Downregulation of FTO aggravates osteoarthritis with obesity by erasing m<sup>6</sup>A methylation of PDP2

Xu-Ying Sun; Jing-Yue Su; Xin Chen; Yi-Xin Yang; Sheng-Wu Yang; Chun-Wu Zhang; Yu-Sheng Li; Jian Xu; Zhen-Han Deng

doi:10.1016/j.mmr.2026.100054

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Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2

RESEARCH | Updated：2026-08-21

- Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2
- Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2
- 军事医学研究（英文） 2026年
- Affiliations：
  
  Department of Orthopedics, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  Department of Orthopedics, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  Geriatrics Center, the First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang, China
  Department of Epidemiology, University of California, Los Angeles, CA 90095, USA
  Department of Orthopedics, Xiangya Hospital, Central South University, Changsha 410008, China
  Department of Orthopedics, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
- Author bio：
  
  Jian Xu, 0022029@zju.edu.cn
  *Zhen-Han Deng, dengzhenhan@wmu.edu.cn;
- Funds：
  
  the National Natural Science Foundation of China(82472495;82472559);the Medical and Health Research Project of Zhejiang Province(2024KY1270);the Key Discipline of Traditional Chinese Medicine of Zhejiang Province-Clinical Integration of Chinese and Western Medicine (TCM Orthopedics and Traumatology) of the First Affiliated Hospital of Wenzhou Medical University(2024-XK-50);Zhejiang Clinovation Pride (Fragility Fracture Primary Osteoporosis);the Provincial Advantageous Characteristic Discipline of Wenzhou Medical University (Clinical Medicine)
- DOI：10.1016/j.mmr.2026.100054
  中图分类号：
- 收稿：2025-03-13，
  
  录用：2026-07-09，
  
  纸质出版：2026-07
- Accepted：
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Xu-Ying Sun, Jing-Yue Su, Xin Chen, 等. Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2[J/OL]. 军事医学研究（英文）, 2026. DOI: 10.1016/j.mmr.2026.100054.

Sun XY, Su JY, Chen X, Yang YX, Yang SW, Zhang CW, et al. Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2. Mil Med Res. 2026;13(1):100054. DOI: 10.1016/j.mmr.2026.100054.
Xu-Ying Sun, Jing-Yue Su, Xin Chen, 等. Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2[J/OL]. 军事医学研究（英文）, 2026. DOI: 10.1016/j.mmr.2026.100054. DOI：

Sun XY, Su JY, Chen X, Yang YX, Yang SW, Zhang CW, et al. Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2. Mil Med Res. 2026;13(1):100054. DOI: 10.1016/j.mmr.2026.100054. DOI：

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Downregulation of FTO aggravates osteoarthritis with obesity by erasing m6A methylation of PDP2

Downregulation of FTO aggravates osteoarthritis with obesity by erasing m6A methylation of PDP2

DOI：10.1016/j.mmr.2026.100054

Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2

Downregulation of FTO aggravates osteoarthritis with obesity by erasing m⁶A methylation of PDP2