ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in <italic style="font-style: italic">Klebsiella pneumoniae</italic>-induced sepsis

Li-Ting Deng; Huan Yang; Xu-Fei Zhang; Ze-Xing Lin; Ni Kuang; Hai-Yang Jiang; Pei-Zhao Liu; Yang-Guang Li; Xuan-Heng Li; Wei-Zhen Li; Chu-Jun Ni; Ming-Jie Qiu; Yue Chao; Yu-Fei Pan; Yi-Yu Yang; Ye-Ting Zhu; Yun Zhao; Jian-An Ren; Xiu-Wen Wu

doi:10.1016/j.mmr.2026.100059

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ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis

RESEARCH | Updated：2026-08-21

- ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis
- ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis
- 军事医学研究（英文） 2026年
- Affiliations：
  
  School of Medicine, Southeast University, Nanjing 210009, China
  Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210002, China
  Department of General Surgery, Clinical Translational Research Center for Surgical Infection and Immunity, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing 210026, China
  Department of General Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China
  Department of Infectious Diseases, Chongqing Key Laboratory for Research of Infectious Diseases, Southwest Hospital, Army Medical University, Chongqing 400038, China
  Department of Emergency Surgery, the Affiliated Hospital of Qingdao University, Qingdao 266000, Shandong, China
  Nanjing Medical University, Nanjing 210000, China
  Nanjing Medical Key Laboratory of Laryngopharynx-Head and Neck Oncology, the Affiliated BenQ Hospital of Nanjing Medical University, Nanjing 210026, China
- Author bio：
  
  *Yun Zhao, zhaoyun@njmu.edu.cn;
  Jian-An Ren, jiananr@nju.edu.cn;
  Xiu-Wen Wu, wuxiuwen@nju.edu.cn
- Funds：
  
  the National Natural Science Foundation of China(82272237;82430083);the Jiangsu Provincial Distinguished Young Scholar Program(BK20250108);the Jiangsu Provincial Medical Innovation Center(CXZX202217)
- DOI：10.1016/j.mmr.2026.100059
  中图分类号：
- 收稿：2025-05-14，
  
  录用：2026-07-24，
  
  纸质出版：2026-07
- Accepted：
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Li-Ting Deng, Huan Yang, Xu-Fei Zhang, 等. ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis[J/OL]. 军事医学研究（英文）, 2026. DOI: 10.1016/j.mmr.2026.100059.

Deng LT, Yang H, Zhang XF, Lin ZX, Kuang N, Jiang HY, et al. ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis. Mil Med Res. 2026;13(1):100059.
Li-Ting Deng, Huan Yang, Xu-Fei Zhang, 等. ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis[J/OL]. 军事医学研究（英文）, 2026. DOI: 10.1016/j.mmr.2026.100059. DOI：

Deng LT, Yang H, Zhang XF, Lin ZX, Kuang N, Jiang HY, et al. ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis. Mil Med Res. 2026;13(1):100059. DOI： 10.1016/j.mmr.2026.100059.

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ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis

ZBP1 activated by mitochondrial damage binds to STAT3 to suppress Legumain production and exacerbate macrophage inflammation in Klebsiella pneumoniae-induced sepsis

DOI：10.1016/j.mmr.2026.100059