A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation

Valentina Mastrorilli; Siro Luvisetto; Veronica Ruggieri; Giada Raparelli; Luca Madaro; Lucia Amalia Paggi; Chiara Parisi; Francesca De Santa; Federica De Angelis; Annunziata D’Elia; Roberto Massari; Susanna Amadio; Ornella Rossetto; Valentina Vacca; Maurizia Caruso; Gianluca Sferrazza; Flaminia Pavone; Sara Marinelli

doi:10.1016/j.mmr.2026.100049

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A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation

RESEARCH | Updated：2026-08-21

- A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation
- A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation
- 军事医学研究（英文） 2026年
- Affiliations：
  
  National Research Council of Italy, Institute of Biochemistry and Cell Biology, 00015 Monterotondo (RM), Italy
  Department of Anatomical, Histological, Forensic Sciences and Orthopedics, Sapienza University of Rome, 00161 Rome, Italy
  Laboratory affiliated to Istituto Pasteur Italia-Fondazione Cenci Bolognetti, 00161 Rome, Italy
  Department of Biological, Geological, and Environmental Sciences, Alma Mater Studiorum University of Bologna, 40126 Bologna, Italy
  Cellular Neurobiology Unit, Santa Lucia Foundation, 00179 Rome, Italy
  Department of Biomedical Sciences, University of Padova and National Research Council of Italy, Institute of Neuroscience, 35131 Padova, Italy
  Department of Biomedical Science, National Research Council of Italy, 00185 Rome, Italy
- Author bio：
  
  *Sara Marinelli, sara.marinelli@cnr.it
- Funds：
  
  the 2021 SCI-BTXA PoC MISE - Proof of Concept – Italian Ministry of Economic Development (to Sara Marinelli);the French Muscular Dystrophy Association (AFM-Telethon) Research Grant(#24349);the “Progetti di Ricerca di Rilevante Interesse Nazionale” (PRIN) 2022(2022WN338R)
- DOI：10.1016/j.mmr.2026.100049
  中图分类号：
- 收稿：2025-08-21，
  
  录用：2026-06-23，
  
  纸质出版：2026-06
- Accepted：
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Valentina Mastrorilli, Siro Luvisetto, Veronica Ruggieri, 等. A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation[J/OL]. 军事医学研究（英文）, 2026.

Mastrorilli V, Luvisetto S, Ruggieri V, Raparelli G, Madaro L, Amalia Paggi L, et al. A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation. Mil Med Res. 2026;13(1):100049.
Valentina Mastrorilli, Siro Luvisetto, Veronica Ruggieri, 等. A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation[J/OL]. 军事医学研究（英文）, 2026. DOI： 10.1016/j.mmr.2026.100049.

Mastrorilli V, Luvisetto S, Ruggieri V, Raparelli G, Madaro L, Amalia Paggi L, et al. A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation. Mil Med Res. 2026;13(1):100049. DOI： 10.1016/j.mmr.2026.100049.

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A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation

A translational preclinical strategy for chronic spinal cord injury: neuroprotective and regenerative potential of botulinum neurotoxin type A combined with muscle atrophy prevention via electrostimulation

DOI：10.1016/j.mmr.2026.100049