Type 2 diabetes does not inevitably shorten life expectancy

Huai-Dong Du

doi:10.1016/j.mmr.2026.100029

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Type 2 diabetes does not inevitably shorten life expectancy

COMMENTARY | Updated：2026-05-11

- Type 2 diabetes does not inevitably shorten life expectancy
- Type 2 diabetes does not inevitably shorten life expectancy
- 军事医学研究（英文） 2026年
- Affiliations：
  
  Clinical Trial Service Unit and Epidemiological Studies Unit, Nuffield Department of Population Health, University of Oxford, Oxford OX3 7LF, UK
- Author bio：
  
  *Huai-Dong Du, Huaidong.du@ndph.ox.ac.uk
- Funds：
- DOI：10.1016/j.mmr.2026.100029
  中图分类号：
- 收稿：2026-03-23，
  
  录用：2026-03-26，
  
  纸质出版：2026-04
- Accepted：
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Huai-Dong Du. Type 2 diabetes does not inevitably shorten life expectancy[J/OL]. 军事医学研究（英文）, 2026.

Du HD. Type 2 diabetes does not inevitably shorten life expectancy. Mil Med Res. 2026;13(1):100029.
Huai-Dong Du. Type 2 diabetes does not inevitably shorten life expectancy[J/OL]. 军事医学研究（英文）, 2026. DOI： 10.1016/j.mmr.2026.100029.

Du HD. Type 2 diabetes does not inevitably shorten life expectancy. Mil Med Res. 2026;13(1):100029. DOI： 10.1016/j.mmr.2026.100029.

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references

Bragg F , Holmes MV , Iona A , Guo Y , Du H , Chen Y , et al . Association between diabetes and cause-specific mortality in rural and urban areas of China . JAMA . 2017 ; 317 ( 3 ): 280 - 9 .

Qiu ZX , Qian F , Zhang YB , Liu J , Geng TT , Li R , et al . Risk factor control in relation to mortality and life expectancy among people with type 2 diabetes: results from 3 nationwide cohort studies . Mil Med Res . 2025 ; 12 ( 1 ): 89 .

Lean ME , Leslie WS , Barnes AC , Brosnahan N , Thom G , McCombie L , et al . Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial . Lancet . 2018 ; 391 ( 10120 ): 541 - 51 .

Taheri S , Zaghloul H , Chagoury O , Elhadad S , Ahmed SH , El Khatib N , et al . Effect of intensive lifestyle intervention on bodyweight and glycaemia in early type 2 diabetes (DIADEM-I): an open-label, parallel-group, randomised controlled trial . Lancet Diabetes Endocrinol . 2020 ; 8 ( 6 ): 477 - 89 .

Bhaskaran K , Dos-Santos-Silva I , Leon DA , Douglas IJ , Smeeth L . Association of BMI with overall and cause-specific mortality: a population-based cohort study of 3.6 million adults in the UK . Lancet Diabetes Endocrinol . 2018 ; 6 ( 12 ): 944 - 53 .

Iona A , Bragg F , Guo Y , Yang L , Chen Y , Pei P , et al . Adiposity and risks of vascular and non-vascular mortality among Chinese adults with type 2 diabetes: a 10-year prospective study . BMJ Open Diabetes Res Care . 2022 ; 10 ( 1 ): e002489 .

Lean ME , Leslie WS , Barnes AC , Brosnahan N , Thom G , McCombie L , et al . 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study . Lancet Diabetes Endocrinol . 2024 ; 12 ( 4 ): 233 - 46 .

Frias JP , Davies MJ , Rosenstock J , Perez Manghi FC , Fernandez Lando L , Bergman BK , et al . Tirzepatide versus semaglutide once weekly in patients with type 2 diabetes . N Engl J Med . 2021 ; 385 ( 6 ): 503 - 15 .

Lincoff AM , Brown-Frandsen K , Colhoun HM , Deanfield J , Emerson SS , Esbjerg S , et al . Semaglutide and cardiovascular outcomes in obesity without diabetes . N Engl J Med . 2023 ; 389 ( 24 ): 2221 - 32 .

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