Department of Microbiology and Immunology, Burns Institute, First Hospital Affiliated to the Chinese PLA General Hospital, Beijing 100048, China
*: c_ff@sina.com
纸质出版:2014-06
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Septic encephalopathy: When cytokines interact with acetylcholine in the brain[J]. MMR, 2014,1(2):115-124.
Zhang et al.: Septic encephalopathy: when cytokines interact with acetylcholine in the brain. Mil Med Res 2014, 1: 20
Septic encephalopathy: When cytokines interact with acetylcholine in the brain[J]. MMR, 2014,1(2):115-124. DOI: 10.1186/2054-9369-1-20.
Zhang et al.: Septic encephalopathy: when cytokines interact with acetylcholine in the brain. Mil Med Res 2014, 1: 20 DOI: 10.1186/2054-9369-1-20.
Sepsis-associated encephalopathy (SAE) is a brain dysfunction that occurs secondary to infection in the body
characterized by alteration of consciousness
ranging from delirium to coma
seizure or focal neurological signs. SAE involves a number of mechanisms
including neuroinflammation
in which the interaction between cytokines and acetylcholine results in neuronal loss and alterations in cholinergic signaling. Moreover
the interaction also occurs in the periphery
accelerating a type of immunosuppressive state. Although its diagnosis is not specific in biochemistry and imaging tests
it could potentiate severe outcomes
including increased mortality
cognitive decline
progressive immunosuppression
cholinergic anti-inflammatory deficiency
and even metabolic and hydroelectrolyte imbalance. Therefore
the bilateral communication between SAE and the multiple peripheral organs and especially the immune system should be emphasized in sepsis management.
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