Mechanisms of Natural Killer Cell-mediated Tumor Cell Cytolysis at a Single Cell Level

王小宁; 李文简

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Mechanisms of Natural Killer Cell-mediated Tumor Cell Cytolysis at a Single Cell Level

Updated：2026-03-12

- Mechanisms of Natural Killer Cell-mediated Tumor Cell Cytolysis at a Single Cell Level
- Mechanisms of Natural Killer Cell-mediated Tumor Cell Cytolysis at a Single Cell Level
- 解放军医学杂志（英文版） 1987年第2期页码：107-117
- Affiliations：
  
  1. Department of Immunology First Medical College of PLA
  2. ,Guangzhou
- Author bio：
- Funds：
- DOI：
  中图分类号：
- 纸质出版：1987
- Accepted：
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Mechanisms of Natural Killer Cell-mediated Tumor Cell Cytolysis at a Single Cell Level[J]. 解放军医学杂志（英文版）, 1987,(2):107-117.

[1]王小宁,李文简.Mechanisms of Natural Killer Cell-mediated Tumor Cell Cytolysis at a Single Cell Level[J].Journal of Medical Colleges of PLA,1987(02):107-117+192-193.
Mechanisms of Natural Killer Cell-mediated Tumor Cell Cytolysis at a Single Cell Level[J]. 解放军医学杂志（英文版）, 1987,(2):107-117. DOI：

[1]王小宁,李文简.Mechanisms of Natural Killer Cell-mediated Tumor Cell Cytolysis at a Single Cell Level[J].Journal of Medical Colleges of PLA,1987(02):107-117+192-193. DOI：

摘要

Abstract

<正> The interaction between natural killer cell and tumor target cells at asingle cell level was investigated.The study with a modified single cell cytotoxicassay showed the heterogeneity and requirment of target cell membrane fluidity inthe formation of natural killer cell-tumor target cell conjugates

as well as aninternal disintegration model of natural killer cell-mediated target cell lysis

which may have some relation to the increased lysosome reaction in damagedtargtet cells as revealed by ultrastructural study.From this finding

a“target cellsuicide”model of natural killer cell mediated target cell lysis is proposed.Inaddition to these findings

the interaction of natural emperipolesis lymphocyteswith tumor cells and its relationship to natural killer cell-mediated killing werealso studied and are discussed here.

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