Significance of Translation and Transcription in the iRNAMediated LAI Reaction in vitro

韩骅; 王兆裕; 王成济

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Significance of Translation and Transcription in the iRNAMediated LAI Reaction in vitro

Updated：2026-03-12

- Significance of Translation and Transcription in the iRNAMediated LAI Reaction in vitro
- Significance of Translation and Transcription in the iRNAMediated LAI Reaction in vitro
- 解放军医学杂志（英文版） 1988年第2期页码：181-184
- Affiliations：
  
  1. Department of Biochemistry Fourth Millitary Medical University
  2. ,Xi’an
- Author bio：
- Funds：
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  中图分类号：
- 纸质出版：1988
- Accepted：
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Significance of Translation and Transcription in the iRNAMediated LAI Reaction in vitro[J]. 解放军医学杂志（英文版）, 1988,(2):181-184.

[1]韩骅,王兆裕,王成济.Significance of Translation and Transcription in the iRNAMediated LAI Reaction in vitro[J].Journal of Medical Colleges of PLA,1988(02):181-184.
Significance of Translation and Transcription in the iRNAMediated LAI Reaction in vitro[J]. 解放军医学杂志（英文版）, 1988,(2):181-184. DOI：

[1]韩骅,王兆裕,王成济.Significance of Translation and Transcription in the iRNAMediated LAI Reaction in vitro[J].Journal of Medical Colleges of PLA,1988(02):181-184. DOI：

摘要

Abstract

正

The influence of actinomycin D and puromycin on the mediation of cellularimmunity by mouse S

180

ascitic tumor cell-specific iRNA was investigated with

H-Leu-LAItest as an index.The results showed that mouse splenic lymphocytes sensitized with iRNAmaintained their LAI activity after the translation or transcription was blocked bytreatment with puromycin or actinomycin D respectively;and that when first treated withactinomycin D or puromycin

then incubated with iRNA and relevant antigen

thelymphocytes did not show any LAI activity.These results suggest that transcription andtranslation processes in lymphocytes are involved in the mediation of LAI reaction byiRNA

and during the treatment of cancer

the effectivity of iRNA would be reduced by theprevious administration of tumoricidal agents which are suppressive to the RNA and/orprotein synthesis in patient’s lymphocytes.

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