PN , McCaig CD , Penninger JM : Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN . Nature 2006 , 442 : 457 - 460 .
Huttenlocher A , Horwitz AR : Wound healing with electric potential . N Engl J Med 2007 , 356 : 303 .
Vanhaesebroeck B : Charging the batteries to heal wounds through PI3K . Nat Chem Biol 2006 , 2 : 453 - 455 .
Fang KS , Ionides E , Oster G , Nuccitelli R , Isseroff RR : Epidermal growth factor receptor relocalization and kinase activity are necessary for directional migration of keratinocytes in DC electric fields . J Cell Sci 1999 , 112 : 1967 - 1978 .
Liebano RE , Machado AF : Vascular endothelial growth factor release following electrical stimulation in human subjects . Adv Wound Care 2014 , 3 : 98 - 103 .
Bai H , Forrester JV , Zhao M : DC electric stimulation upregulates angiogenic factors in endothelial cells through activation of VEGF receptors . Cytokine 2011 , 55 : 110 - 115 .
Asadi MR , Torkaman G , Hedayati M : Effect of sensory and motor electrical stimulation in vascular endothelial growth factor expression of muscle and skin in full-thickness wound . J Rehabil Res Dev 2011 , 48 : 195 - 201 .
Ferroni P , Roselli M , Guadagni F , Martini F , Mariotti S , Marchitelli E , Cipriani C : Biological effects of a software-controlled voltage pulse generator (PhyBack PBK-2C) on the release of vascular endothelial growth factor (VEGF) . In Vivo 2005 , 19 : 949 - 958 .
Sebastian A , Syed F , Perry D , Balamurugan V , Colthurst J , Chaudhry IH , Bayat A : Acceleration of cutaneous healing by electrical stimulation: Degenerate electrical waveform down-regulates inflammation, up-regulates angiogenesis and advances remodeling in temporal punch biopsies in a human volunteer study . Wound Repair Regen 2011 , 19 : 693 - 708 .
Fu D , Mitra K , Sengupta P , Jarnik M , Lippincott-Schwartz J , Arias IM : Coordinated elevation of mitochondrial oxidative phosphorylation and autophagy help drive hepatocyte polarization . Proc Natl Acad Sci U S A 2013 , 110 : 7288 - 7293 .
Mailer K : Superoxide radical as electron donor for oxidative phosphorylation of ADP . Biochem Biophys Res Commun 1990 , 170 : 59 - 64 .
Nie Y , Wong C : Suppressing the activity of ERRα in 3 T3-L1 adipocytes reduces mitochondrial biogenesis but enhances glycolysis and basal glucose uptake . J Cell Mol Med 2009 , 13 : 3051 - 3060 .
Cheng N , Van Hoof H , Bockx E , Hoogmartens MJ , Mulier JC , De Dijcker FJ , Sansen WM , De Loecker W : The effects of electric currents on ATP generation, protein synthesis, and membrane transport in rat skin . Clin Orthop Relat Res 1982 , 171 : 264 - 272 .
0
浏览量
0
Downloads
0
CSCD
- 网络PDF下载
- Meta-XML下载
- BibTeX下载
- Endnote下载
- RefMan 下载
- NoteExpress下载
- NoteFirst下载
关联资源
相关文章
相关作者
相关机构
- 技术支持由北京北大方正电子有限公司提供 京ICP备09064830号-19
京公网安备11010802024621 - 本系统建议在Chrome、 IE9+ 以上版本浏览器阅读本站内容，360浏览器请切换至极速模式
- Cookies帮助我们提供服务并提供个性化体验。使用本网站，即表示您同意我们使用Cookies