Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

Jing Feng; Yan-Hong Liu; Li-Ming Gong; Wen-Xuan Zhang; Chen-Fei Liu; Cong-Cong Xiao; Li-Qing Chen; Ming-Ji Jin; You-Yan Guan; Zhong-Gao Gao; Wei Huang

doi:10.1016/j.mmr.2026.100036

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Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

RESEARCH | Updated：2026-06-12

- Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer
- Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer
- 军事医学研究（英文） 2026年
- Affiliations：
  
  State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  Beijing Key Laboratory of Key Technologies for Natural Drug Delivery and Novel Formulations, Department of Pharmaceutics, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China
  Department of Pharmacy, the Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School of Nanjing Medical University, Suzhou 215000, Jiangsu, China
  Department of Urology, National Cancer Center, National Clinical Research Center for Cancer, Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100021, China
- Author bio：
  
  *Corresponding author: You-Yan Guan, guanyouyan@cicams.ac.cn;
  Zhong-Gao Gao, zggao@imm.ac.cn;
  Wei Huang, huangwei@imm.ac.cn
- Funds：
  
  the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (CIFMS)(2021-I2M-1-026)
- DOI：10.1016/j.mmr.2026.100036
  中图分类号：
- 收稿：2025-05-12，
  
  录用：2026-04-19，
  
  纸质出版：2026-05
- Accepted：
Scan QR Code
Jing Feng, Yan-Hong Liu, Li-Ming Gong, 等. Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer[J/OL]. 军事医学研究（英文）, 2026.

Feng J, Liu YH, Gong LM, Zhang WX, Liu CF, Xiao CC, et al. Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer. Mil Med Res. 2026;13(1):100036.
Jing Feng, Yan-Hong Liu, Li-Ming Gong, 等. Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer[J/OL]. 军事医学研究（英文）, 2026. DOI： 10.1016/j.mmr.2026.100036.

Feng J, Liu YH, Gong LM, Zhang WX, Liu CF, Xiao CC, et al. Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer. Mil Med Res. 2026;13(1):100036. DOI： 10.1016/j.mmr.2026.100036.

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Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

Targeting intratumoral bacteria reverses MHC-I suppression and enhances nano-based chemoimmunotherapy in colorectal cancer

DOI：10.1016/j.mmr.2026.100036