Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding

Bing Xie; Ming Liang; Da-Peng Zhou; Wen Zhao; Jing-Yang Sun; Jing-Jing Rong; Jing Tian

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Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding

RESEARCH | Updated：2026-03-12

- Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding
- Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding
- MMR 2016年3卷第2期页码：80-86
- Affiliations：
  
  1.Department of Orthopedics, General Hospital of Shenyang Military Region, Shenyang 110016, China
  2.Department of Cardiology, General Hospital of Shenyang Military Region, Shenyang 110016, China
- Author bio：
  
  *: bone@medmail.com.cn
- Funds：
- DOI：
  中图分类号：
- 纸质出版：2016-06
- Accepted：
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Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding[J]. MMR, 2016,3(2):80-86.

Bing Xie, Ming Liang, Da-Peng Zhou, et al. Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding[J]. Military Medical Research, 2016, 3(2): 80-86.
Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding[J]. MMR, 2016,3(2):80-86. DOI：

Bing Xie, Ming Liang, Da-Peng Zhou, et al. Effects of internal iliac artery embolization on systemic inflammatory response syndrome in dogs with simulated-pelvic-fracture combined with massive bleeding[J]. Military Medical Research, 2016, 3(2): 80-86. DOI：

摘要

Abstract

Background:

Pelvic fracture combined with massive bleeding (PFCMB) is a complex issue in clinical practice. Currently

the use of angiography and embolization for the treatment of PFCMB obtains good results. The aim of this study is to observe the effects of early internal iliac artery embolization on the systemic inflammatory response syndrome (SIRS) in dogs with simulated-pelvic-fracture combined with massive bleeding.

Methods:

Twenty adult dogs were randomly divided into an embolization group (EG) and a control group (CG). For the two groups

heart rate

respiratory rate and body temperature and other physiological variables were measured

and IL-6

TNF-α and arterial blood gas levels were monitored. These variables were assayed every 30min until death in the CG

while dogs in the EG underwent arterial angiography after 60min of modeling. The internal iliac artery was embolized on the injured side.

Results:

The average time to SIRS in the CG was 3.56h

occurring at a rate of 90%(9/10) within 24h

with a mortality rate of 50%(5/10); the average time to SIRS for the EG was 5.33h

occurring at a rate of 30%(3/10) within 24h

with a mortality rate of 10%(1/10). When SIRS occurred in the EG

the mean plasma IL-6 level was 52.66±7.38pg/ml and the TNF-α level was 11.45±2.72ng/ml

showing a significant difference with those of the CG (

0.05). In the two groups

the respiratory rate and leukocyte levels were higher at each monitored time after modeling than those before modeling; the mean arterial pressure

levels of hemoglobin and oxygen partial pressure were significantly lower at each time point after modeling than those before modeling except for the mean arterial pressure at 0h in EG; the platelet levels at 4 and 8h were higher than those before modeling; and the differences were statistically significant (

0.05). In the EG

the mean arterial pressure

heart rate

respiratory rate and hemoglobin levels at 2

4 and 8h were lower than those at 0h; the levels of leukocytes

platelets and carbon dioxide partial pressure at 4 and 8h after modeling were higher than those at 0h

and the differences were statistically significant (

0.05

0.01); in the CG after modeling

the mean arterial pressure

levels of hemoglobin and carbon dioxide partial pressure at 2

4 and 8h were lower than those at 0h; the levels of heart rate and leukocytes were higher than those before modeling; the respiratory rate and platelet levels at 4 and 8h were higher than those at 0h; and the differences were statistically significant (

0.05). The levels of the mean arterial pressure and hemoglobin at 4 and 8h and the pH values at 8h after modeling in the EG were significantly higher than those in the CG

while the heart rate and respiratory rate at 4 and 8h were significantly lower than those in the CG. The pH values at 8h after modeling were significantly lower than those of the other monitored times in the CG (

0.05

0.01). The two groups had elevated levels of alkaline phosphatase after injury induction.

Conclusion:

Through the use of an on-spot interventional treatment cabin

early internal iliac artery embolization can control bleeding associated with pelvic fractures

delay the occurrence of SIRS

and improve the success rate of the treatment of pelvic fracture combined with bleeding.

关键词

Keywords

references

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